当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism.

Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism.

Abstract：

:Endocannabinoids are amphiphilic molecules that play crucial neurophysiological functions acting as lipid messengers. Antagonists and knockdown of the classical CB1 and CB2 cannabinoid receptors do not completely abolish many endocannabinoid activities, supporting the idea of a mechanism independent of receptors whose mode of action remains unclear. Here we combine gramicidin A (gA) single channel recordings and membrane capacitance measurements to investigate the lipid bilayer-modifying activity of endocannabinoids. Single channel recordings show that the incorporation of endocannabinoids into lipid bilayers reduces the free energy necessary for gramicidin channels to transit from the monomeric to the dimeric conformation. Membrane capacitance demonstrates that the endocannabinoid anandamide has limited effects on the overall structure of the lipid bilayers. Our results associated with the theory of membrane elastic deformation reveal that the action of endocannabinoids on membrane proteins can involve local adjustments of the lipid/protein hydrophobic interface. The current findings shed new light on the receptor-independent mode of action of endocannabinoids on membrane proteins, with important implications towards their neurobiological function.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Medeiros D,Silva-Gonçalves LC,da Silva AM,Dos Santos Cabrera MP,Arcisio-Miranda M

doi

10.1038/srep41362

subject

Has Abstract

pub_date

2017-01-27 00:00:00

pages

41362

issn

2045-2322

pii

srep41362

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Author Correction: Space-Wave Routing via Surface Waves Using a Metasurface System.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-018-28343-8

    authors： Achouri K,Caloz C

    更新日期：2018-07-03 00:00:00

  • Leukotriene E4 is a full functional agonist for human cysteinyl leukotriene type 1 receptor-dependent gene expression.

    abstract：:Leukotriene E4 (LTE4) the most stable of the cysteinyl leukotrienes (cysLTs) binds poorly to classical type 1 (CysLT1) and 2 (CysLT2) receptors although it induces potent responses in human airways in vivo, such as bronchoconstriction, airway hyperresponsiveness and inflammatory cell influx suggesting the presence of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20461

    authors： Foster HR,Fuerst E,Branchett W,Lee TH,Cousins DJ,Woszczek G

    更新日期：2016-02-02 00:00:00

  • Increasing incidence and improving survival of oral tongue squamous cell carcinoma.

    abstract：:We evaluated changes in incidence, relative survival (RS), and conditional survival (CS) of head and neck squamous cell carcinoma (HNSCC), focusing on oral tongue squamous cell carcinoma (OTSCC). Data of 74 680 HNSCC patients from 1976 to 2015 were obtained from the Surveillance, Epidemiology, and End Results database...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64748-0

    authors： Kim YJ,Kim JH

    更新日期：2020-05-12 00:00:00

  • Mechanized transplanting with side deep fertilization increases yield and nitrogen use efficiency of rice in Eastern China.

    abstract：:The application of nitrogen (N) fertilizer deep in soil at the same time as mechanical transplanting of rice seedlings is an effective alternative to conventional broadcasting of fertilizer, but its effects on yields and profitability have not been analysed in detail. Here, we analysed the effects of a side deep appli...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42039-7

    authors： Zhu C,Xiang J,Zhang Y,Zhang Y,Zhu D,Chen H

    更新日期：2019-04-04 00:00:00

  • Critical features of acute stress-induced cross-sensitization identified through the hypothalamic-pituitary-adrenal axis output.

    abstract：:Stress-induced sensitization represents a process whereby prior exposure to severe stressors leaves animals or humans in a hyper-responsive state to further stressors. Indeed, this phenomenon is assumed to be the basis of certain stress-associated pathologies, including post-traumatic stress disorder and psychosis. On...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep31244

    authors： Belda X,Nadal R,Armario A

    更新日期：2016-08-11 00:00:00

  • Plastic, nutrition and pollution; relationships between ingested plastic and metal concentrations in the livers of two Pachyptila seabirds.

    abstract：:Naturally occurring metals and metalloids [metal(loid)s] are essential for the physiological functioning of wildlife; however, environmental contamination by metal(loid) and plastic pollutants is a health hazard. Metal(loid)s may interact with plastic in the environment and there is mixed evidence about whether plasti...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75024-6

    authors： Roman L,Kastury F,Petit S,Aleman R,Wilcox C,Hardesty BD,Hindell MA

    更新日期：2020-10-22 00:00:00

  • Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H.

