当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression.

Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression.

Abstract：

:There is an unmet need for treatments to reduce abdominal aortic aneurysm (AAA) progression. Vascular smooth muscle cell (VSMC) apoptosis precipitates AAA formation, whereas VSMC proliferation repairs the vessel wall. We previously demonstrated that over-expression of EC4-Fc (truncated N-cadherin), or deletion of matrix-metalloproteinase-7 (Mmp-7) reduced VSMC apoptosis in mouse atherosclerotic plaques. Additionally, MMP-7 promotes VSMC apoptosis by cleavage of N-cadherin. We investigated their combined effect on AAA formation. Increased apoptosis and proliferation were observed in human AAA (HAAA) sections compared to normal aortae (HA). This coincided with increased MMP-7 activity and reduced N-cadherin protein levels in HAAA sections compared to HA. Using a mouse model of aneurysm formation, we showed that the combination of Mmp-7 deletion and EC4-Fc overexpression significantly increased AAA severity. Medial apoptosis and proliferation were both significantly reduced in these mice compared to control mice. In vitro, MMP-7 inhibition and EC4-Fc administration significantly supressed human aortic VSMC apoptosis (via activation of PI-3 kinase/Akt signalling) and proliferation. In conclusion, combined Mmp-7 deletion and systemic over-expression of EC4-Fc reduced both proliferation and apoptosis. Reduced proliferation-mediated repair over-rides any benefit of reduced apoptosis, increasing aneurysm severity. Future studies should therefore focus on retarding VSMC apoptosis whilst promoting VSMC proliferation.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Lyon CA,Williams H,Bianco R,Simmonds SJ,Brown BA,Wadey KS,Smith FCT,Johnson JL,George SJ

doi

10.1038/s41598-017-17700-8

subject

Has Abstract

pub_date

2017-12-11 00:00:00

pages

17342

issue

1

issn

2045-2322

pii

10.1038/s41598-017-17700-8

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Inducible orthogonal aminoacylation demonstrates that charging is required for mitochondrial tRNA import in Trypanosoma brucei.

    abstract：:Orthogonal aminoacyl-tRNA synthetase/tRNA pairs have emerged as powerful means of site-specifically introducing non-standard amino acids into proteins in vivo. Using amino acids with crosslinking moieties this method allows the identification of transient protein-protein interactions. Here we have introduced a previou...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-47268-4

    authors： Huot JL,Shikha S,Schneider A

    更新日期：2019-07-25 00:00:00

  • In vitro replicative fitness of early Transmitted founder HIV-1 variants and sensitivity to Interferon alpha.

    abstract：:Type I interferons, particularly interferon-alpha (IFN-α), play a vital role in the host's anti-viral defenses by interfering with viral replication. However, the virus rapidly evolves to exploit the IFN-α response for its replication, spread, and pathogenic function. In this study, we attempted to determine IFN-α sus...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59596-x

    authors： Ashokkumar M,Sonawane A,Sperk M,Tripathy SP,Neogi U,Hanna LE

    更新日期：2020-02-17 00:00:00

  • SLIME: robust, high-speed 3D microvascular mapping.

    abstract：:Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37313-z

    authors： Liu Y,Broberg MCG,Watanabe M,Rollins AM,Jenkins MW

    更新日期：2019-01-29 00:00:00

  • Thermodynamic Stability and Structural Insights for CH3NH3Pb1-xSixI3, CH3NH3Pb1-xGexI3, and CH3NH3Pb1-xSnxI3 Hybrid Perovskite Alloys: A Statistical Approach from First Principles Calculations.

    abstract：:The recent reaching of 20% of conversion efficiency by solar cells based on metal hybrid perovskites (MHP), e.g., the methylammonium (MA) lead iodide, CH3NH3PbI3 (MAPbI3), has excited the scientific community devoted to the photovoltaic materials. However, the toxicity of Pb is a hindrance for large scale commercial o...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-47192-7

    authors： Guedes-Sobrinho D,Guilhon I,Marques M,Teles LK

    更新日期：2019-07-30 00:00:00

  • Generalized Haldane models on laser-coupling optical lattices.

