Genome-wide analysis of enhancer RNA in gene regulation across 12 mouse tissues.

abstract：:Early ontogenetic periods and postnatal maturation in organisms are sex-specifically sensitive to hypothalamic-pituitary-adrenal (HPA)-axis activities, related glucocorticoid secretions, and their effects on energy balance and homeostasis. Dietary polyunsaturated (PUFAs) and saturated (SFAs) fatty acids potentially pl...

journal_title：Scientific reports

authors： Nemeth M,Millesi E,Schuster D,Quint R,Wagner KH,Wallner B

更新日期：2018-01-11 00:00:00

abstract：:A compact analysis platform for detecting liquid absorption and emission spectra using a set of optical linear variable filters atop a CMOS image sensor is presented. The working spectral range of the analysis platform can be extended without a reduction in spectral resolution by utilizing multiple linear variable fil...

journal_title：Scientific reports

authors： Wan Y,Carlson JA,Kesler BA,Peng W,Su P,Al-Mulla SA,Lim SJ,Smith AM,Dallesasse JM,Cunningham BT

更新日期：2016-07-08 00:00:00

abstract：:The semantic variant of primary progressive aphasia (svPPA) is a clinical syndrome characterized by neurodegeneration and progressive loss of semantic knowledge. Unlike many other forms of frontotemporal lobar degeneration (FTLD), svPPA has a highly consistent underlying pathology composed of TDP-43 (a regulator of RN...

journal_title：Scientific reports

authors： Bonham LW,Steele NZR,Karch CM,Broce I,Geier EG,Wen NL,Momeni P,Hardy J,Miller ZA,Gorno-Tempini ML,Hess CP,Lewis P,Miller BL,Seeley WW,Manzoni C,Desikan RS,Baranzini SE,Ferrari R,Yokoyama JS,International FTD-Genomic

更新日期：2019-07-26 00:00:00

abstract：:Asymmetric cell division is a ubiquitous feature during the development of higher organisms. Asymmetry is achieved by differential localization or activities of biological molecules such as proteins, and coding and non-coding RNAs. Here, we present subcellular transcriptomic and proteomic analyses along the animal-veg...

journal_title：Scientific reports

authors： Sindelka R,Abaffy P,Qu Y,Tomankova S,Sidova M,Naraine R,Kolar M,Peuchen E,Sun L,Dovichi N,Kubista M

更新日期：2018-05-29 00:00:00

abstract：:Early growth response 1 (EGR1) is a multifunctional transcription factor; Positive and negative functions of EGR1 in various tumors rely on the integrated functions of various genes it regulates. In this study, we observed the role of EGR1 in non-small-cell lung carcinoma (NSCLC) and identified genes that influence ce...

journal_title：Scientific reports

authors： Zhang H,Chen X,Wang J,Guang W,Han W,Zhang H,Tan X,Gu Y

更新日期：2014-07-03 00:00:00

abstract：:This study demonstrates significant visible light photo-detection capability of pristine ZnO nanostructure thin films possessing substantially high percentage of oxygen vacancies [Formula: see text] and zinc interstitials [Formula: see text], introduced by simple tuning of economical solution method. The demonstrated ...

journal_title：Scientific reports

authors： Khokhra R,Bharti B,Lee HN,Kumar R

更新日期：2017-11-08 00:00:00

abstract：:MicroRNAs (miRNAs) are important regulators involved in various cancers, including colorectal cancer (CRC). The functions and mechanisms of the miRNAs involved in CRC progress and metastasis are largely unknown. In this study, miRNA microarray analysis was performed to screen crucial miRNAs involved in CRC progress, a...

journal_title：Scientific reports

authors： Li Q,Liang X,Wang Y,Meng X,Xu Y,Cai S,Wang Z,Liu J,Cai G

更新日期：2016-05-31 00:00:00

abstract：:Centenarians exhibit extreme longevity and a remarkable compression of morbidity. They have a unique capacity to maintain homeostatic mechanisms. Since small non-coding RNAs (including microRNAs) are implicated in the regulation of gene expression, we hypothesised that longevity of centenarians may reflect alterations...

journal_title：Scientific reports

authors： Serna E,Gambini J,Borras C,Abdelaziz KM,Belenguer A,Sanchis P,Avellana JA,Rodriguez-Mañas L,Viña J

更新日期：2012-01-01 00:00:00

abstract：:Many amorphous materials show spatially heterogenous dynamics, as different regions of the same system relax at different rates. Such a signature, known as Dynamic Heterogeneity, has been crucial to understand the nature of the jamming transition in simple model systems and is currently considered very promising to ch...

journal_title：Scientific reports

authors： Pastore R,Pesce G,Caggioni M

更新日期：2017-03-14 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Thomas D,Bagiya MS,Sunil PS,Rolland L,Sunil AS,Mikesell TD,Nayak S,Mangalampalli S,Ramesh DS

