A somatotopic bidirectional hand prosthesis with transcutaneous electrical nerve stimulation based sensory feedback.

Abstract:

:According to amputees, sensory feedback is amongst the most important features lacking from commercial prostheses. Although restoration of touch by means of implantable neural interfaces has been achieved, these approaches require surgical interventions, and their long-term usability still needs to be fully investigated. Here, we developed a non-invasive alternative which maintains some of the advantages of invasive approaches, such as a somatotopic sensory restitution scheme. We used transcutaneous electrical nerve stimulation (TENS) to induce referred sensations to the phantom hand of amputees. These sensations were characterized in four amputees over two weeks. Although the induced sensation was often paresthesia, the location corresponded to parts of the innervation regions of the median and ulnar nerves, and electroencephalographic (EEG) recordings confirmed the presence of appropriate responses in relevant cortical areas. Using these sensations as feedback during bidirectional prosthesis control, the patients were able to perform several functional tasks that would not be possible otherwise, such as applying one of three levels of force on an external sensor. Performance during these tasks was high, suggesting that this approach could be a viable alternative to the more invasive solutions, offering a trade-off between the quality of the sensation, and the invasiveness of the intervention.

journal_name

Sci Rep

journal_title

Scientific reports

authors

D'Anna E,Petrini FM,Artoni F,Popovic I,Simanić I,Raspopovic S,Micera S

doi

10.1038/s41598-017-11306-w

subject

Has Abstract

pub_date

2017-09-07 00:00:00

pages

10930

issue

1

issn

2045-2322

pii

10.1038/s41598-017-11306-w

journal_volume

7

pub_type

杂志文章
  • Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro cholestatic model.

    abstract::Drug-induced cholestasis is a leading cause of drug withdrawal. However, the use of primary human hepatocytes (PHHs), the gold standard for predicting cholestasis in vitro, is limited by their high cost and batch-to-batch variability. Mature hepatocyte characteristics have been observed in human induced hepatocytes (h...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep38694

    authors: Ni X,Gao Y,Wu Z,Ma L,Chen C,Wang L,Lin Y,Hui L,Pan G

    更新日期:2016-12-09 00:00:00

  • Optical percutaneous needle biopsy of the liver: a pilot animal and clinical study.

    abstract::This paper presents the results of the experiments which were performed using the optical biopsy system specially developed for in vivo tissue classification during the percutaneous needle biopsy (PNB) of the liver. The proposed system includes an optical probe of small diameter acceptable for use in the PNB of the li...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71089-5

    authors: Dremin V,Potapova E,Zherebtsov E,Kandurova K,Shupletsov V,Alekseyev A,Mamoshin A,Dunaev A

    更新日期:2020-08-26 00:00:00

  • A Triplet Parallelizing Spiral Microfluidic Chip for Continuous Separation of Tumor Cells.

    abstract::Inertial and deformability- based particles separations gradually attract more significant attentions. In this work, we present a hybrid chip by combining the advantages of inertial and deformability -based principle. The chip is a triplet parallelizing spiral inertial microfluidic chip interconnected with numerable t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-22348-z

    authors: Chen H

    更新日期:2018-03-06 00:00:00

  • Author Correction: Non-invasive, Brain-controlled Functional Electrical Stimulation for Locomotion Rehabilitation in Individuals with Paraplegia.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-019-54834-3

    authors: Selfslagh A,Shokur S,Campos DSF,Donati ARC,Almeida S,Yamauti SY,Coelho DB,Bouri M,Nicolelis MAL

    更新日期:2019-12-04 00:00:00

  • Comprehensive Multi-Dimensional MRI for the Simultaneous Assessment of Cardiopulmonary Anatomy and Physiology.

    abstract::Diagnostic testing often assesses the cardiovascular or respiratory systems in isolation, ignoring the major pathophysiologic interactions between the systems in many diseases. When both systems are assessed currently, multiple modalities are utilized in costly fashion with burdensome logistics and decreased accessibi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04676-8

    authors: Cheng JY,Zhang T,Alley MT,Uecker M,Lustig M,Pauly JM,Vasanawala SS

    更新日期:2017-07-13 00:00:00

  • One dimensional transport in silicon nanowire junction-less field effect transistors.

    abstract::Junction-less nanowire transistors are being investigated to solve short channel effects in future CMOS technology. Here we demonstrate 8 nm diameter silicon nanowire junction-less transistors with metallic doping densities which demonstrate clear 1D electronic transport characteristics. The 1D regime allows excellent...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03138-5

    authors: Mirza MM,Schupp FJ,Mol JA,MacLaren DA,Briggs GAD,Paul DJ

    更新日期:2017-06-07 00:00:00

  • Locally induced neuronal synchrony precisely propagates to specific cortical areas without rhythm distortion.