    abstract：:We propose two generalized Haldane models on laser-coupling optical lattices. Laser-assisted nearest neighbour tunnelings generate artificial staggered magnetic flux, facilitating the realization of topological nontrivial band structures. As generalizations of Haldane model, these models support topological insulator ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30503-9

    authors： Liu W,Lin Z,Wang ZD,Chen Y

    更新日期：2018-08-27 00:00:00

  • Randomized, Multicenter, Double-Blind Study of the Safety and Efficacy of 1%D-3-Hydroxybutyrate eye drops for Dry Eye Disease.

    abstract：:In a previous study, we demonstrated that topical D-beta-hydroxybutyrate ameliorates corneal epithelial erosion and superficial punctate keratopathy in a rat model of dry eye disease. In the current investigation, we performed a prospective, randomized, multicentre, double-blind, placebo-controlled study to assess the...

    journal_title：Scientific reports

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/srep20855

    authors： Kawakita T,Uchino M,Fukagawa K,Yoshino K,Shimazaki S,Toda I,Tanaka M,Arai H,Sakatani K,Hata S,Okano T,Tsubota K

    更新日期：2016-02-11 00:00:00

  • A Reduction-Based Sensor for Acrolein Conjugates with the Inexpensive Nitrobenzene as an Alternative to Monoclonal Antibody.

    abstract：:Acrolein, a highly toxic α, β-unsaturated aldehyde, has been a longstanding key biomarker associated with a range of disorders related to oxidative stresses. One of the most promising methods for detecting acrolein involves the use of antibodies that can recognize the acrolein-lysine conjugate, 3-formyl-3, 4-dehydropi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35872

    authors： Takamatsu M,Fukase K,Oka R,Kitazume S,Taniguchi N,Tanaka K

    更新日期：2016-10-26 00:00:00

  • Decision and coordination of low-carbon supply chain considering technological spillover and environmental awareness.

    abstract：:We focus on the impacts of technological spillovers and environmental awareness in a two-echelon supply chain with one-single supplier and one-single manufacturer to reduce carbon emission. In this supply chain, carbon abatement investment becomes one of key factors of cutting costs and improving profits, which is red...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03270-2

    authors： Xu L,Wang C,Li H

    更新日期：2017-06-08 00:00:00

  • Engineering of versatile redox partner fusions that support monooxygenase activity of functionally diverse cytochrome P450s.

    abstract：:Most bacterial cytochrome P450 monooxygenases (P450s or CYPs) require two redox partner proteins for activity. To reduce complexity of the redox chain, the Bacillus subtilis flavodoxin YkuN (Y) was fused to the Escherichia coli flavodoxin reductase Fpr (R), and activity was tuned by placing flexible (GGGGS)n or rigid ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10075-w

    authors： Bakkes PJ,Riehm JL,Sagadin T,Rühlmann A,Schubert P,Biemann S,Girhard M,Hutter MC,Bernhardt R,Urlacher VB

    更新日期：2017-08-29 00:00:00

  • A Broadly Cross-protective Vaccine Presenting the Neighboring Epitopes within the VP1 GH Loop and VP2 EF Loop of Enterovirus 71.

    abstract：:Human enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the major etiological agents of hand, foot and mouth disease (HFMD) and are often associated with neurological complications. Currently, several vaccine types are being developed for EV71 and CA16. In this study, we constructed a bivalent chimeric virus-lik...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12973

    authors： Xu L,He D,Yang L,Li Z,Ye X,Yu H,Zhao H,Li S,Yuan L,Qian H,Que Y,Kuo Shih JW,Zhu H,Li Y,Cheng T,Xia N

    更新日期：2015-08-05 00:00:00

  • Immune complexes in chronic Chagas disease patients are formed by exovesicles from Trypanosoma cruzi carrying the conserved MASP N-terminal region.

