Abstract:
:Phthalates are commonly included as ingredients in personal care products such as cosmetics, shampoos and perfumes. Diethyl phthalate (DEP) has been found to be anti-androgenic and linked with adverse reproductive effects on males, but effects on females are poorly understood. We designed an integrative and translational study to experimentally examine the effects of DEP exposure at a human-equivalent dose on the mammary transcriptome in rats and to subsequently examine the DEP gene signature in breast tissues (both pre-malignant and tumor) from a population study. In Sprague-Dawley rats treated orally with DEP from birth to adulthood, we identified a signature panel of 107 genes predominantly down-regulated by DEP exposure. Univariate analysis of this 107 DEP gene signature in pre-malignant breast tissues revealed that six genes (P4HA1, MPZL3, TMC4, PLEKHA6, CA8, AREG) were inversely associated with monoethyl phthalate (MEP; the urinary metabolite of DEP) concentration (p < 0.05) among postmenopausal women; all six genes loaded on to one of seven factors identified by factor analysis. Transcription factor enrichment analysis revealed that genes in this factor were enriched for androgen receptor binding sites. These six genes were also significantly down-regulated in pre-malignant adjacent tissues compared to the corresponding tumor tissues in pair-wise analyses (p < 0.05). Results from our translational study indicate that low level exposure to diethyl phthalate results in measurable genomic changes in breast tissue with implications in breast carcinogenesis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Gopalakrishnan K,Aushev VN,Manservisi F,Falcioni L,Panzacchi S,Belpoggi F,Parada H Jr,Garbowski G,Hibshoosh H,Santella RM,Gammon MD,Teitelbaum SL,Chen Jdoi
10.1038/s41598-020-63904-wsubject
Has Abstractpub_date
2020-04-27 00:00:00pages
7067issue
1issn
2045-2322pii
10.1038/s41598-020-63904-wjournal_volume
10pub_type
杂志文章abstract::Prophages are known to encode important virulence factors in the human pathogen Vibrio cholerae. However, little is known about the occurrence and composition of prophage-encoded traits in environmental vibrios. A database of 5,674 prophage-like elements constructed from 1,874 Vibrio genome sequences, covering sixty-f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28326-9
更新日期:2018-07-02 00:00:00
abstract::HIV-1 env sequencing enables predictions of viral coreceptor tropism and phylogenetic investigations of transmission events. The aim of the study was to estimate the contribution of non-R5 strains to the viral spread in Poland. Partial proviral env sequences were retrieved from baseline blood samples of patients with ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41407-7
更新日期:2019-03-21 00:00:00
abstract::Environmentally persistent free radicals (EPFRs) have attracted increasing research interest in recent years. Herein, the generation of EPFRs during the hydrothermal carbonization of sewage sludge (SS) was studied. First, the surface morphology, functional groups, constituent elements and free radicals were characteri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53781-3
更新日期:2019-11-19 00:00:00
abstract::Carbon coated TiO2 (TiO2@C) is fabricated by a convenient and green one-pot solvothermal method, in which ethylene glycol serve as both the reaction medium and carbon source without the addition of any other carbon additives. During the solvothermal process, ethylene glycol polymerize and coordinate with Ti4+ to form ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43895
更新日期:2017-03-03 00:00:00
abstract::Porcine reproductive and respiratory syndrome virus (PRRSV) activates NF-κB during infection. We examined the ability of all 22 PRRSV genes for NF-κB regulation and determined the nucleocapsid (N) protein as the NF-κB activator. Protein inhibitor of activated STAT1 (signal transducer and activator of transcription 1) ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47495-9
更新日期:2019-07-30 00:00:00
abstract::The neural representation of auditory duration remains unknown. Here, we used electroencephalogram (EEG) recordings to investigate neural oscillations during the maintenance of auditory duration in working memory (WM). EEG analyses indicated that the auditory duration length was not associated with changes in the thet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06078-2
更新日期:2017-07-18 00:00:00
abstract::Controlling thickness and tightness of surface passivation shells is crucial for many applications of core-shell nanoparticles (NP). Usually, to determine shell thickness, core and core/shell particle are measured individually requiring the availability of both nanoobjects. This is often not fulfilled for functional n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77530-z
