Author Correction: Node property of weighted networks considering connectability to nodes within two degrees of separation.

abstract：:Novel tools in humane animal research should benefit the animal as well as the experimentally obtained data. Imaging technologies have proven to be versatile and also in accordance with the demands of the 3 R principle. However, most imaging technologies are either limited by the target organs, number of repetitive im...

journal_title：Scientific reports

authors： Bahlmann J,Madrahimov N,Daniel F,Theidel D,DeTemple DE,Buettner M,Bleich A,Haverich A,Heisterkamp A,Kalies S

更新日期：2020-06-08 00:00:00

abstract：:Antagonist pleiotropy, where a gene exerts a beneficial effect at early stages and a deleterious effect later on in an animal's life, may explain the evolutionary persistence of devastating genetic diseases such as Huntington's disease (HD). To date, however, there is little direct experimental evidence to support thi...

journal_title：Scientific reports

authors： Morton AJ,Skillings EA,Wood NI,Zheng Z

更新日期：2019-01-10 00:00:00

abstract：:Development of highly efficient and potential material for toxic p-nitrophenol is an important design for sensitive detection of hazardous species from ecology and environment. Here it is developed, an efficient as well as selective of p-nitrophenol using binary material by electrochemical performances, including good...

journal_title：Scientific reports

authors： Rahman MM

更新日期：2019-12-17 00:00:00

abstract：:Myocardial ischemia/reperfusion (I/R) injury detrimentally alters the prognosis of patients undergoing revascularization after acute myocardial infarction. Our previous study demonstrated that NF-κB-induced autophagy plays a detrimental role in cardiac I/R injury using a rabbit myocardial I/R model. In this study, we ...

journal_title：Scientific reports

authors： Zeng M,Wei X,Wu Z,Li W,Zheng Y,Li B,Meng X,Fu X,Fei Y

更新日期：2016-11-18 00:00:00

abstract：:Genes central to drug absorption, distribution, metabolism and elimination (ADME) also regulate numerous endogenous molecules. The Remote Sensing and Signaling Hypothesis argues that an ADME gene-centered network-including SLC and ABC "drug" transporters, "drug" metabolizing enzymes (DMEs), and regulatory genes-is ess...

journal_title：Scientific reports

authors： Rosenthal SB,Bush KT,Nigam SK

更新日期：2019-08-15 00:00:00

abstract：:The temporal correspondence between two arbitrarily chosen pairs of alternating features can generally be reported for rates up to 3-4 Hz. This limit is however surpassed for specialised visual mechanisms that encode conjunctions of features. Here we show that this 3-4 Hz limit is exceeded for eye gaze and eyebrow pai...

journal_title：Scientific reports

authors： Harrison C,Binetti N,Mareschal I,Johnston A

更新日期：2018-06-13 00:00:00

abstract：:The glycocalyx regulates the interaction of mammalian cells with extracellular molecules, such as cytokines. However, it is unknown to which extend the glycocalyx of distinct cancer cells control the binding and uptake of nanoparticles. In the present study, exome sequencing data of cancer patients and analysis of dis...

journal_title：Scientific reports

authors： von Palubitzki L,Wang Y,Hoffmann S,Vidal-Y-Sy S,Zobiak B,Failla AV,Schmage P,John A,Osorio-Madrazo A,Bauer AT,Schneider SW,Goycoolea FM,Gorzelanny C

更新日期：2020-12-31 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the elderly. Zinc (Zn) ion interacts with the pathogenic hallmark, amyloid-β (Aβ), and is enriched in senile plaques in brain of AD patients. To understand Zn-chelated Aβ (ZnAβ) species, here we systematically characterized ZnAβ aggregates by ...

journal_title：Scientific reports

authors： Lee MC,Yu WC,Shih YH,Chen CY,Guo ZH,Huang SJ,Chan JCC,Chen YR

更新日期：2018-03-19 00:00:00

abstract：:The Law of the Minimum is often implemented using t-norm or fuzzy intersection. We propose the use of t-conorm or fuzzy union for climate suitability assessment of a grass species using annual ryegrass (Lolium multiflorum Lam.) as an example and evaluate the performance for alfalfa (Medicago sativa L.) and sorghum (So...

journal_title：Scientific reports

authors： Kim H,Hyun SW,Hoogenboom G,Porter CH,Kim KS

更新日期：2018-07-05 00:00:00

abstract：:Multisensory integration is a powerful mechanism for constructing body awareness and key for the sense of selfhood. Recent evidence has shown that the specialised C tactile modality that gives rise to feelings of pleasant, affective touch, can enhance the experience of body ownership during multisensory integration. N...

journal_title：Scientific reports

authors： Panagiotopoulou E,Filippetti ML,Tsakiris M,Fotopoulou A

更新日期：2017-10-10 00:00:00

abstract：:Results on the relationships between vitamin D receptor (VDR) gene polymorphisms and postmenopausal osteoporosis (PMOP) susceptibility and bone mineral density (BMD) are conflicting. The aim of the study is to identify more eligible studies that calculated pooled OR and WMD with 95% CI to assess their associations. Ov...

