Abstract：
:SOX7 as a tumor suppressor belongs to the SOX F gene subfamily and is associated with a variety of human cancers, including breast cancer, but the mechanisms involved are largely unclear. In the current study, we investigated the interactions between SOX7 and AXIN2 in their co-regulation on the Wnt/β-catenin signal pathway, using clinical specimens and microarray gene expression data from the GEO database, for their roles in breast cancer. We compared the expression levels of SOX7 and other co-expressed genes in the Wnt/β-catenin pathway and found that the expression of SOX7, SOX17 and SOX18 was all reduced significantly in the breast cancer tissues compared to normal controls. AXIN2 had the highest co-relativity with SOX7 in the Wnt/β-catenin signaling pathway. Clinicopathological analysis demonstrated that the down-regulated SOX7 was significantly correlated with advanced stages and poorly differentiated breast cancers. Consistent with bioinformatics predictions, SOX7 was correlated positively with AXIN2 and negatively with β-catenin, suggesting that SOX7 and AXIN2 might play important roles as co-regulators through the Wnt-β-catenin pathway in the breast tissue to affect the carcinogenesis process. Our results also showed Smad7 as the target of SOX7 and AXIN2 in controlling breast cancer progression through the Wnt/β-catenin signaling pathway.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu H,Mastriani E,Yan ZQ,Yin SY,Zeng Z,Wang H,Li QH,Liu HY,Wang X,Bao HX,Zhou YJ,Kou JJ,Li D,Li T,Liu J,Liu Y,Yin L,Qiu L,Gong L,Liu SLdoi
10.1038/srep26136subject
Has Abstractpub_date
2016-05-18 00:00:00pages
26136issn
2045-2322pii
srep26136journal_volume
6pub_type
杂志文章abstract：:Hereditary Parkinson's disease is commonly caused by mutations in the protein kinase PINK1 or the E3 ubiquitin ligase Parkin, which function together to eliminate damaged mitochondria. PINK1 phosphorylates both Parkin and ubiquitin to stimulate ubiquitination of dozens of proteins on the surface of the outer mitochond...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33019
更新日期：2016-09-08 00:00:00
abstract：:Neurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer's disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurodegenerative diseases and ana...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78832-y
更新日期：2020-12-17 00:00:00
abstract：:The objective was to measure the association between badger culling and bovine tuberculosis (TB) incidents in cattle herds in three areas of England between 2013-2017 (Gloucestershire and Somerset) and 2015-2017 (Dorset). Farming industry-selected licensed culling areas were matched to comparison areas. A TB incident ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49957-6
更新日期：2019-10-11 00:00:00
abstract：:Organ transplantation remains the most effective treatment for patients with late stage organ failure. Transgenic pigs provide an alternative organ donor source to the limited availability of human organs. However, cellular rejection still remains to be the obstacle for xenotransplantation. Superior to other methods, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04322-3
更新日期：2017-06-21 00:00:00
abstract：:Rotator cuff tears are common and are associated with shoulder pain, disability, and dysfunction. Previous studies that have reported different arthroscopic techniques are controversial. A network meta-analysis with indirect and direct evidence was performed to compare the effectiveness of arthroscopic techniques for ...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-019-40641-3
更新日期：2019-03-11 00:00:00
abstract：:Electrochemically active bacteria (EAB) are ubiquitous in environment and have important application in the fields of biogeochemistry, environment, microbiology and bioenergy. However, rapid and sensitive methods for EAB identification and evaluation of their extracellular electron transfer ability are still lacking. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01315
更新日期：2013-01-01 00:00:00
abstract：:Over the history of carbon, it is generally acknowledged that Bernal AB stacking of the sp2 carbon layers is the unique crystalline form of graphite. The universal graphite structure is synthesized at 2,600~3,000 °C and exhibits a micro-polycrystalline feature. In this paper, we provide evidence for a metastable form ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39624
更新日期：2016-12-21 00:00:00
