Abstract:
:The Langendorff-perfused heart technique has become the model of choice for multiparametric optical mapping of cardiac function and electrophysiology. However, photon scattering in tissues represents a significant drawback of the optical imaging approach, fundamentally limiting its mapping capacity to the heart surface. This work presents the first implementation of the optoacoustic approach for 4D imaging of the entire beating isolated mouse heart. The method combines optical excitation and acoustic detection to simultaneously render rich optical contrast and high spatio-temporal resolution at centimeter-scale depths. We demonstrate volumetric imaging of deeply located cardiac features, including the interventricular septum, chordae tendineae, and papillary muscles while further tracking the heart beat cycle and the motion of the pulmonary, mitral, and tricuspid valves in real time. The technique possesses a powerful combination between high imaging depth, fast volumetric imaging speed, functional and molecular imaging capacities not available with other imaging modalities currently used in cardiac research.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lin HA,Déan-Ben XL,Reiss M,Schöttle V,Wahl-Schott CA,Efimov IR,Razansky Ddoi
10.1038/s41598-018-32317-1subject
Has Abstractpub_date
2018-09-20 00:00:00pages
14132issue
1issn
2045-2322pii
10.1038/s41598-018-32317-1journal_volume
8pub_type
杂志文章abstract::The origin and domestication of cultivated barley have long been under debate. A population-based resequencing and phylogenetic analysis of the single copy of RPB2 gene was used to address barley domestication, to explore genetic differentiation of barley populations on the worldwide scale, and to understand gene-pool...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36122
更新日期:2016-10-27 00:00:00
abstract::Non-traumatic osteonecrosis (ON) of the femoral head is a common disease affecting a young population as the peak age of diagnosis is in the 40 s. The natural history of non-traumatic ON leads to a collapse of the femoral head requiring prosthetic replacement in a 60% of cases. Although trabecular bone involvement in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00162-3
更新日期:2017-03-07 00:00:00
abstract::Iron is vital for nearly all living organisms, but during infection, not readily available to pathogens. Infectious bacteria therefore depend on specialized mechanisms to survive when iron is limited. These mechanisms make attractive targets for new drugs. Here, by genome-wide phenotypic profiling, we identify and cat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47905-y
更新日期:2019-08-06 00:00:00
abstract::During skin healing, periostin facilitates myofibroblast differentiation through a β1 integrin/FAK dependent mechanism and continued expression is associated with scarring. In contrast to skin, gingival tissue does not typically scar upon injury, but the role of periostin in gingival healing has never been investigate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35805-6
更新日期:2019-02-25 00:00:00
abstract::The incidence of resistant Candida isolates, especially Candida albicans, has increased continuously. To overcome the resistance, research on antifungal agent sensitizers has attracted considerable attention. Omeprazole and lansoprazole were found to inhibit the growth of sensitive C. albicans and hyphae formation in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57174-4
更新日期:2020-01-16 00:00:00
abstract::California has experienced a dry 21(st) century capped by severe drought from 2012 through 2015 prompting questions about hydroclimatic sensitivity to anthropogenic climate change and implications for the future. We address these questions using a Holocene lake sediment record of hydrologic change from the Sierra Neva...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33325
更新日期:2016-09-15 00:00:00
abstract::The local flexibility of an enzyme's active center plays pivotal roles in catalysis, however, little is known about how the flexibility of these flexible residues affects stability. In this study, we proposed an active center stabilization (ACS) strategy to improve the kinetic thermostability of Candida rugosa lipase1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33797
更新日期:2016-09-26 00:00:00
abstract::Heavy metals are environmental pollutants affect the integrity and distribution of living organisms in the ecosystem and also humans across the food chain. The study targeted the removal of copper (Cu2+) from aqueous solutions, depending on the biosorption process. The bacterial candidate was identified using 16S rRNA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66101-x
更新日期:2020-06-11 00:00:00
abstract::Animals execute sensorimotor sequences to optimize performance of complex actions series. However, the sensory aspects of these sequences and their dynamic control are often poorly understood. We trained bats to fly to targets at different distances, and analysed their sensory behavior before and during flight to test...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00543-8
更新日期:2017-03-28 00:00:00
abstract::TRPV1 is a polymodal nociceptor for diverse physical and chemical stimuli that interact with different parts of the channel protein. Recent cryo-EM studies revealed detailed channel structures, opening the door for mapping structural elements mediating activation by each stimulus. Towards this goal, here we have combi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33827
更新日期:2016-09-26 00:00:00
abstract::Glucocorticoids (GC) display pleiotropic effects on the immune system. Macrophages are a major target for GC action. Here we show that dexamethasone (DEX), a synthetic GC, decreased viability of naïve bone marrow-derived macrophages (BMDM), involving an apoptotic mechanism. Administration of DEX together with lipopoly...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04323
更新日期:2014-03-10 00:00:00
abstract::To investigate changes in the size of the population of patients who are receiving long-term, active treatment for neovascular age-related macular degeneration (AMD). This retrospective, observational study included 18,165 patients who received anti-vascular endothelial growth factor injections (3,974 eyes). The injec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49749-y
更新日期:2019-09-13 00:00:00
abstract::Severely injured patients frequently suffer compromised fracture healing because of systemic post-traumatic inflammation. An important trigger of the posttraumatic immune response is the complement anaphylatoxin C5a, which acts via two receptors, C5aR1 and C5aR2, expressed on immune and bone cells. The blockade of C5a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14444-3
更新日期:2017-10-25 00:00:00