    abstract：:The exovesicles (EVs) are involved in pathologic host-parasite immune associations and have been recently used as biomarkers for diagnosis of infectious diseases. The release of EVs by Trypanosoma cruzi, the causative agent of Chagas disease, has recently been described, with different protein cargoes including the MA...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44451

    authors： Díaz Lozano IM,De Pablos LM,Longhi SA,Zago MP,Schijman AG,Osuna A

    更新日期：2017-03-15 00:00:00

  • Hydrogen segregation and its roles in structural stability and metallization: silane under pressure.

    abstract：:We present results from first-principles calculations on silane (SiH4) under pressure. We find that a three dimensional P-3 structure becomes the most stable phase above 241 GPa. A prominent structural feature, which separates the P-3 structure from previously observed/predicted SiH4 structures, is that a fraction of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13039

    authors： Cui W,Shi J,Liu H,Yao Y,Wang H,Iitaka T,Ma Y

    更新日期：2015-08-12 00:00:00

  • The effect of refractive error on optokinetic nystagmus.

    abstract：:Subjective refraction is the gold-standard for prescribing refractive correction, but its accuracy is limited by patient's subjective judgment about their clarity of vision. We asked if an involuntary eye movement, optokinetic nystagmus (OKN), could serve as an objective measure of visual-clarity, specifically measuri...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76865-x

    authors： Doustkouhi SM,Turnbull PRK,Dakin SC

    更新日期：2020-11-18 00:00:00

  • Electronic structure engineering of Cu2O film/ZnO nanorods array all-oxide p-n heterostructure for enhanced photoelectrochemical property and self-powered biosensing application.

    abstract：:We have engineered the electronic structure at the interface between Cu2O and ZnO nanorods (NRs) array, through adjusting the carrier concentration of Cu2O. The electrodeposition of Cu2O at pH 11 acquired the highest carrier concentration, resulting in the largest interfacial electric field between Cu2O and ZnO, which...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep07882

    authors： Kang Z,Yan X,Wang Y,Bai Z,Liu Y,Zhang Z,Lin P,Zhang X,Yuan H,Zhang X,Zhang Y

    更新日期：2015-01-20 00:00:00

  • The global regulator Ncb2 escapes from the core promoter and impacts transcription in response to drug stress in Candida albicans.

    abstract：:Ncb2, the β subunit of NC2 complex, a heterodimeric regulator of transcription was earlier shown to be involved in the activated transcription of CDR1 gene in azole resistant isolate (AR) of Candida albicans. This study examines its genome-wide role by profiling Ncb2 occupancy between genetically matched pair of azole...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep46084

    authors： Shariq M,Dhamgaye S,Nair R,Goyal N,Jain V,Mukhopadhyay A,Mondal AK,Mukhopadhyay G,Prasad R

    更新日期：2017-04-06 00:00:00

  • Light-induced rotations of chiral birefringent microparticles in optical tweezers.

    abstract：:We study the rotational dynamics of solid chiral and birefringent microparticles induced by elliptically polarized laser light in optical tweezers. We find that both reflection of left circularly polarized light and residual linear retardance affect the particle dynamics. The degree of ellipticity of laser light neede...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep31977

    authors： Donato MG,Mazzulla A,Pagliusi P,Magazzù A,Hernandez RJ,Provenzano C,Gucciardi PG,Maragò OM,Cipparrone G

    更新日期：2016-09-07 00:00:00

  • Human perinatal stem cell derived extracellular matrix enables rapid maturation of hiPSC-CM structural and functional phenotypes.

    abstract：:The immature phenotype of human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) is a major limitation to the use of these valuable cells for pre-clinical toxicity testing and for disease modeling. Here we tested the hypothesis that human perinatal stem cell derived extracellular matrix (ECM) promotes ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76052-y

    authors： Block T,Creech J,da Rocha AM,Marinkovic M,Ponce-Balbuena D,Jiménez-Vázquez EN,Griffey S,Herron TJ

