当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Aurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation.

Aurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation.

Abstract：

:The emergence of resistance to imatinib mediated by mutations in the BCR-ABL has become a major challenge in the treatment of chronic myeloid leukemia (CML). Alternative therapeutic strategies to override imatinib-resistant CML are urgently needed. In this study, we investigated the effect of AKI603, a novel small molecule inhibitor of Aurora kinase A (AurA) to overcome resistance mediated by BCR-ABL-T315I mutation. Our results showed that AKI603 exhibited strong anti-proliferative activity in leukemic cells. AKI603 inhibited cell proliferation and colony formation capacities in imatinib-resistant CML cells by inducing cell cycle arrest with polyploidy accumulation. Surprisingly, inhibition of AurA by AKI603 induced leukemia cell senescence in both BCR-ABL wild type and T315I mutation cells. Furthermore, the induction of senescence was associated with enhancing reactive oxygen species (ROS) level. Moreover, the anti-tumor effect of AKI603 was proved in the BALB/c nude mice KBM5-T315I xenograft model. Taken together, our data demonstrate that the small molecule AurA inhibitor AKI603 may be used to overcome drug resistance induced by BCR-ABL-T315I mutation in CML.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wang LX,Wang JD,Chen JJ,Long B,Liu LL,Tu XX,Luo Y,Hu Y,Lin DJ,Lu G,Long ZJ,Liu Q

doi

10.1038/srep35533

subject

Has Abstract

pub_date

2016-11-08 00:00:00

pages

35533

issn

2045-2322

pii

srep35533

journal_volume

6

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • An All-vanadium Continuous-flow Photoelectrochemical Cell for Extending State-of-charge in Solar Energy Storage.

    abstract：:Greater levels of solar energy storage provide an effective solution to the inherent nature of intermittency, and can substantially improve reliability, availability, and quality of the renewable energy source. Here we demonstrated an all-vanadium (all-V) continuous-flow photoelectrochemical storage cell (PESC) to ach...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00585-y

    authors： Wei Z,Shen Y,Liu D,Liu F

    更新日期：2017-04-04 00:00:00

  • Evidence of language-related left hypofrontality in Major Depression: An EEG Beta band study.

    abstract：:Major depression (MDD) has been associated with an altered EEG frontal asymmetry measured in resting state; nevertheless, this association has showed a weak consistency across studies. In the present study, which starts from an evolutionistic view of psychiatric disorders, we investigated frontal asymmetry in MDD, usi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65168-w

    authors： Spironelli C,Maffei A,Romeo Z,Piazzon G,Padovan G,Magnolfi G,Pasini I,Gomez Homen F,Concari G,Angrilli A

    更新日期：2020-05-18 00:00:00

  • Flax latitudinal adaptation at LuTFL1 altered architecture and promoted fiber production.

    abstract：:After domestication in the Near East around 10,000 years ago several founder crops, flax included, spread to European latitudes. On reaching northerly latitudes the architecture of domesticated flax became more suitable to fiber production over oil, with longer stems, smaller seeds and fewer axillary branches. Latitud...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37086-5

    authors： Gutaker RM,Zaidem M,Fu YB,Diederichsen A,Smith O,Ware R,Allaby RG

    更新日期：2019-01-30 00:00:00

  • Pterostilbene, a natural phenolic compound, synergizes the antineoplastic effects of megestrol acetate in endometrial cancer.

    abstract：:Endometrial cancer is the most common gynecologic cancer in the United States and its incidence and mortality has been rising over the past decade. Few treatment options are available for patients with advanced and recurring endometrial cancers. Novel therapies, which are frequently toxic, are difficult to establish i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12922-2

    authors： Wen W,Lowe G,Roberts CM,Finlay J,Han ES,Glackin CA,Dellinger TH

    更新日期：2017-10-06 00:00:00

  • Effect of ionic liquid treatment on the ultrastructural and topochemical features of compression wood in Japanese cedar (Cryptomeria japonica).

    abstract：:The morphological and topochemical changes in wood tissues in compression wood of Japanese cedar (Cryptomeria japonica) upon treated with two types of ionic liquids, 1-ethyl-3-methylimidazolium chloride ([C2mim][Cl]) and 1-ethylpyridinium bromide ([EtPy][Br]) were investigated. Compression wood tracheids were swollen ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep30147

    authors： Kanbayashi T,Miyafuji H

    更新日期：2016-07-18 00:00:00

  • Long-range propagation of protons in single-crystal VO2 involving structural transformation to HVO2.

