Abstract：
:It is well recognized that osteocytes communicate with each other via gap junctions and that connxin43 (Cx43) shows its great potential in gap junction for the contribution enabling transmission of small molecules and operating in an autocrine/a paracrine manner. Fibroblast growth factors (FGFs) play significant roles in new bone formation and adult bone remodeling, and FGF signaling is regulated by the precise spatiotemporal approaches. However, the influence of FGF7 on osteocyte cell processes is not well elucidated. In this study, we aimed to examine the impact of FGF7 on osteocyte cell processes by characterizing the expression of Cx43 and to reveal the underlying mechanism regulating this cell process. We first found that the mRNA level of FGF7 was higher relative to other FGF family members both in osteocytes cell line (MLO-Y4) and bone tissue. We then demonstrated that FGF7 could increase the expression of Cx43 in osteocytes and promote the cell processes in the form of gap junctions between osteocytes. This modulation was due to the FGF7-induced cytoplasmic accumulation and resultant nuclear translocation of β-catenin. Our results could help us to further understand the importance of FGF7 on bone cell behavior and bone physiology and even pathology.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu XY,Li X,Bai MR,Chen X,Wang CL,Xie J,Ye Ldoi
10.1038/s41598-018-33247-8subject
Has Abstractpub_date
2018-10-04 00:00:00pages
14792issue
1issn
2045-2322pii
10.1038/s41598-018-33247-8journal_volume
8pub_type
杂志文章abstract：:In this study, 111 Cryptosporidium parvum IId isolates from several species of animals in China, Sweden, and Egypt were subtyped by multilocus sequence typing (MLST). One to eleven subtypes were detected at each of the 12 microsatellite, minisatellite, and single nucleotide polymorphism (SNP) loci, forming 25 MLST sub...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04208
更新日期：2014-02-27 00:00:00
abstract：:Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). However, the inability to manufacture large quantities of functional cells from a single donor as well as donor-dependent variability in quality limits their clinical utility. Human embr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17685
更新日期：2015-12-02 00:00:00
abstract：:In this work we study theoretically and experimentally the multi-particle structure of the so-called type-II quantum dots with spatially separated electrons and holes. Our calculations based on customarily developed full configuration interaction ap- proach reveal that exciton complexes containing holes interacting wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45568
更新日期：2017-03-30 00:00:00
abstract：:Graphene and related materials have come to the forefront of research in electrochemical sensors during recent years due to the promising properties of these nanomaterials. Further applications of these nanomaterials have been hampered by insufficient sensitivity offered by these nanohybrids for the type of molecules ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00877
更新日期：2012-01-01 00:00:00
abstract：:It is challenging to create artificial catalysts that approach enzymes with regard to catalytic efficiency and selectivity. The enantioselective catalysis ranks the privileged characteristic of enzymatic transformations. Here, we report two pyridine-linked bis(β-cyclodextrin) (bisCD) copper(II) complexes that enantios...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22080
更新日期：2016-02-26 00:00:00
abstract：:Transient receptor potential melastatin 8 (TRPM8), a nonselective cation channel, is the predominant mammalian cold temperature thermosensor and it is activated by cold temperatures and cooling compounds, such as menthol and icilin. Because of its role in cold allodynia, cold hyperalgesia and painful syndromes TRPM8 a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11194-0
更新日期：2017-09-08 00:00:00
abstract：:Infection of humans with Chlamydia trachomatis, a bacterial pathogen with a unique intracellular replication cycle, may cause a variety of clinical manifestations. These are linked to various serovars of the pathogen; trachoma to serovars A-C, oculogenital infections to serovars D-K, and lymphogranuloma venereum to se...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54886-5
更新日期：2019-12-04 00:00:00
abstract：:Much attention has been given in the literature to the effects of astrophysical events on human and land-based life. However, little has been discussed on the resilience of life itself. Here we instead explore the statistics of events that completely sterilise an Earth-like planet with planet radii in the range 0.5-1....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05796-x
