当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Dynamic changes of phenotypically different circulating tumor cells sub-populations in patients with recurrent/refractory small cell lung cancer treated with pazopanib.

Dynamic changes of phenotypically different circulating tumor cells sub-populations in patients with recurrent/refractory small cell lung cancer treated with pazopanib.

Abstract：

:The aim of the study was to investigate the effect of 2nd-line pazopanib on the different CTCs subpopulations in SCLC patients and evaluate the clinical relevance of their changes. Different CTCs subpopulations were evaluated before pazopanib initiation (n = 56 patients), after one-cycle (n = 35) and on disease progression (n = 45) by CellSearch and double immunofluorescence using anti-CKs and anti-Ki67, anti-M30 or anti-Vimentin antibodies. Before treatment, CTCs were detected in 50% of patients by CellSearch whereas 53.4%, 15.5% and 74.1% patients had CK+/Ki67+, CK+/M30+ and CK+/Vim+ CTCs, respectively. One pazopanib cycle significantly decreased the number of CTCs as detected by CellSearch (p = 0.043) as well as the number of CK+/Ki67+ (p < 0.001), CK+/M30+ (p = 0.015) and CK+/Vim+ (p < 0.001) cells. On disease progression, both the incidence and CTC numbers were significantly increased (CellSearch, p = 0.027; CK+/Ki67+, p < 0.001; CK+/M30+, p = 0.001 and CK+/Vim+, p < 0.001). In multivariate analysis, the detection of CK+/Vim+ CTCs after one treatment cycle (HR: 7.9, 95% CI: 2.9-21.8; p < 0.001) and CTCs number on disease progression, as assessed by CellSearch, (HR: 2.0, 95% CI: 1.0-6.0; p = 0.005) were emerged as independent factors associated with decreased OS. In conclusion, pazopanib can eliminate different CTC subpopulations in patients with relapsed SCLC. The analysis of CTCs could be used as a dynamic biomarker of treatment efficacy.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Messaritakis I,Politaki E,Koinis F,Stoltidis D,Apostolaki S,Plataki M,Dermitzaki EK,Georgoulias V,Kotsakis A

doi

10.1038/s41598-018-20502-1

subject

Has Abstract

pub_date

2018-02-02 00:00:00

pages

2238

issue

1

issn

2045-2322

pii

10.1038/s41598-018-20502-1

journal_volume

8

pub_type

杂志文章,多中心研究

相关文献

Scientific Reports文献大全
  • Habitual use of GPS negatively impacts spatial memory during self-guided navigation.

    abstract：:Global Positioning System (GPS) navigation devices and applications have become ubiquitous over the last decade. However, it is unclear whether using GPS affects our own internal navigation system, or spatial memory, which critically relies on the hippocampus. We assessed the lifetime GPS experience of 50 regular driv...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62877-0

    authors： Dahmani L,Bohbot VD

    更新日期：2020-04-14 00:00:00

  • The autofluorescence characteristics of bacterial intracellular and extracellular substances during the operation of anammox reactor.

    abstract：:Anammox is a cost-effective process to treat nitrogenous wastewater. In this work, excitation-emission matrix (EEM) fluorescence spectroscopy was used to characterize the intracellular and extracellular substances of anammox sludge during reactor operation of 276 days. Four main fluorophores were identified from the i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep39289

    authors： Hou X,Liu S,Feng Y

    更新日期：2017-01-16 00:00:00

  • Same habitat types but different use: evidence of context-dependent habitat selection in roe deer across populations.

    abstract：:With the surge of GPS-technology, many studies uncovered space use of mobile animals and shed light on the underlying behavioral mechanisms of habitat selection. Habitat selection and variation in either occurrence or strength of functional responses (i.e. how selection changes with availability) have given new insigh...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-23111-0

    authors： William G,Jean-Michel G,Sonia S,Christophe B,Atle M,Nicolas M,Maryline P,Clément C

