Abstract:
:In this study, we identified a CD105+CD90.1-CD133-CD55- (CD133-CD55-) population in the fetal skeletal element that can generate bone and bone marrow. Besides osteoblasts and chondrocytes, the CD133-CD55- common progenitors can give rise to marrow reticular stromal cells and perivascular mesenchymal progenitors suggesting they function as the fetal common skeletal progenitor. Suppression of CXCL12 and Kitl expression in CD133-CD55- common progenitors severely disrupted the BM niche formation but not bone generation. Thus, CD133-CD55- common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Weng L,Hu X,Kumar B,Garcia M,Todorov I,Jung X,Marcucci G,Forman SJ,Chen CCdoi
10.1038/srep38632subject
Has Abstractpub_date
2016-12-08 00:00:00pages
38632issn
2045-2322pii
srep38632journal_volume
6pub_type
杂志文章abstract::Air-core magnetometers are amongst the most commonly used magnetic field detectors in biomedical instruments. They offer excellent sensitivity, low fabrication complexity and a robust, cost-effective solution. However, air-core magnetometers must be tailored to the specific application to achieve high sensitivity, whi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02099-z
更新日期:2017-05-23 00:00:00
abstract::Although the cognitive impairment in Alzheimer's disease (AD) is believed to be caused by amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), several postmortem studies have reported cognitive normal subjects with AD brain pathology. As the mechanism underlying these discrepancies has not been clarified, we foc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19442-7
更新日期:2018-01-26 00:00:00
abstract::Invasive alien species are regarded a nuisance. This extends into a lack of conservation efforts in their native range. As a consequence, conservation of e.g. range-edge populations is neglected. Gobiidae have many representatives of alien species in European freshwaters, and therefore they have a bad reputation. Obje...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56264-7
更新日期:2019-12-23 00:00:00
abstract::Crosslinking is an effective way to fabricate high-selective CO2 separation membranes because of its unique crosslinking framework. Thus, it is essentially significant to study the influence of crosslinking degree on the permeation selectivities of CO2. Herein, we report a successful and facile synthesis of a series o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40082
更新日期:2017-01-04 00:00:00
abstract::Incorporation of Zn atoms into a nanosize Cu lattice is known to alter the electronic properties of Cu, improving catalytic performance in a number of industrially important reactions. However the structural influence of Zn on the Cu phase is not well studied. Here, we show that Cu nano-clusters modified with increasi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20527
更新日期:2016-02-09 00:00:00
abstract::X-linked Alport syndrome (XLAS) is a congenital renal disease caused by mutations in COL4A5. In XLAS cases suspected of being caused by aberrant splicing, transcript analysis needs to be conducted to determine splicing patterns and assess the pathogenicity. However, such analysis is not always available. We conducted ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48990-9
更新日期:2019-09-03 00:00:00
abstract::The high metabolic activity associated with endurance flights and intense fuelling of migrant birds may produce large quantities of reactive oxygen species, which cause oxidative damage. Yet it remains unknown how long-lived birds prepare for oxidative challenges prior to extreme flights. We combined blood measurement...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54057-6
更新日期:2019-11-26 00:00:00
abstract::It is well recognized that osteocytes communicate with each other via gap junctions and that connxin43 (Cx43) shows its great potential in gap junction for the contribution enabling transmission of small molecules and operating in an autocrine/a paracrine manner. Fibroblast growth factors (FGFs) play significant roles...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33247-8
更新日期:2018-10-04 00:00:00
abstract::Mastery over the structure of nanoparticles might be an effective way to enhance their performance for a given application. Herein we demonstrate the design of cage-bell nanostructures to enhance the methanol tolerance of platinum (Pt) nanoparticles while remaining their catalytic activity for oxygen reduction reactio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16219
更新日期:2015-11-18 00:00:00
abstract::Although the effects of osteoporosis on the skeleton are well studied, site-specific and long-term studies on the mandible are still lacking. This study investigated the time-course changes of the bone microarchitecture in the mandibular condyle in comparison to the corresponding changes in the alveolar bone, body of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50554-w
更新日期:2019-10-02 00:00:00
abstract::Fusarium Head Blight (FHB) caused by Fusarium graminearum pathogens constitutes a major threat to agricultural production because it frequently reduces the yield and quality of the crop. The disease severity is predicted to increase in various regions owing to climate change. Integrated management where biocontrol pla...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37718-w
更新日期:2019-01-24 00:00:00
abstract::Dysregulation of iron metabolism, and resultant cytotoxicity, has been implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative processes. Iron accumulation promotes cytotoxicity through various mechanisms including oxidative stress and glutamate toxicity, and occurs in both MS patients an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48087-3
更新日期:2019-08-12 00:00:00
abstract::The live attenuated yellow fever (YF) vaccine is a highly effective human vaccine and induces long-term protective neutralizing antibodies directed against the viral envelope protein E. The generation of such antibodies requires the help of CD4 T cells which recognize peptides derived from proteins in virus particles ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09331-w
更新日期:2017-08-21 00:00:00
abstract::The cuticle of the beetle Chrysina chrysargyrea reflects left-handed polarized light in the broad spectral range from 340 to 1000 nm. Interference oscillations in the experimental Mueller-matrix spectroscopic ellipsometry data reveal that transparent materials comprise the cuticle. A spectral analysis of the interfere...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24761-w
更新日期:2018-04-24 00:00:00
