Profiling the MAPK/ERK dependent and independent activity regulated transcriptional programs in the murine hippocampus in vivo.

abstract：:For many applications heterogeneity is a direct indicator of material quality. Reliable determination of chemical heterogeneity is however not a trivial task. Spectral imaging can be used for determining the spatial distribution of an analyte in a sample, thus transforming each pixel of an image into a sampling cell. ...

journal_title：Scientific reports

authors： Mäkelä M,Geladi P

更新日期：2018-07-11 00:00:00

abstract：:Large-offset oceanic detachment faults are a characteristic of slow- and ultraslow-spreading ridges, leading to the formation of oceanic core complexes (OCCs) that expose upper mantle and lower crustal rocks on the seafloor. The lithospheric extension accommodated by these structures is now recognized as a fundamental...

journal_title：Scientific reports

authors： Maffione M,Morris A,Anderson MW

更新日期：2013-01-01 00:00:00

abstract：:Multiple predatory insect lineages have developed a raptorial lifestyle by which they strike and hold prey using modified forelegs armed with spine-like structures and other integumentary specialisations. However, how structures enabling the raptorial function evolved in insects remains largely hypothetical or inferre...

journal_title：Scientific reports

authors： Pérez-de la Fuente R,Peñalver E

更新日期：2019-09-13 00:00:00

abstract：:Agriculture provides livelihood for 65% of Nepal's population contributing for 27% of its GDP. Smallholder farms constitute 60% of farming segment. Distress farming, with inadequate minimum support price, subsidies and inadequate revenue generation force 29% of the general population to be malnourished. Farming system...

journal_title：Scientific reports

authors： Ramanathan K,Sangeeviraman V,Chandrahasan P,Chaudhary BN,Ramachandra SS

更新日期：2020-06-29 00:00:00

abstract：:Cassava is one of the most important root crops as a reliable source of food and carbohydrates. Carbohydrate metabolism and starch accumulation in cassava storage root is a cascade process that includes large amounts of proteins and cofactors. Here, comparative proteomics were conducted in cassava root at nine develop...

journal_title：Scientific reports

authors： Wang X,Chang L,Tong Z,Wang D,Yin Q,Wang D,Jin X,Yang Q,Wang L,Sun Y,Huang Q,Guo A,Peng M

更新日期：2016-01-21 00:00:00

abstract：:Analysis of volatile organic compounds (VOCs) is a promising approach for non-invasive, fast and potentially inexpensive diagnostics. Here, we present a new methodology for profiling the body chemistry by using the volatile fraction of molecules in various body fluids. Using mass spectrometry and cross-reactive nanoma...

journal_title：Scientific reports

authors： Broza YY,Zuri L,Haick H

更新日期：2014-04-09 00:00:00

abstract：:Triple-negative breast cancers (TNBC) are unlikely to respond to hormonal therapies and anti-HER2-targeted therapies. TNBCs overexpress EGFR and exhibit constitutive activation of the PI3K/AKT/mTOR signalling pathway. We hypothesized that simultaneously blocking EGFR and mTOR could be a potential therapeutic strategy ...

journal_title：Scientific reports

authors： El Guerrab A,Bamdad M,Bignon YJ,Penault-Llorca F,Aubel C

更新日期：2020-04-14 00:00:00

abstract：:Biomarkers reflecting the extent of Mycobacterium tuberculosis-induced pathology and normalization during anti-tuberculosis treatment (ATT) would considerably facilitate trials of new treatment regimens and the identification of patients with treatment failure. Therefore, in a cohort of 99 Indian children with intrath...

journal_title：Scientific reports

authors： Jenum S,Bakken R,Dhanasekaran S,Mukherjee A,Lodha R,Singh S,Singh V,Haks MC,Ottenhoff TH,Kabra SK,Doherty TM,Ritz C,Grewal HM

更新日期：2016-12-12 00:00:00

abstract：:Worldwide, prostate cancer (PCa) is the second most common malignancy in males. We undertook a meta-analysis to compare the efficacy and safety of conventional laparoscopic radical prostatectomy with a transperitoneal (TLRP) approach, versus that of an extraperitoneal (ELRP) approach, for treatment of localized PCa. A...

journal_title：Scientific reports

authors： De Hong C,Liang Ren L,Qiang W,Jia W,Ying Chun H,Lu Y,Zheng Hua L,Heng Ping L,Shi Bing Y,Yun Xiang L

更新日期：2015-10-13 00:00:00

abstract：:Boolean multiplex (multilevel) networks (BMNs) are currently receiving considerable attention as theoretical arguments for modeling of biological systems and system level analysis. Studying control-related problems in BMNs may not only provide new views into the intrinsic control in complex biological systems, but als...

