当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > DNA repair protein Rad18 restricts LINE-1 mobility.

DNA repair protein Rad18 restricts LINE-1 mobility.

Abstract：

:Long interspersed element-1 (LINE-1, L1) is a mobile genetic element comprising about 17% of the human genome. L1 utilizes an endonuclease to insert L1 cDNA into the target genomic DNA, which induces double-strand DNA breaks in the human genome and activates the DNA damage signaling pathway, resulting in the recruitment of DNA-repair proteins. This may facilitate or protect L1 integration into the human genome. Therefore, the host DNA repair machinery has pivotal roles in L1 mobility. In this study, we have, for the first time, demonstrated that the DNA repair protein, Rad18, restricts L1 mobility. Notably, overexpression of Rad18 strongly suppressed L1 retrotransposition as well as L1-mediated Alu retrotransposition. In contrast, L1 retrotransposition was enhanced in Rad18-deficient or knockdown cells. Furthermore, the Rad6 (E2 ubiquitin-conjugated enzyme)-binding domain, but not the Polη-binding domain, was required for the inhibition of L1 retrotransposition, suggesting that the E3 ubiquitin ligase activity of Rad18 is important in regulating L1 mobility. Accordingly, wild-type, but not the mutant Rad18-lacking Rad6-binding domain, bound with L1 ORF1p and sequestered with L1 ORF1p into the Rad18-nuclear foci. Altogether, Rad18 restricts L1 and Alu retrotransposition as a guardian of the human genome against endogenous retroelements.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Ariumi Y,Kawano K,Yasuda-Inoue M,Kuroki M,Fukuda H,Siddiqui R,Turelli P,Tateishi S

doi

10.1038/s41598-018-34288-9

subject

Has Abstract

pub_date

2018-10-26 00:00:00

pages

15894

issue

1

issn

2045-2322

pii

10.1038/s41598-018-34288-9

journal_volume

8

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Dynamic changes of phenotypically different circulating tumor cells sub-populations in patients with recurrent/refractory small cell lung cancer treated with pazopanib.

    abstract：:The aim of the study was to investigate the effect of 2nd-line pazopanib on the different CTCs subpopulations in SCLC patients and evaluate the clinical relevance of their changes. Different CTCs subpopulations were evaluated before pazopanib initiation (n = 56 patients), after one-cycle (n = 35) and on disease progre...

    journal_title：Scientific reports

    pub_type： 杂志文章,多中心研究

    doi：10.1038/s41598-018-20502-1

    authors： Messaritakis I,Politaki E,Koinis F,Stoltidis D,Apostolaki S,Plataki M,Dermitzaki EK,Georgoulias V,Kotsakis A

    更新日期：2018-02-02 00:00:00

  • Labeling and analysis of chicken taste buds using molecular markers in oral epithelial sheets.

    abstract：:In chickens, the sensory organs for taste are the taste buds in the oral cavity, of which there are ~240-360 in total number as estimated by scanning electron microscopy (SEM). There is not an easy way to visualize all taste buds in chickens. Here, we report a highly efficient method for labeling chicken taste buds in...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37247

    authors： Rajapaksha P,Wang Z,Venkatesan N,Tehrani KF,Payne J,Swetenburg RL,Kawabata F,Tabata S,Mortensen LJ,Stice SL,Beckstead R,Liu HX

    更新日期：2016-11-17 00:00:00

  • Physiological responses to daily light exposure.

    abstract：:Long daylength artificial light exposure associates with disorders, and a potential physiological mechanism has been proposed. However, previous studies have examined no more than three artificial light treatments and limited metabolic parameters, which have been insufficient to demonstrate mechanical responses. Here,...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24808

    authors： Yang Y,Yu Y,Yang B,Zhou H,Pan J

    更新日期：2016-04-21 00:00:00

  • Fast non-Abelian geometric gates via transitionless quantum driving.

    abstract：:A practical quantum computer must be capable of performing high fidelity quantum gates on a set of quantum bits (qubits). In the presence of noise, the realization of such gates poses daunting challenges. Geometric phases, which possess intrinsic noise-tolerant features, hold the promise for performing robust quantum ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep18414

    authors： Zhang J,Kyaw TH,Tong DM,Sjöqvist E,Kwek LC

    更新日期：2015-12-21 00:00:00

  • The assessment of liver fibrosis in children with obesity on two methods: transient and two dimensional shear wave elastography.

    abstract：:The aim of this study was to assess the liver stiffness values in children with obesity versus healthy children on 2D-SWE and TE taking into account different laboratory parameters. We performed a case-control study on 287 children aged between 3 to 18 years, admitted in a Romanian Pediatric Tertiary Hospital, which w...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56358-2

    authors： Mărginean CO,Meliţ LE,Ghiga DV,Săsăran MO

    更新日期：2019-12-24 00:00:00

  • Halogenated Chrysins Inhibit Dengue and Zika Virus Infectivity.