    abstract：:Vanadium dioxide (VO2) is a strongly correlated electronic material with a metal-insulator transition (MIT) near room temperature. Ion-doping to VO2 dramatically alters its transport properties and the MIT temperature. Recently, insulating hydrogenated VO2 (HVO2) accompanied by a crystal structure transformation from ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56685-4

    authors： Muraoka K,Kanki T

    更新日期：2019-12-27 00:00:00

  • Population-specific signatures of intra-individual mitochondrial DNA heteroplasmy and their potential evolutionary advantages.

    abstract：:Heteroplasmy is the existence of more than one mitochondrial DNA (mtDNA) variant within a cell. The evolutionary mechanisms of heteroplasmy are not fully understood, despite being a very common phenomenon. Here we combined heteroplasmy measurements using high throughput sequencing on green turtles (Chelonia mydas) wit...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56918-6

    authors： Tikochinski Y,Carreras C,Tikochinski G,Vilaça ST

    更新日期：2020-01-14 00:00:00

  • Prognostic significance of the digit ratio after hormone therapy for prostate cancer: a prospective multicenter study.

    abstract：:The digit ratio has been used as a retrospective noninvasive biomarker to investigate the putative effects of prenatal exposure to androgens. In recent years, many scholars have paid attention to the association between 2D:4D (the second and fourth digits) and prostatic cancer. This study explored the prognostic signi...

    journal_title：Scientific reports

    pub_type： 杂志文章,多中心研究

    doi：10.1038/s41598-017-05638-w

    authors： Li G,Sun K,Guo J,Li S,Li B,Cao J,Lu P,Yang J,Zhang Y,Yang X,Gao L,He Y,Cui T,Ma B

    更新日期：2017-07-12 00:00:00

  • Rassf Proteins as Modulators of Mst1 Kinase Activity.

    abstract：:Rassf1A/5 tumor suppressors serve as adaptor proteins possessing a modular architecture with the C-terminal consisting of a coiled-coil SARAH (Salvador-Rassf-Hippo) domain and the central portion being composed of Ras associated (RA) domain. Here, we investigate the effect of Rassf effectors on Mst1 function by mappin...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45020

    authors： Bitra A,Sistla S,Mariam J,Malvi H,Anand R

    更新日期：2017-03-22 00:00:00

  • Graft revascularization is essential for non-invasive monitoring of transplanted islets with radiolabeled exendin.

    abstract：:Islet transplantation is a novel promising strategy to cure type 1 diabetes. However, the long-term outcome is still poor, because both function and survival of the transplant decline over-time. Non-invasive imaging methods have the potential to enable monitoring of islet survival after transplantation and the effects...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep15521

    authors： Eter WA,Bos D,Frielink C,Boerman OC,Brom M,Gotthardt M

    更新日期：2015-10-22 00:00:00

  • The Incidence, Risk Factors and Outcomes of Postoperative Acute Kidney Injury in Neurosurgical Critically Ill Patients.

    abstract：:We investigated the incidence, perioperative risk factors, and outcomes of postoperative acute kidney injury (AKI) in neurosurgical critically ill patients. A prospective multicenter cohort study was conducted, enrolling adult patients who underwent neurosurgical procedure and admitted to the neurosurgical intensive c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04627-3

    authors： Deng Y,Yuan J,Chi R,Ye H,Zhou D,Wang S,Mai C,Nie Z,Wang L,Zhai Y,Gao L,Zhang D,Hu L,Deng Y,Chen C

    更新日期：2017-06-26 00:00:00

  • DNA repair protein Rad18 restricts LINE-1 mobility.

    abstract：:Long interspersed element-1 (LINE-1, L1) is a mobile genetic element comprising about 17% of the human genome. L1 utilizes an endonuclease to insert L1 cDNA into the target genomic DNA, which induces double-strand DNA breaks in the human genome and activates the DNA damage signaling pathway, resulting in the recruitme...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34288-9

    authors： Ariumi Y,Kawano K,Yasuda-Inoue M,Kuroki M,Fukuda H,Siddiqui R,Turelli P,Tateishi S

    更新日期：2018-10-26 00:00:00

  • PRINT: A Protein Bioconjugation Method with Exquisite N-terminal Specificity.

    abstract：:Chemical conjugation is commonly used to enhance the pharmacokinetics, biodistribution, and potency of protein therapeutics, but often leads to non-specific modification or loss of bioactivity. Here, we present a simple, versatile and widely applicable method that allows exquisite N-terminal specific modification of p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep18363

    authors： Sur S,Qiao Y,Fries A,O'Meally RN,Cole RN,Kinzler KW,Vogelstein B,Zhou S

    更新日期：2015-12-17 00:00:00

  • Low-flux scanning electron diffraction reveals substructures inside the ordered membrane domain.

