Abstract：
:Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin cancer. SKH-1 hairless and immunocompetent mice (n = 180) were fed AIN-93G or AIN-93G + 10% tangerine or red tomato powder for 35 weeks. From weeks 11-20, mice (n = 120) were exposed to 2240 J/m2 UV-B light, 3x/week, and tumors were tracked weekly. Control mice were fed the same diets but not exposed to UV. Tumor number was significantly lower in male mice consuming red tomato diets (1.73 ± 0.50, P = 0.015) or pooled tomato diets (2.03 ± 0.45, P = 0.017) compared to controls (4.04 ± 0.65). Carotenoid levels in plasma and skin were quantitated, with total lycopene higher in skin of tangerine fed animals despite a lower dose. Metabolomic analyses elucidated compounds derived from tomato glycoalkaloids (including tomatidine and hydroxylated-tomatidine) as significantly different metabolites in skin after tomato exposure. Here, we describe that tomato consumption can modulate risk for keratinocyte carcinomas; however, the role of the newly identified specific phytochemicals possibly responsible for this action require further investigation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Cooperstone JL,Tober KL,Riedl KM,Teegarden MD,Cichon MJ,Francis DM,Schwartz SJ,Oberyszyn TMdoi
10.1038/s41598-017-05568-7subject
Has Abstractpub_date
2017-07-11 00:00:00pages
5106issue
1issn
2045-2322pii
10.1038/s41598-017-05568-7journal_volume
7pub_type
杂志文章abstract：:Stable electroluminescence from micro-pixelated light-emitting diode (μLED) occurs when electrons and holes are continuously injected from external electrodes. Different from the general recognition, in this work, μLED works in an operation mode, namely, non-electrical contact and non-carrier injection mode, and can b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65092-z
更新日期：2020-05-15 00:00:00
abstract：:Obstructive sleep apnea (OSA) is associated with increasing risk of recurrent stroke and mortality. Nasogastric tubes used by dysphagic stroke patients may interfere with nasal continuous positive airway pressure (CPAP) due to air leakage. This study was evaluated the effects and short-term tolerability of high-flow n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65335-z
更新日期：2020-05-22 00:00:00
abstract：:The aim of this study was to assess the systemic and analgesic effects of epidural dexmedetomidine in thoracic epidural anaesthesia (TEA) combined with total intravenous anaesthesia during thoracic surgery. Seventy-one patients undergoing open thoracotomy were included in this study and randomly divided into three gro...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-017-04382-5
更新日期：2017-06-21 00:00:00
abstract：:Tyrosinase efficiently catalyzes the ortho-hydroxylation of monophenols and the oxidation of diphenols without any additional cofactors. Although it is of significant interest for the biosynthesis of catechol derivatives, the rapid catechol oxidase activity and inactivation of tyrosinase have hampered its practical ut...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17635-0
更新日期：2017-12-08 00:00:00
abstract：:Photoreceptor function is impaired in many retinal diseases like age-related macular degeneration. Currently, assessment of the photoreceptor function for the early diagnosis and monitoring of these diseases is either subjective, as in visual field testing, requires contact with the eye, like in electroretinography, o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50057-8
更新日期：2019-09-20 00:00:00
abstract：:Comparable taxonomic ranks within clades can facilitate more consistent classifications and objective comparisons among taxa. Here we use a temporal approach to identify taxonomic ranks. This is an extension of the temporal banding approach including a Temporal Error Score that finds an objective cut-off for each taxo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02477-7
更新日期：2017-05-23 00:00:00
abstract：:The neuropathology of Parkinson's disease (PD) involves the frontal-subcortical circuit, an area responsible for processing affective theory of mind (ToM). Patients with PD are expected to experience deficits in the affective ToM. This study aims to investigate whether the ability to infer emotion in others is affecte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33988-6
更新日期：2018-10-30 00:00:00
abstract：:The effect of initial evenness on the temporal trajectory of synthetic communities in comprehensive, low-volume microcosm studies remains unknown. We used flow cytometric fingerprinting and 16S rRNA gene amplicon sequencing to assess the impact of time on community structure in one hundred synthetic ecosystems of fixe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18668-1
更新日期：2018-01-10 00:00:00
abstract：:Quaternary ammonium compounds (QACs) are classified as cationic surfactants, and are known for their biocidal activity. However, their modes of action are thus far not completely understood. In this study, we synthesized a gemini QAC, PMT12-BF4 and found that it exerted unsurpassed broad-spectrum antifungal activity a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59750-5
更新日期：2020-02-19 00:00:00
abstract：:We propose a hybrid sequential prediction model called "Deep Sequence", integrating radiomics-engineered imaging features, demographic, and visual factors, with a recursive neural network (RNN) model in the same platform to predict the risk of exudation within a future time-frame in non-exudative AMD eyes. The propose...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72359-y
更新日期：2020-09-22 00:00:00
abstract：:Pond-dwelling cyclic parthenogens are often proposed to be highly vagile. However, the Holarctic biogeography of parthenogens has been hampered by very limited sampling in the eastern Palearctic. Here we examine the geographic boundaries, diversity, and connectivity across the Palearctic for the Daphnia curvirostris c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43281-9
更新日期：2019-05-02 00:00:00
abstract：:To construct a machine learning algorithm model of lymph node metastasis (LNM) in patients with poorly differentiated-type intramucosal gastric cancer. 1169 patients with postoperative gastric cancer were divided into a training group and a test group at a ratio of 7:3. The model for lymph node metastasis was establis...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80582-w
更新日期：2021-01-14 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-78291-5