    abstract：:Dengue virus infection is a global threat for which no specific treatment has not been established. Previous reports suggested chrysin and flavanone derivatives were potential flaviviral inhibitors. Here, we reported two halogenated chrysins, abbreviated FV13 and FV14, were highly potent against DENV1-4 and ZIKV infec...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-14121-5

    authors： Suroengrit A,Yuttithamnon W,Srivarangkul P,Pankaew S,Kingkaew K,Chavasiri W,Boonyasuppayakorn S

    更新日期：2017-10-20 00:00:00

  • Rigid soles improve balance in beam walking, but improvements do not persist with bare feet.

    abstract：:Maintaining balance while walking on a narrow beam is a challenging motor task. One important factor is that the foot's ability to exert torque on the support surface is limited by the beam width. Still, the feet serve as a critical interface between the body and the external environment, and it is unclear how the mec...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64035-y

    authors： Huber ME,Chiovetto E,Giese M,Sternad D

    更新日期：2020-05-06 00:00:00

  • 4-D photoacoustic tomography.

    abstract：:Photoacoustic tomography (PAT) offers three-dimensional (3D) structural and functional imaging of living biological tissue with label-free, optical absorption contrast. These attributes lend PAT imaging to a wide variety of applications in clinical medicine and preclinical research. Despite advances in live animal ima...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01113

    authors： Xiang L,Wang B,Ji L,Jiang H

    更新日期：2013-01-01 00:00:00

  • The zebrafish ventricle: A hub of cardiac endothelial cells for in vitro cell behavior studies.

    abstract：:Despite our increasing understanding of zebrafish heart development and regeneration, there is limited information about the distribution of endothelial cells (ECs) in the adult zebrafish heart. Here, we investigate and compare the distribution of cardiac ECs (cECs) in adult mouse and zebrafish ventricles. Surprisingl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02461-1

    authors： Patra C,Kontarakis Z,Kaur H,Rayrikar A,Mukherjee D,Stainier DYR

    更新日期：2017-06-02 00:00:00

  • Phenylalanine ammonia-lyase2.1 contributes to the soybean response towards Phytophthora sojae infection.

    abstract：:Phytophthora root and stem rot of soybean [Glycine max (L.) Merr.] caused by Phytophthora sojae is a destructive disease worldwide. Phenylalanine ammonia-lyase (PAL) is one of the most extensively studied enzymes related to plant responses to biotic and abiotic stresses. However, the molecular mechanism of PAL in soyb...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07832-2

    authors： Zhang C,Wang X,Zhang F,Dong L,Wu J,Cheng Q,Qi D,Yan X,Jiang L,Fan S,Li N,Li D,Xu P,Zhang S

    更新日期：2017-08-03 00:00:00

  • HBcAb seropositivity is correlated with poor HIV viremia control in an Italian cohort of HIV/HBV-coinfected patients on first-line therapy.

    abstract：:The morbidity and mortality rates of human immunodeficiency virus (HIV)-hepatitis B virus (HBV) coinfection are higher than that of either infection alone. Outcomes and the virological response to antiretrovirals (combination antiretroviral therapy, cART) were explored in HIV/HBV subjects in a cohort of Italian patien...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46976-1

    authors： Malagnino V,Cerva C,Maffongelli G,Teti E,Foroghi Biland L,Cesta N,De Masi M,Stingone C,Armenia D,Svicher V,Salpini R,Andreoni M,Sarmati L

    更新日期：2019-08-16 00:00:00

  • A meta-analysis of gene expression data highlights synaptic dysfunction in the hippocampus of brains with Alzheimer's disease.

    abstract：:Since the world population is ageing, dementia is going to be a growing concern. Alzheimer's disease is the most common form of dementia. The pathogenesis of Alzheimer's disease is extensively studied, yet unknown remains. Therefore, we aimed to extract new knowledge from existing data. We analysed about 2700 upregula...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41598-020-64452-z

    authors： Hosseinian S,Arefian E,Rakhsh-Khorshid H,Eivani M,Rezayof A,Pezeshk H,Marashi SA

    更新日期：2020-05-20 00:00:00

  • Improvement in predicting drug sensitivity changes associated with protein mutations using a molecular dynamics based alchemical mutation method.

    abstract：:While molecular-targeted drugs have demonstrated strong therapeutic efficacy against diverse diseases such as cancer and infection, the appearance of drug resistance associated with genetic variations in individual patients or pathogens has severely limited their clinical efficacy. Therefore, precision medicine approa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-58877-9

    authors： Ono F,Chiba S,Isaka Y,Matsumoto S,Ma B,Katayama R,Araki M,Okuno Y

    更新日期：2020-02-07 00:00:00

  • Analysis of diet-induced differential methylation, expression, and interactions of lncRNA and protein-coding genes in mouse liver.