    更新日期：2020-11-04 00:00:00

  • The oasis effect and summer temperature rise in arid regions - case study in Tarim Basin.

    abstract：:This study revealed the influence of the oasis effect on summer temperatures based on MODIS Land Surface Temperature (LST) and meteorological data. The results showed that the oasis effect occurs primarily in the summer. For a single oasis, the maximum oasis cold island intensity based on LST (OCILST) was 3.82 °C and ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35418

    authors： Hao X,Li W,Deng H

    更新日期：2016-10-14 00:00:00

  • Mycobacterium llatzerense, a waterborne Mycobacterium, that resists phagocytosis by Acanthamoeba castellanii.

    abstract：:Nontuberculous mycobacteria (NTM) are environmental bacteria increasingly associated to public health problems. In water systems, free-living amoebae (FLA) feed on bacteria by phagocytosis, but several bacteria, including many NTM, are resistant to this predation. Thus, FLA can be seen as a training ground for pathoge...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep46270

    authors： Delafont V,Samba-Louaka A,Cambau E,Bouchon D,Moulin L,Héchard Y

    更新日期：2017-04-10 00:00:00

  • Identification of Tp0751 (Pallilysin) as a Treponema pallidum Vascular Adhesin by Heterologous Expression in the Lyme disease Spirochete.

    abstract：:Treponema pallidum subsp. pallidum, the causative agent of syphilis, is a highly invasive spirochete pathogen that uses the vasculature to disseminate throughout the body. Identification of bacterial factors promoting dissemination is crucial for syphilis vaccine development. An important step in dissemination is bact...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01589-4

    authors： Kao WA,Pětrošová H,Ebady R,Lithgow KV,Rojas P,Zhang Y,Kim YE,Kim YR,Odisho T,Gupta N,Moter A,Cameron CE,Moriarty TJ

    更新日期：2017-05-08 00:00:00

  • Reversible hydrophobic to hydrophilic transition in graphene via water splitting induced by UV irradiation.

    abstract：:Although the reversible wettability transition between hydrophobic and hydrophilic graphene under ultraviolet (UV) irradiation has been observed, the mechanism for this phenomenon remains unclear. In this work, experimental and theoretical investigations demonstrate that the H2O molecules are split into hydrogen and h...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06450

    authors： Xu Z,Ao Z,Chu D,Younis A,Li CM,Li S

    更新日期：2014-09-23 00:00:00

  • Flexible thermoelectric films formed using integrated nanocomposites with single-wall carbon nanotubes and Bi2Te3 nanoplates via solvothermal synthesis.

    abstract：:Single-wall carbon nanotubes (SWCNTs) and Bi2Te3 nanoplates are very promising thermoelectric materials for energy harvesting. When these two materials are combined, the resulting nanocomposites exhibit high thermoelectric performance and excellent flexibility. However, simple mixing of these materials is not effectiv...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73808-4

    authors： Yabuki H,Yonezawa S,Eguchi R,Takashiri M

    更新日期：2020-10-12 00:00:00

  • Anti-correlated cortical networks arise from spontaneous neuronal dynamics at slow timescales.

    abstract：:In the highly interconnected architectures of the cerebral cortex, recurrent intracortical loops disproportionately outnumber thalamo-cortical inputs. These networks are also capable of generating neuronal activity without feedforward sensory drive. It is unknown, however, what spatiotemporal patterns may be solely at...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18097-0

    authors： Kodama NX,Feng T,Ullett JJ,Chiel HJ,Sivakumar SS,Galán RF

    更新日期：2018-01-12 00:00:00

  • Bony labyrinth morphology clarifies the origin and evolution of deer.

