当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > A clinicohaematological prognostic model for nasal-type natural killer/T-cell lymphoma: A multicenter study.

A clinicohaematological prognostic model for nasal-type natural killer/T-cell lymphoma: A multicenter study.

Abstract：

:Extranodal NK/T-cell lymphoma, nasal type (NKTL) is an aggressive type of non-Hodgkin lymphoma closely associated with Epstein-Barr virus and characterized by varying degrees of systemic inflammation. We aim to examine the prognostic significance of peripheral blood neutrophil-lymphocyte ratio (NLR) in patients with NKTL. Therefore, we conducted a retrospective review of 178 patients with biopsy-proven NKTL from the National Cancer Centre Singapore and Samsung Medical Center, South Korea. Using receiver operating curve analysis, an optimal cut-off for high NLR (>3.5) in predicting overall survival (OS) was derived. Survival analysis was performed using the Kaplan-Meier method and multivariable Cox proportional regression. In patients with high NLR, estimated 5-year OS was 25% compared to 53% in those with low NLR. In multivariable analysis, high NLR, in addition to age ≥60 years, presence of B-symptoms and stage III/IV at diagnosis, was independently correlated with worse OS (HR 2.08; 95% CI 1.36 to 3.18; p = 0.0008) and progression-free survival (HR 1.66; 95% CI 1.11 to 2.46; p = 0.0128). A new prognostic index (NABS score) derived from these factors stratified patients into low (0), low-intermediate (1), high-intermediate (2) and high (3-4) risk subgroups, which were associated with 5-year OS of 76.5%, 55.7%, 29.2% and 0% respectively. In conclusion, high NLR is an independent prognostic marker and the NABS model can be used to risk-stratify NKTL patients.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Tan KM,Chia B,Lim JQ,Khoo LP,Cheng CL,Tan L,Poon E,Somasundaram N,Farid M,Tang TPL,Tao M,Cheah DMZ,Laurensia Y,Pang JWL,Song T,Tan J,Huang D,Kim SJ,Kim WS,Ong CK,Lim ST,Chan JY

doi

10.1038/s41598-019-51522-0

subject

Has Abstract

pub_date

2019-10-18 00:00:00

pages

14961

issue

1

issn

2045-2322

pii

10.1038/s41598-019-51522-0

journal_volume

9

pub_type

杂志文章,多中心研究

相关文献

Scientific Reports文献大全
  • Fabrication of copper(II)-coated magnetic core-shell nanoparticles Fe3O4@SiO2-2-aminobenzohydrazide and investigation of its catalytic application in the synthesis of 1,2,3-triazole compounds.

    abstract：:In the present work, an attempt has been made to synthesize the 1,2,3-triazole derivatives resulting from the click reaction, in a mild and green environment using the new copper(II)-coated magnetic core-shell nanoparticles Fe3O4@SiO2 modified by isatoic anhydride. The structure of the catalyst has been determined by ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81632-7

    authors： Rajabi-Moghaddam H,Naimi-Jamal MR,Tajbakhsh M

    更新日期：2021-01-22 00:00:00

  • Author Correction: Hidden diversity in the Brazilian Atlantic rainforest: the discovery of Jurasaidae, a new beetle family (Coleoptera, Elateroidea) with neotenic females.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-60629-8

    authors： Rosa SP,Costa C,Kramp K,Kundrata R

    更新日期：2020-02-25 00:00:00

  • Characterization of a novel reassortant influenza A virus (H2N2) from a domestic duck in Eastern China.

    abstract：:While H2N2 viruses have been sporadically isolated from wild and domestic birds, H2N2 viruses have not been detected among human populations since 1968. Should H2N2 viruses adapt to domestic poultry they may pose a risk of infection to people, as most anyone born after 1968 would likely be susceptible to their infecti...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep07588

    authors： Ma MJ,Yang XX,Qian YH,Zhao SY,Hua S,Wang TC,Chen SH,Ma GY,Sang XY,Liu LN,Wu AP,Jiang TJ,Gao YW,Gray GC,Zhao T,Ling X,Wang JL,Lu B,Qian J,Cao WC

    更新日期：2014-12-23 00:00:00

  • Corrigendum: Effect of age on pro-inflammatory miRNAs contained in mesenchymal stem cell-derived extracellular vesicles.

    abstract：:This corrects the article DOI: 10.1038/srep43923. ...

    journal_title：Scientific reports

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/srep46850

    authors： Fafián-Labora J,Lesende-Rodriguez I,Fernández-Pernas P,Sangiao-Alvarellos S,Monserrat L,Arntz OJ,van de Loo FAJ,Mateos J,Arufe MC

    更新日期：2017-06-15 00:00:00

  • Prognostic significance of distal subtotal gastrectomy with standard D2 and extended D2 lymphadenectomy for locally advanced gastric cancer.

