An Efficient LCM-Based Method for Tissue Specific Expression Analysis of Genes and miRNAs.

abstract：:HIV maturation inhibitors are an emerging class of anti-retroviral compounds that inhibit the viral protease-mediated cleavage of the Gag, CA-SP1 (capsid-spacer peptide 1) peptide to mature CA. The first-in-class maturation inhibitor bevirimat (BVM) displayed potent activity against HIV-1 clade B but was ineffective a...

journal_title：Scientific reports

authors： Ghimire D,Timilsina U,Srivastava TP,Gaur R

更新日期：2017-03-02 00:00:00

abstract：:HPIVs are serologically and genetically grouped into four species that account for up to 10% of all hospitalizations due to acute respiratory infection in children under the age of five. Genetic and epidemiological data for the four HPIVs derived from two pediatric cohorts in Viet Nam are presented. Respiratory sample...

journal_title：Scientific reports

authors： Linster M,Do LAH,Minh NNQ,Chen Y,Zhe Z,Tuan TA,Tuan HM,Su YCF,van Doorn HR,Moorthy M,Smith GJD

更新日期：2018-05-01 00:00:00

abstract：:Cylindrical shell fused silica resonators coated with 8 axisymmetric Pb(Zr0.53Ti0.47)O3 (PZT) thin film electrodes (thickness ~2 μm) were reported. The resonators were firstly designed and fabricated, then annealed and processed by chemical etching to increase mechanical quality factor (Q factor) of resonators, which ...

journal_title：Scientific reports

authors： Luo Y,Qu T,Cui Y,Pan Y,Yu M,Luo H,Jia Y,Tan Z,Liu J,Zhang B

更新日期：2019-07-01 00:00:00

abstract：:Chimpanzees (Pan troglodytes), one of humankinds' closest living relatives, are known to hunt and consume the meat of various animal taxa. Although some researchers have presented indirect evidence that chimpanzees may also prey on tortoises, until now, direct observations of this behaviour did not exist. Here, we pro...

journal_title：Scientific reports

authors： Pika S,Klein H,Bunel S,Baas P,Théleste E,Deschner T

更新日期：2019-05-23 00:00:00

abstract：:Neuropsychological assessment of human visual processing capabilities strongly depends on visual testing conditions including room lighting, stimuli, and viewing-distance. This limits standardization, threatens reliability, and prevents the assessment of core visual functions such as visual processing speed. Increasin...

journal_title：Scientific reports

authors： Foerster RM,Poth CH,Behler C,Botsch M,Schneider WX

更新日期：2016-11-21 00:00:00

abstract：:Self-assembly of a nucleoside on Au(111) was studied to ascertain whether polymerization on well-defined substrates constitutes a promising approach for making sequence-controlled polymers. Scanning tunneling microscopy and density functional theory were used to investigate the self-assembly on Au(111) of (RS)-N(9)-(2...

journal_title：Scientific reports

authors： Wang J,Bonnesen PV,Rangel E,Vallejo E,Sanchez-Castillo A,James Cleaves Ii H,Baddorf AP,Sumpter BG,Pan M,Maksymovych P,Fuentes-Cabrera M

更新日期：2016-01-04 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Girardeau-Hubert S,Deneuville C,Pageon H,Abed K,Tacheau C,Cavusoglu N,Donovan M,Bernard D,Asselineau D

更新日期：2020-10-21 00:00:00

abstract：:When exploited as cell factories, Saccharomyces cerevisiae cells are exposed to harsh environmental stresses impairing titer, yield and productivity of the fermentative processes. The development of robust strains therefore represents a pivotal challenge for the implementation of cost-effective bioprocesses. Altering ...

journal_title：Scientific reports

authors： Martani F,Marano F,Bertacchi S,Porro D,Branduardi P

更新日期：2015-12-14 00:00:00

abstract：:Chemotherapy (CTx)-induced premature ovarian failure (POF) in woman remains clinically irreversible. Amniotic fluid stem cells (AFSCs) have shown the potential to treat CTx-induced POF; however, the underlying mechanism is unclear. Here we demonstrate that AFSC-derived exosomes recapitulate the anti-apoptotic effect o...

journal_title：Scientific reports

authors： Xiao GY,Cheng CC,Chiang YS,Cheng WT,Liu IH,Wu SC

更新日期：2016-03-16 00:00:00

abstract：:Pioneering epidemiological work has established strong association of sedentary lifestyle and obesity with the risk of colorectal cancer, while the detailed underlying mechanism remains unknown. Here we show that Hotair (HOX transcript antisense RNA) is a pro-adipogenic long non-coding RNA highly expressed in gluteal-...