    更新日期：2018-03-23 00:00:00

  • Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-induced Smad1/5/8 phosphorylation.

    abstract：:Bone morphogenetic proteins (BMPs) regulate hard tissue formation, including bone and tooth. Growth differentiation factor 5 (GDF5), a known BMP, is expressed in cartilage and regulates chondrogenesis, and mutations have been shown to cause osteoarthritis. Notably, GDF5 is also expressed in periodontal ligament tissue...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23670

    authors： Liu J,Saito K,Maruya Y,Nakamura T,Yamada A,Fukumoto E,Ishikawa M,Iwamoto T,Miyazaki K,Yoshizaki K,Ge L,Fukumoto S

    更新日期：2016-03-31 00:00:00

  • Using static method to measure tolmetin solubility at different pressures and temperatures in supercritical carbon dioxide.

    abstract：:Tolmetin is a non-steroidal anti-inflammatory drug being used to decrease the level of hormones which are the reasons for pain, swelling, tiredness, and stiffness for osteoarthritis and rheumatoid arthritis cases. We evaluated its solubility in supercritical carbon dioxide (SC-CO2) with the aim of drug nanonization, c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76330-9

    authors： Pishnamazi M,Zabihi S,Sarafzadeh P,Borousan F,Marjani A,Pelalak R,Shirazian S

    更新日期：2020-11-11 00:00:00

  • Establish pre-clinical diagnostic efficacy for parathyroid hormone as a point-of-surgery-testing-device (POST).

    abstract：:Measuring the Parathyroid hormone (PTH) levels assists in the investigation and management of patients with parathyroid disorders. Rapid PTH monitoring is a valid tool for accurate assessment intraoperatively. Rapid Electro-Analytical Device (READ) is a point-of-care device that uses impedance change between target an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75856-2

    authors： Tanak AS,Muthukumar S,Hashim IA,Prasad S

    更新日期：2020-11-02 00:00:00

  • IVIG regulates the survival of human but not mouse neutrophils.

    abstract：:Intravenous immunoglobulin (IVIG) are purified IgG preparations made from the pooled plasma from thousands of healthy donors and are being tested in preclinical mouse models. Inherent challenges, however, are the pluripotency of IVIG and its xenogeneicity in animals. IVIG can alter the viability of human neutrophils v...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01404-0

    authors： Schneider C,Wicki S,Graeter S,Timcheva TM,Keller CW,Quast I,Leontyev D,Djoumerska-Alexieva IK,Käsermann F,Jakob SM,Dimitrova PA,Branch DR,Cummings RD,Lünemann JD,Kaufmann T,Simon HU,von Gunten S

    更新日期：2017-05-02 00:00:00

  • High information capacity DNA-based data storage with augmented encoding characters using degenerate bases.

    abstract：:DNA-based data storage has emerged as a promising method to satisfy the exponentially increasing demand for information storage. However, practical implementation of DNA-based data storage remains a challenge because of the high cost of data writing through DNA synthesis. Here, we propose the use of degenerate bases a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43105-w

    authors： Choi Y,Ryu T,Lee AC,Choi H,Lee H,Park J,Song SH,Kim S,Kim H,Park W,Kwon S

    更新日期：2019-04-29 00:00:00

  • Drone exposure to the systemic insecticide Fipronil indirectly impairs queen reproductive potential.

    abstract：:A species that requires sexual reproduction but cannot reproduce is doomed to extinction. The important increasing loss of species emphasizes the ecological significance of elucidating the effects of environmental stressors, such as pesticides, on reproduction. Despite its special reproductive behavior, the honey bee ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep31904

    authors： Kairo G,Provost B,Tchamitchian S,Ben Abdelkader F,Bonnet M,Cousin M,Sénéchal J,Benet P,Kretzschmar A,Belzunces LP,Brunet JL

    更新日期：2016-08-23 00:00:00

  • An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations.