    abstract：:This study was conducted to investigate prognosis and survival of patients undergoing distal subtotal gastrectomy with D2 and D2+ lymphadenectomy for patients with locally advanced gastric cancer. Overall survival rates of 416 patients with locally advanced gastric cancer were compared between D2 and D2+ lymphadenecto...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep17273

    authors： Zhang CD,Shen MY,Zhang JK,Ning FL,Zhou BS,Dai DQ

    更新日期：2015-11-25 00:00:00

  • Simple oral mucosal epithelial transplantation in a rabbit model.

    abstract：:This study investigated a rabbit model of autologous simple oral mucosal epithelium transplantation (SOMET) for limbal stem cell deficiency (LSCD). LSCD was created in the SOMET group and the Control group. In the SOMET group, oral mucosa harvested from the buccal region was treated with dispase, cut into small pieces...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54571-7

    authors： Inamochi A,Tomioka A,Kitamoto K,Miyai T,Usui T,Aihara M,Yamagami S

    更新日期：2019-12-02 00:00:00

  • Barley grain (1,3;1,4)-β-glucan content: effects of transcript and sequence variation in genes encoding the corresponding synthase and endohydrolase enzymes.

    abstract：:The composition of plant cell walls is important in determining cereal end uses. Unlike other widely consumed cereal grains barley is comparatively rich in (1,3;1,4)-β-glucan, a source of dietary fibre. Previous work showed Cellulose synthase-like genes synthesise (1,3;1,4)-β-glucan in several tissues. HvCslF6 encodes...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53798-8

    authors： Garcia-Gimenez G,Russell J,Aubert MK,Fincher GB,Burton RA,Waugh R,Tucker MR,Houston K

    更新日期：2019-11-21 00:00:00

  • Development of Polymer Blends Based on PVA:POZ with Low Dielectric Constant for Microelectronic Applications.

    abstract：:There is a huge request for the development of low dielectric constant polymeric materials for microelectronic applications. In thisstudy, polymer blends based on PVA:POZ with low dielectric constant has been fabricated. The results of XRD indicate that crystalline domain is enhanced at higher POZ concentration. Brill...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49715-8

    authors： Aziz SB,Kadir MFZ,Hamsan MH,Woo HJ,Brza MA

    更新日期：2019-09-11 00:00:00

  • Author Correction: Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-019-42948-7

    authors： Röttgerding F,Wagemakers A,Koetsveld J,Fingerle V,Kirschfink M,Hovius JW,Zipfel PF,Wallich R,Kraiczy P

    更新日期：2019-05-02 00:00:00

  • Hydrogen reverses the clustering tendency of carbon in amorphous silicon oxycarbide.

    abstract：:Amorphous silicon oxycarbide (SiOC) is of great technological interest. However, its atomic-level structure is not well understood. Using density functional theory calculations, we show that the clustering tendency of C atoms in SiOC is extremely sensitive to hydrogen (H): without H, the C-C interaction is attractive,...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13051

    authors： Ding H,Demkowicz MJ

    更新日期：2015-08-13 00:00:00

  • Multiplex epitope mapping using bacterial surface display reveals both linear and conformational epitopes.

    abstract：:As antibody-based diagnosis and therapy grow at an increased pace, there is a need for methods which rapidly and accurately determine antibody-antigen interactions. Here, we report a method for the multiplex determination of antibody epitopes using bacterial cell-surface display. A protein-fragment library with 10(7) ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00706

    authors： Hudson EP,Uhlen M,Rockberg J

    更新日期：2012-01-01 00:00:00

  • Phase Diagram of Continuous Binary Nanoalloys: Size, Shape, and Segregation Effects.

    abstract：:The phase diagrams of continuous binary nanoalloys are important in providing guidance for material designs and industrial applications. However, experimental determination of the nano-phase diagram is scarce since calorimetric measurements remain quite challenging at the nanoscale. Based on the size-dependent cohesiv...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41990

    authors： Cui M,Lu H,Jiang H,Cao Z,Meng X

    更新日期：2017-02-07 00:00:00

  • Automatic Knee Osteoarthritis Diagnosis from Plain Radiographs: A Deep Learning-Based Approach.

    abstract：:Knee osteoarthritis (OA) is the most common musculoskeletal disorder. OA diagnosis is currently conducted by assessing symptoms and evaluating plain radiographs, but this process suffers from subjectivity. In this study, we present a new transparent computer-aided diagnosis method based on the Deep Siamese Convolution...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-20132-7

    authors： Tiulpin A,Thevenot J,Rahtu E,Lehenkari P,Saarakkala S

    更新日期：2018-01-29 00:00:00

  • Novel instrumented frame for standing exercising of users with complete spinal cord injuries.