journal_title：Scientific reports

authors： Lu X,Bai D,Liu X,Zhou C,Yang G

更新日期：2017-03-31 00:00:00

abstract：:The use of lithium (Li) metal anodes has been reconsidered because of the necessity for a higher energy density in secondary batteries. However, Li metal anodes suffer from 'dead' Li formation and surface deactivation which consequently form a porous layer of redundant Li aggregates. In this work, a fibrous metal felt...

journal_title：Scientific reports

authors： Lee H,Song J,Kim YJ,Park JK,Kim HT

更新日期：2016-08-03 00:00:00

abstract：:Many behaviors of cancer, such as progression, metastasis and drug resistance etc., cannot be fully understood by genetic mutations or intracellular signaling alone. Instead, they are emergent properties of the cell community which forms a tumor. Studies of tumor heterogeneity reveal that many cancer behaviors critica...

journal_title：Scientific reports

authors： Zhou JX,Taramelli R,Pedrini E,Knijnenburg T,Huang S

更新日期：2017-08-18 00:00:00

abstract：:An encapsulated formulation of Bacillus thuringiensis (Bt) was produced by the Pickering emulsion technique to improve its activity and stability under UV-A radiation. In this technique latex particles, GO nanosheets, olive oil, ethanol, and water were used to encapsulate Bt in colloidosomes. The protective efficacy o...

journal_title：Scientific reports

authors： Jalali E,Maghsoudi S,Noroozian E

更新日期：2020-11-26 00:00:00

abstract：:Drug resistance caused by excessive and indiscriminate antibiotic usage has become a serious public health problem. The need of finding new antibacterial drugs is more urgent than ever before. Tyrosyl-tRNA synthase was proved to be a potent target in combating drug-resistant bacteria. In silico methodologies including...

journal_title：Scientific reports

authors： Li S,Fan J,Peng C,Chang Y,Guo L,Hou J,Huang M,Wu B,Zheng J,Lin L,Xiao G,Chen W,Liao G,Guo J,Sun P

更新日期：2017-09-14 00:00:00

abstract：:Deprivation of maternal care during early development markedly affects emotional development, but the underlying neuromolecular mechanisms are not fully understood. In a mouse model of disrupted mother-infant relationship, early weaning causes long-term impacts on pups to exhibit increased corticosterone secretion, an...

journal_title：Scientific reports

authors： Kikusui T,Kanbara N,Ozaki M,Hirayama N,Ida K,Tokita M,Tanabe N,Mitsuyama K,Abe H,Yoshida M,Nagasawa M,Mogi K

更新日期：2019-03-08 00:00:00

abstract：:It is challenging task to detect and measure genuine multipartite entanglement. We investigate the problem by considering the average based positive partial transposition(PPT) criterion and the realignment criterion. Sufficient conditions for detecting genuine tripartite entanglement are presented. We also derive lowe...

journal_title：Scientific reports

authors： Li M,Wang J,Shen S,Chen Z,Fei SM

更新日期：2017-12-08 00:00:00

abstract：:The proneural transcription factor Ascl1 is a master regulator of neurogenesis, coordinating proliferation and differentiation in the central nervous system. While its expression is well characterised, post-translational regulation is much less well understood. Here we demonstrate that a population of chromatin-bound ...

journal_title：Scientific reports

authors： Gillotin S,Davies JD,Philpott A

更新日期：2018-03-15 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited therapeutic options. KCa3.1 ion channels play a critical role in TGFβ1-dependent pro-fibrotic responses in human lung myofibroblasts. We aimed to develop a human lung parenchymal model of fibrogenesis and test the efficacy of t...

journal_title：Scientific reports

authors： Roach KM,Sutcliffe A,Matthews L,Elliott G,Newby C,Amrani Y,Bradding P

更新日期：2018-01-10 00:00:00

abstract：:The (p)ppGpp signal molecules play a central role in the stringent response (SR) to adapt to nutrient starvation in bacteria, yet the carbohydrate starvation induced adaptive response and the roles of SR in this response is not well characterized, especially in Gram-positives. Here, two (p)ppGpp synthetases RelA and R...

journal_title：Scientific reports

authors： Zhang T,Zhu J,Wei S,Luo Q,Li L,Li S,Tucker A,Shao H,Zhou R

更新日期：2016-06-03 00:00:00

abstract：:Invasive pulmonary Aspergillosis is a leading cause of morbidity and mortality in immunosuppressed patients and treatment outcomes using oral antifungal triazoles remain suboptimal. Here we show that combining topical treatment using PC945, a novel inhaled triazole, with systemic treatment using known triazoles demons...