    abstract：:Ordered/disordered phase separation occurring in bio-membranes has piqued researchers' interest because these ordered domains, called lipid rafts, regulate important biological functions. The structure of the ordered domain has been examined with artificial membranes, which undergo macroscopic ordered/disordered phase...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79083-7

    authors： Kinoshita M,Yamaguchi S,Matsumori N

    更新日期：2020-12-21 00:00:00

  • Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans.

    abstract：:Cardiovascular risk rapidly increased following exposure to air pollution. Changes in human autonomic regulation have been implicated based on epidemiological associations between exposure estimates and indirect autonomic nervous system measurements. We conducted a mechanistic study to test the hypothesis that, in hea...

    journal_title：Scientific reports

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/s41598-019-40343-w

    authors： Heusser K,Tank J,Holz O,May M,Brinkmann J,Engeli S,Diedrich A,Framke T,Koch A,Großhennig A,Jan Danser AH,Sweep FCGJ,Schindler C,Schwarz K,Krug N,Jordan J,Hohlfeld JM

    更新日期：2019-03-06 00:00:00

  • Why large porphyry Cu deposits like high Sr/Y magmas?

    abstract：:Porphyry systems supply most copper and significant gold to our economy. Recent studies indicate that they are frequently associated with high Sr/Y magmatic rocks, but the meaning of this association remains elusive. Understanding the association between high Sr/Y magmatic rocks and porphyry-type deposits is essential...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00685

    authors： Chiaradia M,Ulianov A,Kouzmanov K,Beate B

    更新日期：2012-01-01 00:00:00

  • Deep learning based prediction of prognosis in nonmetastatic clear cell renal cell carcinoma.

    abstract：:Survival analyses for malignancies, including renal cell carcinoma (RCC), have primarily been conducted using the Cox proportional hazards (CPH) model. We compared the random survival forest (RSF) and DeepSurv models with the CPH model to predict recurrence-free survival (RFS) and cancer-specific survival (CSS) in non...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80262-9

    authors： Byun SS,Heo TS,Choi JM,Jeong YS,Kim YS,Lee WK,Kim C

    更新日期：2021-01-13 00:00:00

  • UniBic: Sequential row-based biclustering algorithm for analysis of gene expression data.

    abstract：:Biclustering algorithms, which aim to provide an effective and efficient way to analyze gene expression data by finding a group of genes with trend-preserving expression patterns under certain conditions, have been widely developed since Morgan et al. pioneered a work about partitioning a data matrix into submatrices ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23466

    authors： Wang Z,Li G,Robinson RW,Huang X

    更新日期：2016-03-22 00:00:00

  • Anatase TiO2 Nanoparticles with Exposed {001} Facets for Efficient Dye-Sensitized Solar Cells.

    abstract：:Anatase TiO2 nanoparticles with exposed {001} facets were synthesized from Ti powder via a sequential hydrothermal reaction process. At the first-step hydrothermal reaction, H-titanate nanowires were obtained in NaOH solution with Ti powder, and at second-step hydrothermal reaction, anatase TiO2 nanoparticles with exp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12143

    authors： Chu L,Qin Z,Yang J,Li X

    更新日期：2015-07-20 00:00:00

  • The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression.

    abstract：:Expression of the mismatch repair gene MutL homolog 1 (MLH1) is silenced in a clinically important subgroup of sporadic colorectal cancers. These cancers exhibit hypermutability with microsatellite instability (MSI) and differ from microsatellite-stable (MSS) colorectal cancers in both prognosis and response to therap...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41598-019-49952-x

    authors： Thomas R,Trapani D,Goodyer-Sait L,Tomkova M,Fernandez-Rozadilla C,Sahnane N,Woolley C,Davis H,Chegwidden L,Kriaucionis S,Maughan T,Leedham S,Palles C,Furlan D,Tomlinson I,Lewis A

    更新日期：2019-09-17 00:00:00

  • Biofilm formation in enterococci: genotype-phenotype correlations and inhibition by vancomycin.

    abstract：:Enterococci are nosocomial pathogens that can form biofilms, which contribute to their virulence and antibiotic resistance. Although many genes involved in biofilm formation have been defined, their distribution among enterococci has not been comprehensively studied on a genome scale, and their diagnostic ability to p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05901-0

    authors： Hashem YA,Amin HM,Essam TM,Yassin AS,Aziz RK

    更新日期：2017-07-18 00:00:00

  • Engineering of soybean mosaic virus as a versatile tool for studying protein-protein interactions in soybean.

