Identification and characterization of SEC24D as a susceptibility gene for hepatitis B virus infection.

abstract：:Balancing the upper body is pivotal for upright and efficient gait. While models have identified potentially useful characteristics of biarticular thigh muscles for postural control of the upper body, experimental evidence for their specific role is lacking. Based on theoretical findings, we hypothesised that biarticu...

journal_title：Scientific reports

authors： Schumacher C,Berry A,Lemus D,Rode C,Seyfarth A,Vallery H

更新日期：2019-10-10 00:00:00

abstract：:Several lines of evidence indicate that Fibronectin Extra Domain A (EDA) promotes metastatic capacity of tumor cells by engaging cell surface α9β1 integrins. This interaction mediated by the C-C loop of EDA activates pro-oncogenic signaling pathways leading to epithelial to mesenchymal transition (EMT) of tumor cells,...

journal_title：Scientific reports

authors： Amin A,Chikan NA,Mokhdomi TA,Bukhari S,Koul AM,Shah BA,Gharemirshamlu FR,Wafai AH,Qadri A,Qadri RA

更新日期：2016-11-16 00:00:00

abstract：:Recent advances in our ability to design DNA binding factors with specificity for desired sequences have resulted in a revolution in genetic engineering, enabling directed changes to the genome to be made relatively easily. Technologies that facilitate specific and precise genome editing, such as knock-in, are critica...

journal_title：Scientific reports

authors： Wu M,Wei C,Lian Z,Liu R,Zhu C,Wang H,Cao J,Shen Y,Zhao F,Zhang L,Mu Z,Wang Y,Wang X,Du L,Wang C

更新日期：2016-04-11 00:00:00

abstract：:Histone deacetylases (HDACs) can enzymatically transferred acetyl functional group from protein or lysine residues of histone, so they can regulate the expression of lots of genes. Now HDACs are used as drug targets and many HDAC inhibitors (HDACis) were approved for cancer therapy or in clinical trials. However, the ...

journal_title：Scientific reports

authors： Song Q,Li M,Fan C,Liu Y,Zheng L,Bao Y,Sun L,Yu C,Song Z,Sun Y,Wang G,Huang Y,Li Y

更新日期：2019-02-20 00:00:00

abstract：:Within the last fifteen years, network theory has been successfully applied both to natural sciences and to socioeconomic disciplines. In particular, bipartite networks have been recognized to provide a particularly insightful representation of many systems, ranging from mutualistic networks in ecology to trade networ...

journal_title：Scientific reports

authors： Saracco F,Di Clemente R,Gabrielli A,Squartini T

更新日期：2015-06-01 00:00:00

abstract：:Multifactorial lifestyle intervention is known to be more effective for ameliorating cognitive decline than single factor intervention; however, the effects of combining exercise with long-chain polyunsaturated fatty acids (LCPUFA) on the elderlies' cognitive function remain unclear. We conducted a randomised, single-...

journal_title：Scientific reports

authors： Tokuda H,Ito M,Sueyasu T,Sasaki H,Morita S,Kaneda Y,Rogi T,Kondo S,Kouzaki M,Tsukiura T,Shibata H

更新日期：2020-07-31 00:00:00

abstract：:Laser Capture Microdissection (LCM) is a powerful tool to isolate and study gene expression pattern of desired and less accessible cells or tissues from a heterogeneous population. Existing LCM-based methods fail to obtain high quality RNA including small RNAs from small microdissected plant tissue and therefore, are ...

journal_title：Scientific reports

authors： Gautam V,Singh A,Singh S,Sarkar AK

更新日期：2016-02-10 00:00:00

abstract：:Although guidelines recommend BRCA testing for all women with non-mucinous epithelial ovarian cancer, there is significant variability in access to testing across the UK. A germline BRCA mutation (BRCAm) in ovarian cancer patients provides prognostic and predictive information and influences clinical management, such ...

journal_title：Scientific reports

authors： Rumford M,Lythgoe M,McNeish I,Gabra H,Tookman L,Rahman N,George A,Krell J

更新日期：2020-02-25 00:00:00

abstract：:Co-existing infection/inflammation and birth asphyxia potentiate the risk of developing neonatal encephalopathy (NE) and adverse outcome. In a newborn piglet model we assessed the effect of E. coli lipopolysaccharide (LPS) infusion started 4 h prior to and continued for 48 h after hypoxia on brain cell death and syste...

journal_title：Scientific reports

authors： Martinello KA,Meehan C,Avdic-Belltheus A,Lingam I,Ragab S,Hristova M,Tann CJ,Peebles D,Hagberg H,Wolfs TGAM,Klein N,Tachtsidis I,Golay X,Kramer BW,Fleiss B,Gressens P,Robertson NJ

更新日期：2019-07-15 00:00:00

abstract：:Spotted seal (Phoca largha) is a critically endangered pinniped in China and South Korea. The conventional method to protect and maintain the P. largha population is to keep them captive in artificially controlled environments. However, little is known about the physiological differences between wild and captive P. la...