    abstract：:Long non-coding RNAs (lncRNAs) regulate expression of protein-coding genes in cis through chromatin modifications including DNA methylation. Here we interrogated whether lncRNA genes may regulate transcription and methylation of their flanking or overlapping protein-coding genes in livers of mice exposed to a 12-week ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29993-4

    authors： Silva JP,van Booven D

    更新日期：2018-08-01 00:00:00

  • Rapid Regeneration and Reuse of Silica Columns from PCR Purification and Gel Extraction Kits.

    abstract：:Silica columns from PCR purification and gel extraction kits are widely used in laboratories worldwide to assist in gene cloning. However, the use of these columns can generate plastic waste that has an environmental impact due to their one-off design and massive consumption. Thus, it is important to develop a novel m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30316-w

    authors： Zhou Y,Zhang Y,He W,Wang J,Peng F,Huang L,Zhao S,Deng W

    更新日期：2018-08-27 00:00:00

  • Novel multiarm polyethylene glycol-dihydroartemisinin conjugates enhancing therapeutic efficacy in non-small-cell lung cancer.

    abstract：:The clinical application of dihydroartemisinin (DHA) has been hampered due to its poor water-solubility. To overcome this hurdle, we devised a novel polymer-drug conjugate, multiarm polyethylene glycol-dihydroartemisinin (PEG-DHA), made by linking DHA with multiarm polyethylene glycol. Herein, we investigated PEG-DHA ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05871

    authors： Dai L,Wang L,Deng L,Liu J,Lei J,Li D,He J

    更新日期：2014-07-29 00:00:00

  • Minocycline, a microglial inhibitor, reduces 'honey trap' risk in human economic exchange.

    abstract：:Recently, minocycline, a tetracycline antibiotic, has been reported to improve symptoms of psychiatric disorders and to facilitate sober decision-making in healthy human subjects. Here we show that minocycline also reduces the risk of the 'honey trap' during an economic exchange. Males tend to cooperate with physicall...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01685

    authors： Watabe M,Kato TA,Tsuboi S,Ishikawa K,Hashiya K,Monji A,Utsumi H,Kanba S

    更新日期：2013-01-01 00:00:00

  • PedMap: a pediatric diseases map generated from clinical big data from Hangzhou, China.

    abstract：:Epidemiological knowledge of pediatric diseases may improve professionals' understanding of the pathophysiology of and risk factors for diseases and is also crucial for decision making related to workforce and resource planning in pediatric departments. In this study, a pediatric disease epidemiology knowledgebase cal...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54439-w

    authors： Li H,Yu G,Dong C,Jia Z,An J,Duan H,Shu Q

    更新日期：2019-11-28 00:00:00

  • Publisher Correction: Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model.

    abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41598-018-20340-1

    authors： Bauer S,Wennberg Huldt C,Kanebratt KP,Durieux I,Gunne D,Andersson S,Ewart L,Haynes WG,Maschmeyer I,Winter A,Ämmälä C,Marx U,Andersson TB

    更新日期：2018-01-23 00:00:00

  • High HMGB1 levels in sputum are related to pneumococcal bacteraemia but not to disease severity in community-acquired pneumonia.

    abstract：:During bacterial infections, damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) activate immune cells. Here, we investigated whether plasma and sputum levels of High Mobility Group Box 1 (HMGB1), a prototypic DAMP, are associated with disease severity and aetiology in commu...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-018-31504-4

    authors： Alpkvist H,Athlin S,Mölling P,Norrby-Teglund A,Strålin K

    更新日期：2018-09-07 00:00:00

  • NAD+ augmentation ameliorates acute pancreatitis through regulation of inflammasome signalling.

    abstract：:Acute pancreatitis (AP) is a complicated disease without specific drug therapy. The cofactor nicotinamide adenine dinucleotide (NAD+) is an important regulator of cellular metabolism and homeostasis. However, it remains unclear whether modulation of NAD+ levels has an impact on caerulein-induced AP. Therefore, in this...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03418-0

    authors： Shen A,Kim HJ,Oh GS,Lee SB,Lee SH,Pandit A,Khadka D,Choe SK,Kwak SC,Yang SH,Cho EY,Kim HS,Kim H,Park R,Kwak TH,So HS

    更新日期：2017-06-07 00:00:00

  • A quantitative description of the transition between intuitive altruism and rational deliberation in iterated Prisoner's Dilemma experiments.