abstract::Inflammation is considered as a major contributor to brain injury following cerebral ischemia. The therapeutic potential of both MLC601/MLC901, which are herbal extract preparations derived from Chinese Medicine, has been reported both in advanced stroke clinical trials and also in animal and cellular models. The aim ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36138-0
更新日期:2018-12-24 00:00:00
abstract::We propose a scheme for generating an entangled state for two atoms trapped in two separate cavities coupled to each other. The scheme is based on the competition between the unitary dynamics induced by the classical fields and the collective decays induced by the dissipation of two non-local bosonic modes. In this sc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17933-7
更新日期:2017-12-15 00:00:00
abstract::Blood transfusion is fundamental in managing hematologic malignancies. We sought to evaluate the need and availability of blood products for patients with hematological malignancies at Uganda Cancer Institute. We prospectively studied the demand and supply of blood for patients with thrombocytopenia (platelet count ≤5...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59773-y
更新日期:2020-02-18 00:00:00
abstract::The incidence of myopia is increasing worldwide, and the investigation on pathophysiology of myopia is becoming more important. This retrospective study aimed to compare the thicknesses of individual retinal layers between high-myopic and control eyes, and to evaluate the effects of age and sex on each retinal layer t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50306-w
更新日期:2019-09-30 00:00:00
abstract::In the course of sample preparation for Next Generation Sequencing (NGS), DNA is fragmented by various methods. Fragmentation shows a persistent bias with regard to the cleavage rates of various dinucleotides. With the exception of CpG dinucleotides the previously described biases were consistent with results of the D...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65406-1
更新日期:2020-05-25 00:00:00
abstract::Astrocyte reactivation has been discovered to be an important contributor to several neurological diseases. In vitro models involving human astrocytes have the potential to reveal disease-specific mechanisms of these cells and to advance research on neuropathological conditions. Here, we induced a reactive phenotype i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53414-9
更新日期:2019-11-15 00:00:00
abstract::Distillers grains are co-products of the corn ethanol industry widely used in animal feed. We examined the effects of erythromycin, penicillin, and virginiamycin at low concentrations reflective of those detected in distillers grains on bacterial resistance selection. At 0.1 µg/ml erythromycin, macrolide-resistant mut...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09593-4
更新日期:2017-09-08 00:00:00
abstract::The 2,5-Diketopiperazines (DKPs) constitute a large family of natural products with important biological activities. Bicyclomycin is a clinically-relevant DKP antibiotic that is the first and only member in a class known to target the bacterial transcription termination factor Rho. It derives from cyclo-(L-isoleucyl-L...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56747-7
更新日期:2019-12-27 00:00:00
abstract::We have investigated the rotating magnetocaloric effect (R-MCE) of TmB4 - an anisotropic magnetic system with geometrical frustration of Shastry-Sutherland type. The R-MCE was obtained from detailed temperature dependencies of heat capacity in various magnetic fields of a single crystalline sample for crystal axes ori...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29399-2
更新日期:2018-07-19 00:00:00
abstract::We report the counterintuitive mechanism of increasing boiling heat transfer by incorporating low-conductivity materials at the interface between the surface and fluid. By embedding an array of non-conductive lines into a high-conductivity substrate, in-plane variations in the local surface temperature are created. Du...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13145
更新日期:2015-08-18 00:00:00
abstract::Freshwater mussels are ecosystem engineers and keystone species in aquatic environments. Unfortunately, due to dramatic declines this fauna is among the most threatened globally. Here, we clarify the taxonomy and biogeography of Russian Unionidae species based on the most comprehensive multi-locus dataset sampled to d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59867-7
更新日期:2020-02-20 00:00:00
abstract::A possible association between depression and either the severity of constipation or dysosmia in Parkinson's disease (PD) patients was investigated in this cross-sectional study. One-hundred six patients who had the history of PD for less than 5 years were recruited. Depression was measured using the Beck Depression I...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72381-0
更新日期:2020-09-23 00:00:00
abstract::Clinical benefit from trastuzumab and other anti-human epidermal growth factor receptor-2 (HER2) therapies in patients with HER2-positive gastric cancer (GC) remains limited by primary or acquired resistance. We aimed to investigate the impact of concomitant molecular alterations to HER2 amplification on the clinical ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09289
更新日期:2015-03-19 00:00:00
abstract::Supported by histological and genetic evidence implicating myelin, neuroinflammation and oligodendrocyte dysfunction in schizophrenia spectrum disorders (SZ), diffusion tensor imaging (DTI) studies have consistently shown white matter (WM) abnormalities when compared to healthy controls (HC). The diagnostic specificit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32355-9
更新日期:2018-09-20 00:00:00
abstract::Three-dimensional (3D) spheroidal cell cultures are now recognised as better models of cancers as compared to traditional cell cultures. However, established 3D cell culturing protocols and techniques are time-consuming, manually laborious and often expensive due to the excessive consumption of reagents. Microfluidics...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72952-1
更新日期:2020-09-28 00:00:00
abstract::In the present study, a surface-active enzyme, lipase was immobilized in polyethyleneimine (PEI) microcapsules and then modified with oxidized multiwall carbon nanotubes (MWCNTs). The resulting lipase microcapsules exhibited higher activity and stability, since the activity of microcapsules was 21.9 folds than that of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29670
更新日期:2016-07-18 00:00:00
abstract::The present work focuses on the postseismic deformation observed in the region of L'Aquila (central Italy) following the Mw 6.3 earthquake that occurred on April 6, 2009. A new, 16-month-long dataset of COSMO-SkyMed SAR images was analysed using the Persistent Scatterer Pairs interferometric technique. The analysis re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16558
更新日期:2015-11-10 00:00:00