Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system.

abstract：:Haemoparasites are responsible for some of the most prevalent and debilitating canine illnesses across the globe, whilst also posing a significant zoonotic risk to humankind. Nowhere are the effects of such parasites more pronounced than in developing countries in the tropics where the abundance and diversity of ectop...

journal_title：Scientific reports

authors： Huggins LG,Koehler AV,Ng-Nguyen D,Wilcox S,Schunack B,Inpankaew T,Traub RJ

更新日期：2019-09-02 00:00:00

abstract：:Nano-sized hydroxyapatite (n-HA) is considered as a bio-active material, which is often mixed into bone implant material, polyetheretherketone (PEEK). To reveal the global protein expression modulations of osteoblast in response to direct contact with the PEEK composite containing high level (40%) nano-sized hydroxyap...

journal_title：Scientific reports

authors： Zhao M,Li H,Liu X,Wei J,Ji J,Yang S,Hu Z,Wei S

更新日期：2016-03-09 00:00:00

abstract：:The relationship between biodiversity and ecological functioning is a central issue in freshwater ecology, but how this relationship is influenced by hydrological connectivity stress is still unknown. In this study we analyzed the dynamic of the phytoplankton alpha diversity indices and their relationships with trophi...

journal_title：Scientific reports

authors： Meng F,Li Z,Li L,Lu F,Liu Y,Lu X,Fan Y

更新日期：2020-12-07 00:00:00

abstract：:Culturomics is a high-throughput culture approach that has dramatically contributed to the recent renewal of culture. While metagenomics enabled substantial advances in exploring the microbiota, culturomics significantly expanded our knowledge regarding the bacterial gut repertoire through the discovery and the descri...

journal_title：Scientific reports

authors： Diakite A,Dubourg G,Dione N,Afouda P,Bellali S,Ngom II,Valles C,Tall ML,Lagier JC,Raoult D

更新日期：2020-06-15 00:00:00

abstract：:BiFeO3 is one of the most promising multiferroic materials but undergoes two major drawbacks: low dielectric susceptibility and high dielectric loss. Here we report high in-plane dielectric permittivity (ε' ∼2500) and low dielectric loss (tan δ < 0.01) obtained on Bi0.95Y0.05FeO3 films epitaxially grown on SrTiO3 (001...

journal_title：Scientific reports

authors： Scarisoreanu ND,Craciun F,Birjega R,Ion V,Teodorescu VS,Ghica C,Negrea R,Dinescu M

更新日期：2016-05-09 00:00:00

abstract：:The charge transport properties of hybrid halide perovskites are investigated with a combination of density functional theory including van der Waals interaction and the Boltzmann theory for diffusive transport in the relaxation time approximation. We find the mobility of electrons to be in the range 5-10 cm(2)V(-1)s(...

journal_title：Scientific reports

authors： Motta C,El-Mellouhi F,Sanvito S

更新日期：2015-08-03 00:00:00

abstract：:The preparation of mesoporous iron oxides with controllable physiochemical properties for effective therapeutic drug delivery remains a formidable challenge. Herein, iron oxide mesoporous magnetic microparticles (IO-MMMs) were prepared by a modified reverse hard-templating approach using, for the first time, acid-prep...

journal_title：Scientific reports

authors： El-Boubbou K,Ali R,Al-Zahrani H,Trivilegio T,Alanazi AH,Khan AL,Boudjelal M,AlKushi A

更新日期：2019-07-01 00:00:00

abstract：:The Toarcian Oceanic Anoxic Event (TOAE, Early Jurassic, ~182 Ma ago) was characterised by severe environmental perturbations which led to habitat degradation and extinction of marine species. Warming-induced anoxia is usually identified as main driver, but because marine life was also affected in oxygenated environme...

journal_title：Scientific reports

authors： Piazza V,Ullmann CV,Aberhan M

更新日期：2020-03-13 00:00:00

abstract：:Aging is a multifactorial process that results in progressive loss of regenerative capacity and tissue function while simultaneously favoring the development of a large array of age-related diseases. Evidence suggests that the accumulation of senescent cells in tissue promotes both normal and pathological aging. Oxic ...

journal_title：Scientific reports

authors： Ottaviani A,Eid R,Zoccola D,Pousse M,Dubal JM,Barajas E,Jamet K,Lebrigand K,Lapébie P,Baudoin C,Giraud-Panis MJ,Rouan A,Beauchef G,Guéré C,Vié K,Barbry P,Tambutté S,Gilson E,Allemand D

更新日期：2020-11-17 00:00:00

abstract：:The dispersion properties of metamaterials and photonic crystals (PhCs) lead to an intensive research in the development of cavity resonators for the confinement of electromagnetic (e-m) radiation. In this work, we investigate the formation of Fabry-Pérot (FP) modes associated with hyperbolic-like dispersion (HLD) reg...