journal_title：Scientific reports

authors： Zhang L,Yin X,Wang J,Xu D,Wang Y,Yang J,Tao Y,Zhang S,Feng X,Yan C

更新日期：2018-01-17 00:00:00

abstract：:Copper is an essential trace metal that has been implicated in angiogenesis, the formation of new blood vessels. As tumor growth relies on establishing a functional capillary network for blood supply, copper chelation therapy may hold promise as an anti-cancer strategy by suppressing angiogenesis. To test the anti-ang...

journal_title：Scientific reports

authors： Heuberger DM,Harankhedkar S,Morgan T,Wolint P,Calcagni M,Lai B,Fahrni CJ,Buschmann J

更新日期：2019-10-01 00:00:00

abstract：:Protein aggregation is a common biological phenomenon, observed in different physiological and pathological conditions. Decreased protein solubility and a tendency to aggregate is also observed during physiological aging but the causes are currently unknown. Herein we performed a biophysical separation of aging-relate...

journal_title：Scientific reports

authors： Tanase M,Urbanska AM,Zolla V,Clement CC,Huang L,Morozova K,Follo C,Goldberg M,Roda B,Reschiglian P,Santambrogio L

更新日期：2016-01-18 00:00:00

abstract：:The queens of eusocial bees, ants and wasps mate only during a very short period early in life and males therefore produce ejaculates consisting of large numbers of high quality sperm. Such extreme selection for high fecundity resulted in males investing minimally into their somatic survival, including their immune sy...

journal_title：Scientific reports

authors： Peng Y,Baer-Imhoof B,Millar AH,Baer B

更新日期：2015-06-30 00:00:00

abstract：:Histone deacetylase inhibition (HDACi) has been suggested as a promising approach to bolster TLR-mediated induction of antimicrobial peptides such as human β-defensin 2 (hBD2). In inflammatory bowel disease (IBD), Crohn's disease (CD) patients display an attenuated expression of hBD2 as compared to ulcerative colitis ...

journal_title：Scientific reports

authors： Stebe-Frick S,Ostaff MJ,Stange EF,Malek NP,Wehkamp J

更新日期：2018-08-27 00:00:00

abstract：:In this paper, 4-(dicyanomethylene)-2-t-butyl-6(1,1,7,7-tetramethyljulolidyl-9-enyl)-4H-pyran (DCJTB) has been used in interface modification of dye-sensitized solar cells (DSCs) with combined effects of retarding charge recombination and Förster resonant energy transfer (FRET). DCJTB interface modification significan...

journal_title：Scientific reports

authors： Gao R,Cui Y,Liu X,Wang L

更新日期：2014-07-04 00:00:00

abstract：:Previously, we cloned a new gene termed 'tongue cancer resistance-associated protein 1' (TCRP1), which modulates tumorigenesis, enhances cisplatin (cDDP) resistance in cancers, and may be a potential target for reversing drug resistance. However, the mechanisms for regulating TCRP1 expression remain unclear. Herein, w...

journal_title：Scientific reports

authors： Jia X,Zhang Z,Luo K,Zheng G,Lu M,Song Y,Liu H,Qiu H,He Z

更新日期：2017-06-16 00:00:00

abstract：:We perform a detailed theoretical and experimental investigation of supercontinuum generation in large-mode-area photonic crystal fibers pumped by a high-energy, high-repetition rate picosecond Nd:YVO4 laser, with the goal of using it as the Stokes beam in coherent anti-Stokes Raman scattering setup. We analyze the in...

journal_title：Scientific reports

authors： Shen Y,Voronin AA,Zheltikov AM,O'Connor SP,Yakovlev VV,Sokolov AV,Scully MO

更新日期：2018-06-22 00:00:00

abstract：:Given that drug abuse and dependence are common reasons for hospitalization, we aimed to derive and validate a model allowing early identification of life-threatening hospital admissions for drug dependence or abuse. Using the French National Hospital Discharge Data Base, we extracted 66,101 acute inpatient stays for ...

journal_title：Scientific reports

authors： Nguyen TL,Boudemaghe T,Leguelinel-Blache G,Eiden C,Kinowski JM,Le Manach Y,Peyrière H,Landais P

更新日期：2017-03-14 00:00:00

abstract：:Transplantation of cardiomyocytes derived from induced pluripotent stem cell (iPSC-CMs) is a promising approach for increasing functional CMs during end-stage heart failure. Although major histocompatibility complex (MHC) class I matching between donor cells and recipient could reduce acquired immune rejection, innate...

journal_title：Scientific reports

authors： Nakamura Y,Miyagawa S,Yoshida S,Sasawatari S,Toyofuku T,Toda K,Sawa Y

更新日期：2019-07-25 00:00:00

abstract：:This study was initiated to improve E. coli succinate production by engineering the E. coli global transcription factor, Cra (catabolite repressor/activator). Random mutagenesis libraries were generated through error-prone PCR of cra. After re-screening and mutation site integration, the best mutant strain was Tang154...