    abstract：:Meckel syndrome (MKS) is an inherited autosomal recessive hepatorenal fibrocystic syndrome, caused by mutations in TMEM67, characterized by occipital encephalocoele, renal cysts, hepatic fibrosis, and polydactyly. Here we describe an ovine model of MKS, with kidney and liver abnormalities, without polydactyly or occip...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01519-4

    authors： Stayner C,Poole CA,McGlashan SR,Pilanthananond M,Brauning R,Markie D,Lett B,Slobbe L,Chae A,Johnstone AC,Jensen CG,McEwan JC,Dittmer K,Parker K,Wiles A,Blackburne W,Leichter A,Leask M,Pinnapureddy A,Jennings M,Hor

    更新日期：2017-05-09 00:00:00

  • Acute effects of aerobic exercise promote learning.

    abstract：:The benefits that physical exercise confers on cardiovascular health are well known, whereas the notion that physical exercise can also improve cognitive performance has only recently begun to be explored and has thus far yielded only controversial results. In the present study, we used a sample of young male subjects...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25440

    authors： Perini R,Bortoletto M,Capogrosso M,Fertonani A,Miniussi C

    更新日期：2016-05-05 00:00:00

  • Concurrent guiding of light and heat by transformation optics and transformation thermodynamics via soft matter.

    abstract：:Controlling light and heat via metamaterials has presented interesting technological applications using transformation optics (TO) and transformation thermodynamics (TT). However, such devices are commonly mono-physics and mono-purpose, because the used metamaterial is designed to deal with one type of physical mechan...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29866-w

    authors： Barros WKP,Pereira E

    更新日期：2018-07-30 00:00:00

  • Magnetic inhomogeneity on a triangular lattice: the magnetic-exchange versus the elastic energy and the role of disorder.

    abstract：:Inhomogeneity in the ground state is an intriguing, emergent phenomenon in magnetism. Recently, it has been observed in the magnetostructural channel of the geometrically frustrated α-NaMnO2, for the first time in the absence of active charge degrees of freedom. Here we report an in-depth numerical and local-probe exp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09272

    authors： Zorko A,Kokalj J,Komelj M,Adamopoulos O,Luetkens H,Arčon D,Lappas A

    更新日期：2015-03-19 00:00:00

  • High resolution low kV EBSD of heavily deformed and nanocrystalline Aluminium by dictionary-based indexing.

    abstract：:We demonstrate the capability of a novel Electron Backscatter Diffraction (EBSD) dictionary indexing (DI) approach by means of orientation mapping of a highly deformed graded microstructure in a shot peened Aluminium 7075-T651 alloy. A low microscope accelerating voltage was used to extract, for the first time from a ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29315-8

    authors： Singh S,Guo Y,Winiarski B,Burnett TL,Withers PJ,De Graef M

    更新日期：2018-07-20 00:00:00

  • Whole genome sequencing of a banana wild relative Musa itinerans provides insights into lineage-specific diversification of the Musa genus.

    abstract：:Crop wild relatives are valuable resources for future genetic improvement. Here, we report the de novo genome assembly of Musa itinerans, a disease-resistant wild banana relative in subtropical China. The assembled genome size was 462.1 Mb, covering 75.2% of the genome (615.2Mb) and containing 32, 456 predicted protei...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep31586

    authors： Wu W,Yang YL,He WM,Rouard M,Li WM,Xu M,Roux N,Ge XJ

    更新日期：2016-08-17 00:00:00

  • Passive immunization with anti-ActA and anti-listeriolysin O antibodies protects against Listeria monocytogenes infection in mice.

    abstract：:Listeria monocytogenes is an intracellular pathogen that causes listeriosis. Due to its intracellular niche, L. monocytogenes has evolved to limit immune recognition and response to infection. Antibodies that are slightly induced by listerial infection are completely unable to protect re-infection of L. monocytogenes....