更新日期:2020-11-26 00:00:00
abstract::Stochastic differential equations (SDEs) are ubiquitous across disciplines, and uncovering SDEs driving observed time series data is a key scientific challenge. Most previous work on this topic has relied on restrictive assumptions, undermining the generality of these approaches. We present a novel technique to uncove...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81162-2
更新日期:2021-01-29 00:00:00
abstract::Sleep has been hypothesised to maintain a close relationship with metabolism. Here we focus on the brain structure that triggers slow-wave sleep, the ventrolateral preoptic nucleus (VLPO), to explore the cellular and molecular signalling pathways recruited by an increase in glucose concentration. We used infrared vide...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19107
更新日期:2016-01-12 00:00:00
abstract::RNA editing is a molecular event that alters specific nucleotides in RNA post-transcriptionally. RNA editing has the potential to impact a variety of cellular processes and is implicated in diseases such as cancer. Yet, the precise mechanisms by which RNA editing controls cellular processes are poorly understood. Here...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23226
更新日期:2016-03-16 00:00:00
abstract::Antiretroviral therapy-naive HIV-1 infected infants experience poor viral containment and rapid disease progression compared to adults. Viral factors (e.g. transmitted cytotoxic T- lymphocyte (CTL) escape mutations) or infant factors (e.g. reduced CTL functional capacity) may explain this observation. We assessed CTL ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29536
更新日期:2016-07-12 00:00:00
abstract::Liver segmentation is an essential procedure in computer-assisted surgery, radiotherapy, and volume measurement. It is still a challenging task to extract liver tissue from 3D CT images owing to nearby organs with similar intensities. In this paper, an automatic approach integrating multi-dimensional features into gra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28787-y
更新日期:2018-07-16 00:00:00
abstract::Resistance to adjuvant systemic treatment, including taxanes (docetaxel and paclitaxel) is a major clinical problem for breast cancer patients. lncRNAs (long non-coding RNAs) are non-coding transcripts, which have recently emerged as important players in a variety of biological processes, including cancer development ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36231-4
更新日期:2018-12-19 00:00:00
abstract::Comparable taxonomic ranks within clades can facilitate more consistent classifications and objective comparisons among taxa. Here we use a temporal approach to identify taxonomic ranks. This is an extension of the temporal banding approach including a Temporal Error Score that finds an objective cut-off for each taxo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02477-7
更新日期:2017-05-23 00:00:00
abstract::Multi-wavelength lasers have widespread applications (e.g. fiber telecommunications, pump-probe measurements, terahertz generation). Here, we report a nanotube-mode-locked all-fiber ultrafast oscillator emitting three wavelengths at the central wavelengths of about 1540, 1550, and 1560 nm, which are tunable by stretch...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02718
更新日期:2013-01-01 00:00:00
abstract::The Langendorff-perfused heart technique has become the model of choice for multiparametric optical mapping of cardiac function and electrophysiology. However, photon scattering in tissues represents a significant drawback of the optical imaging approach, fundamentally limiting its mapping capacity to the heart surfac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32317-1
更新日期:2018-09-20 00:00:00
abstract::Interleukin-36 (IL-36) represents three cytokines, IL-36α, IL-36β and IL-36γ, which bind to the same receptor, IL-1RL2; however, their physiological function(s) remain poorly understood. Here, the role of IL-36 in immunity against HSV-1 was examined using the flank skin infection mouse model. Expression analyses revea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05363-4
更新日期:2017-07-19 00:00:00
abstract::Cell and animal studies have demonstrated that circadian rhythm is governed by autonomous rhythmicity of clock genes. Although disturbances in circadian rhythm have been implicated in metabolic disease development, it remains unknown whether muscle circadian rhythm is altered in human models of type 2 diabetes. Here w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35047
更新日期:2016-10-19 00:00:00