更新日期：2018-11-01 00:00:00

abstract：:It has been an old unsolved puzzle to evolutionary theorists on which mechanisms would increase large-scale cooperation in human societies. Thus, how such mechanisms operate in a biological network is still not well understood. This study addresses these questions with empirical evidence from agent-based models design...

journal_title：Scientific reports

authors： Ezeigbo IC

更新日期：2017-12-11 00:00:00

abstract：:Transient ischemia produces postischemic tingling sensation. Ischemia also produces nerve conduction block that may modulate spinal neural circuits. In the present study, reduced mechanical thresholds for hindpaw-withdrawal reflex were found in mice after transient hindpaw ischemia, which was produced by a high pressu...

journal_title：Scientific reports

authors： Watanabe T,Sasaki M,Komagata S,Tsukano H,Hishida R,Kohno T,Baba H,Shibuki K

更新日期：2015-07-13 00:00:00

abstract：:The ability to control the spatial distribution and temporal release of a therapeutic remains a central challenge for biomedical research. Here, we report the development and optimization of a novel substrate mediated therapeutic delivery system comprising of hyaluronic acid covalently functionalized liposomes (HALNPs...

journal_title：Scientific reports

authors： Hayward SL,Francis DM,Sis MJ,Kidambi S

更新日期：2015-10-01 00:00:00

abstract：:2-Bromo-5-(2-bromo-2-nitrovinyl)furan (G1 or Furvina) is an antimicrobial with a direct reactivity against thiol groups. It is active against Gram-positive and Gram-negative bacteria, yeasts and filamentous fungi. By reacting with thiol groups it causes direct damage to proteins but, as a result, is very short-living ...

journal_title：Scientific reports

authors： Allas UL,Toom L,Selyutina A,Mäeorg U,Medina R,Merits A,Rinken A,Hauryliuk V,Kaldalu N,Tenson T

更新日期：2016-11-10 00:00:00

abstract：:In contrast to mild infections of Group A Streptococcus (GAS) invasive infections of GAS still pose a serious health hazard: GAS disseminates from sterile sites into the blood stream or deep tissues and causes sepsis or necrotizing fasciitis. In this case antibiotics do not provide an effective cure as the bacteria ar...

journal_title：Scientific reports

authors： Rox K,Jansen R,Loof TG,Gillen CM,Bernecker S,Walker MJ,Chhatwal GS,Müller R

更新日期：2017-09-18 00:00:00

abstract：:Numerical aberration of the centrosome results in chromosome missegregation, eventually leading to chromosomal instability, a hallmark of human tumor malignancy. Large tumor suppressors 1 and 2 (Lats1 and Lats2) are central kinases in the Hippo pathway and regulate development and tumorigenesis by coordinating the bal...

journal_title：Scientific reports

authors： Mukai S,Yabuta N,Yoshida K,Okamoto A,Miura D,Furuta Y,Abe T,Nojima H

更新日期：2015-11-04 00:00:00

abstract：:Protein kinases are frequently mutated in human cancers, which leads to altered signaling pathways and contributes to tumor growth and progression. ERK3 is an atypical mitogen-activated protein kinase (MAPK) containing an S-E-G activation motif rather than the conserved T-X-Y motif in conventional MAPKs such as ERK1/2...

journal_title：Scientific reports

authors： Alsaran H,Elkhadragy L,Shakya A,Long W

更新日期：2017-11-03 00:00:00

abstract：:Dolphin morbillivirus (DMV) has been responsible for several outbreaks of systemic infection and has resulted in cetacean strandings in the Mediterranean. In August-October 2016, seven striped dolphins (Stenella coeruleoalba) stranded on the Sicilian coastline (Italy) tested positive for DMV. Tissue samples from brain...

journal_title：Scientific reports

authors： Mira F,Rubio-Guerri C,Purpari G,Puleio R,Caracappa G,Gucciardi F,Russotto L,Loria GR,Guercio A

更新日期：2019-07-05 00:00:00

abstract：:The circadian clock coordinates an organism's growth, development and physiology with environmental factors. One illuminating example is the rhythmic growth of hypocotyls and cotyledons in Arabidopsis thaliana. Such daily oscillations in leaf position are often referred to as sleep movements or nyctinasty. Here, we re...

journal_title：Scientific reports

authors： Lagercrantz U,Billhardt A,Rousku SN,Ljung K,Eklund DM

更新日期：2020-05-26 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are immune cells that exert immunosuppression within the tumor, protecting cancer cells from the host's immune system and/or exogenous immunotherapies. While current research has been mostly focused in countering MDSC-driven immunosuppression, little is known about the mechanis...

