Abstract:
:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Bosshard M,Aprigliano R,Gattiker C,Palibrk V,Markkanen E,Backe PH,Pellegrino S,Raymond FL,Froyen G,Altmeyer M,Bjørås M,Dianov GL,Loon BVdoi
10.1038/s41598-018-24189-2subject
Has Abstractpub_date
2018-04-12 00:00:00pages
6010issue
1issn
2045-2322pii
10.1038/s41598-018-24189-2journal_volume
8pub_type
已发布勘误abstract::Global change is predicted to cause shifts in species distributions and biodiversity in arctic tundra. We applied factorial warming and nutrient manipulation to a nutrient and species poor alpine/arctic heath community for seven years. Vascular plant abundance in control plots increased by 31%. There were also notable...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10197
更新日期:2015-05-07 00:00:00
abstract::Perinatal depression involves interplay between individual chronic and acute disease burdens, biological and psychosocial environmental and behavioural factors. Here we explored the predictive potential of specific psycho-socio-demographic characteristics for antenatal and postpartum depression symptoms and contributi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30874-z
更新日期:2018-08-24 00:00:00
abstract::Gapmer antisense oligonucleotides cleave target RNA effectively in vivo, and is considered as promising therapeutics. Especially, gapmers modified with locked nucleic acid (LNA) shows potent knockdown activity; however, they also cause hepatotoxic side effects. For developing safe and effective gapmer drugs, a deeper ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30377
更新日期:2016-07-27 00:00:00
abstract::Clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology is a powerful tool to manipulate the genome with extraordinary simplicity and speed. To generate genetically modified animals, CRISPR/Cas9-mediated genome editing is typically accomplished by microinjectio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42244
更新日期:2017-02-08 00:00:00
abstract::Ribosome biogenesis and turnover are processes necessary for cell viability and proliferation, and many kinds of proteins are known to regulate these processes. However, many questions still remain, especially in the Archaea. Generally, several ribonucleases are required to process precursor rRNAs to their mature form...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13062-3
更新日期:2017-10-04 00:00:00
abstract::Energy metabolism, involving the ATP-dependent AMPK-PgC-Ppar pathway impacts metabolic health immensely, in that its impairment can lead to obesity, giving rise to disease. Based on observations that individuals with Gilbert's syndrome (GS; UGT1A1(*)28 promoter mutation) are generally lighter, leaner and healthier tha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30051
更新日期:2016-07-21 00:00:00
abstract::p53 is a representative transcription factor that activates multiple target genes. To realize stimulus-dependent specificities, p53 has to recognize targets with structural variety, of which molecular mechanisms are largely unknown. Here, we conducted a series of long-time scale (totally more than 100-ms) coarse-grain...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17107
更新日期:2015-11-24 00:00:00
abstract::We provide a proof for the necessity of quantizing fundamental interactions demonstrating that a quantum version is needed for any non trivial conservative interaction whose strength depends on the relative distance between two objects. Our proof is based on a consistency argument that in the presence of a classical f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47844-8
更新日期:2019-08-06 00:00:00
abstract::In ART programs in sub-Saharan Africa, a growing proportion of HIV-infected persons initiating first-line antiretroviral therapy (ART) have a history of prior antiretroviral drug use (PAU). We assessed the effect of PAU on the risk of pre-treatment drug resistance (PDR) and virological failure (VF) in a multicountry c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33538-0
更新日期:2018-10-25 00:00:00
abstract::Spatial tuning properties of retinal ganglion cells (RGCs) are sharpened by lateral inhibition originating at both the outer and inner plexiform layers. Lateral inhibition in the retina contributes to local contrast enhancement and sharpens edges. In this study, we used dynamic clamp recordings to examine the contribu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21966
更新日期:2016-02-24 00:00:00
abstract::Rotaviruses (RVs) are the most common cause of severe diarrheal disease. To date two rotavirus oral vaccines are licensed: Rotarix and Rotateq. Our aim was to contribute to the post-marketing evaluation of these vaccines safety profile. We collected all RV vaccines-related reports of Adverse Events Following Immunizat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70653-3
更新日期:2020-08-12 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) patients are at higher risk of developing lung cancer and its metastasis, but no suitable biomarker has been reported for differential diagnosis of these patients. Levels of serum biomarkers (VEGF, IL-8, MMP-9 and MMP-2) were analyzed in these patients, which were compared ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36065
更新日期:2016-11-04 00:00:00
abstract::Structural cardiac remodeling, accompanying cytoskeletal reorganization of cardiac cells, is a major clinical outcome of diastolic heart failure. A highly local Ca2+ influx across the plasma membrane has been suggested to code signals to induce Rho GTPase-mediated fibrosis, but it is obscure how the heart specifically...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39383
更新日期:2016-12-19 00:00:00
abstract::Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05568-7
更新日期:2017-07-11 00:00:00
abstract::Agricultural irrigation in the middle reaches of the Heihe River Basin consumes approximately 80% of the total river water. Whether the irrigation depth matches the water uptake depth of crops is one of the most important factors affecting the efficiency of irrigation water use. Our results indicated that the influenc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15206