更新日期：2020-12-01 00:00:00
abstract：:In this study, to fabricate stable floating photocatalytic spheres, facile alcohol solvothermal reduction was first employed to modify commercial TiO2 (P25) photocatalysts to harvest visible light and improve their performances for photodegrading phenol in seawater exciting by visible light. Floating photocatalytic sp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50457-w
更新日期：2019-09-25 00:00:00
abstract：:We have sequenced the genome of the largest freshwater fish species of the world, the arapaima. Analysis of gene family dynamics and signatures of positive selection identified genes involved in the specific adaptations and unique features of this iconic species, in particular it's large size and fast growth. Genome s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41457-x
更新日期：2019-03-28 00:00:00
abstract：:Loss of stromal Caveolin-1 (CAV1) expression is associated with poor prognosis in various cancers. We evaluated the prognostic value of CAV1 expression of both cancer cells and stromal cells in colorectal liver metastases (CRLM) in patients undergoing hepatectomy. In this retrospective study, 109 patients were enrolle...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02251-9
更新日期：2017-05-17 00:00:00
abstract：:The Late Pleistocene Campanian Ignimbrite (CI) super-eruption (Southern Italy) is the largest known volcanic event in the Mediterranean area. The CI tephra is widely dispersed through western Eurasia and occurs in close stratigraphic association with significant palaeoclimatic and Palaeolithic cultural events. Here we...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45940
更新日期：2017-04-06 00:00:00
abstract：:In vertebrates, growth hormone/insulin-like growth factor (GH/IGF) axis signaling plays a critical role in regulating somatic growth. Understanding the direct upstream regulators of GH/IGF axis remains a major challenge. Our studies of the zebrafish reveal that the conserved miR-200 family members are critical regulat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15906
更新日期：2015-10-28 00:00:00
abstract：:A novel strategy for amplification full-length cDNA and promoter sequences has been developed using bioinformatics technology and multiplexed PCR methods in this study. The amplification of 3' ends of cDNA is performed according to the modified classic 3' RACE techniques, therein the more efficient and effective oligo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19420
更新日期：2016-01-13 00:00:00
abstract：:The interaction between roots and bacterial communities in halophytic species is poorly understood. Here, we used Jerusalem artichoke cultivar Nanyu 1 (NY-1) to characterise root distribution patterns and determine diversity and abundance of bacteria in the rhizosphere soil under variable salinity. Root growth was not...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20687
更新日期：2016-02-08 00:00:00
abstract：:Within the last fifteen years, network theory has been successfully applied both to natural sciences and to socioeconomic disciplines. In particular, bipartite networks have been recognized to provide a particularly insightful representation of many systems, ranging from mutualistic networks in ecology to trade networ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10595
更新日期：2015-06-01 00:00:00
abstract：:The green bacterial biosynthesis of lead sulfide nanocrystallites by L-cysteine-desulfurizing bacterium Lysinibacillus sphaericus SH72 was demonstrated in this work. Nanocrystals formed by this bacterial method were characterized using the mineralogical and morphological approaches. The results revealed that the micro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80450-7
更新日期：2021-01-13 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-22947-w
更新日期：2018-03-12 00:00:00
abstract：:Solution-processed gate dielectrics were fabricated with the combined ZrO2 and Al2O3 (ZAO) in the form of mixed and stacked types for oxide thin film transistors (TFTs). ZAO thin films prepared with double coatings for solid gate dielectrics were characterized by analytical tools. For the first time, the capacitance o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33576
更新日期：2016-09-19 00:00:00
abstract：:Liver stage Plasmodium parasites reside in a parasitophorous vacuole (PV) that associates with lysosomes. It has previously been shown that these organelles can have beneficial as well as harmful effects on the parasite. Yet it is not clear how the association of lysosomes with the parasite is controlled and how inter...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44449-z
更新日期：2019-05-28 00:00:00
abstract：:Sarcopenia is an aging condition involving low muscle mass and function. Fetuin-A (FetA) appears to be a factor for body composition remodeling. We hypothesized that age increases FetA levels and deteriorates the myocardial function by affecting diastolic function, especially in people with sarcopenia. We enrolled 541...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12078
更新日期：2015-07-10 00:00:00
abstract：:A simple, environmentally friendly and cost-effective nonsurfactant template method was used to synthesize tannic-acid-templated mesoporous silica nanoparticles (TMSNs), and then dopamine functionalized TMSNs (Dop-TMSNs) which was synthesized by a facile and biomimetic coating strategy, was developed as a new sorbent ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45215
更新日期：2017-03-22 00:00:00
abstract：:The pearl oyster is one of the rare animal models that support two distinct genomes, through the surgical graft process operated for culture pearl production. This grafted organism is assimilated to a chimera whose physiological functioning remains poorly known. The question of the energy expenditure comparison betwee...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25360-5
更新日期：2018-05-14 00:00:00
abstract：:Cellular interactions can be modeled as complex dynamical systems represented by weighted graphs. The functionality of such networks, including measures of robustness, reliability, performance, and efficiency, are intrinsically tied to the topology and geometry of the underlying graph. Utilizing recently proposed geom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12323
更新日期：2015-07-14 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-73944-x
更新日期：2020-10-09 00:00:00
