Abstract：
:Segmentation of the vertebrate hindbrain is an evolutionarily conserved process. Here, we identify the transcription factor early growth response 4 (egr4) as a novel regulator of posterior hindbrain development in Xenopus. egr4 is specifically and transiently expressed in rhombomeres 5 and 6 (r5/r6), and Egr4 knockdown causes a loss of mafb/kreisler and krox20/egr2 expression in r5/r6 and r5, respectively. This phenotype can be fully rescued by injection of frog or mouse Egr4 mRNA. Moreover Egr4-depleted embryos exhibit a specific loss of the neural crest stream adjacent to r5, and have inner ear defects. While the homeodomain protein vHnf1/Hnf1b directly activates Mafb and Krox20 expression in the mouse hindbrain to specify r5, we show that in Xenopus this process is indirect through the activation of Egr4. We provide evidence that rearrangements in the regulatory sequences around egr4 and mafb genes may account for this difference.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Bae CJ,Jeong J,Saint-Jeannet JPdoi
10.1038/srep07750subject
Has Abstractpub_date
2015-01-13 00:00:00pages
7750issn
2045-2322pii
srep07750journal_volume
5pub_type
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pub_type： 杂志文章
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pub_type： 杂志文章
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