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Effects of low concentrations of erythromycin, penicillin, and virginiamycin on bacterial resistance development in vitro.

Abstract：

:Distillers grains are co-products of the corn ethanol industry widely used in animal feed. We examined the effects of erythromycin, penicillin, and virginiamycin at low concentrations reflective of those detected in distillers grains on bacterial resistance selection. At 0.1 µg/ml erythromycin, macrolide-resistant mutants were induced in one Campylobacter coli and one Enterococcus faecium strain, while these strains plus three additional C. coli, one additional E. faecium, and one C. jejuni also developed resistance when exposed to 0.25 µg/ml erythromycin. At 0.5 µg/ml erythromycin, a total of eight strains (four Campylobacter and four Enterococcus) obtained macrolide-resistant mutants, including two strains from each genus that were not selected at lower erythromycin concentrations. For penicillin, three of five E. faecium strains but none of five Enterococcus faecalis strains consistently developed resistance at all three selection concentrations. Virginiamycin at two M1:S1 ratios did not induce resistance development in four out of five E. faecium strains; however, increased resistance was observed in the fifth one under 0.25 and 0.5 µg/ml virginiamycin selections. Although not yet tested in vivo, these findings suggest a potential risk of stimulating bacterial resistance development in the animal gut when distillers grains containing certain antibiotic residues are used in animal feed.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Ge B,Domesle KJ,Yang Q,Young SR,Rice-Trujillo CL,Bodeis Jones SM,Gaines SA,Keller MW,Li X,Piñeiro SA,Whitney BM,Harbottle HC,Gilbert JM

doi

10.1038/s41598-017-09593-4

subject

Has Abstract

pub_date

2017-09-08 00:00:00

pages

11017

issue

1

issn

2045-2322

pii

10.1038/s41598-017-09593-4

journal_volume

7

pub_type

杂志文章

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