更新日期：2017-07-14 00:00:00
abstract：:This prospective multicenter randomized comparative cross-over trial aimed at evaluating the influence of hemodialysis vs post-dilution hemodiafiltration with high-flux dialyzers in solute clearance and biocompatibility profile. 32 patients were sequentially dialyzed with Leoceed-21HX, Polypure-22S+, Rexsys-27H and VI...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/s41598-019-54404-7
更新日期：2019-12-04 00:00:00
abstract：:α-Dystroglycanopathy (α-DGP) is a group of muscular dystrophy characterized by abnormal glycosylation of α-dystroglycan (α-DG), including Fukuyama congenital muscular dystrophy (FCMD), muscle-eye-brain disease, Walker-Warburg syndrome, and congenital muscular dystrophy type 1D (MDC1D), etc. LARGE, the causative gene f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08316
更新日期：2015-02-09 00:00:00
abstract：:Improving the prevention efficacy of health screening campaigns by increasing their attendance rate represents a challenge that calls for new strategies. This paper analyzes the response to a Pap test screening campaign of 155,000 women over the last decade. Using a mathematical model of statistical physics origins we...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09904
更新日期：2015-04-23 00:00:00
abstract：:The applications of machine learning/deep learning (ML/DL) methods in meteorology have developed considerably in recent years. Massive amounts of meteorological data are conducive to improving the training effect and model performance of ML/DL, but the establishment of training datasets is often time consuming, especi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71831-z
更新日期：2020-09-14 00:00:00
abstract：:Accumulation of advanced glycation end products (AGEs) is linked with development or aggravation of many degenerative processes or disorders, including aging and atherosclerosis. AGEs production in skin cells is known to promote stiffness and loss of elasticity through their buildup in connective tissue. However, the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27848
更新日期：2016-06-13 00:00:00
abstract：:The development of high energy-density lithium-ion secondary batteries as storage batteries in vehicles is attracting increasing attention. In this study, high-voltage bipolar stacked batteries with a quasi-solid-state electrolyte containing a Li-Glyme complex were prepared, and the performance of the device was evalu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08869
更新日期：2015-03-09 00:00:00
abstract：:Constrained by the diffraction limit, a lens can only resolve features larger than half of the incident wavelength owing to the decaying nature of evanescent waves. Several novel devices have been proposed, for example, superlenses and hyperlenses to break this limit. In this work, we present a flat hyperlens composed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62243-0
更新日期：2020-03-24 00:00:00
abstract：:The spectral distribution of light emitted from a scanning tunnelling microscope junction not only bears its intrinsic plasmonic signature but is also imprinted with the characteristics of optical frequency fluc- tuations of the tunnel current. Experimental spectra from gold-gold tunnel junctions are presented that sh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03766-x
更新日期：2017-06-14 00:00:00
abstract：:The macular ellipsoid zone intensity (mEZi) is a known marker of disease severity in a number of diverse ocular diseases. The purpose of this study was to establish an automated method (AM) for mEZi quantification and to compare the method's performance with that of a manual method (MM) for glaucoma patients and healt...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-56337-7
更新日期：2019-12-24 00:00:00
abstract：:Glucocorticoid receptor (GR) is a hormone-activated transcription regulatory protein involved in metabolism as well as adrenocortical responses to psychosocial stress. Ligand-activated GR localizes to the nucleus, where GR homodimers regulate gene transcription via direct binding to glucocorticoid response elements (G...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25393-w
更新日期：2018-05-10 00:00:00
abstract：:Metapristone is the primary metabolite of the abortifacient mifepristone (RU486), and is being developed as a safe and effective cancer metastatic chemopreventive agent for both sexes. Here, we systematically investigated the sex-related pharmacokinetics of metapristone in both rats and dogs, and explored the related ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17225-0
