Abstract：
:Blood transfusion is fundamental in managing hematologic malignancies. We sought to evaluate the need and availability of blood products for patients with hematological malignancies at Uganda Cancer Institute. We prospectively studied the demand and supply of blood for patients with thrombocytopenia (platelet count ≤50 × 109/L), anemia (hemoglobin ≤10 g/dL), and bleeding (WHO grade ≥2). We used Poisson generalized estimating equation regression models for longitudinal binary outcomes. Among 91 patients, the median age was 26 years (IQR, 11-47). Thrombocytopenia occurred on ≥1 day in 58% of patients and on 49% of hospital days. Platelets were transfused to 39% of patients. The mean number of platelet units requested per day was 16.2 (range 0-30); 5.1 (range 0-15) were received. Anemia occurred on ≥1 day in 90% of patients; on 78% of days; and 68% received at least one blood transfusion. The mean number of blood units requested was 36.3 (range 8-57) units per day; 14 (range 0-30) were received. Bleeding occurred on ≥1 day in 19% of patients on 8% of hospital days. Thrombocytopenia and anemia were common, but product availability was substantially below that requested. We recommend increased blood collection and adherence to strict transfusion triggers as strategies to improve blood availability.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ddungu H,Krantz EM,Kajja I,Naluzze S,Nabbanja H,Nalubwama F,Phipps W,Orem J,Wald A,Kiwanuka Ndoi
10.1038/s41598-020-59773-ysubject
Has Abstractpub_date
2020-02-18 00:00:00pages
2825issue
1issn
2045-2322pii
10.1038/s41598-020-59773-yjournal_volume
10pub_type
杂志文章abstract：:SLC30A2 encodes a zinc (Zn) transporter (ZnT2) that imports Zn into vesicles in highly-specialized secretory cells. Numerous mutations and non-synonymous variants in ZnT2 have been reported in humans and in breastfeeding women; ZnT2 variants are associated with abnormally low milk Zn levels and can lead to severe infa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21505-8
更新日期：2018-02-23 00:00:00
abstract：:A number of human and animal in vitro or in vivo studies have investigated the relationship between dietary choline and betaine and cancer risk, suggesting that choline and betaine consumption may be protective for cancer. There are also a few epidemiologic studies exploring this relationship, however, with inconsiste...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep35547
更新日期：2016-10-19 00:00:00
abstract：:In plants, pathogen triggered programmed cell death (PCD) is frequently mediated by polar lipid molecules referred as long chain bases (LCBs) or ceramides. PCD interceded by LCBs is a well-organized process where several cell organelles play important roles. In fact, light-dependent reactions in the chloroplast have b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65186-8
更新日期：2020-06-25 00:00:00
abstract：:Plants deploy several ammonium transporter (AMT) and nitrate transporter (NRT) genes to acquire NH4+ and NO3- from the soil into the roots and then transport them to other plant organs. Coding sequences of wheat genes obtained from ENSEMBL were aligned to known AMT and NRT sequences of Arabidopsis, barley, maize, rice...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25430-8
更新日期：2018-05-04 00:00:00
abstract：:Alkaline sulfide-rich hot springs provide a unique environment for microbial community and arsenic (As) biogeochemistry. In this study, a representative alkaline sulfide-rich hot spring, Zimeiquan in the Tengchong geothermal area, was chosen to study arsenic geochemistry and microbial community using Illumina MiSeq se...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25262
更新日期：2016-04-29 00:00:00
abstract：:The major virulence factors of Clostridium difficile are toxins A and B. These toxins are encoded by tcdA and tcdB genes, which form a pathogenicity locus (PaLoc) together with three additional genes that have been implicated in regulation (tcdR and tcdC) and secretion (tcdE). To date, the PaLoc has always been found ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15023
更新日期：2015-10-08 00:00:00
abstract：:Synthetic fungicides are pesticides widely used in agriculture to control phytopathogenic fungi. The systemicity, persistency and intense application of some of these fungicides, such as boscalid, leads to long periods of exposure for honeybees via contaminated water, pollen and nectar. We exposed adult honeybees in t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24746-9
更新日期：2018-05-08 00:00:00
