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In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor.

Abstract：

:The Hyperpolarized gas Chemical Exchange Saturation Transfer (HyperCEST) Magnetic Resonance (MR) technique has the potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent. Signal enhancement is accomplished by selectively depolarizing the xenon within a cage molecule which, upon exchange, reduces the signal in the dissolved phase pool. Herein we demonstrate the in vivo detection of the cucurbit[6]uril (CB6) contrast agent within the vasculature of a living rat. Our work may be used as a stepping stone towards using the HyperCEST technique as a molecular imaging modality.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Hane FT,Li T,Smylie P,Pellizzari RM,Plata JA,DeBoef B,Albert MS

doi

10.1038/srep41027

subject

Has Abstract

pub_date

2017-01-20 00:00:00

pages

41027

issn

2045-2322

pii

srep41027

journal_volume

7

pub_type

杂志文章

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