    abstract：:What is intuitive: pro-social or anti-social behaviour? To answer this fundamental question, recent studies analyse decision times in game theory experiments under the assumption that intuitive decisions are fast and that deliberation is slow. These analyses keep track of the average time taken to make decisions under...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52359-3

    authors： Gallotti R,Grujić J

    更新日期：2019-11-19 00:00:00

  • Response of aboveground biomass and diversity to nitrogen addition - a five-year experiment in semi-arid grassland of Inner Mongolia, China.

    abstract：:Understanding the response of the plant community to increasing nitrogen (N) deposition is helpful for improving pasture management in semi-arid areas. We implemented a 5-year N addition experiment in a Stipa krylovii steppe of Inner Mongolia, northern China. The aboveground biomass (AGB) and species richness were mea...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep31919

    authors： He K,Qi Y,Huang Y,Chen H,Sheng Z,Xu X,Duan L

    更新日期：2016-08-30 00:00:00

  • Targeted MinION sequencing of transgenes.

    abstract：:The presence of genetically modified organisms (GMO) is commonly assessed using real-time PCR methods targeting the most common transgenic elements found in GMOs. Once the presence of GM material has been established using these screening methods, GMOs are further identified using a battery of real-time PCR methods, e...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71614-6

    authors： Boutigny AL,Fioriti F,Rolland M

    更新日期：2020-09-15 00:00:00

  • Region-specific growth restriction of brain following preterm birth.

    abstract：:Regional brain sizes of very-preterm infants at term-equivalent age differ from those of term-born peers, which have been linked with later cognitive impairments. However, dependence of regional brain volume loss on gestational age has not been studied in detail. To investigate the spatial pattern of brain growth in n...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep33995

    authors： Iwata S,Katayama R,Kinoshita M,Saikusa M,Araki Y,Takashima S,Abe T,Iwata O

    更新日期：2016-09-23 00:00:00

  • A facile approach to synthesize stable CNTs@MnO electrocatalyst for high energy lithium oxygen batteries.

    abstract：:A composite of manganese monoxide loaded onto carbon nanotubes (CNTs@MnO) has been synthesized by a facile approach, in which the CNTs form a continuous conductive network connecting the electrocatalyst MnO nanoparticles together to facilitate good electrochemical performance. The electrocatalyst MnO shows favourable ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08012

    authors： Luo WB,Chou SL,Jia-Zhao Wang,Zhai YC,Liu HK

    更新日期：2015-01-30 00:00:00

  • Pharmacological targeting of glucose-6-phosphate dehydrogenase in human erythrocytes by Bay 11-7082, parthenolide and dimethyl fumarate.

    abstract：:In mature erythrocytes, glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) yield NADPH, a crucial cofactor of the enzyme glutathione reductase (GR) converting glutathione disulfide (GSSG) into its reduced state (GSH). GSH is essential for detoxification processes in and survival of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep28754

    authors： Ghashghaeinia M,Giustarini D,Koralkova P,Köberle M,Alzoubi K,Bissinger R,Hosseinzadeh Z,Dreischer P,Bernhardt I,Lang F,Toulany M,Wieder T,Mojzikova R,Rossi R,Mrowietz U

    更新日期：2016-06-29 00:00:00

  • Microstructural deformation observed by Mueller polarimetry during traction assay on myocardium samples.

    abstract：:Despite recent advances, the myocardial microstructure remains imperfectly understood. In particular, bundles of cardiomyocytes have been observed but their three-dimensional organisation remains debated and the associated mechanical consequences unknown. One of the major challenges remains to perform multiscale obser...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76820-w

    authors： Tueni N,Vizet J,Genet M,Pierangelo A,Allain JM

    更新日期：2020-11-25 00:00:00

  • Atypical age-related changes in cortical thickness in autism spectrum disorder.

    abstract：:Recent longitudinal neuroimaging and neurophysiological studies have shown that tracking relative age-related changes in neural signals, rather than a static snapshot of a neural measure, could offer higher sensitivity for discriminating typically developing (TD) individuals from those with autism spectrum disorder (A...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67507-3

    authors： Nunes AS,Vakorin VA,Kozhemiako N,Peatfield N,Ribary U,Doesburg SM

    更新日期：2020-07-06 00:00:00

  • Low blood cell counts in wild Japanese monkeys after the Fukushima Daiichi nuclear disaster.

    abstract：:In April 2012 we carried out a 1-year hematological study on a population of wild Japanese monkeys inhabiting the forest area of Fukushima City. This area is located 70 km from the Fukushima Daiichi Nuclear Power Plant (NPP), which released a large amount of radioactive material into the environment following the Grea...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05793

    authors： Ochiai K,Hayama S,Nakiri S,Nakanishi S,Ishii N,Uno T,Kato T,Konno F,Kawamoto Y,Tsuchida S,Omi T

    更新日期：2014-07-24 00:00:00