Abstract：
:Dysregulation of iron metabolism, and resultant cytotoxicity, has been implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative processes. Iron accumulation promotes cytotoxicity through various mechanisms including oxidative stress and glutamate toxicity, and occurs in both MS patients and in the experimental autoimmune encephalomyelitis (EAE) model of MS. Divalent Metal Transporter1, a major iron importer in cells, is stimulated by signaling of Dexras1, a small G protein member of the Ras family. Dexras1 is activated by S-nitrosylation by nitric oxide (NO) produced by either inducible nitric oxide synthase in activated microglia/macrophages or neuronal nitric oxide synthase in neurons. Here we show Dexras1 exacerbates oxidative stress-induced neurodegeneration in experimental optic neuritis, an inflammatory demyelinating optic nerve condition that occurs in MS and EAE. Dexras1 deletion, as well as treatment with the iron chelator deferiprone, preserves vision and attenuates retinal ganglion cell (RGC) and axonal loss during EAE optic neuritis. These results suggest that iron entry triggered by NO-activated Dexras1 signaling is a potential mechanism of neuronal death in experimental optic neuritis. The current data suggest modulation of Dexras1 signaling and iron chelation are potential novel treatment strategies for optic neuritis and MS, and possibly other optic neuropathies as well.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Khan RS,Baumann B,Dine K,Song Y,Dunaief JL,Kim SF,Shindler KSdoi
10.1038/s41598-019-48087-3subject
Has Abstractpub_date
2019-08-12 00:00:00pages
11664issue
1issn
2045-2322pii
10.1038/s41598-019-48087-3journal_volume
9pub_type
杂志文章abstract：:Osteochondral defects contain damage to both the articular cartilage and underlying subchon- dral bone, which remains a significant challenge in orthopedic surgery. Layered structure of bone, cartilage and the bone-cartilage interface must be taken into account in the case of biofabrication of the osteochondral (OC) i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69960-6
更新日期：2020-08-04 00:00:00
abstract：:Cognition has been found to constrain several aspects of human behaviour, such as the number of friends and the number of favourite places a person keeps stable over time. This limitation has been empirically defined in the physical and social spaces. But do people exhibit similar constraints in the digital space? We ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47493-x
更新日期：2019-07-29 00:00:00
abstract：:Intense geomagnetic storms can cause severe damage to electrical systems and communications. This work proposes a counting process with Weibull inter-occurrence times in order to estimate the probability of extreme geomagnetic events. It is found that the scale parameter of the inter-occurrence time distribution grows...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38918-8
更新日期：2019-02-20 00:00:00
abstract：:A novel type of sub-lattice of the Jahn-Teller (JT) centers was arranged in Ti-doped barium hexaferrite BaFe12O19. In the un-doped crystal all iron ions, sitting in five different crystallographic positions, are Fe3+ in the high-spin configuration (S = 5/2) and have a non-degenerate ground state. We show that the elec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63915-7
更新日期：2020-04-27 00:00:00
abstract：:Extranodal NK/T-cell lymphoma, nasal type (NKTL) is an aggressive type of non-Hodgkin lymphoma closely associated with Epstein-Barr virus and characterized by varying degrees of systemic inflammation. We aim to examine the prognostic significance of peripheral blood neutrophil-lymphocyte ratio (NLR) in patients with N...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/s41598-019-51522-0
更新日期：2019-10-18 00:00:00
abstract：:Spectrometers now offer the field strengths necessary to visualize mammalian cells but were not designed to accommodate imaging of live tissues. As such, spectrometers pose significant challenges--the most evident of which are spatial limitations--to conducting experiments in living tissue. This limitation becomes pro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18095
更新日期：2015-12-15 00:00:00
abstract：:Angiosperm mitochondrial genomes (mtDNA) exhibit variable quantities of alien sequences. Many of these sequences are acquired by intracellular gene transfer (IGT) from the plastid. In addition, frequent events of horizontal gene transfer (HGT) between mitochondria of different species also contribute to their expanded...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43402
更新日期：2017-03-06 00:00:00