    abstract::Propagation of oscillatory spike firing activity at specific frequencies plays an important role in distributed cortical networks. However, there is limited evidence for how such frequency-specific signals are induced or how the signal spectra of the propagating signals are modulated during across-layer (radial) and i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26054-8

    authors: Toda H,Kawasaki K,Sato S,Horie M,Nakahara K,Bepari AK,Sawahata H,Suzuki T,Okado H,Takebayashi H,Hasegawa I

    更新日期:2018-05-16 00:00:00

  • Optimization of Quantum Dot Thin Films using Electrohydrodynamic Jet Spraying for Solution-Processed Quantum Dot Light-Emitting Diodes.

    abstract::The electrohydrodynamic (EHD) jet spraying process is a good method for making quantum dot (QD) layers in light-emitting diodes (LEDs). However, controlling the morphology and large-scale fabrication of the QD layers are critical for realizing all-solution-processed QD-LEDs with high performance. Three spraying techni...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50181-5

    authors: Nguyen TC,Can TTT,Choi WS

    更新日期:2019-09-25 00:00:00

  • Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions.

    abstract::The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and pathology of Parkinson's disease. Native monomeric αSyn exists in an intrinsically disordered ensemble of interconverting conformations, which has made its therapeutic targeting by small molecules highly challenging. Nonetheless, her...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52598-4

    authors: Tóth G,Neumann T,Berthet A,Masliah E,Spencer B,Tao J,Jobling MF,Gardai SJ,Bertoncini CW,Cremades N,Bova M,Ballaron S,Chen XH,Mao W,Nguyen P,Tabios MC,Tambe MA,Rochet JC,Junker HD,Schwizer D,Sekul R,Ott I,Ander

    更新日期:2019-11-18 00:00:00

  • SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer.

    abstract::SOX7 as a tumor suppressor belongs to the SOX F gene subfamily and is associated with a variety of human cancers, including breast cancer, but the mechanisms involved are largely unclear. In the current study, we investigated the interactions between SOX7 and AXIN2 in their co-regulation on the Wnt/β-catenin signal pa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26136

    authors: Liu H,Mastriani E,Yan ZQ,Yin SY,Zeng Z,Wang H,Li QH,Liu HY,Wang X,Bao HX,Zhou YJ,Kou JJ,Li D,Li T,Liu J,Liu Y,Yin L,Qiu L,Gong L,Liu SL

    更新日期:2016-05-18 00:00:00

  • Cre/lox-Recombinase-Mediated Cassette Exchange for Reversible Site-Specific Genomic Targeting of the Disease Vector, Aedes aegypti.

    abstract::Site-specific genome modification (SSM) is an important tool for mosquito functional genomics and comparative gene expression studies, which contribute to a better understanding of mosquito biology and are thus a key to finding new strategies to eliminate vector-borne diseases. Moreover, it allows for the creation of ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43883

    authors: Häcker I,Harrell Ii RA,Eichner G,Pilitt KL,O'Brochta DA,Handler AM,Schetelig MF

    更新日期:2017-03-07 00:00:00

  • Structural Basis for DNA Recognition of a Single-stranded DNA-binding Protein from Enterobacter Phage Enc34.

    abstract::Modern DNA sequencing capabilities have led to the discovery of a large number of new bacteriophage genomes, which are a rich source of novel proteins with an unidentified biological role. The genome of Enterobacter cancerogenus bacteriophage Enc34 contains several proteins of unknown function that are nevertheless co...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15774-y

    authors: Cernooka E,Rumnieks J,Tars K,Kazaks A

    更新日期:2017-11-14 00:00:00

  • Cardiovascular Disease Risk Varies by Birth Month in Canines.

    abstract::The canine heart is a robust physiological model for the human heart. Recently, birth month associations have been reported and replicated in humans using clinical health records. While animals respond readily to their environment in the wild, a systematic investigation of birth season dependencies among pets and spec...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-25199-w

    authors: Boland MR,Kraus MS,Dziuk E,Gelzer AR

    更新日期:2018-05-17 00:00:00

  • 'Genome skimming' with the MinION hand-held sequencer identifies CITES-listed shark species in India's exports market.

    abstract::Chondrichthyes - sharks, rays, skates, and chimeras, are among the most threatened and data deficient vertebrate species. Global demand for shark and ray derived products, drives unregulated and exploitative fishing practices, which are in turn facilitated by the lack of ecological data required for effective conserva...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40940-9

    authors: Johri S,Solanki J,Cantu VA,Fellows SR,Edwards RA,Moreno I,Vyas A,Dinsdale EA

