Abstract：
:Blood transfusion is fundamental in managing hematologic malignancies. We sought to evaluate the need and availability of blood products for patients with hematological malignancies at Uganda Cancer Institute. We prospectively studied the demand and supply of blood for patients with thrombocytopenia (platelet count ≤50 × 109/L), anemia (hemoglobin ≤10 g/dL), and bleeding (WHO grade ≥2). We used Poisson generalized estimating equation regression models for longitudinal binary outcomes. Among 91 patients, the median age was 26 years (IQR, 11-47). Thrombocytopenia occurred on ≥1 day in 58% of patients and on 49% of hospital days. Platelets were transfused to 39% of patients. The mean number of platelet units requested per day was 16.2 (range 0-30); 5.1 (range 0-15) were received. Anemia occurred on ≥1 day in 90% of patients; on 78% of days; and 68% received at least one blood transfusion. The mean number of blood units requested was 36.3 (range 8-57) units per day; 14 (range 0-30) were received. Bleeding occurred on ≥1 day in 19% of patients on 8% of hospital days. Thrombocytopenia and anemia were common, but product availability was substantially below that requested. We recommend increased blood collection and adherence to strict transfusion triggers as strategies to improve blood availability.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ddungu H,Krantz EM,Kajja I,Naluzze S,Nabbanja H,Nalubwama F,Phipps W,Orem J,Wald A,Kiwanuka Ndoi
10.1038/s41598-020-59773-ysubject
Has Abstractpub_date
2020-02-18 00:00:00pages
2825issue
1issn
2045-2322pii
10.1038/s41598-020-59773-yjournal_volume
10pub_type
杂志文章abstract：:Hepatitis E virus is a common hepatotropic virus that causes serious gastrointestinal symptoms. Data of reported HEV cases in Zhejiang Province was collected between 2007 and 2012. Descriptive epidemiological methods and spatial-temporal epidemiological methods were used to investigate the epidemiological trends and i...
journal_title：Scientific reports
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
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