journal_title：Scientific reports

authors： Tian J,Du J,Han J,Bao X,Song X,Lu Z

更新日期：2020-10-30 00:00:00

abstract：:To examine the association between 18F-fluorodeoxyglucose (18F-FDG) uptake in positron emission tomography/computed tomography (PET/CT) and the response to anti-programmed cell death-1 (PD-1) monoclonal antibody therapy in non-small cell lung cancer (NSCLC) patients, 89 patients with advanced or recurrent NSCLC were r...

journal_title：Scientific reports

authors： Takada K,Toyokawa G,Yoneshima Y,Tanaka K,Okamoto I,Shimokawa M,Wakasu S,Haro A,Osoegawa A,Tagawa T,Oda Y,Nakanishi Y,Mori M

更新日期：2019-09-16 00:00:00

abstract：:We are presenting a compact radar range system with a scale factor of 105. Replacing the radio frequency (RF) by optical wavelength (300 THz), the system easily fit on a tabletop. We used interferometric time-of-flight to reproduce radar ranging measurements. Sub-micron range accuracy was achieved with a 100 fs laser ...

journal_title：Scientific reports

authors： Blanche PA,Neifeld M,Tuo M,Xin H,Peyghambarian N

更新日期：2018-09-27 00:00:00

abstract：:The application of a lattice structure in the lightweight design of compressor impellers can reduce their mass and moment of inertia, hence improving the effective carrying of aircraft and reducing the start and braking moments of the impeller. The feasibility of a processing-lattice compressor impeller is the prerequ...

journal_title：Scientific reports

authors： Jia D,Li F,Zhang Y

更新日期：2020-01-17 00:00:00

abstract：:Preventing the protein-protein interaction of the cellular chromatin binding protein Lens Epithelium-Derived Growth Factor (LEDGF) and human immunodeficiency virus (HIV) integrase is an important possible strategy for anti-viral treatment for AIDS. We have used Intracellular Antibody Capture technology to isolate a si...

journal_title：Scientific reports

authors： Bao L,Hannon C,Cruz-Mignoni A,Ptchelkine D,Sun MY,Miller A,Bunjobpol W,Quevedo CE,Derveni M,Chambers J,Simmons A,Phillips SEV,Rabbitts TH

更新日期：2017-12-04 00:00:00

abstract：:Condensin complexes play crucial roles in chromosome condensation that is a fundamental process to establish the "rod-like" shape of chromosome structure in mitosis. Failure of the chromosome assembly causes chromosome segregation errors and subsequent genomic instability. However, a molecular mechanism that controls ...

journal_title：Scientific reports

authors： Kagami Y,Ono M,Yoshida K

更新日期：2017-07-17 00:00:00

abstract：:Cotton leaf curl disease (CLCuD), caused by cotton leaf curl viruses (CLCuVs), is among the most devastating diseases in cotton. While the widely cultivated cotton species Gossypium hirsutum is generally susceptible, the diploid species G. arboreum is a natural source for resistance against CLCuD. However, the influen...

journal_title：Scientific reports

authors： Naqvi RZ,Zaidi SS,Akhtar KP,Strickler S,Woldemariam M,Mishra B,Mukhtar MS,Scheffler BE,Scheffler JA,Jander G,Mueller LA,Asif M,Mansoor S

更新日期：2017-11-21 00:00:00

abstract：:With the advent of nanotechnology, a variety of nanoarchitectures with varied physicochemical properties have been designed. Owing to the unique characteristics, DNAs have been used as a functional building block for novel nanoarchitecture. In particular, a self-assembly of long DNA molecules via a piece DNA staple ha...

journal_title：Scientific reports

authors： Song IH,Shin SW,Park KS,Lansac Y,Jang YH,Um SH

更新日期：2015-12-04 00:00:00

abstract：:Epilepsy is a chronic neurological disease with a variable therapeutic response. To design effective treatment strategies for epilepsy, it is important to understand treatment responses and predictive factors. However, limited data are available in Africa, including Ethiopia. The aim of this study was therefore to ass...

journal_title：Scientific reports

authors： Gidey K,Chelkeba L,Gemechu TD,Daba FB

更新日期：2019-11-07 00:00:00

abstract：:Aluminium alloys are re-evaluated as most feasible way to satisfy the industrial needs of light-weight structural materials. However, unlike conventional structural metals such as iron and titanium, aluminium does not have easily accessible secondary phases, which means that aluminium-based alloys cannot be strengthen...

journal_title：Scientific reports

authors： Tsuru T,Shimizu K,Yamaguchi M,Itakura M,Ebihara K,Bendo A,Matsuda K,Toda H

更新日期：2020-04-06 00:00:00

abstract：:Traditionally, dynamic atomic force microscopy (AFM) techniques are based on the analysis of the quasi-steady state response of the cantilever deflection in terms of Fourier analysis. Here we describe a technique that instead exploits the often disregarded transient response of the cantilever through a relatively mode...