journal_title：Scientific reports

authors： Wu Y,Xu J,Sun XM,Wang W

更新日期：2017-04-28 00:00:00

abstract：:One fundamental question in prey luring systems is to understand how visual signals are interpreted by the receiver. Predators lure prey by falsely imitating the signal of a model, or may exploit sensory preferences of the receivers, which search for rewarding signals. Crab spiders reflect ultraviolet (UV) light, ambu...

journal_title：Scientific reports

authors： Vieira C,Ramires EN,Vasconcellos-Neto J,Poppi RJ,Romero GQ

更新日期：2017-08-23 00:00:00

abstract：:Alternations in the p53 regulatory network may render cancer cells resistant to the radiation-induced apoptosis. In this theoretical study we search for the best protocols combining targeted therapy with radiation to treat cancers with wild-type p53, but having downregulated expression of PTEN or overexpression of Wip...

journal_title：Scientific reports

authors： Hat B,Jaruszewicz-Błońska J,Lipniacki T

更新日期：2020-07-28 00:00:00

abstract：:G-proteins are implicated in plant productivity, but their genome-wide roles in regulating agronomically important traits remain uncharacterized. Transcriptomic analyses of rice G-protein alpha subunit mutant (rga1) revealed 2270 differentially expressed genes (DEGs) including those involved in C/N and lipid metabolis...

journal_title：Scientific reports

authors： Pathak RR,Mandal VK,Jangam AP,Sharma N,Madan B,Jaiswal DK,Raghuram N

更新日期：2021-01-27 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Prywer J,Torzewska A

更新日期：2020-01-27 00:00:00

abstract：:Age of complementary foods introduction is associated with childhood anemia, but the ideal age for the introduction of complementary foods to infants is a continuing topic of debate. We examined the longitudinal association between complementary foods introduction age and risk of anemia in 18,446 children from the Jia...

journal_title：Scientific reports

authors： Wang F,Liu H,Wan Y,Li J,Chen Y,Zheng J,Huang T,Li D

更新日期：2017-03-23 00:00:00

abstract：:The exposure of humans to erionite fibres of appropriate morphology and dimension has been unambiguously linked to the occurrence of Malignant Mesothelioma. For this reason, a detailed morpho-structural investigation through Electron Microscopy techniques has been performed on erionite samples collected at two differe...

journal_title：Scientific reports

authors： Matassa R,Familiari G,Relucenti M,Battaglione E,Downing C,Pacella A,Cametti G,Ballirano P

更新日期：2015-11-16 00:00:00

abstract：:Knowing the distribution of marine animals is central to understanding climatic and other environmental influences on population ecology. This information has proven difficult to gain through capture-based methods biased by capture location. Here we show that marine location can be inferred from animal tissues. As the...

journal_title：Scientific reports

authors： MacKenzie KM,Palmer MR,Moore A,Ibbotson AT,Beaumont WR,Poulter DJ,Trueman CN

更新日期：2011-01-01 00:00:00

abstract：:The low-temperature heat capacity of (U1-yThy)O2 and 238Pu-doped UO2 samples were determined using hybrid adiabatic relaxation calorimetry. Results of the investigated systems revealed the presence of the magnetic transition specific for UO2 in all three intermediate compositions of the uranium-thorium dioxide (y = 0....

journal_title：Scientific reports

authors： Vălu SO,De Bona E,Popa K,Griveau JC,Colineau E,Konings RJM

更新日期：2019-10-21 00:00:00

abstract：:Ubiquinol-cytochrome c reductase hinge protein (UQCRH) is the hinge protein for the multi-subunit complex III of the mitochondrial electron transport chain and is involved in the electron transfer reaction between cytochrome c1 and c. Recent genome-wide transcriptomic and epigenomic profiling of clear cell renal cell ...

journal_title：Scientific reports

authors： Luo Y,Medina Bengtsson L,Wang X,Huang T,Liu G,Murphy S,Wang C,Koren J 3rd,Schafer Z,Lu X

更新日期：2020-09-14 00:00:00

abstract：:Cardiac arrhythmias are often associated with mutations in ion channels or other proteins. To enable drug development for distinct arrhythmias, model systems are required that allow implementing patient-specific mutations. We assessed a muscular pump in Caenorhabditis elegans. The pharynx utilizes homologues of most o...

journal_title：Scientific reports

authors： Schüler C,Fischer E,Shaltiel L,Steuer Costa W,Gottschalk A

更新日期：2015-09-24 00:00:00

abstract：:We study the coherent and semi-coherent Al/α-Al2O3 interfaces using molecular dynamics simulations with a mixed, metallic-ionic atomistic model. For the coherent interfaces, both Al-terminated and O-terminated nonstoichiometric interfaces have been studied and their relative stability has been established. To understa...

