Abstract:
:Although intestinal trefoil factor (ITF) can alleviate the burn-induced intestinal mucosa injury, the underlying mechanisms remains elusive. In this study, we investigated if ITF alters glutamine transport on the brush border membrane vesicles (BBMVs) of the intestines in Sprague-Dawley rats inflicted with 30% TBSA and the underlying mechanisms. We found that ITF significantly stimulated intestinal glutamine transport in burned rats. Mechanistically, ITF enhanced autophagy, reduces endoplasmic reticulum stress (ERS), and alleviates the impaired PDI, ASCT2, and B0AT1 in IECs and BBMVs after burn injury likely through AMPK activation. Therefore, ITF may protect intestinal epithelial cells from burn-induced injury through improving glutamine transport by alleviating ERS.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hu J,Shi Y,Wang C,Wan H,Wu D,Wang H,Peng Xdoi
10.1038/s41598-018-21282-4subject
Has Abstractpub_date
2018-02-16 00:00:00pages
3201issue
1issn
2045-2322pii
10.1038/s41598-018-21282-4journal_volume
8pub_type
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