FGF-7 Dictates Osteocyte Cell Processes Through Beta-Catenin Transduction.


:It is well recognized that osteocytes communicate with each other via gap junctions and that connxin43 (Cx43) shows its great potential in gap junction for the contribution enabling transmission of small molecules and operating in an autocrine/a paracrine manner. Fibroblast growth factors (FGFs) play significant roles in new bone formation and adult bone remodeling, and FGF signaling is regulated by the precise spatiotemporal approaches. However, the influence of FGF7 on osteocyte cell processes is not well elucidated. In this study, we aimed to examine the impact of FGF7 on osteocyte cell processes by characterizing the expression of Cx43 and to reveal the underlying mechanism regulating this cell process. We first found that the mRNA level of FGF7 was higher relative to other FGF family members both in osteocytes cell line (MLO-Y4) and bone tissue. We then demonstrated that FGF7 could increase the expression of Cx43 in osteocytes and promote the cell processes in the form of gap junctions between osteocytes. This modulation was due to the FGF7-induced cytoplasmic accumulation and resultant nuclear translocation of β-catenin. Our results could help us to further understand the importance of FGF7 on bone cell behavior and bone physiology and even pathology.


Sci Rep


Scientific reports


Liu XY,Li X,Bai MR,Chen X,Wang CL,Xie J,Ye L




Has Abstract


2018-10-04 00:00:00












  • Previous crop and rotation history effects on maize seedling health and associated rhizosphere microbiome.

    abstract::To evaluate crop rotation effects on maize seedling performance and its associated microbiome, maize plants were grown in the greenhouse in soils preceded by either maize, pea, soybean or sunflower. Soils originated from a replicated field experiment evaluating different four-year rotation combinations. In the greenho...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Benitez MS,Osborne SL,Lehman RM

    更新日期:2017-11-16 00:00:00

  • Figure-ground perception in the awake mouse and neuronal activity elicited by figure-ground stimuli in primary visual cortex.

    abstract::Figure-ground segregation is the process by which the visual system identifies image elements of figures and segregates them from the background. Previous studies examined figure-ground segregation in the visual cortex of monkeys where figures elicit stronger neuronal responses than backgrounds. It was demonstrated in...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Schnabel UH,Bossens C,Lorteije JAM,Self MW,Op de Beeck H,Roelfsema PR

    更新日期:2018-12-12 00:00:00

  • Enhanced segregation of concurrent sounds with similar spectral uncertainties in individuals with autism spectrum disorder.

    abstract::When acoustic signals from different sound sources are mixed upon arrival at the ears, the auditory system organizes these acoustic elements by their features. This study shows that individuals with autism spectrum disorder (ASD) performed better in terms of hearing a target sequence among distractors that had similar...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lin IF,Yamada T,Komine Y,Kato N,Kashino M

    更新日期:2015-05-22 00:00:00

  • Coupling optogenetics and light-sheet microscopy, a method to study Wnt signaling during embryogenesis.

    abstract::Optogenetics allows precise, fast and reversible intervention in biological processes. Light-sheet microscopy allows observation of the full course of Drosophila embryonic development from egg to larva. Bringing the two approaches together allows unparalleled precision into the temporal regulation of signaling pathway...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kaur P,Saunders TE,Tolwinski NS

    更新日期:2017-11-30 00:00:00

  • Integrated transcriptomic and metabolomic data reveal the flavonoid biosynthesis metabolic pathway in Perilla frutescens (L.) leaves.

    abstract::Perilla frutescens (L.) is an important medicinal and edible plant in China with nutritional and medical uses. The extract from leaves of Perilla frutescens contains flavonoids and volatile oils, which are mainly used in traditional Chinese medicine. In this study, we analyzed the transcriptomic and metabolomic data o...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Jiang T,Guo K,Liu L,Tian W,Xie X,Wen S,Wen C

    更新日期:2020-10-01 00:00:00

  • Behavioural characterisation of chronic unpredictable stress based on ethologically relevant paradigms in rats.

    abstract::The chronic unpredictable stress (CUS) paradigm is extensively used in preclinical research. However, CUS exhibits translational inconsistencies, some of them resulting from the use of adult rodents, despite the evidence that vulnerability for many psychiatric disorders accumulates during early life. Here, we assessed...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Sequeira-Cordero A,Salas-Bastos A,Fornaguera J,Brenes JC

    更新日期:2019-11-22 00:00:00

  • Selective spatial attention modulates bottom-up informational masking of speech.