    更新日期:2019-03-14 00:00:00

  • Flow-driven micro-scale pH variability affects the physiology of corals and coralline algae under ocean acidification.

    abstract::Natural variability in pH in the diffusive boundary layer (DBL), the discrete layer of seawater between bulk seawater and the outer surface of organisms, could be an important factor determining the response of corals and coralline algae to ocean acidification (OA). Here, two corals with different morphologies and one...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49044-w

    authors: Comeau S,Cornwall CE,Pupier CA,DeCarlo TM,Alessi C,Trehern R,McCulloch MT

    更新日期:2019-09-06 00:00:00

  • Magma fragmentation and particle size distributions in low intensity mafic explosions: the July/August 2015 Piton de la Fournaise eruption.

    abstract::Understanding magma fragmentation mechanisms in explosive eruptions is a key requirement for volcanic hazard assessment, eruption management and risk mitigation. This paper focuses on a type case small explosivity eruption (July-August 2015 eruption of Piton de la Fournaise). These eruptions, despite being often overl...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69976-y

    authors: Edwards MJ,Pioli L,Harris AJL,Gurioli L,Thivet S

    更新日期:2020-08-18 00:00:00

  • Nyctinastic thallus movement in the liverwort Marchantia polymorpha is regulated by a circadian clock.

    abstract::The circadian clock coordinates an organism's growth, development and physiology with environmental factors. One illuminating example is the rhythmic growth of hypocotyls and cotyledons in Arabidopsis thaliana. Such daily oscillations in leaf position are often referred to as sleep movements or nyctinasty. Here, we re...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65372-8

    authors: Lagercrantz U,Billhardt A,Rousku SN,Ljung K,Eklund DM

    更新日期:2020-05-26 00:00:00

  • Understanding tie strength in social networks using a local "bow tie" framework.

    abstract::Understanding factors associated with tie strength in social networks is essential in a wide variety of settings. With the internet and cellular phones providing additional avenues of communication, measuring and inferring tie strength has become much more complex. We introduce the social bow tie framework, which cons...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27290-8

    authors: Mattie H,Engø-Monsen K,Ling R,Onnela JP

    更新日期:2018-06-19 00:00:00

  • Interaction between hexon and L4-100K determines virus rescue and growth of hexon-chimeric recombinant Ad5 vectors.

    abstract::The immunogenicity of recombinant adenovirus serotype 5 (rAd5) vectors has been shown to be suppressed by neutralizing antibodies (NAbs) directed primarily against hexon hypervariable regions (HVRs). Preexisting immunity can be circumvented by replacing HVRs of rAd5 hexon with those derived from alternate adenovirus s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep22464

    authors: Yan J,Dong J,Wu J,Zhu R,Wang Z,Wang B,Wang L,Wang Z,Zhang H,Wu H,Yu B,Kong W,Yu X

    更新日期:2016-03-03 00:00:00

  • Dislocation-free Ge Nano-crystals via Pattern Independent Selective Ge Heteroepitaxy on Si Nano-Tip Wafers.

    abstract::The integration of dislocation-free Ge nano-islands was realized via selective molecular beam epitaxy on Si nano-tip patterned substrates. The Si-tip wafers feature a rectangular array of nanometer sized Si tips with (001) facet exposed among a SiO2 matrix. These wafers were fabricated by complementary metal-oxide-sem...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep22709

    authors: Niu G,Capellini G,Schubert MA,Niermann T,Zaumseil P,Katzer J,Krause HM,Skibitzki O,Lehmann M,Xie YH,von Känel H,Schroeder T

    更新日期:2016-03-04 00:00:00

  • Structural dynamics of Populus euphratica forests in different stages in the upper reaches of the Tarim River in China.

    abstract::We selected four Populus euphratica Oliv. forest plots (100 m × 100 m) in the upper reaches of the Tarim River in the Xinjiang Uygur Autonomous Region of China. Each of the four forest plots was chosen to represent a different growth and death stage of P. euphratica forest: juvenile forest, mature forest, dying forest...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-60139-7

    authors: Miao N,Jiao P,Tao W,Li M,Li Z,Hu B,Moermond TC

    更新日期:2020-02-21 00:00:00

  • Mutual association of Broad bean wilt virus 2 VP37-derived tubules and plasmodesmata obtained from cytological observation.