更新日期：2017-12-07 00:00:00
abstract：:We present a prototype for conducting rapid, inexpensive and point-of-care-compatible nucleic acid amplification tests (NAATs) for tuberculosis (TB). The fluorescent isothermal paper-and-plastic NAAT (FLIPP-NAAT) uses paper-based loop mediated isothermal amplification (LAMP) for DNA detection. The cost of materials re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51873-8
更新日期：2019-10-25 00:00:00
abstract：:The study of the synchronization patterns of small neuron networks that control several biological processes has become an interesting growing discipline. Some of these synchronization patterns of individual neurons are related to some undesirable neurological diseases, and they are believed to play a crucial role in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23622
更新日期：2016-03-29 00:00:00
abstract：:Two-dimensional (2D) transition-metal dichalcogenides (TMDs), most notably, MoS2 and WS2, have attracted significant attention due to their sizable and direct bandgap characteristics. Although several interesting MoS2 and WS2-based optoelectronic devices have been reported, their processability and reproducibility are...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13783
更新日期：2015-09-08 00:00:00
abstract：:Bee pollination is an indispensable component of global food production and plays a crucial role in sustainable agriculture. The worldwide decline of bee populations, including wild pollinators, poses a threat to this system. However, most studies to date are situated in temperate regions where Apini and Bombini are v...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32547
更新日期：2016-09-02 00:00:00
abstract：:Pediatric obstructive sleep-disordered breathing is associated with growth retardation, but also with obesity that has a tendency to persist following treatment. We investigated the effect of upper airways obstruction (AO) and of obstruction removal (OR) in juvenile rats on gut-derived ghrelin and related hypothalamic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02843-5
更新日期：2017-06-02 00:00:00
abstract：:Licorice-induced pseudoaldosteronism is a common adverse effect in traditional Japanese Kampo medicine, and 3-monoglucuronyl glycyrrhetinic acid (3MGA) was considered as a causative agent of it. Previously, we found 22α-hydroxy-18β-glycyrrhetyl-3-O-sulfate-30-glucuronide (1), one of the metabolites of glycyrrhizin (GL...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38182-2
更新日期：2019-02-07 00:00:00
abstract：:Laryngeal squamous cell carcinoma is a major medical problem worldwide. Although our understanding of genetic changes and their consequences in laryngeal cancer has opened new therapeutic pathways over the years, the diagnostic as well as treatment options still need to be improved. In our previous study, we identifie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56870-5
更新日期：2020-01-08 00:00:00
abstract：:The use of metabolomic and lipidomic strategies for selecting potential biomarkers for obstructive sleep apnoea (OSA) has been little explored. We examined adult male patients with OSA (defined by an apnoea-hypopnoea index ≥15 events/hour), as well as age-, gender-, and fat-composition-matched volunteers without OSA. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29727-6
更新日期：2018-07-26 00:00:00
abstract：:Northern and tropical peatlands represent a globally significant carbon reserve accumulated over thousands of years of waterlogged conditions. It is unclear whether moderate drying predicted for northern peatlands will stimulate burning and carbon losses as has occurred in their smaller tropical counterparts where the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08063
更新日期：2015-01-27 00:00:00
abstract：:The optimal approach for continuous measurement of intraocular pressure (IOP), including pressure transducer location and measurement frequency, is currently unknown. This study assessed the capability of extraocular (EO) and intraocular (IO) pressure transducers, using different IOP sampling rates and duty cycles, to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77880-8
更新日期：2020-12-01 00:00:00
abstract：:Natural medicines (i.e., herbal medicines, traditional formulas) are useful for treatment of multifactorial and chronic diseases. Here, we present KampoDB ( http://wakanmoview.inm.u-toyama.ac.jp/kampo/ ), a novel platform for the analysis of natural medicines, which provides various useful scientific resources on Japa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29516-1
更新日期：2018-07-25 00:00:00