abstract：:Experiments on the Ultimatum Game (UG) repeatedly show that people's behaviour is far from rational. In UG experiments, a subject proposes how to divide a pot and the other can accept or reject the proposal, in which case both lose everything. While rational people would offer and accept the minimum possible amount, i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19503-x
更新日期：2018-01-19 00:00:00
abstract：:To achieve a better understanding of the "vinegar syndrome" phenomenon, which has caused serious damage to triacetyl cellulose-based motion picture films, the white powder obtained from damaged film surfaces was analysed in this study. The powder was found to be soluble in acetone, diethyl ether, dimethylformamide, an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80498-5
更新日期：2021-01-15 00:00:00
abstract：:Maternal overnutrition increases the risk of long-term metabolic dysfunction in offspring. Exercise improves metabolism partly by upregulating mitochondrial biogenesis or function, via increased levels of nicotinamide adenine dinucleotide (NAD+). We have shown that the NAD+ precursor, nicotinamide mononucleotide (NMN)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14866-z
更新日期：2017-11-08 00:00:00
abstract：:Ants are a dominant insect group in terrestrial ecosystems and many myrmecophilous species evolve to associate with ants to gain benefits. One iconic example is myrmecophilous butterflies that often produce ant-mimicking vibrational calls to modulate ant behaviors. Despite its popularity, empirical exploration of how ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54966-6
更新日期：2019-12-06 00:00:00
abstract：:A long-standing debate regarding the configuration of Pangea during the Late Paleozoic has been going on among the paleomagnetic community concerning the validity of one of two significantly different Pangea reconstructions (Pangea A vs Pangea B) since the proposal of Pangea B. Although, Pangea B avoids any continenta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25873-z
更新日期：2018-05-31 00:00:00
abstract：:Cell wall disruption is necessary to maximize lipid extraction yields in conventional species of mass-cultivated microalgae. This study investigated the effect of sonication, solvent choice and number of extractions on the lipid yield, lipid class composition and fatty acid composition of the diatom Porosira glacialis...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79269-z
更新日期：2020-12-17 00:00:00
abstract：:Doxorubicin (Dox) is a highly effective anticancer drug but cause acute ventricular dysfunction, and also induce late-onset cardiomyopathy and heart failure. Despite extensive studies, the pathogenic sequelae leading to the progression of Dox-associated cardiomyopathy remains unknown. We assessed temporal changes in a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37862-3
更新日期：2019-02-14 00:00:00
abstract：:Electrically pumped GaAsBi/GaAs quantum well lasers are a promising new class of near-infrared devices where, by use of the unusual band structure properties of GaAsBi alloys, it is possible to suppress the dominant energy-consuming Auger recombination and inter-valence band absorption loss mechanisms, which greatly i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28863
更新日期：2016-07-01 00:00:00
abstract：:The successful determination of reliable protein interaction networks (PINs) in several species in the post-genomic era has hitherto facilitated the quest to understanding systems and structural properties of such networks. It is envisaged that a clearer understanding of their intrinsic topological properties would el...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07628
更新日期：2015-02-27 00:00:00
abstract：:Although most papillary thyroid carcinomas (PTCs) have a good prognosis, a small but certain fraction shows aggressive behavior. Therefore, a novel and well-performing molecular marker is needed. In the present study, we assessed the impact of the combination of the TERT promoter/BRAF mutations and Ki-67 labeling inde...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41752
更新日期：2017-02-02 00:00:00
abstract：:The aim of this study was to fabricate a novel polymer-free everolimus-eluting stent with nanostructure using a femtosecond laser (FSL). The stent were coated with everolimus (EVL) using FSL and electrospinning processes. The surface was rendered hydrophobic, which negatively affected both platelet adhesion (82.1%) an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25629-9
更新日期：2018-05-09 00:00:00
abstract：:There are large health, societal, and economic costs associated with attrition from psychological services. The recently emerged, innovative statistical tool of complex network analysis was used in the present proof-of-concept study to improve the prediction of attrition. Fifty-eight patients undergoing psychological ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25953-0