    abstract::The movement protein VP37 of broad bean wilt virus 2 (BBWV 2) forms tubules in the plasmodesmata (PD) for the transport of virions between cells. This paper reports a mutual association between the BBWV 2 VP37-tubule complex and PD at the cytological level as determined by transmission electron microscopy. The generat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep21552

    authors: Xie L,Shang W,Liu C,Zhang Q,Sunter G,Hong J,Zhou X

    更新日期:2016-02-23 00:00:00

  • Elucidation of in vitro cellular steps induced by antitumor treatment with plasma-activated medium.

    abstract::Numerous studies have reported cold atmospheric plasma cytotoxic activities in various cancer cell lines, either by direct exposure to non-thermal plasma or indirectly by activating a medium (plasma-activated medium, PAM) prior to cell treatment. We suggested the use of in vitro 3D tumor model spheroids to determine t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-41408-6

    authors: Chauvin J,Gibot L,Griseti E,Golzio M,Rols MP,Merbahi N,Vicendo P

    更新日期:2019-03-19 00:00:00

  • Profiling the MAPK/ERK dependent and independent activity regulated transcriptional programs in the murine hippocampus in vivo.

    abstract::Activity-dependent alteration of the transcriptional program is central for shaping neuronal connectivity. Constitutively expressed transcription factors orchestrate the initial response to neuronal stimulation and serve as substrates for second messenger-regulated kinase signalling cascades. The mitogen-activated pro...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45101

    authors: Blüthgen N,van Bentum M,Merz B,Kuhl D,Hermey G

    更新日期:2017-03-28 00:00:00

  • Origami-based self-folding of co-cultured NIH/3T3 and HepG2 cells into 3D microstructures.

    abstract::This paper describes an origami-inspired self-folding method to form three-dimensional (3D) microstructures of co-cultured cells. After a confluent monolayer of fibroblasts (NIH/3T3 cells) with loaded hepatocytes (HepG2 cells) was cultured onto two-dimensional (2D) microplates, degradation of the alginate sacrificial ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-22598-x

    authors: He Q,Okajima T,Onoe H,Subagyo A,Sueoka K,Kuribayashi-Shigetomi K

    更新日期:2018-03-14 00:00:00

  • Sensillar expression and responses of olfactory receptors reveal different peripheral coding in two Helicoverpa species using the same pheromone components.

    abstract::Male moths efficiently recognize conspecific sex pheromones thanks to their highly accurate and specific olfactory system. The Heliothis/Helicoverpa species are regarded as good models for studying the perception of sex pheromones. In this study, we performed a series of experiments to investigate the peripheral mecha...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18742

    authors: Chang H,Guo M,Wang B,Liu Y,Dong S,Wang G

    更新日期:2016-01-08 00:00:00

  • Hyperthyroidism and vascular cell adhesion molecule-1 are associated with a low ankle-brachial index.

    abstract::We aimed to assess the ankle-brachial index (ABI) in patients with Graves' disease. In the cross-sectional assessments, 81 patients with drug-naïve Graves' disease and 235 with euthyroidism were enrolled. ABI and vascular cell adhesion molecule-1 (VCAM-1) levels were assessed. In the prospective follow-up, 32 patients...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-74267-7

    authors: Li YH,Lee IT

    更新日期:2020-10-13 00:00:00

  • Metabolic and protein interaction sub-networks controlling the proliferation rate of cancer cells and their impact on patient survival.

    abstract::Cancer cells can have a broad scope of proliferation rates. Here we aim to identify the molecular mechanisms that allow some cancer cell lines to grow up to 4 times faster than other cell lines. The correlation of gene expression profiles with the growth rate in 60 different cell lines has been analyzed using several ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03041

    authors: Feizi A,Bordel S

    更新日期:2013-10-24 00:00:00

  • HAUSP-nucleolin interaction is regulated by p53-Mdm2 complex in response to DNA damage response.

    abstract::HAUSP (herpes virus-associated ubiquitin specific protease, known as ubiquitin specific protease 7), one of DUBs, regulates the dynamics of the p53 and Mdm2 network in response to DNA damage by deubiquitinating both p53 and its E3 ubiquitin ligase, Mdm2. Its concerted action increases the level of functional p53 by pr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12793

    authors: Lim KH,Park JJ,Gu BH,Kim JO,Park SG,Baek KH

    更新日期:2015-08-04 00:00:00

  • Vision is protected against blue defocus.

    abstract::Due to chromatic aberration, blue images are defocused when the eye is focused to the middle of the visible spectrum, yet we normally are not aware of chromatic blur. The eye suffers from monochromatic aberrations which degrade the optical quality of all images projected on the retina. The combination of monochromatic...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79911-w

    authors: Benedi-Garcia C,Vinas M,Dorronsoro C,Burns SA,Peli E,Marcos S

    更新日期:2021-01-11 00:00:00