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep39628

    authors： Asano K,Sashinami H,Osanai A,Hirose S,Ono HK,Narita K,Hu DL,Nakane A

    更新日期：2016-12-22 00:00:00

  • Nano-volcanic Eruption of Silver.

    abstract：:Silver (Ag) is one of the seven metals of antiquity and an important engineering material in the electronic, medical, and chemical industries because of its unique noble and catalytic properties. Ag thin films are extensively used in modern electronics primarily because of their oxidation-resistance. Here we report a ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34769

    authors： Lin SK,Nagao S,Yokoi E,Oh C,Zhang H,Liu YC,Lin SG,Suganuma K

    更新日期：2016-10-05 00:00:00

  • Erratum: Corrigendum: Investigating starch gelatinization through Stokes vector resolved second harmonic generation microscopy.

    abstract：:Scientific Reports 7: Article number: 45816; published online: 06 April 2017; updated: 16 May 2017. The original version of this Article contained an error in Affiliation 2, which was incorrectly given as: 'Department of Biophysics, School of Life Sciences, Manipal University, Manipal, 567014, India'. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/srep46803

    authors： Mazumder N,Xiang LY,Qiu J,Kao FJ

    更新日期：2017-05-16 00:00:00

  • Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression.

    abstract：:There is an unmet need for treatments to reduce abdominal aortic aneurysm (AAA) progression. Vascular smooth muscle cell (VSMC) apoptosis precipitates AAA formation, whereas VSMC proliferation repairs the vessel wall. We previously demonstrated that over-expression of EC4-Fc (truncated N-cadherin), or deletion of matr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17700-8

    authors： Lyon CA,Williams H,Bianco R,Simmonds SJ,Brown BA,Wadey KS,Smith FCT,Johnson JL,George SJ

    更新日期：2017-12-11 00:00:00

  • Nonreciprocal Transverse Photonic Spin and Magnetization-Induced Electromagnetic Spin-Orbit Coupling.

    abstract：:We present a formulation of electromagnetic spin-orbit coupling in magneto-optic media, and propose an alternative source of spin-orbit coupling to non-paraxial optics vortices. Our treatment puts forth a formulation of nonreciprocal transverse-spin angular-momentum-density shifts for evanescent waves in magneto-optic...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep39972

    authors： Levy M,Karki D

    更新日期：2017-01-06 00:00:00

  • Late-responding normal tissue cells benefit from high-precision radiotherapy with prolonged fraction delivery times via enhanced autophagy.

    abstract：:High-precision radiotherapy (HPR) has established its important role in the treatment of tumors due to its precise dose distribution. Given its more complicated delivery process, HPR commonly requires more fraction delivery time (FDT). However, it is unknown whether it has an identical response of prolonged FDT on dif...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09119

    authors： Yao Q,Zheng R,Xie G,Liao G,Du S,Ren C,Li R,Lin X,Hu D,Yuan Y

    更新日期：2015-03-13 00:00:00

  • Novel Hg2+-Selective Signaling Probe Based on Resorufin Thionocarbonate and its μPAD Application.

    abstract：:In this study, a novel resorufin thionocarbonate-based Hg2+-selective signaling probe (RT) for microfluidic paper-based analytical device (μPAD) applications is reported. The designed probe, RT, was readily synthesized by the one-step reaction of resorufin with phenyl thionochloroformate. The RT probe displayed a prom...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40169-6

    authors： Choi MG,Park SY,Park KY,Chang SK

    更新日期：2019-03-04 00:00:00

  • Non-destructive elemental analysis of a carbonaceous chondrite with direct current Muon beam at MuSIC.

    abstract：:Electron- or X-ray-induced characteristic X-ray analysis has been widely used to determine chemical compositions of materials in vast research fields. In recent years, analysis of characteristic X-rays from muonic atoms, in which a muon is captured, has attracted attention because both a muon beam and a muon-induced c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-15719-5

    authors： Terada K,Sato A,Ninomiya K,Kawashima Y,Shimomura K,Yoshida G,Kawai Y,Osawa T,Tachibana S