abstract：:The existing acoustic emission (AE) source location methods assume that acoustic waves propagate along straight lines, and the source location is determined by average wave velocity. Because of the heterogeneity of materials, location results often fail to meet the accuracy requirement. For this reason, an AE source l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07371-w
更新日期：2017-08-07 00:00:00
abstract：:College students, as a large part of young adults, are a vulnerable group to several risky behaviors including smoking and drug abuse. This study aimed to utilize and to compare count regression models to identify correlates of cigarette smoking among college students. This was a cross-sectional study conducted on stu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65813-4
更新日期：2020-06-01 00:00:00
abstract：:Hand preference is a conspicuous variation in human behaviour, with a worldwide proportion of around 90% of people preferring to use the right hand for many tasks, and 10% the left hand. We used the large cohort of the UK biobank (~500,000 participants) to study possible relations between early life factors and adult ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37423-8
更新日期：2019-01-24 00:00:00
abstract：:Quantum coherence is one of the primary non-classical features of quantum systems. While protocols such as the Leggett-Garg inequality (LGI) and quantum tomography can be used to test for the existence of quantum coherence and dynamics in a given system, unambiguously detecting inherent "quantumness" still faces serio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00885
更新日期：2012-01-01 00:00:00
abstract：:Sex hormones fluctuate during the menstrual cycle. Evidence from animal studies suggests similar subtle fluctuations in hippocampal structure, predominantly linked to estrogen. Hippocampal abnormalities have been observed in several neuropsychiatric pathologies with prominent sexual dimorphism. Yet, the potential impa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32833
更新日期：2016-10-07 00:00:00
abstract：:Plastic represents 60-80% of litter in the ocean. Degradation of plastic to small fragments leads to the formation of microplastics (MPs <5 mm) and nanoplastics (NPs <1 µm). One of the most widely used and representative plastics found in the ocean is polystyrene (PS). Among marine organisms, the immune system of biva...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65596-8
更新日期：2020-05-25 00:00:00
abstract：:Current and expected changes in global climate are major threat for biological diversity affecting individuals, communities and ecosystems. However, there is no general trend in the plants response to the climate change. The aim of present study was to evaluate impact of the future climate changes on the distribution ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13088-7
更新日期：2017-10-05 00:00:00
abstract：:Friction is a major inhibitor in almost every mechanical system. Enlightened by the Leidenfrost effect - a droplet can be levitated by its own vapor layer on a sufficiently hot surface - we demonstrate for the first time that a small cart can also be levitated by Leidenfrost vapor. The levitated cart can carry certain...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00797
更新日期：2012-01-01 00:00:00
abstract：:Hypertension is a public health issue in Iran. The study aimed to estimate the prevalence, awareness, treatment, and control of hypertension, and to explore their determinants among 10,040 Kurdish adults from Ravansar Non-Communicable Disease (RaNCD) cohort study in Iran. Univariate, and multivariate analyses were use...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48232-y
更新日期：2019-08-27 00:00:00
abstract：:Bacterial microcompartments (BMCs) are promising natural protein structures for applications that require the segregation of certain metabolic functions or molecular species in a defined microenvironment. To understand how endogenous cargos are packaged inside the protein shell is key for using BMCs as nano-scale reac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33074-x
更新日期：2018-10-10 00:00:00
abstract：:Arrestin domain-containing 3 (ARRDC3) is a tumor suppressor whose expression is either lost or suppressed in basal-like breast cancer (BLBC). However, the mechanism by which BLBC suppresses ARRDC3 expression is not established. Here, we show that expression of ARRDC3 in BLBC cells is suppressed at the transcriptional ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03846
更新日期：2014-01-24 00:00:00
abstract：:Immunoproteasomes are known for their involvement in antigen presentation. However, their broad tissue presence and other evidence are indicative of nonimmune functions. We examined a role for immunoproteasomes in cellular responses to the endogenous and environmental carcinogen formaldehyde (FA) that binds to cytosol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00757-w