abstract：:Adenoviruses are very efficient vectors for delivering therapeutic genes in preclinical and clinical trials. However, randomized controlled human trials have often been lacking clear clinically relevant results. We hypothesized that high lipid levels and specific lipoproteins could significantly decrease adenoviral tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00376-5
更新日期：2017-03-24 00:00:00
abstract：:The cannabinoid type 1 (CB1) receptor and the capsaicin receptor (TRPV1) exhibit co-expression and complex, but largely unknown, functional interactions in a sub-population of primary sensory neurons (PSN). We report that PSN co-expressing CB1 receptor and TRPV1 form two distinct sub-populations based on their pharmac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33307
更新日期：2016-09-22 00:00:00
abstract：:Cystic fibrosis (CF) patients experience heightened levels of anxiety and depression. Stress from dealing with chronic disease and rigorous treatment regimens certainly are primary contributors to these outcomes. We previously have demonstrated that microtubule alterations in CF are linked to a number of CF phenotypes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73298-4
更新日期：2020-10-01 00:00:00
abstract：:We have designed a fully automated optical microscope running at high-speed and achieving a very high spatial resolution. In order to overcome the resolution limit of optical microscopes, it exploits the localized surface plasmon resonance phenomenon. The customized setup using a polarization analyzer, based on liquid...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75883-z
更新日期：2020-11-02 00:00:00
abstract：:The application of metabolic phenotyping in clinical and epidemiological studies is limited by a poor understanding of inter-individual, intra-individual and temporal variability in metabolic phenotypes. Using 1H NMR spectroscopy we characterised short-term variability in urinary metabolites measured from 20 children ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46082
更新日期：2017-04-19 00:00:00
abstract：:Ankle arthrodesis with the Ilizarov method is an accepted form of treatment of advanced degenerative changes of the ankle joint. Incorrect balance and load distribution on the lower limbs may result in pain and dysfunction. The aim of the study was to assess the change of balance and load distribution in lower extremi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34016-3
更新日期：2018-10-24 00:00:00
abstract：:Our motor system can generate representations which carry information about the goals of another agent's actions. However, it is not known whether motor representations play a deeper role in social understanding, and, in particular, whether they enable tracking others' beliefs. Here we show that, for adult observers, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68240-7
更新日期：2020-07-09 00:00:00
abstract：:Cues previously paired with rewarding stimuli induce a time-dependent increase in the motivational craving state (incubation of craving). Whether there is an increase in craving for high-fat (HF) food over time, which may contribute to overeating and obesity, has not been determined. We hypothesized that cues paired w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30900
更新日期：2016-08-03 00:00:00
abstract：:Neutrophil gelatinase-associated lipocalin (NGAL, lipocalin 2 or LCN2) is an iron carrier protein whose circulating level is increased by kidney injury, bacterial infection and obesity, but its metabolic consequence remains elusive. To study physiological role of LCN2 in energy homeostasis, we challenged female Lcn2 k...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15825-4
更新日期：2017-11-14 00:00:00
abstract：:Geranylated 4-phenylcoumarins DMDP-1 and DMDP-2 isolated from Mesua elegans were elucidated for their role in inducing caspase-independent programmed cell death (CI-PCD) in prostate cancer cell lines, PC-3 and DU 145, respectively. Cell homeostasis disruption was demonstrated upon treatment, as shown by the increase i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57781-6
更新日期：2020-01-22 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron loss that ultimately leads to fatal paralysis. Reducing levels or function of the tyrosine kinase, ephrin type-A receptor 4 (EphA4), has been suggested as a potential approach for slowing disease progression in ALS. Becaus...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72723-y
更新日期：2020-09-24 00:00:00
abstract：:Bradysia odoriphaga and Bradysia difformis are devastating pests of vegetable, ornamental crops and edible mushrooms causing significant losses. Temperature may be an important factor restricting their population abundance in the summer. To determine the effects of short-term heat shock on adults, their survival, long...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13560-4