    abstract::To hear out a conversation against other talkers listeners overcome energetic and informational masking. Largely attributed to top-down processes, information masking has also been demonstrated using unintelligible speech and amplitude-modulated maskers suggesting bottom-up processes. We examined the role of speech-li...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Carlile S,Corkhill C

    更新日期:2015-03-02 00:00:00

  • Discovery of Cancer Driver Long Noncoding RNAs across 1112 Tumour Genomes: New Candidates and Distinguishing Features.

    abstract::Long noncoding RNAs (lncRNAs) represent a vast unexplored genetic space that may hold missing drivers of tumourigenesis, but few such "driver lncRNAs" are known. Until now, they have been discovered through changes in expression, leading to problems in distinguishing between causative roles and passenger effects. We h...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lanzós A,Carlevaro-Fita J,Mularoni L,Reverter F,Palumbo E,Guigó R,Johnson R

    更新日期:2017-01-27 00:00:00

  • Kinetic 15N-isotope effects on algal growth.

    abstract::Stable isotope labeling is a standard technique for tracing material transfer in molecular, ecological and biogeochemical studies. The main assumption in this approach is that the enrichment with a heavy isotope has no effect on the organism metabolism and growth, which is not consistent with current theoretical and e...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Andriukonis E,Gorokhova E

    更新日期:2017-03-10 00:00:00

  • Effects of inhaled nitric oxide on outcome after prolonged cardiac arrest in mild therapeutic hypothermia treated rats.

    abstract::Guidelines endorse targeted temperature management to reduce neurological sequelae and mortality after cardiac arrest (CA). Additional therapeutic approaches are lacking. Inhaled nitric oxide (iNO) given post systemic ischemia/reperfusion injury improves outcomes. Attenuated inflammation by iNO might be crucial in bra...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Brücken A,Bleilevens C,Berger P,Nolte K,Gaisa NT,Rossaint R,Marx G,Derwall M,Fries M

    更新日期:2018-04-30 00:00:00

  • Genome-wide analysis of tomato long non-coding RNAs and identification as endogenous target mimic for microRNA in response to TYLCV infection.

    abstract::Recently, a large number of long noncoding RNAs (lncRNAs) have emerged as important regulators of many biological processes in animals and plants. However, how lncRNAs function during plant DNA virus infection is largely unknown. We performed strand-specific paired-end RNA sequencing of tomato samples infected with To...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang J,Yu W,Yang Y,Li X,Chen T,Liu T,Ma N,Yang X,Liu R,Zhang B

    更新日期:2015-12-18 00:00:00

  • Computational modelling of patient specific spring assisted lambdoid craniosynostosis correction.

    abstract::Lambdoid craniosynostosis (LC) is a rare non-syndromic craniosynostosis characterised by fusion of the lambdoid sutures at the back of the head. Surgical correction including the spring assisted cranioplasty is the only option to correct the asymmetry at the skull in LC. However, the aesthetic outcome from spring assi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Bozkurt S,Borghi A,van de Lande LS,Jeelani NUO,Dunaway DJ,Schievano S

    更新日期:2020-10-29 00:00:00

  • Calcium binding and voltage gating in Cx46 hemichannels.

    abstract::The opening of connexin (Cx) hemichannels in the membrane is tightly regulated by calcium (Ca2+) and membrane voltage. Electrophysiological and atomic force microscopy experiments indicate that Ca2+ stabilizes the hemichannel closed state. However, structural data show that Ca2+ binding induces an electrostatic seal p...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Pinto BI,Pupo A,García IE,Mena-Ulecia K,Martínez AD,Latorre R,Gonzalez C

    更新日期:2017-11-20 00:00:00

  • Dynamic impact of temporal context of Ca²⁺ signals on inhibitory synaptic plasticity.

    abstract::Neuronal activity-dependent synaptic plasticity, a basis for learning and memory, is tightly correlated with the pattern of increase in intracellular Ca(2+) concentration ([Ca(2+)](i)). Here, using combined application of electrophysiological experiments and systems biological simulation, we show that such a correlati...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kawaguchi SY,Nagasaki N,Hirano T

    更新日期:2011-01-01 00:00:00

  • Biophysical and structural characterization of the thermostable WD40 domain of a prokaryotic protein, Thermomonospora curvata PkwA.

    abstract::WD40 proteins belong to a big protein family with members identified in every eukaryotic proteome. However, WD40 proteins were only reported in a few prokaryotic proteomes. Using WDSP ( http://wu.scbb.pkusz.edu.cn/wdsp/ ), a prediction tool, we identified thousands of prokaryotic WD40 proteins, among which few protein...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Shen C,Du Y,Qiao F,Kong T,Yuan L,Zhang D,Wu X,Li D,Wu YD

