Abstract：
:DNA-based data storage has emerged as a promising method to satisfy the exponentially increasing demand for information storage. However, practical implementation of DNA-based data storage remains a challenge because of the high cost of data writing through DNA synthesis. Here, we propose the use of degenerate bases as encoding characters in addition to A, C, G, and T, which augments the amount of data that can be stored per length of DNA sequence designed (information capacity) and lowering the amount of DNA synthesis per storing unit data. Using the proposed method, we experimentally achieved an information capacity of 3.37 bits/character. The demonstrated information capacity is more than twice when compared to the highest information capacity previously achieved. The proposed method can be integrated with synthetic technologies in the future to reduce the cost of DNA-based data storage by 50%.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Choi Y,Ryu T,Lee AC,Choi H,Lee H,Park J,Song SH,Kim S,Kim H,Park W,Kwon Sdoi
10.1038/s41598-019-43105-wsubject
Has Abstractpub_date
2019-04-29 00:00:00pages
6582issue
1issn
2045-2322pii
10.1038/s41598-019-43105-wjournal_volume
9pub_type
杂志文章abstract：:The high manufacturing cost for metallic glasses hampers actual commercial applications of this class of fascinating materials. In this letter, the effect of oxygen impurity on the glass forming ability and tensile properties of Zr-BMG composites were studied. Our results have demonstrated that oxygen was absorbed and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02097
更新日期：2013-01-01 00:00:00
abstract：:Since 2001, hundreds of thousands of hours of underwater acoustic recordings have been made throughout the Southern Ocean south of 60° S. Detailed analysis of the occurrence of marine mammal sounds in these circumpolar recordings could provide novel insights into their ecology, but manual inspection of the entirety of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78995-8
更新日期：2021-01-12 00:00:00
abstract：:The emergence of single-cell RNA sequencing (scRNA-seq) technologies has enabled us to measure the expression levels of thousands of genes at single-cell resolution. However, insufficient quantities of starting RNA in the individual cells cause significant dropout events, introducing a large number of zero counts in t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34688-x
更新日期：2018-11-05 00:00:00
abstract：:Metagenome studies are becoming increasingly widespread, yielding important insights into microbial communities covering diverse environments from terrestrial and aquatic ecosystems to human skin and gut. With the advent of high-throughput sequencing platforms, the use of large scale shotgun sequencing approaches is n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19233
更新日期：2016-01-18 00:00:00
abstract：:Blowflies and houseflies are mechanical vectors inhabiting synanthropic environments around the world. They feed and breed in fecal and decaying organic matter, but the microbiome they harbour and transport is largely uncharacterized. We sampled 116 individual houseflies and blowflies from varying habitats on three co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16353-x
更新日期：2017-11-24 00:00:00
abstract：:We have designed, fabricated and characterized dual-wavelength metasurfaces that function at two assigned terahertz wavelengths with independent phase and amplitude control at each wavelength. Specifically, we have designed a dual-wavelength achromatic metasurface-based deflector deflecting the incident wave to the sa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34020
更新日期：2016-09-23 00:00:00
abstract：:Developing the high-efficient and green synthetic method for chiral amino alcohols is an intriguing target. We have developed the Mg(2+)-doped Cu/ZnO/Al2O3 catalyst for hydrogenation of L-phenylalanine methyl ester to chiral L-phenylalaninol without racemization. The effect of different L-phenylalanine esters on this ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33196
更新日期：2016-09-13 00:00:00
abstract：:The incidence of myopia is increasing worldwide, and the investigation on pathophysiology of myopia is becoming more important. This retrospective study aimed to compare the thicknesses of individual retinal layers between high-myopic and control eyes, and to evaluate the effects of age and sex on each retinal layer t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50306-w
更新日期：2019-09-30 00:00:00
abstract：:Here we quantify the effects of artisanal fisheries on the ecology of a small cetacean, the Ganges River dolphin (Platanista gangetica gangetica, GRD), in a large river system of Nepal. We examine the size-classes of fisheries' catches, behavioural changes in GRD in response to fishing activities, and diel overlap bet...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75997-4
更新日期：2020-11-02 00:00:00
abstract：:Strengthening by precipitation of second phase is the guiding principle for the development of a host of high strength structural alloys, in particular, aluminium alloys for transportation sector. Higher efficiency and lower emission demands use of alloys at higher operating temperatures (200 °C-250 °C) and stresses, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11540-2
更新日期：2017-09-11 00:00:00
abstract：:Although aversive memory has been mainly addressed by analysing the changes occurring in average populations, the study of neuronal mechanisms of outliers allows understanding the involvement of individual differences in fear conditioning and extinction. We recently developed an innovative experimental model of indivi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21205
更新日期：2016-02-15 00:00:00
abstract：:The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration. To enable systematic insights into this phenomenon, we generated and integrated a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26822
更新日期：2016-05-31 00:00:00
abstract：:Protein phosphorylation enables a rapid adjustment of cellular activities to diverse intracellular and environmental stimuli. Many phosphoproteins are targeted on more than one site, which allows the integration of multiple signals and the implementation of complex responses. However, the hierarchy and interplay betwe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80357-3
更新日期：2021-01-13 00:00:00
abstract：:The arthropod-transmitted chikungunya virus (CHIKV) causes a flu-like disease that is characterized by incapacitating arthralgia. The re-emergence of CHIKV and the continual risk of new epidemics have reignited research in CHIKV pathogenesis. Virus-specific antibodies have been shown to control virus clearance, but an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20305-4