更新日期：2018-05-18 00:00:00
abstract：:The detection of pruritic (itchy) stimuli is mediated by a variety of receptors and channels expressed by primary sensory neurons. The G protein-coupled receptor (GPCR) MRGPRD is selectively expressed by a subset of mouse non-peptidergic nociceptors and functions as the molecular receptor for the itch-inducing chemica...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12770-0
更新日期：2017-10-24 00:00:00
abstract：:In most applications based on chemical vapor deposition (CVD) graphene, the transfer from the growth to the target substrate is a critical step for the final device performance. Manual procedures are time consuming and depend on handling skills, whereas existing automatic roll-to-roll methods work well for flexible su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21676
更新日期：2016-02-10 00:00:00
abstract：:The time evolution of the distribution and shareability of quantum coherence of a tripartite system in a non-Markovian environment is examined. The total coherence can be decomposed into various contributions, ranging from local, global bipartite and global tripartite, which characterize the type of state. We identify...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39027-2
更新日期：2019-02-20 00:00:00
abstract：:The role of transforming growth factor-β (TGF-β) signaling in cancer progression is still under debate. To determine the function of TGF-β signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carcinogenesis. We foun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29479
更新日期：2016-07-05 00:00:00
abstract：:Enterohemorrhagic Escherichia coli (EHEC) are major food-borne pathogens whose survival and virulence in the human digestive tract remain unclear owing to paucity of relevant models. EHEC interact with the follicle-associated epithelium of Peyer's patches of the distal ileum and translocate across the intestinal epith...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44655
更新日期：2017-03-20 00:00:00
abstract：:Hybrid cells of Nicotiana suaveolens x N. tabacum grow normally at 36 °C, but immediately express lethality due to probable autoimmune response when transferred from 36 to 28 °C. Our recent study showed that the temperature-sensitive lethality of these hybrid cells occurs through autolytic programmed cell death (PCD)....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46619-5
更新日期：2019-07-15 00:00:00
abstract：:Noise-induced hearing loss (NIHL) is a common health concern with significant social, psychological, and cognitive implications. Moderate levels of acoustic overstimulation associated with tinnitus and impaired speech perception cause cochlear synaptopathy, characterized physiologically by reduction in wave I of the s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75058-w
更新日期：2020-10-22 00:00:00
abstract：:Alzheimer's disease (AD) is characterized by excessive production and deposition of amyloid-beta (Aβ) proteins as well as synapse dysfunction and loss. While soluble Aβ oligomers (AβOs) have deleterious effects on synapse function and reduce synapse number, the underlying molecular mechanisms are not well understood. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42548
更新日期：2017-02-13 00:00:00
abstract：:Very little is known about how fimbriae of Bacteroidetes bacteria are assembled. To shed more light on this process, we solved the crystal structures of the shaft protein Mfa1, the regulatory protein Mfa2, and the tip protein Mfa3 from the periodontal pathogen Porphyromonas gingivalis. Together these build up part of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20067-z
更新日期：2018-01-29 00:00:00
abstract：:Accumulating evidence suggests that neuroinflammatory processes are implicated in the initiation and progression of amyotrophic lateral sclerosis (ALS). Previous reports have demonstrated an increase in microgliosis and astrogliosis in the lumbar spinal cord of SOD1G93A transgenic mice before the onset of symptoms, a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53982-w
更新日期：2019-11-27 00:00:00
abstract：:The demand for high efficiency intermediate band (IB) solar cells is driving efforts in producing high quality IB photovoltaic materials. Here, we demonstrate ZnTe:O highly mismatched alloys synthesized by high dose ion implantation and pulsed laser melting exhibiting optically active IB states and efficient sub-gap p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44399
更新日期：2017-03-10 00:00:00