journal_title：Scientific reports

authors： Darthy RR,Venkateswaran C,Subramanian V,Ouyang Z,Yogesh N

更新日期：2020-07-06 00:00:00

abstract：:Quaternized polyacrylic polymer has many applications in water treatment because of its ion exchange effects, but its further industrial applications are largely restricted because of its poor mechanical strength. In this work, a magnetic anion exchange resin with a polyacrylic matrix (MAP) was prepared by incorporati...

journal_title：Scientific reports

authors： Zhang G,Li S,Shuang C,Mu Y,Li A,Tan L

更新日期：2020-03-23 00:00:00

abstract：:Virtual-hand-illusion studies often use explicit and implicit measures of body ownership but no agreed-on implicit measure of agency exists. We investigated whether the Intentional Binding (IB) effect could serve as such a measure. A pilot study confirmed that current consistency increases both perceived agency and IB...

journal_title：Scientific reports

authors： Ma K,Hommel B,Chen H

更新日期：2019-03-07 00:00:00

abstract：:Tin selenide has attracted much research interest due to its unprecedentedly high thermoelectric figure of merit (ZT). For real applications, it is desirable to increase the ZT value in the lower-temperature range, as the peak ZT value currently exists near the melting point. It is shown in this paper that the structu...

journal_title：Scientific reports

authors： Yu H,Dai S,Chen Y

更新日期：2016-05-19 00:00:00

abstract：:Five selected carbazole derivatives, namely carbazole, 3,6-dibromocarbazole, 2-hydroxycarbazole, 1,2,3,4-tetrahydrocarbazole and 9-(2-ethylhexyl)carbazole-3,6-dicarboxaldehyde were investigated for their inhibitive effects on Desulfovibrio vulgaris (D. vulgaris) induced corrosion of mild steel and in 1 M HCl medium us...

journal_title：Scientific reports

authors： Nwankwo HU,Olasunkanmi LO,Ebenso EE

更新日期：2017-05-26 00:00:00

abstract：:Recent studies suggest that glypican-1 (GPC-1) is a biomarker for prostate cancer, but there are few studies elucidating the role of GPC-1 in prostate cancer progression. We observed high expression of GPC-1 in more aggressive prostate cancer cell lines such as PC-3 and DU-145. While inhibition of GPC-1 expression in ...

journal_title：Scientific reports

authors： Quach ND,Kaur SP,Eggert MW,Ingram L,Ghosh D,Sheth S,Nagy T,Dawson MR,Arnold RD,Cummings BS

更新日期：2019-08-07 00:00:00

abstract：:Despite the fact that magnetic thrombolytic composites is an emerging area, all known so far systems are based on the similar mechanism of action: thrombolytic enzyme releases from the magnetic carrier leaving non-active matrix, thus making the whole system active only for a limited period of time. Such systems often ...

journal_title：Scientific reports

authors： Drozdov AS,Vinogradov VV,Dudanov IP,Vinogradov VV

更新日期：2016-06-20 00:00:00

abstract：:Applications for high resolution 3D profiles, so-called grayscale lithography, exist in diverse fields such as optics, nanofluidics and tribology. All of them require the fabrication of patterns with reliable absolute patterning depth independent of the substrate location and target materials. Here we present a comple...

journal_title：Scientific reports

authors： Rawlings CD,Zientek M,Spieser M,Urbonas D,Stöferle T,Mahrt RF,Lisunova Y,Brugger J,Duerig U,Knoll AW

更新日期：2017-11-28 00:00:00

abstract：:FGF10 is a member of fibroblast growth factors (FGFs). We previously showed that FGF10 protects neuron against oxygen-glucose deprivation injury in vitro; however, the effect of FGF10 in ischemic stroke in vivo is unknown. In the present study, we showed that FGF10 was mainly expressed in neurons but not astrocytes, a...

journal_title：Scientific reports

authors： Li YH,Fu HL,Tian ML,Wang YQ,Chen W,Cai LL,Zhou XH,Yuan HB

更新日期：2016-01-27 00:00:00

abstract：:The objective of this study was to investigate the associations between selenium exposure and cancer risk. We identified 69 studies and applied meta-analysis, meta-regression and dose-response analysis to obtain available evidence. The results indicated that high selenium exposure had a protective effect on cancer ris...

journal_title：Scientific reports

authors： Cai X,Wang C,Yu W,Fan W,Wang S,Shen N,Wu P,Li X,Wang F

更新日期：2016-01-20 00:00:00

abstract：:Several proteins and peptides in saliva were shown to stimulate gingival wound repair, but the role of salivary metabolites in this process remains unexplored. In vitro gingival re-epithelialization kinetics were determined using unstimulated saliva samples from healthy individuals collected during an experimental gin...

journal_title：Scientific reports

authors： Fernandez-Gutierrez MM,Imangaliyev S,Prodan A,Loos BG,Keijser BJF,Kleerebezem M