journal_title：Scientific reports

authors： Colley T,Sehra G,Daly L,Kimura G,Nakaoki T,Nishimoto Y,Kizawa Y,Strong P,Rapeport G,Ito K

更新日期：2019-07-01 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Paul F,Otte J,Schmitt I,Grande FD

更新日期：2018-11-16 00:00:00

abstract：:The causes of the severest crisis in the history of life around the Permian-Triassic boundary (PTB) remain controversial. Here we report that the latest Permian alluvial plains in Shanxi, North China, went through a rapid transition from meandering rivers to braided rivers and aeolian systems. Soil carbonate carbon is...

journal_title：Scientific reports

authors： Zhu Z,Liu Y,Kuang H,Benton MJ,Newell AJ,Xu H,An W,Ji S,Xu S,Peng N,Zhai Q

更新日期：2019-11-14 00:00:00

abstract：:The synthetic Angiotensin Converting Enzyme (ACE) inhibitors have side effects and hence demands for natural ACE inhibitors have been rising. The aim of this study is to purify and introduce natural ACE inhibitors extracted from Zizyphus jujuba fruits. Proteins from Zizyphus jujuba were lysed by trypsin, papain and th...

journal_title：Scientific reports

authors： Memarpoor-Yazdi M,Zare-Zardini H,Mogharrab N,Navapour L

更新日期：2020-03-04 00:00:00

abstract：:Hair regenerative medicine has emerged as a promising approach for the treatment of severe hair loss. Recent advances in three-dimensional tissue engineering, such as formation of hair follicle germs (HFGs), have considerably improved hair regeneration after transplantation in animal models. Here, we proposed an appro...

journal_title：Scientific reports

authors： Kageyama T,Chun YS,Fukuda J

更新日期：2021-01-12 00:00:00

abstract：:Most Atlantic hurricanes form in the Main Development Region between 9°N to 20°N along the northern edge of the Intertropical Convergence Zone (ITCZ). Previous research has suggested that meridional shifts in the ITCZ position on geologic timescales can modulate hurricane activity, but continuous and long-term storm r...

journal_title：Scientific reports

authors： van Hengstum PJ,Donnelly JP,Fall PL,Toomey MR,Albury NA,Kakuk B

更新日期：2016-02-24 00:00:00

abstract：:Caragana korshinskii Kom. has a significant function in desert-grassland revegetation in arid regions. Plant reproduction in arid regions can be restricted due to inadequate pollen receipt and reduced pollen transfer. An assessment of pollination success as a result of pollen limitation and pollinator visitation in va...

journal_title：Scientific reports

authors： Chen M,Zhao XY

更新日期：2019-07-05 00:00:00

abstract：:HIV-1 Tat plays an important role in HIV-associated neurocognitive disorders (HAND) by disrupting neurotransmission including dopamine uptake by human dopamine transporter (hDAT). Previous studies have demonstrated that HIV-1 Tat directly binds to hDAT and some amino-acid mutations that attenuate the hDAT-Tat binding ...

journal_title：Scientific reports

authors： Yuan Y,Quizon PM,Sun WL,Yao J,Zhu J,Zhan CG

更新日期：2016-06-02 00:00:00

abstract：:Radiation weighting factor wR for photons and electrons has been defined as unity independently of the energy of the particles. However, the biological effects depend on the incident energies according to in vitro experimental data. In this study, we have quantified the energy concentration along electron tracks in te...

journal_title：Scientific reports

authors： Yachi Y,Yoshii Y,Matsuya Y,Mori R,Oikawa J,Date H

更新日期：2019-11-27 00:00:00

abstract：:In many cancers, the establishment of a patient's future treatment regime often relies on histopathological assessment of tumor tissue specimens in order to determine the extent of the 'pathological response' to a given therapy. However, histopathological assessment of pathological response remains subjective. Here we...

journal_title：Scientific reports

authors： Patterson NH,Alabdulkarim B,Lazaris A,Thomas A,Marcinkiewicz MM,Gao ZH,Vermeulen PB,Chaurand P,Metrakos P

更新日期：2016-11-14 00:00:00

abstract：:Generally confinement size is considered to determine the dimensionality of nanostructures. While the exciton Bohr radius is used as a criterion to define either weak or strong confinement in optical experiments, the binding energy of confined excitons is difficult to measure experimentally. One alternative is to use ...

journal_title：Scientific reports

authors： Kim H,Lee W,Park S,Kyhm K,Je K,Taylor RA,Nogues G,Dang LS,Song JD

更新日期：2017-01-05 00:00:00