journal_title：Scientific reports

authors： Duarte-Sanmiguel S,Shukla V,Benner B,Moore J,Lemmerman L,Lawrence W,Panic A,Wang S,Idzkowski N,Guio-Vega G,Higuita-Castro N,Ghadiali S,Carson WE,Gallego-Perez D

更新日期：2020-01-27 00:00:00

abstract：:Although semantic processing has traditionally been associated with brain responses maximal at 350-400 ms, recent studies reported that words of different semantic types elicit topographically distinct brain responses substantially earlier, at 100-200 ms. These earlier responses have, however, been achieved using insu...

journal_title：Scientific reports

authors： Moseley RL,Pulvermüller F,Shtyrov Y

更新日期：2013-01-01 00:00:00

abstract：:Climatic fluctuations largely affects species turnover and cause major shifts of terrestrial ecosystem. In the present study the five decade old herbarium specimens of lichens were compared with recent collection from Darjeeling district with respect to elements, PAHs accumulation and carbon isotope composition (δ(13)...

journal_title：Scientific reports

authors： Bajpai R,Mishra S,Dwivedi S,Upreti DK

更新日期：2016-08-09 00:00:00

abstract：:Various MRI techniques, including myelin water imaging, T1w/T2w ratio mapping and diffusion-based imaging can be used to characterize tissue microstructure. However, surprisingly few studies have examined the degree to which these MRI measures are related within and between various brain regions. Therefore, whole-brai...

journal_title：Scientific reports

authors： Uddin MN,Figley TD,Solar KG,Shatil AS,Figley CR

更新日期：2019-02-21 00:00:00

abstract：:Transplantation of cardiomyocytes derived from induced pluripotent stem cell (iPSC-CMs) is a promising approach for increasing functional CMs during end-stage heart failure. Although major histocompatibility complex (MHC) class I matching between donor cells and recipient could reduce acquired immune rejection, innate...

journal_title：Scientific reports

authors： Nakamura Y,Miyagawa S,Yoshida S,Sasawatari S,Toyofuku T,Toda K,Sawa Y

更新日期：2019-07-25 00:00:00

abstract：:Selection may favour individuals of the same population to differ consistently in nutritional preference, for example, because optimal diets covary with morphology or personality. We provided Southern field crickets (Gryllus bimaculatus) with two synthetic food sources (carbohydrates and proteins) and quantified repea...

journal_title：Scientific reports

authors： Han CS,Jäger HY,Dingemanse NJ

更新日期：2016-06-30 00:00:00

abstract：:Endovascular methods have been increasingly applied in treating cervicocranial artery dissection (CCAD). Anti-thrombotic therapy, which is used in non-interventional care of CCAD patients, has differential effects in East Asian patients. Therefore, we aimed to compare the clinical outcomes of endovascular versus non-i...

journal_title：Scientific reports

authors： Huang R,Niu L,Wang Y,Jia G,Jia L,Wang Y,Jiang W,Sun Y,Yu L

更新日期：2015-05-20 00:00:00

abstract：:Congruence theory has many applications in physical, social, biological and technological systems. Congruence arithmetic has been a fundamental tool for data security and computer algebra. However, much less attention was devoted to the topological features of congruence relations among natural numbers. Here, we explo...

journal_title：Scientific reports

authors： Yan XY,Wang WX,Chen GR,Shi DH

更新日期：2016-03-31 00:00:00

abstract：:Networks are a powerful abstraction with applicability to a variety of scientific fields. Models explaining their morphology and growth processes permit a wide range of phenomena to be more systematically analysed and understood. At the same time, creating such models is often challenging and requires insights that ma...

journal_title：Scientific reports

authors： Menezes T,Roth C

更新日期：2014-09-05 00:00:00

abstract：:Cladosporium cladosporioides causes asthma and superficial and deep infections, mostly in immunodeficient individuals and animals. This study aimed to investigate whether C. cladosporioides spores can enter the lungs through pulmonary circulation and influence pulmonary immune response. We intravenously injected mice ...

journal_title：Scientific reports

authors： Ma X,Hu J,Yu Y,Wang C,Gu Y,Cao S,Huang X,Wen Y,Zhao Q,Wu R,Zuo Z,Deng J,Ren Z,Yu S,Shen L,Zhong Z,Peng G

更新日期：2021-01-13 00:00:00

abstract：:Although the use of metabarcoding to identify taxa in DNA mixtures is widely approved, its reliability in quantifying taxon abundance is still the subject of debate. In this study we investigated the relationships between the amount of pollen grains in mock solutions and the abundance of high-throughput sequence reads...

journal_title：Scientific reports

authors： Baksay S,Pornon A,Burrus M,Mariette J,Andalo C,Escaravage N

更新日期：2020-03-06 00:00:00