    abstract：:Deer are an iconic group of large mammals that originated in the Early Miocene of Eurasia (ca. 19 Ma). While there is some consensus on key relationships among their members, on the basis of molecular- or morphology-based analyses, or combined approaches, many questions remain, and the bony labyrinth has shown conside...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12848-9

    authors： Mennecart B,DeMiguel D,Bibi F,Rössner GE,Métais G,Neenan JM,Wang S,Schulz G,Müller B,Costeur L

    更新日期：2017-10-13 00:00:00

  • Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing.

    abstract：:Capable of mediating efficient transfection and protein production without eliciting innate immune responses, chemically modified mRNA holds great potential to produce paracrine factors at a physiologically beneficial level, in a spatiotemporally controlled manner, and with low toxicity. Although highly promising in c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35570-6

    authors： Sun N,Ning B,Hansson KM,Bruce AC,Seaman SA,Zhang C,Rikard M,DeRosa CA,Fraser CL,Wågberg M,Fritsche-Danielson R,Wikström J,Chien KR,Lundahl A,Hölttä M,Carlsson LG,Peirce SM,Hu S

    更新日期：2018-11-30 00:00:00

  • The time course of auditory recognition measured with rapid sequences of short natural sounds.

    abstract：:Human listeners are able to recognize accurately an impressive range of complex sounds, such as musical instruments or voices. The underlying mechanisms are still poorly understood. Here, we aimed to characterize the processing time needed to recognize a natural sound. To do so, by analogy with the "rapid visual seque...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43126-5

    authors： Isnard V,Chastres V,Viaud-Delmon I,Suied C

    更新日期：2019-05-29 00:00:00

  • No impact of transgenic cry1Ie maize on the diversity, abundance and composition of soil fauna in a 2-year field trial.

    abstract：:Soil fauna play an essential role in the soil ecosystem, but they may be influenced by insecticidal Cry proteins derived from Bacillus thuringiensis (Bt) maize. In this study, a 2-year field trial was conducted to study the effects of transgenic cry1Ie maize, a type of Bt maize (Event IE09S034), on soil fauna, with th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46851-z

    authors： Fan C,Wu F,Dong J,Wang B,Yin J,Song X

    更新日期：2019-07-17 00:00:00

  • Gene expression profiles for low-dose exposure to diethyl phthalate in rodents and humans: a translational study with implications for breast carcinogenesis.

    abstract：:Phthalates are commonly included as ingredients in personal care products such as cosmetics, shampoos and perfumes. Diethyl phthalate (DEP) has been found to be anti-androgenic and linked with adverse reproductive effects on males, but effects on females are poorly understood. We designed an integrative and translatio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-63904-w

    authors： Gopalakrishnan K,Aushev VN,Manservisi F,Falcioni L,Panzacchi S,Belpoggi F,Parada H Jr,Garbowski G,Hibshoosh H,Santella RM,Gammon MD,Teitelbaum SL,Chen J

    更新日期：2020-04-27 00:00:00

  • Pro-arrhythmogenic effects of CACNA1C G1911R mutation in human ventricular tachycardia: insights from cardiac multi-scale models.

    abstract：:Mutations in the CACNA1C gene are associated with ventricular tachycardia (VT). Although the CACNA1C mutations were well identified in patients with cardiac arrhythmias, mechanisms by which cardiac arrhythmias are generated in such genetic mutation conditions remain unclear. In this study, we identified a novel mechan...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep31262

    authors： Bai J,Wang K,Li Q,Yuan Y,Zhang H

    更新日期：2016-08-09 00:00:00

  • Genomic structure of the horse major histocompatibility complex class II region resolved using PacBio long-read sequencing technology.

    abstract：:The mammalian Major Histocompatibility Complex (MHC) region contains several gene families characterized by highly polymorphic loci with extensive nucleotide diversity, copy number variation of paralogous genes, and long repetitive sequences. This structural complexity has made it difficult to construct a reliable ref...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45518

    authors： Viļuma A,Mikko S,Hahn D,Skow L,Andersson G,Bergström TF

    更新日期：2017-03-31 00:00:00