    abstract：:This paper describes a Functional Electrical Stimulation (FES) standing system for rehabilitation of bone mineral density (BMD) in people with Spinal Cord Injury (SCI). BMD recovery offers an increased quality of life for people with SCI by reducing their risk of fractures. The standing system developed comprises an i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49237-3

    authors： Zoulias ID,Armengol M,Poulton A,Andrews B,Gibbons R,Harwin WS,Holderbaum W

    更新日期：2019-09-10 00:00:00

  • Superconductivity in two-dimensional ferromagnetic MnB.

    abstract：:Using the universal structure predictor algorithm, we proposed that two-dimensional MnB structures with p4mmm (α-MnB) and pmma (β-MnB) symmetries could be synthesized. This finding was verified by calculating the dynamical stability, molecular dynamics, and mechanical properties. The α-MnB had an in-plane stiffness Y ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17235-y

    authors： Farooq MU,Hashmi A,Khan I,Hong J

    更新日期：2017-12-06 00:00:00

  • Iron oxide nanocatalyst with titanium and silver nanoparticles: Synthesis, characterization and photocatalytic activity on the degradation of Rhodamine B dye.

    abstract：:Nowadays, there is a growing concern about the environmental impacts of colored wastewater. Thus, the present work aims the synthesis, characterization and determination of photocatalytic activity of iron oxide (Fe2O3) nanocatalyst, evaluating the effect of hybridization with titanium (TiNPs-Fe2O3) and silver (AgNPs-F...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59987-0

    authors： Muraro PCL,Mortari SR,Vizzotto BS,Chuy G,Dos Santos C,Brum LFW,da Silva WL

    更新日期：2020-02-20 00:00:00

  • N-hypermannose glycosylation disruption enhances recombinant protein production by regulating secretory pathway and cell wall integrity in Saccharomyces cerevisiae.

    abstract：:Saccharomyces cerevisiae is a robust host for heterologous protein expression. The efficient expression of cellulases in S. cerevisiae is important for the consolidated bioprocess that directly converts lignocellulose into valuable products. However, heterologous proteins are often N-hyperglycosylated in S. cerevisiae...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25654

    authors： Tang H,Wang S,Wang J,Song M,Xu M,Zhang M,Shen Y,Hou J,Bao X

    更新日期：2016-05-09 00:00:00

  • A perfectly stoichiometric and flat CeO2(111) surface on a bulk-like ceria film.

    abstract：:In surface science and model catalysis, cerium oxide (ceria) is mostly grown as an ultra-thin film on a metal substrate in the ultra-high vacuum to understand fundamental mechanisms involved in diverse surface chemistry processes. However, such ultra-thin films do not have the contribution of a bulk ceria underneath, ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep21165

    authors： Barth C,Laffon C,Olbrich R,Ranguis A,Parent P,Reichling M

    更新日期：2016-02-16 00:00:00

  • Metabolomics Identifies Biomarker Pattern for Early Diagnosis of Hepatocellular Carcinoma: from Diethylnitrosamine Treated Rats to Patients.

    abstract：:Early diagnosis of hepatocellular carcinoma (HCC) remains challenging to date. Characteristic metabolic deregulations of HCC may enable novel biomarkers discovery for early diagnosis. A capillary electrophoresis-time of flight mass spectrometry (CE-TOF/MS)-based metabolomics approach was performed to discover and vali...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16101

    authors： Zeng J,Huang X,Zhou L,Tan Y,Hu C,Wang X,Niu J,Wang H,Lin X,Yin P

    更新日期：2015-11-03 00:00:00

  • Prenatal Maternal Stress from a Natural Disaster Alters Urinary Metabolomic Profiles in Project Ice Storm Participants.

    abstract：:Prenatal stress is known to epigenetically program offspring physiology and behaviour, and may become a risk factor for adult complex diseases. To gain insight into the underlying environment-gene interactions, we used proton nuclear magnetic resonance spectroscopy to analyze urinary metabolomes of male and female ado...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-018-31230-x

    authors： Paxman EJ,Boora NS,Kiss D,Laplante DP,King S,Montina T,Metz GAS

    更新日期：2018-08-28 00:00:00

  • Author Correction: 3D Printed Polyvinyl Alcohol Tablets with Multiple Release Profiles.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-59303-w

    authors： Xu X,Zhao J,Wang M,Wang L,Yang J

    更新日期：2020-02-06 00:00:00

  • Effectiveness of hypnosis for pain management and promotion of health-related quality-of-life among people with haemophilia: a randomised controlled pilot trial.

    abstract：:Joint deterioration and associated chronic pain are common among people with haemophilia (PWH), having an impact on quality-of-life. Though non-pharmacological strategies are recommended, psychological interventions to promote pain control and quality-of-life have scarcely been tested in haemophilia. This randomised c...