journal_title：Scientific reports

authors： Zhu LW,Xia ST,Wei LN,Li HM,Yuan ZP,Tang YJ

更新日期：2016-11-04 00:00:00

abstract：:Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and debilitating disease with no molecular diagnostics and no treatment options. To identify potential markers of this illness, we profiled 48 patients and 52 controls for standard laboratory tests, plasma metabolomics, blood immuno-phenotyping a...

journal_title：Scientific reports

authors： Kitami T,Fukuda S,Kato T,Yamaguti K,Nakatomi Y,Yamano E,Kataoka Y,Mizuno K,Tsuboi Y,Kogo Y,Suzuki H,Itoh M,Morioka MS,Kawaji H,Koseki H,Kikuchi J,Hayashizaki Y,Ohno H,Kuratsune H,Watanabe Y

更新日期：2020-11-16 00:00:00

abstract：:Nociceptive neurons play an essential role in pain sensation by transmitting painful stimuli to the central nervous system. However, investigations of nociceptive neuron biology have been hampered by the lack of accessibility of human nociceptive neurons. Here, we describe a system for efficiently guiding human embryo...

journal_title：Scientific reports

authors： Boisvert EM,Engle SJ,Hallowell SE,Liu P,Wang ZW,Li XJ

更新日期：2015-11-19 00:00:00

abstract：:Milk is a major food of global economic importance, and its consumption is regarded as a classic example of gene-culture evolution. Humans have exploited animal milk as a food resource for at least 8500 years, but the origins, spread, and scale of dairying remain poorly understood. Indirect lines of evidence, such as ...

journal_title：Scientific reports

authors： Warinner C,Hendy J,Speller C,Cappellini E,Fischer R,Trachsel C,Arneborg J,Lynnerup N,Craig OE,Swallow DM,Fotakis A,Christensen RJ,Olsen JV,Liebert A,Montalva N,Fiddyment S,Charlton S,Mackie M,Canci A,Bouwman A,Rüh

更新日期：2014-11-27 00:00:00

abstract：:Compact and power-efficient plastic electronic synapses are of fundamental importance to overcoming the bottlenecks of developing a neuromorphic chip. Memristor is a strong contender among the various electronic synapses in existence today. However, the speeds of synaptic events are relatively slow in most attempts at...

journal_title：Scientific reports

authors： Li Y,Zhong Y,Xu L,Zhang J,Xu X,Sun H,Miao X

更新日期：2013-01-01 00:00:00

abstract：:The current theories of antimalarial mechanism of artemisinin are inadequate to fully explain the observed effects. In our study, "organism-like" formation of Schistosoma hemozoin granules by attaching to and utilizing erythrocytes to form new ones was observed. This indicates that heme iron is transferred from erythr...

journal_title：Scientific reports

authors： Sun J,Li C,Wang S

更新日期：2016-10-03 00:00:00

abstract：:Ceramide, a bioactive lipid and signaling molecule associated with cardiovascular disease, is known to activate extracellular signal regulated kinases 1 and 2 (ERK1/2). Here, we determined that the effect of ceramide on ERK1/2 is mediated by ceramide signaling on an ERK scaffold protein, IQ motif containing GTPase act...

journal_title：Scientific reports

authors： Vetterkind S,Lin QQ,Morgan KG

更新日期：2017-08-24 00:00:00

abstract：:Repeated social defeat stress (R-SDS) induces multiple behavioral changes in mice. However, the relationships between these behavioral changes were not fully understood. In the first experiment, to examine how the social avoidance is related to R-SDS-impaired behavioral flexibility, 10-week-old male C57BL/6N mice rece...

journal_title：Scientific reports

authors： Higashida S,Nagai H,Nakayama K,Shinohara R,Taniguchi M,Nagai M,Hikida T,Yawata S,Ago Y,Kitaoka S,Narumiya S,Furuyashiki T

更新日期：2018-07-11 00:00:00

abstract：:Since fatigue is prevalent in modern societies, it is necessary to clarify the neural mechanisms of fatigue. The regulation of performance through fatigue sensation is one of the mechanisms that decreases performance in fatigue. However, it is unknown whether subjective feeling of fatigue is necessary for the regulati...

journal_title：Scientific reports

authors： Ishii A,Tanaka M,Yoshikawa T,Watanabe Y

更新日期：2017-11-23 00:00:00

abstract：:Enterococcus faecalis, an organism generally not pathogenic for healthy humans, has the potential to cause disease in susceptible hosts. While it seems to be equipped to interact with and circumvent host immune defense, most of the molecular and cellular mechanisms underlying the enterococcal infectious process remain...

journal_title：Scientific reports

authors： Nunez N,Derré-Bobillot A,Gaubert S,Herry JM,Deschamps J,Wei Y,Baranek T,Si-Tahar M,Briandet R,Serror P,Archambaud C

更新日期：2018-01-29 00:00:00