    abstract：:Neutrophils play an important role in the occurrence and development of acute lung injury (ALI). Leukotriene B4 (LTB4), a hydrolysis product of epoxide leukotriene A4 (LTA4) catalyzed by LTA4 hydrolase (LTA4H), is one of the most potent chemoattractants for neutrophil. Bufexamac is a drug widely used as an anti-inflam...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25298

    authors： Xiao Q,Dong N,Yao X,Wu D,Lu Y,Mao F,Zhu J,Li J,Huang J,Chen A,Huang L,Wang X,Yang G,He G,Xu Y,Lu W

    更新日期：2016-04-29 00:00:00

  • Author Correction: Toxicity evaluation of Wanzhou watershed of Yangtze Three Gorges Reservoir in the flood season in Caenorhabditis elegans.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-018-34064-9

    authors： Xiao G,Zhao L,Huang Q,Yang J,Du H,Guo D,Xia M,Li G,Chen Z,Wang D

    更新日期：2018-10-18 00:00:00

  • C/EBPδ protects from radiation-induced intestinal injury and sepsis by suppression of inflammatory and nitrosative stress.

    abstract：:Ionizing radiation (IR)-induced intestinal damage is characterized by a loss of intestinal crypt cells, intestinal barrier disruption and translocation of intestinal microflora resulting in sepsis-mediated lethality. We have shown that mice lacking C/EBPδ display IR-induced intestinal and hematopoietic injury and leth...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49437-x

    authors： Banerjee S,Fu Q,Shah SK,Melnyk SB,Sterneck E,Hauer-Jensen M,Pawar SA

    更新日期：2019-09-27 00:00:00

  • Silica Gel Coated Spherical Micro resonator for Ultra-High Sensitivity Detection of Ammonia Gas Concentration in Air.

    abstract：:A silica gel coated microsphere resonator is proposed and experimentally demonstrated for measurements of ammonia (NH3) concentration in air with ultra-high sensitivity. The optical properties of the porous silica gel layer change when it is exposed to low (parts per million (ppm)) and even ultra-low (parts per billio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-20025-9

    authors： Mallik AK,Farrell G,Liu D,Kavungal V,Wu Q,Semenova Y

    更新日期：2018-01-26 00:00:00

  • Development of miniaturized walking biological machines.

    abstract：:The quest to 'forward-engineer' and fabricate biological machines remains a grand challenge. Towards this end, we have fabricated locomotive "bio-bots" from hydrogels and cardiomyocytes using a 3D printer. The multi-material bio-bot consisted of a 'biological bimorph' cantilever structure as the actuator to power the ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00857

    authors： Chan V,Park K,Collens MB,Kong H,Saif TA,Bashir R

    更新日期：2012-01-01 00:00:00

  • Electrically Tunable and Negative Schottky Barriers in Multi-layered Graphene/MoS2 Heterostructured Transistors.

    abstract：:We fabricated multi-layered graphene/MoS2 heterostructured devices by positioning mechanically exfoliated bulk graphite and single-crystalline 2H-MoS2 onto Au metal pads on a SiO2/Si substrate via a contamination-free dry transfer technique. We also studied the electrical transport properties of Au/MoS2 junction devic...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13743

    authors： Qiu D,Kim EK

    更新日期：2015-09-03 00:00:00

  • Author Correction: Whole exome sequencing reveals rare variants linked to congenital pouch colon.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-018-32119-5

    authors： Mathur P,Medicherla KM,Chaudhary S,Patel M,Bagali P,Suravajhala P

    更新日期：2018-09-11 00:00:00

  • The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism.

    abstract：:Autistic spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social communication and restricted/repetitive behavior patterns or interests. Antagonists targeting histamine H3 receptor (H3R) are considered potential therapeutic agents for the therapeutic management of different brain...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-31385-7

    authors： Eissa N,Jayaprakash P,Azimullah S,Ojha SK,Al-Houqani M,Jalal FY,Łażewska D,Kieć-Kononowicz K,Sadek B

    更新日期：2018-08-30 00:00:00

  • The subpolar gyre regulates silicate concentrations in the North Atlantic.

    abstract：:The North Atlantic is characterized by diatom-dominated spring blooms that results in significant transfer of carbon to higher trophic levels and the deep ocean. These blooms are terminated by limiting silicate concentrations in summer. Numerous regional studies have demonstrated phytoplankton community shifts to ligh...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-14837-4

    authors： Hátún H,Azetsu-Scott K,Somavilla R,Rey F,Johnson C,Mathis M,Mikolajewicz U,Coupel P,Tremblay JÉ,Hartman S,Pacariz SV,Salter I,Ólafsson J