    abstract：:Transient gene expression approaches are valuable tools for rapid introduction of genes of interest and characterization of their functions in plants. Although agroinfiltration is the most effectively and routinely used method for transient expression of multiple genes in various plant species, this approach has been ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep22436

    authors： Seo JK,Choi HS,Kim KH

    更新日期：2016-02-29 00:00:00

  • Clinical courses and complications of young adults with Autosomal Recessive Polycystic Kidney Disease (ARPKD).

    abstract：:Autosomal recessive polycystic kidney disease (ARPKD) is a severe pediatric hepatorenal disorder with pronounced phenotypic variability. A substantial number of patients with early diagnosis reaches adulthood and some patients are not diagnosed until adulthood. Yet, clinical knowledge about adult ARPKD patients is sca...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43488-w

    authors： Burgmaier K,Kilian S,Bammens B,Benzing T,Billing H,Büscher A,Galiano M,Grundmann F,Klaus G,Mekahli D,Michel-Calemard L,Milosevski-Lomic G,Ranchin B,Sauerstein K,Schaefer S,Shroff R,Sterenborg R,Verbeeck S,Weber LT,W

    更新日期：2019-05-28 00:00:00

  • Publisher Correction: Temperature-dependent excitonic superfluid plasma frequency evolution in an excitonic insulator, Ta2NiSe5.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-61010-5

    authors： Seo YS,Eom MJ,Kim JS,Kang CJ,Min BI,Hwang J

    更新日期：2020-03-03 00:00:00

  • The effects of symmetrical arrangement on quantum metrology.

    abstract：:An obstacle for precision improvement in quantum metrology is the information loss causing by the unavoidable interaction between probe system and environment. Quantum fluctuations are environment no system can be isolated from and it will make the precision of initial parameter estimation of the probe atom decrease w...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00544-7

    authors： Jin Y

    更新日期：2017-03-24 00:00:00

  • Regulation of Airway Inflammation by G-protein Regulatory Motif Peptides of AGS3 protein.

    abstract：:Respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and lung infections have critical consequences on mortality and morbidity in humans. The aims of the present study were to examine the mechanisms by which CXCL12 affects MUC1 transcription and airway inflammation, which depend on activa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27054

    authors： Choi IW,Ahn do W,Choi JK,Cha HJ,Ock MS,You E,Rhee S,Kim KC,Choi YH,Song KS

    更新日期：2016-06-07 00:00:00

  • A Novel Recombinant Enterovirus Type EV-A89 with Low Epidemic Strength in Xinjiang, China.

    abstract：:Enterovirus A89 (EV-A89) is a novel member of the EV-A species. To date, only one full-length genome sequence (the prototype strain) has been published. Here, we report the molecular identification and genomic characterization of a Chinese EV-A89 strain, KSYPH-TRMH22F/XJ/CHN/2011, isolated in 2011 from a contact of an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep18558

    authors： Fan Q,Zhang Y,Hu L,Sun Q,Cui H,Yan D,Sikandaner H,Tang H,Wang D,Zhu Z,Zhu S,Xu W

    更新日期：2015-12-21 00:00:00

  • Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver.

    abstract：:Sodium taurocholate cotransporting polypeptide (NTCP) is a recently discovered hepatitis B virus (HBV) receptor. In the present study, we used TK-NOG mice with a humanized liver to examine the impact of endogenous NTCP expression on HBV infection. Upon inoculation with HBV, these mice exhibited clear viremia in 2 week...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27782

    authors： Nakabori T,Hikita H,Murai K,Nozaki Y,Kai Y,Makino Y,Saito Y,Tanaka S,Wada H,Eguchi H,Takahashi T,Suemizu H,Sakamori R,Hiramatsu N,Tatsumi T,Takehara T

    更新日期：2016-06-09 00:00:00

  • Network-based Responses to the Psychomotor Vigilance Task during Lapses in Adolescents after Short and Extended Sleep.

    abstract：:Neuroimaging studies of the Psychomotor Vigilance Task (PVT) have revealed brain regions involved in attention lapses in sleep-deprived and well-rested adults. Those studies have focused on individual brain regions, rather than integrated brain networks, and have overlooked adolescence, a period of ongoing brain devel...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-50180-6

    authors： DiFrancesco MW,Van Dyk T,Altaye M,Drummond SPA,Beebe DW

    更新日期：2019-09-26 00:00:00

  • Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations.

    abstract：:Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05568-7

    authors： Cooperstone JL,Tober KL,Riedl KM,Teegarden MD,Cichon MJ,Francis DM,Schwartz SJ,Oberyszyn TM

    更新日期：2017-07-11 00:00:00