    更新日期:2018-08-28 00:00:00

  • Biological analysis of cancer specific microRNAs on function modeling in osteosarcoma.

    abstract::Osteosarcoma (OS) is the most common bone tumor characterized with a high risk of amputation and malignant morbidity among teenagers and adolescents. However, relevant pathogenic/biological mechanisms underlying OS-genesis remains to be ambiguous. The aim of this study was to elucidate functional relationship about mi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang H,Tang M,Ou L,Hou M,Feng T,Huang YE,Jin Y,Zhang H,Zuo G

    更新日期:2017-07-14 00:00:00

  • Tailoring Plasmonic Enhanced Upconversion in Single NaYF4:Yb(3+)/Er(3+) Nanocrystals.

    abstract::By using silver nanoplatelets with a widely tunable localized surface plasmon resonance (LSPR), and their corresponding local field enhancement, here we show large manipulation of plasmonic enhanced upconversion in NaYF4:Yb(3+)/Er(3+) nanocrystals at the single particle level. In particular, we show that when the plas...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang YL,Mohammadi Estakhri N,Johnson A,Li HY,Xu LX,Zhang Z,Alù A,Wang QQ,Shih CK

    更新日期:2015-05-15 00:00:00

  • Defect controlled magnetism in FeP/graphene/Ni(111).

    abstract::Spin switching of organometallic complexes by ferromagnetic surfaces is an important topic in the area of molecular nanospintronics. Moreover, graphene has been shown as a 2D surface for physisorption of molecular magnets and strain engineering on graphene can tune the spin state of an iron porphyrin (FeP) molecule fr...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Bhandary S,Eriksson O,Sanyal B

    更新日期:2013-12-03 00:00:00

  • β-hydroxybutyrate and hydroxycarboxylic acid receptor 2 agonists activate the AKT, ERK and AMPK pathways, which are involved in bovine neutrophil chemotaxis.

    abstract::Elevated plasma concentrations of the ketone body β-hydroxybutyrate (BHB), an endogenous agonist of the hydroxycarboxylic acid receptor 2 (HCA2), is associated with an increased incidence of inflammatory diseases during lactation in dairy cows. In the early stages of this pathology, an increase in neutrophil recruitme...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Carretta MD,Barría Y,Borquez K,Urra B,Rivera A,Alarcón P,Hidalgo MA,Burgos RA

    更新日期:2020-07-27 00:00:00

  • Lower serum calcium is independently associated with CKD progression.

    abstract::Disturbances in calcium metabolism are common in individuals with chronic kidney disease (CKD), but whether they are associated with subsequent kidney function decline is less clear. In a CKD 3-5 cohort of 15,755 adult citizens of Stockholm with creatinine tests taken during 2006-2011 and concurrent calcium testing at...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Janmaat CJ,van Diepen M,Gasparini A,Evans M,Qureshi AR,Ärnlöv J,Barany P,Elinder CG,Rotmans JI,Vervloet M,Dekker FW,Carrero JJ

    更新日期:2018-03-26 00:00:00

  • Thiamine antagonists trigger p53-dependent apoptosis in differentiated SH-SY5Y cells.

    abstract::Accumulating evidences suggest that p53 is a key coordinator of cellular events triggered by oxidative stress often associated with the impairment in thiamine metabolism and its functions. However, there are limited data regarding the pursuant feedback between p53 transactivation and thiamine homeostasis. Impairment i...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Chornyy S,Parkhomenko Y,Chorna N

    更新日期:2017-09-06 00:00:00

  • Augmentation of CD134 (OX40)-dependent NK anti-tumour activity is dependent on antibody cross-linking.

    abstract::CD134 (OX40) is a member of the tumour necrosis factor receptor superfamily (TNFRSF). It acts as a costimulatory receptor on T cells, but its role on NK cells is poorly understood. CD137, another TNFRSF member has been shown to enhance the anti-tumour activity of NK cells in various malignancies. Here, we examine the ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Turaj AH,Cox KL,Penfold CA,French RR,Mockridge CI,Willoughby JE,Tutt AL,Griffiths J,Johnson PWM,Glennie MJ,Levy R,Cragg MS,Lim SH

    更新日期:2018-02-02 00:00:00

  • The ion microscope as a tool for quantitative measurements in the extreme ultraviolet.