journal_title：Scientific reports

authors： Pilania G,Thijsse BJ,Hoagland RG,Lazić I,Valone SM,Liu XY

更新日期：2014-03-27 00:00:00

abstract：:Despite technical advances in brain machine interfaces (BMI), for as-yet unknown reasons the ability to control a BMI remains limited to a subset of users. We investigate whether individual differences in BMI control based on motor imagery (MI) are related to differences in MI ability. We assessed whether differences ...

journal_title：Scientific reports

authors： Marchesotti S,Bassolino M,Serino A,Bleuler H,Blanke O

更新日期：2016-04-07 00:00:00

abstract：:Protein kinase B (PKB) also known as Akt is involved in many signal transduction pathways. As alterations of the PKB pathway are found in a number of human malignancies, PKB is considered an important drug target for cancer therapy. However, production of sufficient amounts of active PKB for biochemical and structural...

journal_title：Scientific reports

authors： Maesaki R,Satoh R,Taoka M,Kanaba T,Asano T,Fujita C,Fujiwara T,Ito Y,Isobe T,Hakoshima T,Maenaka K,Mishima M

更新日期：2014-08-15 00:00:00

abstract：:Uncovering complex oil-water flow structure represents a challenge in diverse scientific disciplines. This challenge stimulates us to develop a new distributed conductance sensor for measuring local flow signals at different positions and then propose a novel approach based on multi-frequency complex network to uncove...

journal_title：Scientific reports

authors： Gao ZK,Yang YX,Fang PC,Jin ND,Xia CY,Hu LD

更新日期：2015-02-04 00:00:00

abstract：:Baeyer-Villiger monooxygenases (BVMOs) can be used for the biosynthesis of lactones and esters from ketones. However, the BVMO-based biocatalysts are not so stable under process conditions. Thereby, this study focused on enhancing stability of the BVMO-based biocatalysts. The biotransformation of ricinoleic acid into ...

journal_title：Scientific reports

authors： Woo JM,Jeon EY,Seo EJ,Seo JH,Lee DY,Yeon YJ,Park JB

更新日期：2018-07-06 00:00:00

abstract：:The aims of the study were to clarify the impact of storage time and centrifugation strategy on brain-derived neurotrophic factor (BDNF) levels in human serum and plasma samples. In addition, we analyzed associations between BDNF levels, cardiorespiratory fitness and waist circumference. Seventeen healthy males (25.2 ...

journal_title：Scientific reports

authors： Gejl AK,Enevold C,Bugge A,Andersen MS,Nielsen CH,Andersen LB

更新日期：2019-07-04 00:00:00

abstract：:Based on the geological conditions of overburden rock, the dynamic development law of overburden breakage was investigated by theoretical analysis and similarity model experiments in this paper. The formula of the compressive strength and No. ratio was obtained by testing the compressive strength of cylinder samples o...

journal_title：Scientific reports

authors： Zhu H,Fang S,Huo Y,Guo J,Wu Y,Hu L

更新日期：2020-04-16 00:00:00

abstract：:We report that misfolded cytosolic proteins can be cleared from mammalian cells by directing them to endoplasmic reticulum (ER). NAT1 R64W and Parkin R42P are naturally occurring misfolded variants of cytosolic enzymes that acetylate arylamines and ubiquitinate proteins, respectively. We demonstrate that proteasome in...

journal_title：Scientific reports

authors： Liu F,Koepp DM,Walters KJ

更新日期：2015-07-14 00:00:00

abstract：:The Hyperpolarized gas Chemical Exchange Saturation Transfer (HyperCEST) Magnetic Resonance (MR) technique has the potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent. Signal enhancement is accomplished by selectively depolarizing the xenon within a cage molecule which, upon exchange...

journal_title：Scientific reports

authors： Hane FT,Li T,Smylie P,Pellizzari RM,Plata JA,DeBoef B,Albert MS

更新日期：2017-01-20 00:00:00

abstract：:Hetero-nanostructures based on magnetic contrast oxides have been prepared as highly dense nanoconsolidates. Cobalt ferrite-cobalt oxide core-shell type nanoparticles (NPs) were synthesized by seed mediated growth in polyol and subsequently consolidated by Spark Plasma Sintering (SPS) at 500 °C for a few minutes while...

journal_title：Scientific reports

authors： Flores-Martinez N,Franceschin G,Gaudisson T,Haj-Khlifa S,Derouich SG,Yaacoub N,Grenèche JM,Menguy N,Valenzuela R,Ammar S

更新日期：2019-12-19 00:00:00