    更新日期：2017-11-06 00:00:00

  • Brief high fat high sugar diet results in altered energy and fat metabolism during pregnancy in mice.

    abstract：:During pregnancy several maternal adaptations occur in order to support the growing fetus which are further exacerbated by gestational diabetes mellitus (GDM). Previously we developed a mouse model of GDM, however we did not evaluate alterations to energy and fat metabolism. We have also shown that alterations in lipi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-77529-6

    authors： Pennington KA,Dong Y,Ruano SH,van der Walt N,Sangi-Haghpeykar H,Yallampalli C

    更新日期：2020-11-30 00:00:00

  • Controllable thermal rectification realized in binary phase change composites.

    abstract：:Phase transition is a natural phenomenon happened around our daily life, represented by the process from ice to water. While melting and solidifying at a certain temperature, a high heat of fusion is accompanied, classified as the latent heat. Phase change material (PCM) has been widely applied to store and release la...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08884

    authors： Chen R,Cui Y,Tian H,Yao R,Liu Z,Shu Y,Li C,Yang Y,Ren T,Zhang G,Zou R

    更新日期：2015-03-09 00:00:00

  • Quantitative measures of vortex veins in the posterior pole in eyes with pachychoroid spectrum diseases.

    abstract：:Pachychoroid spectrum diseases have attracted increasing attention, though their pathophysiology has yet to be fully elucidated. In this study, we assessed the vascular diameters of vortex veins in pachychoroid spectrum diseases such as central serous chorioretinopathy (CSC), pachychoroid neovasculopathy without polyp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75789-w

    authors： Matsumoto H,Hoshino J,Arai Y,Mukai R,Nakamura K,Kikuchi Y,Kishi S,Akiyama H

    更新日期：2020-11-11 00:00:00

  • Risk factor analysis and idiographic features of mandibular coronoid fractures: A retrospective case-control study.

    abstract：:This study aimed to identify and distinguish various factors that may influence the occurrence of mandibular coronoid fractures. From January 2000 to December 2009, a total of 1131 patients with maxillofacial fractures were enrolled in this statistical study to evaluate the association between mandibular coronoid frac...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02335-6

    authors： Zhou HH,Lv K,Yang RT,Li Z,Li ZB

    更新日期：2017-05-19 00:00:00

  • Improved drought stress tolerance in Arabidopsis by CRISPR/dCas9 fusion with a Histone AcetylTransferase.

    abstract：:Drought episodes decrease plant growth and productivity, which in turn cause high economic losses. Plants naturally sense and respond to water stress by activating specific signalling pathways leading to physiological and developmental adaptations. Genetically engineering genes that belong to these pathways might impr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44571-y

    authors： Roca Paixão JF,Gillet FX,Ribeiro TP,Bournaud C,Lourenço-Tessutti IT,Noriega DD,Melo BP,de Almeida-Engler J,Grossi-de-Sa MF

    更新日期：2019-05-30 00:00:00

  • Permeability-driven selection in a semi-empirical protocell model: the roots of prebiotic systems evolution.

    abstract：:The origin-of-life problem has been traditionally conceived as the chemical challenge to find the type of molecule and free-solution reaction dynamics that could have started Darwinian evolution. Different autocatalytic and 'self-replicative' molecular species have been extensively investigated, together with plausibl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02799-6

    authors： Piedrafita G,Monnard PA,Mavelli F,Ruiz-Mirazo K

    更新日期：2017-06-09 00:00:00

  • Transcriptome analysis of bagging-treated red Chinese sand pear peels reveals light-responsive pathway functions in anthocyanin accumulation.

    abstract：:Bagging is an efficient method to improve fruit colour development. This work reported a transcriptome analysis using bagging-treated red Chinese sand pear peels. In total, 8,870 differentially expressed genes were further analysed by a weighted gene co-expression network analysis and early-, middle- and late light-re...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00069-z

    authors： Bai S,Sun Y,Qian M,Yang F,Ni J,Tao R,Li L,Shu Q,Zhang D,Teng Y

    更新日期：2017-03-03 00:00:00

  • Coexistence of Write Once Read Many Memory and Memristor in blend of Poly(3,4-ethylenedioxythiophene): polystyrene sulfonate and Polyvinyl Alcohol.