更新日期:2015-10-14 00:00:00
abstract::Two cabbage (Brassica oleracea) cultivars 'Tekila' and 'Kilaherb' were identified as resistant to several pathotypes of Plasmodiophora brassicae. In this study, we identified a clubroot resistance gene (Rcr7) in 'Tekila' for resistance to pathotype 3 of P. brassicae from a segregating population derived from 'Tekila' ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36187-5
更新日期:2018-12-05 00:00:00
abstract::Cross-talk between exogenous salicylic acid (SA) and endogenous phytohormone pathways affects the antioxidant defense system and its response to salt stress. The study presented here investigated the effects of SA treatment before and during salt stress on the levels of endogenous plant growth regulators in three barl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70807-3
更新日期:2020-08-17 00:00:00
abstract::Respiratory syncytial virus (RSV) is an important cause of serious lower respiratory tract disease in infants. Several studies have shown evidence pointing to the genome of the host as an important factor determining susceptibility to respiratory disease caused by RSV. We sequenced the complete exomes of 54 patients i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15752-4
更新日期:2017-11-21 00:00:00
abstract::Epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 epoxygenases from arachidonic acid, and their rapid metabolism is mainly through soluble epoxide hydrolase (sEH). EETs exert vasodilatory, anti-inflammatory, anti-apoptotic, and pro-angiogenic effects. Administration of sEH inhibitors before or at the on...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23504-1
更新日期:2018-03-27 00:00:00
abstract::We assessed 1-year outcomes in patients with atrial fibrillation enrolled in the EurObservational Research Programme AF General Pilot Registry (EORP-AF), in relation to kidney function, as assessed by glomerular filtration rate (eGFR). In a cohort of 2398 patients (median age 69 years; 61% male), eGFR (ml/min/1.73 m(2...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究
doi:10.1038/srep30271
更新日期:2016-07-28 00:00:00
abstract::Room-temperature ferromagnetism in Mn-doped chalcopyrites is a desire aspect when applying those materials to spin electronics. However, dominance of high Curie-temperatures due to cluster formation or inhomogeneities limited their consideration. Here we report how an external perturbation such as applied hydrostatic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07720
更新日期:2015-01-12 00:00:00
abstract::Social immunity forms an essential part of the defence repertoire of social insects. In response to infestation by the parasitic mite Varroa destructor and its associated viruses, honey bees (Apis mellifera L.) have developed a specific behaviour (varroa-sensitive hygiene, or VSH) that helps protect the colony from th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25444
更新日期:2016-05-03 00:00:00
abstract::Some previous studies have indicated that valproate (VPA) might change the pharmacokinetics and enhance the effects of propofol. We evaluated whether clinical VPA therapy affected the propofol blood level, the protein-unbound free propofol level, and/or the anesthetic effects of propofol in the clinical setting. The s...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-020-58460-2
更新日期:2020-01-31 00:00:00
abstract::Variations in isotopic composition of water vapor in the atmosphere is an important indicator of the processes within the hydrological cycle. Isotopic signature of water vapor and precipitation can be helpful in partitioning evaporation and transpiration fluxes. It is well known that transpiration from forested region...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55186-8
更新日期:2019-12-09 00:00:00
abstract::Microbubble contrast agents are widely used in ultrasound imaging and therapy, typically with transmission center frequencies in the MHz range. Currently, an ultrasound center frequency near 250 kHz is proposed for clinical trials in which ultrasound combined with microbubble contrast agents is applied to open the blo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34494-5
更新日期:2018-11-05 00:00:00
abstract::Calcitriol, a metabolite of vitamin D, is often used in osteoporosis clinics. However, the material has other bioactivities; for example, it accelerates angiogenesis, has anti-inflammatory properties, and inhibits oxidative stress. We investigated the effects of calcitriol in a random skin flap rat model. "McFarlane f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18945
更新日期:2016-01-06 00:00:00
abstract::Although a slowing of electroencephalographic (EEG) activity during wakefulness and -to some extent- sleep of Alzheimer disease (AD) patients (i.e., increased slow-frequency activity) was documented, recent findings in healthy elderly show a decreased 0.6-1 Hz slow wave activity (SWA) during NREM, which was associated...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39688
更新日期:2017-01-03 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been implicated in cancer biogenesis and prognosis. By repurposing microarray probes, we herein analysed the lncRNA expression...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33535
更新日期:2016-09-15 00:00:00
abstract::Malaria is among the major threats to global health with the main burden of disease being in rural areas of developing countries where accurate diagnosis based on non-invasive samples is in high demand. We here present a novel molecular assay for detection of malaria parasites based on technology that may be adapted f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22378-7
更新日期:2018-03-07 00:00:00
abstract::Individuals with Angelman syndrome (AS) are characterized by severe cognitive impairments alongside an enhanced drive for social engagement. As knowledge on imitation skills in this population is limited, we conducted the first controlled study of imitation in AS. We examined how 23 individuals with AS and 21 typicall...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72079-3
更新日期:2020-10-02 00:00:00