Abstract:
:Blood transfusion is fundamental in managing hematologic malignancies. We sought to evaluate the need and availability of blood products for patients with hematological malignancies at Uganda Cancer Institute. We prospectively studied the demand and supply of blood for patients with thrombocytopenia (platelet count ≤50 × 109/L), anemia (hemoglobin ≤10 g/dL), and bleeding (WHO grade ≥2). We used Poisson generalized estimating equation regression models for longitudinal binary outcomes. Among 91 patients, the median age was 26 years (IQR, 11-47). Thrombocytopenia occurred on ≥1 day in 58% of patients and on 49% of hospital days. Platelets were transfused to 39% of patients. The mean number of platelet units requested per day was 16.2 (range 0-30); 5.1 (range 0-15) were received. Anemia occurred on ≥1 day in 90% of patients; on 78% of days; and 68% received at least one blood transfusion. The mean number of blood units requested was 36.3 (range 8-57) units per day; 14 (range 0-30) were received. Bleeding occurred on ≥1 day in 19% of patients on 8% of hospital days. Thrombocytopenia and anemia were common, but product availability was substantially below that requested. We recommend increased blood collection and adherence to strict transfusion triggers as strategies to improve blood availability.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ddungu H,Krantz EM,Kajja I,Naluzze S,Nabbanja H,Nalubwama F,Phipps W,Orem J,Wald A,Kiwanuka Ndoi
10.1038/s41598-020-59773-ysubject
Has Abstractpub_date
2020-02-18 00:00:00pages
2825issue
1issn
2045-2322pii
10.1038/s41598-020-59773-yjournal_volume
10pub_type
杂志文章abstract::SLC30A2 encodes a zinc (Zn) transporter (ZnT2) that imports Zn into vesicles in highly-specialized secretory cells. Numerous mutations and non-synonymous variants in ZnT2 have been reported in humans and in breastfeeding women; ZnT2 variants are associated with abnormally low milk Zn levels and can lead to severe infa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21505-8
更新日期:2018-02-23 00:00:00
abstract::A number of human and animal in vitro or in vivo studies have investigated the relationship between dietary choline and betaine and cancer risk, suggesting that choline and betaine consumption may be protective for cancer. There are also a few epidemiologic studies exploring this relationship, however, with inconsiste...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep35547
更新日期:2016-10-19 00:00:00
abstract::In plants, pathogen triggered programmed cell death (PCD) is frequently mediated by polar lipid molecules referred as long chain bases (LCBs) or ceramides. PCD interceded by LCBs is a well-organized process where several cell organelles play important roles. In fact, light-dependent reactions in the chloroplast have b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65186-8
更新日期:2020-06-25 00:00:00
abstract::Plants deploy several ammonium transporter (AMT) and nitrate transporter (NRT) genes to acquire NH4+ and NO3- from the soil into the roots and then transport them to other plant organs. Coding sequences of wheat genes obtained from ENSEMBL were aligned to known AMT and NRT sequences of Arabidopsis, barley, maize, rice...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25430-8
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journal_title:Scientific reports
pub_type: 杂志文章
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更新日期:2016-04-29 00:00:00
abstract::The major virulence factors of Clostridium difficile are toxins A and B. These toxins are encoded by tcdA and tcdB genes, which form a pathogenicity locus (PaLoc) together with three additional genes that have been implicated in regulation (tcdR and tcdC) and secretion (tcdE). To date, the PaLoc has always been found ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15023
更新日期:2015-10-08 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24746-9
更新日期:2018-05-08 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
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更新日期:2017-08-07 00:00:00
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pub_type: 杂志文章
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journal_title:Scientific reports
pub_type: 杂志文章
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00885
更新日期:2012-01-01 00:00:00
abstract::Sex hormones fluctuate during the menstrual cycle. Evidence from animal studies suggests similar subtle fluctuations in hippocampal structure, predominantly linked to estrogen. Hippocampal abnormalities have been observed in several neuropsychiatric pathologies with prominent sexual dimorphism. Yet, the potential impa...
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pub_type: 杂志文章
doi:10.1038/srep32833
更新日期:2016-10-07 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65596-8
更新日期:2020-05-25 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
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更新日期:2017-10-05 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00797
更新日期:2012-01-01 00:00:00
abstract::Hypertension is a public health issue in Iran. The study aimed to estimate the prevalence, awareness, treatment, and control of hypertension, and to explore their determinants among 10,040 Kurdish adults from Ravansar Non-Communicable Disease (RaNCD) cohort study in Iran. Univariate, and multivariate analyses were use...
journal_title:Scientific reports
pub_type: 杂志文章
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更新日期:2019-08-27 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33074-x
更新日期:2018-10-10 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03846
更新日期:2014-01-24 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
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journal_title:Scientific reports
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26739-0
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69255-w
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04292
更新日期:2014-03-06 00:00:00
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pub_type: 杂志文章
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42218
更新日期:2017-02-21 00:00:00
abstract::It is challenging to create artificial catalysts that approach enzymes with regard to catalytic efficiency and selectivity. The enantioselective catalysis ranks the privileged characteristic of enzymatic transformations. Here, we report two pyridine-linked bis(β-cyclodextrin) (bisCD) copper(II) complexes that enantios...
journal_title:Scientific reports
pub_type: 杂志文章
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abstract::Aluminium nitride (AlN) is a promising semiconductor material for use as a substrate in high-power, high-frequency electronic and deep-ultraviolet optoelectronic devices. We study the feasibility of a novel AlN fabrication technique by using the Al/GaN substitution reaction method. The substitution method we propose h...
journal_title:Scientific reports
pub_type: 杂志文章
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pub_type: 杂志文章
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