abstract::Neoadjuvant systemic treatment is increasingly being integrated in the standard treatment of pancreatic ductal adenocarcinoma (PDAC) patients to improve oncological outcomes. Current available imaging techniques remain unreliable in assessing response to therapies, as they cannot distinguish between (vital) tumor tiss...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73242-6
更新日期:2020-10-01 00:00:00
abstract::Non-traumatic osteonecrosis (ON) of the femoral head is a common disease affecting a young population as the peak age of diagnosis is in the 40 s. The natural history of non-traumatic ON leads to a collapse of the femoral head requiring prosthetic replacement in a 60% of cases. Although trabecular bone involvement in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00162-3
更新日期:2017-03-07 00:00:00
abstract::The Na+;HCO3- co-transporter NBCn1 (SLC4A7) is a major regulator of intracellular pH yet its trafficking and turnover are essentially unstudied. Here, we used MDCK-II and MCF-7 cells to investigate these processes in epithelial cells. GFP-NBCn1 membrane localization was abolished by truncation of the full NBCn1 C-term...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25059-7
更新日期:2018-05-09 00:00:00
abstract::The feedback between dyke and sill intrusions and the evolution of stresses within volcanic systems is poorly understood, despite its importance for magma transport and volcano instability. Long-lived ocean island volcanoes are crosscut by thousands of dykes, which must be accommodated through a combination of flank s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74361-w
更新日期:2020-10-15 00:00:00
abstract::Silver nanobelts (AgNBs) have attracted a great interest due to their excellent electrical conductivity and mechanical strength, leading a facile synthesis of these AgNBs in great demand. In here, we are reporting a simple, aqueous phase, size tunable synthesis of smooth surfaced 1D-silver nanobelts using a Polyanilin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44796
更新日期:2017-03-20 00:00:00
abstract::Our study aimed to investigate the effect of Pap smear screening on stage at diagnosis of cervical cancer in a heterogeneous population of Thai women. Data was merged from the population-based cancer registry and screening registry based on unique identification numbers from 2006 to 2014. Patients being screened had l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52607-6
更新日期:2019-11-15 00:00:00
abstract::We employ nematic liquid crystals as the nonlinear medium to recover noisy images via stochastic resonance, in which nonlinear coupling allows signals to grow at the expense of noise. The process is theoretically analyzed and the cross-correlation is numerically calculated. It is found that the quality of output image...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40676-6
更新日期:2019-03-08 00:00:00
abstract::Intelligent development is an inevitable choice for the green development of manufacturing enterprises, environmental regulations and green innovation play an important role in the intelligent development of manufacturing enterprises. By analyzing the interrelationships between environmental regulations, green innovat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71423-x
更新日期:2020-09-02 00:00:00
abstract::Airway mucus overproduction is one of the most common symptoms of asthma that causes severe clinical outcomes in patients. Despite the effectiveness of general asthma therapies, specific treatments that prevent mucus overproduction in asthma patients remain lacking. Recent studies have found that activation of GABAA r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32756
更新日期:2016-09-06 00:00:00
abstract::Detecting communities or clusters in a real-world, networked system is of considerable interest in various fields such as sociology, biology, physics, engineering science, and interdisciplinary subjects, with significant efforts devoted in recent years. Many existing algorithms are only designed to identify the compos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24017
更新日期:2016-04-07 00:00:00
abstract::Actinorhizal plants are ecologically and economically important. Symbiosis with nitrogen-fixing bacteria allows these woody dicotyledonous plants to colonise soils under nitrogen deficiency, water-stress or other extreme conditions. However, proteins involved in xerotolerance of symbiotic microorganisms have yet to be...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18839-0
更新日期:2018-01-15 00:00:00
abstract::Gliomas are heterogeneous, primary brain tumours that originate from glial cells. The main type of gliomas is astrocytomas. There are four grades (I-IV) of astrocytoma malignancy. Astrocytoma grade IV known as glioblastoma multiforme (GBM) is the most common and aggressive type of astrocytic gliomas. Metallothioneins ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41974-9
更新日期:2019-04-01 00:00:00
abstract::The marine bacterial strain Desulfovibrio ferrophilus IS5, known for its lithotrophic growth ability to use metallic iron as a sole electron donor and for causing corrosion of steel, was used in the current study. Four commonly used biocides in the oil and gas industry, namely tetrakis(hydroxymethyl) phosphonium sulfa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34789-7
更新日期:2018-11-09 00:00:00
abstract::Acyl-CoA:diacylglycerol acyltransferase I (DGAT1) is a key enzyme in lipogenesis which is increased in metabolically active cells to meet nutrient requirements. DGAT1 has been recognized as an anti-obesity target; however, its role in the tumor microenvironment remains unclear. We postulated that, in prostate cancer (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39537-z
更新日期:2019-02-28 00:00:00
abstract::Investigation of protein-DNA interactions provides crucial information for understanding the mechanisms of gene regulation. Current methods for studying protein-DNA interactions, such as DNaseI footprinting or gel shift assays, involve labeling DNA with radioactive or fluorescent tags, making these methods costly, lab...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21030
更新日期:2016-02-15 00:00:00
abstract::The regulatory (neuro)peptide galanin and its three receptors (GAL1-3R) are involved in immunity and inflammation. Galanin alleviated inflammatory bowel disease (IBD) in rats. However, studies on the galanin receptors involved are lacking. We aimed to determine galanin receptor expression in IBD patients and to evalua...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79456-y
更新日期:2021-01-12 00:00:00