更新日期：2017-10-17 00:00:00
abstract：:The rockpool shrimp Palaemon elegans is an ecologically important crustacean species within the European coastline fauna. In the present study, genetic diversity and population structure and connectivity were assessed by examining 21 polymorphic microsatellite loci at 13 sampling sites located along the natural distri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67824-7
更新日期：2020-07-01 00:00:00
abstract：:Large (>10 kb) palindromic sequences are enriched on mammalian sex chromosomes. In mice, these palindromes harbor gene families (≥2 gene copies) expressed exclusively in post-meiotic testicular germ cells, a time when most single-copy sex-linked genes are transcriptionally repressed. This observation led to the hypoth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27360-x
更新日期：2018-06-12 00:00:00
abstract：:In the present study, channelrhodopsin 2 (ChR2) was specifically introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, which encodes for the enzyme responsible for conversion of noradrenaline to adrenaline. The new murine model enabled the identification of a distinctive class...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40687
更新日期：2017-01-13 00:00:00
abstract：:Age-related hearing loss has been related to a compensatory increase in audio-visual integration and neural reorganization including alterations in functional resting state connectivity. How these two changes are linked in elderly listeners is unclear. The current study explored modulatory effects of hearing threshold...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74012-0
更新日期：2020-10-12 00:00:00
abstract：:Au nanoparticles (AuNPs), which easily aggregate in organic thin film, are observed to well-disperse in chicken albumen thin films. The incorporated AuNPs is distributed uniformly inside the thin film and is as dense as 650 (particles/μm(3)). In addition, enhanced ultraviolet (UV) fluorescence centered at 350 nm is ob...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01505
更新日期：2013-01-01 00:00:00
abstract：:Multiferroic BiFeO3 exhibits excellent magnetoelectric coupling critical for magnetic information processing with minimal power consumption. However, the degenerate nature of the easy spin axis in the (111) plane presents roadblocks for real world applications. Here, we explore the stabilization and switchability of t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12969
更新日期：2015-08-06 00:00:00
abstract：:Hyaluronic acid (HA) is a glycosaminoglycan that plays many roles in health and disease and is a key biomarker of certain cancers. Therefore, its detection at an early stage, by histochemical methods, is of importance. However, intracellular HA can be masked by other HA-binding macromolecules, rendering its visualizat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40348-5
更新日期：2019-03-08 00:00:00
abstract：:Osteopontin (OPN), a multifunctional cytokine that controls liver glycerolipid metabolism, is involved in activation and proliferation of several liver cell types during regeneration, a condition of high metabolic demands. Here we investigated the role of OPN in modulating the liver lipidome during regeneration after ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32919-9
更新日期：2018-10-02 00:00:00
abstract：:Radionuclide molecular imaging of cancer-specific targets is a promising method to identify patients for targeted antibody therapy. Radiolabeled full-length antibodies however suffer from slow clearance, resulting in high background radiation. To overcome this problem, a pretargeting system based on complementary pept...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77523-y
更新日期：2020-11-27 00:00:00
abstract：:The properties of metal matrix composites (MMCs) can be optimized effectively through adjusting the type or the volume fraction of reinforcement. Generally, the coefficient of thermal expansion (CTE) of MMCs can be reduced by increasing the volume fraction of the reinforcement with lower CTE than metal matrix. However...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27118
更新日期：2016-06-03 00:00:00
abstract：:We propose a hybrid plasmonic device consisting of a planar dielectric waveguide covering a gold nanostripe array fabricated on a gold film and investigate its guiding properties at telecom wavelengths. The fundamental modes of a hybrid device and their dependence on the key geometric parameters are studied. A communi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45196
更新日期：2017-03-24 00:00:00