更新日期：2018-01-30 00:00:00
abstract：:The physical mechanism of the anthropogenic triggering of large earthquakes on active faults is studied on the basis of experimental phenomenology, i.e., that earthquakes occur on active tectonic faults, that crustal stress values are those measured in situ and, on active faults, comply to the values of the stress dro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06100
更新日期：2014-08-26 00:00:00
abstract：:Group-IVa elements silicon and germanium are known for their semiconducting properties at room temperature, which are technologically critical. Metallicity and superconductivity are found at higher pressures only, Ge β-tin (tI4) being the first high-pressure metallic phase in the phase diagram. However, recent experim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01466
更新日期：2013-01-01 00:00:00
abstract：:Several systems can be represented as multiplex networks, i.e. in terms of a superposition of various graphs, each related to a different mode of connection between nodes. Hence, the definition of proper mathematical quantities aiming at capturing the added level of complexity of those systems is required. Various ste...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09120
更新日期：2015-03-13 00:00:00
abstract：:This work considers the effects of the Hurst exponent (H) on the local electric field distribution and the slope of the Fowler-Nordheim (FN) plot when considering the cold field electron emission properties of rough Large-Area Conducting Field Emitter Surfaces (LACFESs). A LACFES is represented by a self-affine Weiers...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10175
更新日期：2015-06-02 00:00:00
abstract：:Sharp increase in macromolecular crowding induces abnormal chromatin compaction in the cell nucleus, suggesting its non-negligible impact on chromatin structure and function. However, the details of the crowding-induced chromatin compaction remain poorly understood. In this work, we present a computer simulation study...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23753-0
更新日期：2018-04-03 00:00:00
abstract：:We aimed to assess whether brain volumes may affect the results of deep brain stimulation (DBS) in patients with Parkinson's disease (PD). Eighty-one consecutive patients with PD (male:female 40:41), treated with DBS between June 2012 and December 2017, were enrolled. Total and regional brain volumes were measured usi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79138-9
更新日期：2020-12-16 00:00:00
abstract：:Understanding ethanol-induced stresses and responses in biofuel-producing bacteria at systems level has significant implications in engineering more efficient biofuel producers. We present a computational study of transcriptomic and genomic data of both ethanol-stressed and ethanol-adapted E. coli cells with computati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44150
更新日期：2017-03-16 00:00:00
abstract：:Mammalian spermatogenesis is a classic adult stems cell-dependent process, supported by the self-renewal and differentiation of spermatogonial stem cells (SSCs). However, the identification of SSCs and elucidation of their behaviors in undisturbed testis has long been a big challenge. Here, we generated a knock-in mou...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17594
更新日期：2015-12-01 00:00:00
abstract：:We present a mechanically active cell culture substrate that produces complex strain patterns and generates extremely high strain rates. The transparent miniaturized cell stretcher is compatible with live cell microscopy and provides a very compact and portable alternative to other systems. A cell monolayer is culture...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27915-y
更新日期：2018-07-02 00:00:00
abstract：:We recently reported a greater sensitivity of female rats to rapid antidepressant-like effects of ketamine compared to male rats, and that ovarian-derived estradiol (E2) and progesterone (P4) are essential for this response. However, to what extent testosterone may also contribute, and whether duration of response to ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21322
更新日期：2016-02-18 00:00:00
abstract：:Both attraction and repulsion from linearly polarized light have been observed in zooplankton. A dichotomous choice experiment, consisting of plankton light traps deployed in natural waters at a depth of 30 m that projected either polarized or unpolarized light of the same intensity, was used to test the hypothesis th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35891
更新日期：2016-10-20 00:00:00
abstract：:Recent studies have shown that L-proline is a natural osmoprotectant and an antioxidant to protect cells from injuries such as that caused by freezing and thawing in many species including plant, ram sperm and human endothelial cells. Nevertheless, this nontoxic cryoprotectant has not yet been applied to mammalian ooc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26326
更新日期：2016-07-14 00:00:00
abstract：:Power semiconductor devices require low on-resistivity and high breakdown voltages simultaneously. Vertical-type metal-oxide-semiconductor field-effect transistors (MOSFETs) meet these requirements, but have been incompleteness in diamond. Here we show vertical-type p-channel diamond MOSFETs with trench structures and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28837-5
更新日期：2018-07-13 00:00:00
abstract：:Zika virus (ZIKV) is an arboviral infection that has been shown to be sexually transmitted. The study outlined herein aims to determine if accessory sex glands and epididymal epithelial cells are sources of viral persistence in subacute and chronic ZIKV infection, and if infection of these organs is important in sexua...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44582-9
更新日期：2019-06-06 00:00:00
abstract：:A number of studies have shown that visible and near infrared spectroscopy (VIS-NIRS) offers a rapid on-site measurement tool for the determination of total contaminant concentration of petroleum hydrocarbons compounds (PHC), heavy metals and metalloids (HM) in soil. However none of them have yet assessed the feasibil...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41161-w
更新日期：2019-03-14 00:00:00
abstract：:This study aimed to examine the effect of transcutaneous electrical nerve stimulation (TENS) on stair climbing capacity in individuals with pre-radiographic to mild knee osteoarthritis (OA). This is a secondary analysis of data from a single, participant-blinded, randomized controlled trial with a pre-post design. Par...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-64176-0
更新日期：2020-04-29 00:00:00