更新日期：2017-04-05 00:00:00
abstract：:Perpendicularly magnetized tunnel junctions (p-MTJs) that contain synthetic antiferromagnetic (SAF) frames show promise as reliable building blocks to meet the demands of perpendicular magnetic anisotropy (PMA)-based spintronic devices. In particular, Co/Pd multilayer-based SAFs have been widely employed due to their ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21324
更新日期：2016-02-18 00:00:00
abstract：:Leprosy remains persistently endemic in several low- or middle income countries. Transmission is still ongoing as indicated by the unabated rate of leprosy new case detection, illustrating the insufficiency of current prevention methods. Therefore, low-complexity tools suitable for large scale screening efforts to spe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36323-1
更新日期：2018-12-18 00:00:00
abstract：:We compare two approaches for deriving corrections to the "linear model" of cavity optomechanics, in order to describe effects that are beyond first order in the radiation pressure coupling. In the regime where the mechanical frequency is much lower than the cavity one, we compare: (I) a widely used phenomenological H...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26739-0
更新日期：2018-06-14 00:00:00
abstract：:Ethiopian mustard (Brassica carinata A. Braun) is an emerging sustainable source of vegetable oil, in particular for the biofuel industry. The present study exploited genome assemblies of the Brassica diploids, Brassica nigra and Brassica oleracea, to discover over 10,000 genome-wide SNPs using genotype by sequencing ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69255-w
更新日期：2020-07-28 00:00:00
abstract：:The exopeptidases of family S46 are exceptional, as the closest homologs of these enzymes are the endopeptidases of clan PA. The three-dimensional structure of S46 enzymes is unknown and only one of the catalytic residues, the serine, has been identified. The catalytic histidine and aspartate residues are not experime...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04292
更新日期：2014-03-06 00:00:00
abstract：:The human brain contains areas that respond selectively to faces, bodies and scenes. Neuroimaging studies have shown that a subset of these areas preferentially respond more to moving than static stimuli, but the reasons for this functional dissociation remain unclear. In the present study, we simultaneously mapped th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44663-9
更新日期：2019-06-03 00:00:00
abstract：:Individuals differ in their level of general anxiety as well as in their level of anxiety towards specific activities, such as mathematics and spatial tasks. Both specific anxieties correlate moderately with general anxiety, but the aetiology of their association remains unexplored. Moreover, the factor structure of s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42218
更新日期：2017-02-21 00:00:00
abstract：:It is challenging to create artificial catalysts that approach enzymes with regard to catalytic efficiency and selectivity. The enantioselective catalysis ranks the privileged characteristic of enzymatic transformations. Here, we report two pyridine-linked bis(β-cyclodextrin) (bisCD) copper(II) complexes that enantios...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22080
更新日期：2016-02-26 00:00:00
abstract：:Aluminium nitride (AlN) is a promising semiconductor material for use as a substrate in high-power, high-frequency electronic and deep-ultraviolet optoelectronic devices. We study the feasibility of a novel AlN fabrication technique by using the Al/GaN substitution reaction method. The substitution method we propose h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69992-y
更新日期：2020-08-03 00:00:00
abstract：:Despite the initiative by WHO and other international organizations to eliminate HCV in the medium term, hepatitis C infection is still a major public health problem. Even non-injecting drugs users who engage in harmful or addictive drug use are at greater risk of acquiring the infection, when compared to the general ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35657-0
更新日期：2019-01-24 00:00:00
abstract：:Bisphosphonates have benefits in breast cancer and multiple myeloma patients and have been used with adoptive immunotherapy with γδ T cells expressing Vγ2 Vδ2 TCRs. Although treatment with γδ T cells is safe, it has shown limited efficacy. Present bisphosphonates stimulate γδ T cells but were designed to inhibit bone ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05553-0
更新日期：2017-07-20 00:00:00
