Abstract：
:Tudor domain containing protein 3 (TDRD3) is a modular protein identified based on its ability to recognize methylated arginine motifs through its Tudor domain. We have previously shown that TDRD3 localizes to cytoplasmic stress granules, a structure shown to promote survival upon treatment with chemotherapeutic drugs in cancer cells. Here, we report TDRD3 as a novel regulator of cell proliferation and invasion in breast cancer cells. Our study also demonstrates that TDRD3 depletion inhibits tumor formation and metastasis to the lung in vivo. Furthermore, we show that TDRD3 regulates the expression of a number of key genes associated with promotion of breast cancer tumorigenesis and disease progression. Strikingly, we report that TDRD3 regulates some of these key targets at the level of translation. These findings provide the first experimental demonstration of a functional role for TDRD3 in promoting breast cancer development and progression, and identify TDRD3 as a potential new therapeutic target for breast cancer.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Morettin A,Paris G,Bouzid Y,Baldwin RM,Falls TJ,Bell JC,Côté Jdoi
10.1038/s41598-017-04955-4subject
Has Abstractpub_date
2017-07-11 00:00:00pages
5153issue
1issn
2045-2322pii
10.1038/s41598-017-04955-4journal_volume
7pub_type
杂志文章abstract：:A novel turn-off colorimetric sensor for sequence-specific recognition of single-stranded DNA (ssDNA) was established by combining Y-shaped DNA duplex and G-quadruplex-hemin DNAzyme. A G-rich single-stranded DNA (Oligo-1) displays peroxidase mimicking catalytic activity due to the specific binding with hemin in the pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30529-z
更新日期：2018-08-13 00:00:00
abstract：:The effect of substrate surface roughening on the capacitance of Ni(OH)2/NiOOH nanowall array samples produced via chemical bath deposition for 2, 4, 6, 24 and 48 h on an as-received stainless steel substrate and the same substrate after sandblasting has been investigated. Symmetric cells were subjected to 120,000 cha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53365-1
更新日期：2019-11-14 00:00:00
abstract：:This study aimed to develop a cationic nanosuspension of chitosan (CS) and methoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) for ocular delivery of diclofenac (DIC). MPEG-PCL-CS block polymer was synthesized by covalent coupling of MPEG-PCL with CS. The critical micelle concentration of the MPEG-PCL-CS blo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11337
更新日期：2015-06-12 00:00:00
abstract：:Facial mimicry has been suggested to be a behavioral index for emotional empathy. The present study is the first to investigate the link between facial muscle activity and empathy for pain by facial electromyographic (EMG) recording while observers watched videos depicting real-life painful events. Three types of visu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16988
更新日期：2015-12-09 00:00:00
abstract：:Multiple parasitic arthropods of medical importance depend on symbiotic bacteria. While the link between scabies and secondary bacterial infections causing post infective complications of Group A streptococcal and staphylococcal pyoderma is increasingly recognized, very little is known about the microbiota of Sarcopte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47892-0
更新日期：2019-08-13 00:00:00
abstract：:The evolution to bipedalism forced humans to develop suitable strategies for dynamically controlling their balance, ensuring stability, and preventing falling. The natural aging process and traumatic events such as lower-limb loss can alter the human ability to control stability significantly increasing the risk of fa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46721
更新日期：2017-05-11 00:00:00
abstract：:Poor oral health is not only associated with diabetes and cardiovascular disease but adverse pregnancy outcomes. However the influence of dental caries on pregnancy is unknown. The aim of this study was to evaluate the association between dental caries and adverse pregnancy outcomes and the effect of treatment for den...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62306-2
更新日期：2020-03-24 00:00:00
abstract：:In the surface-enhanced fluorescence (SEF) process, it is well known that the plasmonic nanostructure can enhance the light emission of fluorescent emitters. With the help of atomic force microscopy, a hybrid system consisting of a fluorescent nanodiamond and a gold nanoparticle was assembled step-by-step for in situ ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22019-z
更新日期：2018-02-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78275-5
更新日期：2020-12-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22921-6
更新日期：2018-03-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32639
更新日期：2016-09-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24358-3
更新日期：2018-04-18 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep42627. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep46966
更新日期：2018-04-06 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65241-4
更新日期：2020-05-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00695-7
更新日期：2017-04-06 00:00:00