    abstract：:In this work, the coexistence of Write Once Read Many Memory (WORM) and memristor can be achieved in a single device of Poly(3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT: PSS) and Polyvinyl Alcohol (PVA) blend organic memory system. In memristor mode, the bistable resistance states of the device can be cy...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep38816

    authors： Nguyen VC,Lee PS

    更新日期：2016-12-12 00:00:00

  • Little-Parks effect governed by magnetic nanostructures with out-of-plane magnetization.

    abstract：:Little-Parks effect names the oscillations in the superconducting critical temperature as a function of the magnetic field. This effect is related to the geometry of the sample. In this work, we show that this effect can be enhanced and manipulated by the inclusion of magnetic nanostructures with perpendicular magneti...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67317-7

    authors： de Ory MC,Rollano V,Gomez A,Menghini M,Muñoz-Noval A,Gonzalez EM,Vicent JL

    更新日期：2020-06-25 00:00:00

  • Parasitoid envenomation alters the Galleria mellonella midgut microbiota and immunity, thereby promoting fungal infection.

    abstract：:Gut bacteria influence the development of different pathologies caused by bacteria, fungi and parasitoids in insects. Wax moth larvae became more susceptible to fungal infections after envenomation by the ectoparasitoid Habrobracon hebetor. In addition, spontaneous bacterioses occurred more often in envenomated larvae...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40301-6

    authors： Polenogova OV,Kabilov MR,Tyurin MV,Rotskaya UN,Krivopalov AV,Morozova VV,Mozhaitseva K,Kryukova NA,Alikina T,Kryukov VY,Glupov VV

    更新日期：2019-03-08 00:00:00

  • Intracerebroventricular injection of ouabain causes mania-like behavior in mice through D2 receptor activation.

    abstract：:Intracerebroventricular (ICV) administration of ouabain, an inhibitor of the Na, K-ATPase, is an approach used to study the physiological functions of the Na, K-ATPase and cardiotonic steroids in the central nervous system, known to cause mania-like hyperactivity in rats. We describe a mouse model of ouabain-induced m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52058-z

    authors： Lopachev A,Volnova A,Evdokimenko A,Abaimov D,Timoshina Y,Kazanskaya R,Lopacheva O,Deal A,Budygin E,Fedorova T,Gainetdinov R

    更新日期：2019-10-30 00:00:00

  • Understanding and mimicking the dual optimality of the fly ear.

    abstract：:The fly Ormia ochracea has the remarkable ability, given an eardrum separation of only 520 μm, to pinpoint the 5 kHz chirp of its cricket host. Previous research showed that the two eardrums are mechanically coupled, which amplifies the directional cues. We have now performed a mechanics and optimization analysis whic...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02489

    authors： Liu H,Currano L,Gee D,Helms T,Yu M

    更新日期：2013-01-01 00:00:00

  • Structure-Activity Analysis of Gram-positive Bacterium-producing Lasso Peptides with Anti-mycobacterial Activity.

    abstract：:Lariatin A, an 18-residue lasso peptide encoded by the five-gene cluster larABCDE, displays potent and selective anti-mycobacterial activity. The structural feature is an N-terminal macrolactam ring, through which the C-terminal passed to form the rigid lariat-protoknot structure. In the present study, we established ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep30375

    authors： Inokoshi J,Koyama N,Miyake M,Shimizu Y,Tomoda H

    更新日期：2016-07-26 00:00:00

  • Toll like receptor7 polymorphisms in relation to disease susceptibility and progression in Chinese patients with chronic HBV infection.

    abstract：:Toll-like receptors (TLRs) play a key role in innate and adaptive immunity, protecting the host from viral pathogens. We studied the effect of TLR7 polymorphisms on disease susceptibility and progression of chronic hepatitis B (CHB) infection in Chinese adults. Blood samples were taken from 612 patients with confirmed...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12698-5

    authors： Zhu J,Zhang T,Cao L,Li A,Zheng K,Zhang N,Su B,Chen Z,Chen N,Wu H,He Q

    更新日期：2017-09-29 00:00:00

  • Evidence for trivial Berry phase and absence of chiral anomaly in semimetal NbP.

    abstract：:The discovery of Weyl semimetals (WSM) has brought forth the condensed matter realization of Weyl fermions, which were previously theorized as low energy excitations in high energy particle physics. Recently, transition metal mono-pnictides are under intense investigation for understanding properties of inversion-symm...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep46062

    authors： Sudesh,Kumar P,Neha P,Das T,Patnaik S

    更新日期：2017-04-10 00:00:00