    更新日期：2017-11-13 00:00:00

  • Internal surface electric charge characterization of mesoporous silica.

    abstract：:Mesoporous silica is an emerging technology to solve problems of existing and to support projected revolutionary applications ranging from targeted drug delivery to artificial kidney. However, one of the major driving mechanisms, electric charging of internal mesoporous surfaces, has not been characterized yet. In the...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-36487-w

    authors： Sen T,Barisik M

    更新日期：2019-01-15 00:00:00

  • Acute pathophysiological myocardial changes following intra-cardiac electrical shocks using a proteomic approach in a sheep model.

    abstract：:Implantable cardioverter-defibrillators (ICD) are meant to fight life-threatening ventricular arrhythmias and reduce overall mortality. Ironically, life-saving shocks themselves have been shown to be independently associated with an increased mortality. We sought to identify myocardial changes at the protein level imm...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-77346-x

    authors： Bodin A,Labas V,Bisson A,Teixeira-Gomes AP,Blasco H,Tomas D,Combes-Soia L,Marcelo P,Miquelestorena-Standley E,Baron C,Angoulvant D,Babuty D,Clementy N

    更新日期：2020-11-20 00:00:00

  • Role of intestinal trefoil factor in protecting intestinal epithelial cells from burn-induced injury.

    abstract：:Although intestinal trefoil factor (ITF) can alleviate the burn-induced intestinal mucosa injury, the underlying mechanisms remains elusive. In this study, we investigated if ITF alters glutamine transport on the brush border membrane vesicles (BBMVs) of the intestines in Sprague-Dawley rats inflicted with 30% TBSA an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-21282-4

    authors： Hu J,Shi Y,Wang C,Wan H,Wu D,Wang H,Peng X

    更新日期：2018-02-16 00:00:00

  • Author Correction: A new species of early-diverging Sauropodiformes from the Lower Jurassic Fengjiahe Formation of Yunnan Province, China.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-74208-4

    authors： de Fabrègues CP,Bi S,Li H,Li G,Yang L,Xu X

    更新日期：2020-10-06 00:00:00

  • Role of freeze-thaw cycles and chlorpyrifos insecticide use on diffuse Cd loss and sediment accumulation.

    abstract：:Freeze-thaw cycles are predicted to increase in cold temperate regions. The potential influence of the interactions of freeze-thaw cycles and agrochemicals on the release of Cd into river water is unknown. In this study, the interactions of freeze-thaw cycles and chlorpyrifos (FC) on Cd mobility in soils were analysed...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27302

    authors： Wang F,Ouyang W,Hao F,Jiao W,Shan Y,Lin C

    更新日期：2016-06-02 00:00:00

  • The liposomal delivery of hydrophobic oxidovanadium complexes imparts highly effective cytotoxicity and differentiating capacity in neuroblastoma tumour cells.

    abstract：:Oxidovanadium complexes with organic ligands are well known to have cytotoxic or differentiating capabilities against a range of cancer cell types. Their limited use in clinical testing though has resulted largely from uncertainties about the long-term toxicities of such complexes, due in part to the speciation to van...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73539-6

    authors： Irving E,Tagalakis AD,Maeshima R,Hart SL,Eaton S,Lehtonen A,Stoker AW

    更新日期：2020-10-07 00:00:00

  • Nanoscale Spatially Resolved Mapping of Uranium Enrichment.

    abstract：:Spatially resolved analysis of uranium (U) isotopes in small volumes of actinide-bearing materials is critical for a variety of technical disciplines, including earth and planetary sciences, environmental monitoring, bioremediation, and the nuclear fuel cycle. However, achieving subnanometer-scale spatial resolution f...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-48479-5

    authors： Kautz E,Burkes D,Joshi V,Lavender C,Devaraj A

    更新日期：2019-08-23 00:00:00