abstract::An intensified and continuous West Nile virus (WNV) spread across northern Italy has been observed since 2008, which caused more than one hundred reported human infections until 2016. Veneto is one of the Italian regions where WNV is considered endemic, and the greatest intensity of circulation was observed during 201...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32401-6
更新日期:2018-09-18 00:00:00
abstract::Emergence of new molecules acting directly on the hepatitic C virus (HCV) has improved treatment outcomes. However, there is a risk of selecting viral escape mutants, so a new combination is needed using different inhibitors that target different steps of the HCV infectious cycle. Novel single tablet formulations were...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49973-6
更新日期:2019-09-19 00:00:00
abstract::Peripheral blood indices of systemic inflammation such as the neutrophil-lymphocyte ratio (NLR) have been shown to be prognostic in various cancers. We aim to investigate the clinical significance of these indices in patients with soft tissue sarcoma (STS). Seven hundred and twelve patients with available blood counts...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30442-5
更新日期:2018-08-10 00:00:00
abstract::Microbial survival in dynamic environments requires the ability to successfully respond to abrupt changes in osmolarity. The mechanosensitive channel of large conductance (MscL) is a ubiquitous channel that facilitates the survival of bacteria and archaea under severe osmotic downshock conditions by relieving excess t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32536-6
更新日期:2018-10-01 00:00:00
abstract::Gluconobacter oxydans sorbitol dehydrogenase (GoSLDH) exhibits a higher catalytic efficiency than other L-sorbose producing enzymes. During the reaction catalysed by GoSLDH, NADP+ is reduced to NADPH and D-sorbitol is oxidized to L-sorbose. However, GoSLDH activity is inhibited by the NADPH (Ki = 100 μM) formed during...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37401-0
更新日期:2019-01-28 00:00:00
abstract::We report a recent experimental simulation of a controlled-NOT gate operation based on polarization correlation measurements of thermal fields in photon-number fluctuations. The interference between pairs of correlated paths at the very heart of these experiments has the potential for the simulation of correlations be...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30152
更新日期:2016-07-21 00:00:00
abstract::To assess anatomical changes in eyes with progressive myopia, we morphometrically examined the eyes of guinea pigs with lens-induced axial elongation. Starting at an age of 3-4 weeks, guinea pigs in the experimental group (n = 20 animals) developed unilateral lens-induced axial elongation by wearing goggles for 5 week...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43212-8
更新日期:2019-04-29 00:00:00
abstract::In this work, we show that it is possible to overcome the limitations of solid-state MRI for rigid tissues due to large line broadening and short dephasing times by combining Magic Angle Spinning (MAS) with rotating pulsed field gradients. This allows recording ex vivo 31P 3D and 2D slice-selected images of rigid tiss...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08458-0
更新日期:2017-08-15 00:00:00
abstract::Succeeding in breeding super hybrid rice has been considered as a great progress in rice production in China. This on-farm study was conducted with Minirhizotron techniques to identify dynamic root morphological traits and distribution (0-30 cm) under different nitrogen treatments. Five elite super hybrid rice cultiva...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18576-4
更新日期:2018-01-09 00:00:00
abstract::Concussions carry devastating potential for cognitive, neurologic, and socio-emotional disease, but no objective test reliably identifies a concussion and its severity. A variety of neurological insults compromise sound processing, particularly in complex listening environments that place high demands on brain process...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39009
更新日期:2016-12-22 00:00:00
abstract::It is indicated that lipids profiles are associated with carotid plaque and Atherosclerosis. However, studies about the relationship between serum lipid profiles and carotid plaque composition in Chinese Population is limited. We conducted a cross-sectional study among 3,214 participants between January 2015 and Decem...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54285-w
更新日期:2019-11-29 00:00:00
abstract::Intelligent development is an inevitable choice for the green development of manufacturing enterprises, environmental regulations and green innovation play an important role in the intelligent development of manufacturing enterprises. By analyzing the interrelationships between environmental regulations, green innovat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71423-x
更新日期:2020-09-02 00:00:00