journal_title：Scientific reports

authors： López-Guerra EA,Somnath S,Solares SD,Jesse S,Ferrini G

更新日期：2019-09-03 00:00:00

abstract：:To explore the importance of soil microbial community composition on explaining the difference in heterotrophic soil respiration (R(h)) across forests, a field investigation was conducted on Rh and soil physiochemical and microbial properties in four subtropical forests in southern China. We observed that Rh differed ...

journal_title：Scientific reports

authors： Wei H,Xiao G,Guenet B,Janssens IA,Shen W

更新日期：2015-01-19 00:00:00

abstract：:Good mechanical properties and large adiabatic temperature change render Heusler-type Ni2FeGa-based magnetic shape memory alloys as a promising candidate material for solid-state mechanical cooling application at ambient conditions. Superelastic behavior and associated elastocaloric effect strongly reply on deformatio...

journal_title：Scientific reports

authors： Li Y,Zhao D,Liu J

更新日期：2016-05-03 00:00:00

abstract：:Light regulates cGMP concentration in the photoreceptor cytoplasm by activating phosphodiesterase (PDE) molecules through a G-protein signalling cascade. Spontaneous PDE activity is present in rod outer segments even in darkness. This basal PDE activity (βdark) has not been determined in wild type mammalian photorecep...

journal_title：Scientific reports

authors： Turunen TT,Koskelainen A

更新日期：2019-02-04 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) represent an almost limitless source of cells for disease modelling and drug screening applications. Here we established an efficient and robust 3D platform for cardiomyocyte (CMs) production from hiPSCs, solely through small-molecule-based temporal modulation of the Wnt s...

journal_title：Scientific reports

authors： Branco MA,Cotovio JP,Rodrigues CAV,Vaz SH,Fernandes TG,Moreira LM,Cabral JMS,Diogo MM

更新日期：2019-06-25 00:00:00

abstract：:In a standard semiconductor laser, electrons and holes recombine via stimulated emission to emit coherent light, in a process that is far from thermal equilibrium. Exciton-polariton condensates-sharing the same basic device structure as a semiconductor laser, consisting of quantum wells coupled to a microcavity-have b...

journal_title：Scientific reports

authors： Horikiri T,Yamaguchi M,Kamide K,Matsuo Y,Byrnes T,Ishida N,Löffler A,Höfling S,Shikano Y,Ogawa T,Forchel A,Yamamoto Y

更新日期：2016-05-19 00:00:00

abstract：:The advent of Fluorescence Microscopy over the last few years have dramatically improved the problem of visualization and tracking of specific cellular objects for biological inference. But like any other imaging system, fluorescence microscopy has its own limitations. The resultant images suffer from the effect of no...

journal_title：Scientific reports

authors： Maji SK,Yahia H

更新日期：2019-05-22 00:00:00

abstract：:We propose a new strategy to design broadband and wide angle diffusion metasurfaces. An anisotropic structure which has opposite phases under x- and y-polarized incidence is employed as the "0" and "1" elements base on the concept of coding metamaterial. To obtain a uniform backward scattering under normal incidence, ...

journal_title：Scientific reports

authors： Zhao Y,Cao X,Gao J,Sun Y,Yang H,Liu X,Zhou Y,Han T,Chen W

更新日期：2016-04-01 00:00:00

abstract：:Although collateral vessel growth is distinctly enhanced by elevated fluid shear stress (FSS), the underlying regulatory mechanism of this process remains incompletely understood. Recent studies have shown that microRNAs (miRNAs) play a pivotal role in vascular development, homeostasis and a variety of diseases. There...

journal_title：Scientific reports

authors： Guan Y,Cai B,Wu X,Peng S,Gan L,Huang D,Liu G,Dong L,Xiao L,Liu J,Zhang B,Cai WJ,Schaper J,Schaper W

更新日期：2017-07-27 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) is a useful noninvasive technique of cortical brain stimulation for the treatment of neurological disorders. Clinical research has demonstrated tDCS with anodal stimulation of primary motor cortex (M1) in Parkinson's disease (PD) patients significantly improved their moto...

journal_title：Scientific reports

authors： Li H,Lei X,Yan T,Li H,Huang B,Li L,Xu L,Liu L,Chen N,Lü L,Ma Y,Xu L,Li J,Wang Z,Zhang B,Hu X

更新日期：2015-07-29 00:00:00

abstract：:We report the high susceptibility of several clinical isolates of Propionibacterium acnes from different sources (skin, bone, wound exudates, abscess or blood contamination) to the head-to-tail cyclized bacteriocin AS-48. This peptide is a feasible candidate for further pharmacological development against this bacteri...

journal_title：Scientific reports

authors： Cebrián R,Arévalo S,Rubiño S,Arias-Santiago S,Rojo MD,Montalbán-López M,Martínez-Bueno M,Valdivia E,Maqueda M

更新日期：2018-08-06 00:00:00