更新日期：2020-02-20 00:00:00

abstract：:Treatment options for chronic spinal cord injury (SCI) remain limited due to unfavourable changes in the microenvironment. Gene therapy can overcome these barriers through continuous delivery of therapeutic gene products to the target tissue. In particular, adeno-associated virus (AAV) vectors are potential candidates...

journal_title：Scientific reports

authors： Hoshino Y,Nishide K,Nagoshi N,Shibata S,Moritoki N,Kojima K,Tsuji O,Matsumoto M,Kohyama J,Nakamura M,Okano H

更新日期：2019-07-08 00:00:00

abstract：:There are approximately 1 million cryptococcal infections per year among HIV+ individuals, resulting in nearly 625,000 deaths. Cryptococcus neoformans and Cryptococcus gattii are the two most common species that cause human cryptococcosis. These two species of Cryptococcus have differences in pathogenicity, diagnosis,...

journal_title：Scientific reports

authors： Hu S,Gu F,Chen M,Wang C,Li J,Yang J,Wang G,Zhou Z,Yang Y

更新日期：2020-07-27 00:00:00

abstract：:Emerging concepts for on-chip biotechnologies aim to replace microfluidic flow by active, molecular-motor driven transport of cytoskeletal filaments, including applications in bio-simulation, biocomputation, diagnostics, and drug screening. Many of these applications require reliable detection, with minimal data acqui...

journal_title：Scientific reports

authors： Lard M,ten Siethoff L,Månsson A,Linke H

更新日期：2013-01-01 00:00:00

abstract：:Mechanosensitive ion channels are pore-forming transmembrane proteins that allow ions to move down their electrochemical gradient in response to mechanical stimuli. They participate in many plant developmental processes including the maintenance of plastid shape, pollen tube growth, etc. Herein, a total of 11, 10, 6, ...

journal_title：Scientific reports

authors： Kaur A,Taneja M,Tyagi S,Sharma A,Singh K,Upadhyay SK

更新日期：2020-10-06 00:00:00

abstract：:The search for new therapeutic approaches to Alzheimer disease (AD) is a major goal in medicine and society, also due to the impressive economic and social costs of this disease. In this scenario, biotechnologies play an important role. Here, it is demonstrated that the Radio Electric Asymmetric Conveyer (REAC), an in...

journal_title：Scientific reports

authors： Lorenzini L,Giuliani A,Sivilia S,Baldassarro VA,Fernandez M,Lotti Margotti M,Giardino L,Fontani V,Rinaldi S,Calzà L

更新日期：2016-10-24 00:00:00

abstract：:Peach is an economically import fruit crop worldwide, and serves as a model species of the Rosaceae family as well. However, peach functional genomics studies are severely hampered due to its recalcitrance to regeneration and stable transformation. Here, we report a fast and efficient Agrobacterium rhizogenes-mediated...

journal_title：Scientific reports

authors： Xu S,Lai E,Zhao L,Cai Y,Ogutu C,Cherono S,Han Y,Zheng B

更新日期：2020-02-18 00:00:00

abstract：:Enhancers play a crucial role in gene regulation but the participation of enhancer transcripts (i.e. enhancer RNA, eRNAs) in regulatory systems remains unclear. We provide a computational analysis on eRNAs using genome-wide data across 12 mouse tissues. The expression of genes targeted by transcribing enhancer is posi...

journal_title：Scientific reports

authors： Cheng JH,Pan DZ,Tsai ZT,Tsai HK

更新日期：2015-07-29 00:00:00

abstract：:Fitness-related costs of evolving insecticide resistance have been reported in a number of insect species, but the interplay between evolutionary adaptation to insecticide pressure and variable environmental conditions has received little attention. We provisioned nymphs from three German cockroach (Blattella germanic...

journal_title：Scientific reports

authors： Jensen K,Ko AE,Schal C,Silverman J

更新日期：2016-06-27 00:00:00

abstract：:Individuals with Angelman syndrome (AS) are characterized by severe cognitive impairments alongside an enhanced drive for social engagement. As knowledge on imitation skills in this population is limited, we conducted the first controlled study of imitation in AS. We examined how 23 individuals with AS and 21 typicall...

journal_title：Scientific reports

authors： Micheletti S,Vivanti G,Renzetti S,Martelli P,Calza S,“Imitation in Angelman” Study Group.,Fazzi E

更新日期：2020-10-02 00:00:00

abstract：:Laser Capture Microdissection (LCM) is a powerful tool to isolate and study gene expression pattern of desired and less accessible cells or tissues from a heterogeneous population. Existing LCM-based methods fail to obtain high quality RNA including small RNAs from small microdissected plant tissue and therefore, are ...

journal_title：Scientific reports

authors： Gautam V,Singh A,Singh S,Sarkar AK

更新日期：2016-02-10 00:00:00