Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor.

Abstract:

:In this study, we identified a CD105+CD90.1-CD133-CD55- (CD133-CD55-) population in the fetal skeletal element that can generate bone and bone marrow. Besides osteoblasts and chondrocytes, the CD133-CD55- common progenitors can give rise to marrow reticular stromal cells and perivascular mesenchymal progenitors suggesting they function as the fetal common skeletal progenitor. Suppression of CXCL12 and Kitl expression in CD133-CD55- common progenitors severely disrupted the BM niche formation but not bone generation. Thus, CD133-CD55- common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Weng L,Hu X,Kumar B,Garcia M,Todorov I,Jung X,Marcucci G,Forman SJ,Chen CC

doi

10.1038/srep38632

subject

Has Abstract

pub_date

2016-12-08 00:00:00

pages

38632

issn

2045-2322

pii

srep38632

journal_volume

6

pub_type

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