    journal_title：Scientific reports

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/s41598-019-49827-1

    authors： Paredes AC,Costa P,Fernandes S,Lopes M,Carvalho M,Almeida A,Pinto PR

    更新日期：2019-09-16 00:00:00

  • Doubly curved nanofiber-reinforced optically transparent composites.

    abstract：:Doubly curved nanofiber-reinforced optically transparent composites with low thermal expansion of 15 ppm/k are prepared by hot pressing vacuum-filtered Pickering emulsions of hydrophobic acrylic resin monomer, hydrophilic chitin nanofibers and water. The coalescence of acrylic monomer droplets in the emulsion is preve...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16421

    authors： Shams MI,Yano H

    更新日期：2015-11-10 00:00:00

  • Nitrogen-doped Graphene-Supported Transition-metals Carbide Electrocatalysts for Oxygen Reduction Reaction.

    abstract：:A novel and facile two-step strategy has been designed to prepare high performance bi-transition-metals (Fe- and Mo-) carbide supported on nitrogen-doped graphene (FeMo-NG) as electrocatalysts for oxygen reduction reactions (ORR). The as-synthesized FeMo carbide -NG catalysts exhibit excellent electrocatalytic activit...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10389

    authors： Chen M,Liu J,Zhou W,Lin J,Shen Z

    更新日期：2015-05-22 00:00:00

  • Maskless plasmonic lithography at 22 nm resolution.

    abstract：:Optical imaging and photolithography promise broad applications in nano-electronics, metrologies, and single-molecule biology. Light diffraction however sets a fundamental limit on optical resolution, and it poses a critical challenge to the down-scaling of nano-scale manufacturing. Surface plasmons have been used to ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00175

    authors： Pan L,Park Y,Xiong Y,Ulin-Avila E,Wang Y,Zeng L,Xiong S,Rho J,Sun C,Bogy DB,Zhang X

    更新日期：2011-01-01 00:00:00

  • Sensitization and synergistic anti-cancer effects of Furanodiene identified in zebrafish models.

    abstract：:Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae, a well-known Chinese medicinal herb that presents anticancer effects in various types of cancer cell lines. In this study, we have successfully established zebrafish xenografts with 5 various human cancer cell lines; and validated these models with ant...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40866-2

    authors： Zhu XY,Guo DW,Lao QC,Xu YQ,Meng ZK,Xia B,Yang H,Li CQ,Li P

    更新日期：2019-03-14 00:00:00

  • Global Spatio-temporal Patterns of Influenza in the Post-pandemic Era.

    abstract：:We study the global spatio-temporal patterns of influenza dynamics. This is achieved by analysing and modelling weekly laboratory confirmed cases of influenza A and B from 138 countries between January 2006 and January 2015. The data were obtained from FluNet, the surveillance network compiled by the the World Health ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep11013

    authors： He D,Lui R,Wang L,Tse CK,Yang L,Stone L

    更新日期：2015-06-05 00:00:00

  • Late-onset Circulatory Collapse and Continuous Positive Airway Pressure are Useful Predictors of Treatment-requiring Retinopathy of Prematurity: A 9-year Retrospective Analysis.

    abstract：:Visual loss caused by retinopathy of prematurity (ROP) will be prevented if treatment-requiring ROP (TR-ROP) can be predicted. In this retrospective study including 418 infants with ≤32 weeks of gestational age (GA) and/or ≤1500 grams of birthweight, we attempted to identify useful predictors. We also examined the eff...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04269-5

    authors： Arima M,Tsukamoto S,Fujiwara K,Murayama M,Fujikawa K,Sonoda KH

    更新日期：2017-06-20 00:00:00

  • TGF-β induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma.

    abstract：:Fundamental cell signaling mechanisms that regulate dynamic remodeling of the extracellular matrix (ECM) in mechanically loaded tissues are not yet clearly understood. Trabecular meshwork (TM) tissue in the eye is under constant mechanical stress and continuous remodeling of ECM is crucial to maintain normal aqueous h...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00845-x

    authors： Tellios N,Belrose JC,Tokarewicz AC,Hutnik C,Liu H,Leask A,Motolko M,Iijima M,Parapuram SK

    更新日期：2017-04-11 00:00:00

  • Fungal volatile compounds induce production of the secondary metabolite Sodorifen in Serratia plymuthica PRI-2C.

    abstract：:The ability of bacteria and fungi to communicate with each other is a remarkable aspect of the microbial world. It is recognized that volatile organic compounds (VOCs) act as communication signals, however the molecular responses by bacteria to fungal VOCs remain unknown. Here we perform transcriptomics and proteomics...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00893-3

    authors： Schmidt R,Jager V,Zühlke D,Wolff C,Bernhardt J,Cankar K,Beekwilder J,Ijcken WV,Sleutels F,Boer W,Riedel K,Garbeva P

    更新日期：2017-04-13 00:00:00