abstract：:The therapeutic management and health challenges caused by atrial fibrillation (AF) differ between different groups. The purpose of this study was to investigate the clinical features of patients hospitalized with AF and to explore the use of anticoagulation treatments in Han and Uygur patients in Xinjiang, northwest ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45884
更新日期：2017-04-10 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22422
更新日期：2016-03-01 00:00:00
abstract：:A conductive, uniform, and ultra-smooth flexible transparent composite film is produced by embedding silver nanowires (AgNWs) into poly(vinyl-butyral) (PVB) without pressure or high-temperature annealing. The adhesion of AgNWs was greatly improved by embedding them in PVB, and surface roughness and sheet resistance (R...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32590-0
更新日期：2018-09-21 00:00:00
abstract：:Screening and in silico modeling are critical activities for the reduction of experimental costs. They also speed up research notably and strengthen the theoretical framework, thus allowing researchers to numerically quantify the importance of a particular subset of information. For example, in fields such as cancer a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33911-z
更新日期：2018-10-24 00:00:00
abstract：:A number of studies have reported that the digit ratio 2D:4D (length of the second finger divided by length of the fourth finger) is smaller (longer fourth digit) in autism spectrum disorder (ASD) than in typically developed (TD) controls. Because form and function are closely related in biological systems, we hypothe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38421-6
更新日期：2019-02-11 00:00:00
abstract：:Supported by histological and genetic evidence implicating myelin, neuroinflammation and oligodendrocyte dysfunction in schizophrenia spectrum disorders (SZ), diffusion tensor imaging (DTI) studies have consistently shown white matter (WM) abnormalities when compared to healthy controls (HC). The diagnostic specificit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32355-9
更新日期：2018-09-20 00:00:00
abstract：:Conventional myeloablative conditioning (MAC) regimens often cause severe regimen-related toxicity (RRT). Furthermore, many patients suffer from poor quality of life in accordance with the increase in long-term survivors. We therefore devised a reduced-toxicity myeloablative conditioning (RTMAC) regimen consisting of ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep06942
更新日期：2014-11-06 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45028
更新日期：2017-03-21 00:00:00
abstract：:Crosstalk between phytohormone pathways is essential in plant growth, development and stress responses. Brassinosteroids (BRs) and ethylene are both pivotal plant growth regulators, and the interaction between these two phytohormones in the tomato response to salt stress is still unclear. Here, we explored the mechani...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35392
更新日期：2016-10-14 00:00:00
abstract：:The significance of antibodies directed against paternal epitopes in the context of obstetric disorders is discussed controversially. In this study anti-HLA and anti-MIC-A antibodies were analysed in sera of women with uneventful pregnancy (n = 101), preeclampsia (PE, n = 55) and gestational diabetes (GDM, n = 36) usi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13275-6
更新日期：2017-10-19 00:00:00
abstract：:TiNb6O17 and TiNb2O7 were synthesized using a solid-state method. The techniques were used to assess the electrochemical performance and lithium diffusion kinetics of TiNb6O17 related to the unit cell volume with TiNb2O7. The charge-discharge curves and cyclic voltammetry revealed TiNb6O17 to have a similar redox pote...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16711-9
更新日期：2017-11-30 00:00:00
abstract：:Botulinum-toxin A (BoNT/A) is used for a wide range of conditions. Intramuscular administration of BoNT/A inhibits the release of acetylcholine at the neuromuscular junction from presynaptic motor neurons causing muscle-paralysis. The aim of the present study was to investigate the effect of high dose intramuscular Bo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14997-3
更新日期：2017-11-07 00:00:00
abstract：:Carotenoids are anti-oxidative agents. Human skin and eyes contain specific carotenoid species known to prevent various pathologies caused by oxidative stress. We quantified skin and eye carotenoid levels and investigated their potential correlation in a population including 985 Japanese patients and staff members of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45751-6
更新日期：2019-06-27 00:00:00
abstract：:Ocean uptake of anthropogenic CO2 reduces pH and saturation state of calcium carbonate materials of seawater, which could reduce the calcification rate of some marine organisms, triggering a negative feedback on the growth of atmospheric CO2. We quantify the effect of this CO2-calcification feedback by conducting a se...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20284
更新日期：2016-02-03 00:00:00
abstract：:Nasoseptal cartilage has been assumed to be isotropic, unlike the well-defined zonal organization of articular cartilage attributed to postnatal biomechanical loading. We know from clinical experience that malrotation of surgical nasoseptal cartilage grafts can lead to increased graft absorption. Other studies have al...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48578-3
更新日期：2019-08-28 00:00:00