    abstract::We demonstrate a tool for quantitative measurements in the extreme ultraviolet (EUV) spectral region measuring spatially resolved atomic ionization products at the focus of an EUV beam. The ionizing radiation is a comb of the 11(th)-15(th) harmonics of a Ti:Sapphire femtosecond laser beam produced in a Xenon gas jet. ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Tsatrafyllis N,Bergues B,Schröder H,Veisz L,Skantzakis E,Gray D,Bodi B,Kuhn S,Tsakiris GD,Charalambidis D,Tzallas P

    更新日期:2016-02-12 00:00:00

  • Managing peatland vegetation for drinking water treatment.

    abstract::Peatland ecosystem services include drinking water provision, flood mitigation, habitat provision and carbon sequestration. Dissolved organic carbon (DOC) removal is a key treatment process for the supply of potable water downstream from peat-dominated catchments. A transition from peat-forming Sphagnum moss to vascul...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ritson JP,Bell M,Brazier RE,Grand-Clement E,Graham NJ,Freeman C,Smith D,Templeton MR,Clark JM

    更新日期:2016-11-18 00:00:00

  • Perception of an ambiguous figure is affected by own-age social biases.

    abstract::Although the perception of faces depends on low-level neuronal processes, it is also affected by high-level social processes. Faces from a social in-group, such as people of a similar age, receive more in-depth processing and are processed holistically. To explore whether own-age biases affect subconscious face percep...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章


    authors: Nicholls MER,Churches O,Loetscher T

    更新日期:2018-08-23 00:00:00

  • Protein-protein interaction network analysis applied to DNA copy number profiling suggests new perspectives on the aetiology of Mayer-Rokitansky-Küster-Hauser syndrome.

    abstract::Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare disease, characterised by the aplasia of vagina and uterus in women with a 46,XX karyotype. Most cases are sporadic, but familial recurrence has also been described. Herein, we investigated an Italian cohort of 36 unrelated MRKH patients to explore the presence ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Pontecorvi P,Bernardini L,Capalbo A,Ceccarelli S,Megiorni F,Vescarelli E,Bottillo I,Preziosi N,Fabbretti M,Perniola G,Benedetti Panici P,Pizzuti A,Grammatico P,Marchese C

    更新日期:2021-01-11 00:00:00

  • Identification of Urine Metabolites as Biomarkers of Early Lyme Disease.

    abstract::Metabolites detectible in human biofluids are attractive biomarkers for the diagnosis of early Lyme disease (ELD), a vector-borne infectious disease. Urine represents an easily obtained clinical sample that can be applied for diagnostic purposes. However, few studies have explored urine for biomarkers of ELD. In this ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Pegalajar-Jurado A,Fitzgerald BL,Islam MN,Belisle JT,Wormser GP,Waller KS,Ashton LV,Webb KJ,Delorey MJ,Clark RJ,Molins CR

    更新日期:2018-08-15 00:00:00

  • BODIPY-cholesterol can be reliably used to monitor cholesterol efflux from capacitating mammalian spermatozoa.

    abstract::Capacitation is the final maturation step spermatozoa undergo prior to fertilisation. The efflux of cholesterol from the sperm membrane to the extracellular environment is a crucial step during capacitation but current methods to quantify this process are suboptimal. In this study, we validate the use of a BODIPY-chol...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Bernecic NC,Zhang M,Gadella BM,Brouwers JFHM,Jansen JWA,Arkesteijn GJA,de Graaf SP,Leahy T

    更新日期:2019-07-08 00:00:00

  • HLA genotypes and cold medicine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications: a systematic review and meta-analysis.

    abstract::Serious cutaneous adverse drug reactions [i.e., SJS/TEN with severe ocular complications (SOC)] associated with cold medicine (CM) were reported in several studies. To assess the risks of CM-induced SJS/TEN with SOC, systematic review and meta-analysis were employed. Studies investigating associations between HLA geno...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析


    authors: Tangamornsuksan W,Chanprasert S,Nadee P,Rungruang S,Meesilsat N,Ueta M,Lohitnavy M

    更新日期:2020-06-29 00:00:00

  • Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma.

    abstract::We have performed a genome-wide association study (GWAS) including 473 Japanese HBV (hepatitis B virus)-positive HCC (hepatocellular carcinoma) patients and 516 HBV carriers including chronic hepatitis and asymptomatic carrier individuals to identify new host genetic factors associated with HBV-derived HCC in Japanese...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Sawai H,Nishida N,Khor SS,Honda M,Sugiyama M,Baba N,Yamada K,Sawada N,Tsugane S,Koike K,Kondo Y,Yatsuhashi H,Nagaoka S,Taketomi A,Fukai M,Kurosaki M,Izumi N,Kang JH,Murata K,Hino K,Nishina S,Matsumoto A,Tanaka

    更新日期:2018-05-21 00:00:00