Assessment of pathological response to therapy using lipid mass spectrometry imaging.

abstract：:The study explored differences in the steroidogenic pathway between obese and nonobese women with polycystic ovary syndrome (PCOS) using liquid chromatography-tandem mass spectrometry (LC-MS/MS). 1044 women with PCOS (including 350 lean, 312 overweight and 382 obese) and 366 control women without PCOS (including 203 l...

journal_title：Scientific reports

authors： Deng Y,Zhang Y,Li S,Zhou W,Ye L,Wang L,Tao T,Gu J,Yang Z,Zhao D,Gu W,Hong J,Ning G,Liu W,Wang W

更新日期：2017-10-26 00:00:00

abstract：:Glioblastoma multiforme has a poor prognosis and is highly chemoresistant. In this study, we implanted biodegradable 1,3-bis[2-chloroethyl]-1-nitroso-urea-, irinotecan-, and cisplatin-eluting poly[(d,l)-lactide-co-glycolide] (BIC/PLGA) and virgin nanofibrous membranes on the brain surface of C6 glioma-bearing rats in ...

journal_title：Scientific reports

authors： Tseng YY,Huang YC,Yang TC,Yang ST,Liu SC,Chang TM,Kau YC,Liu SJ

更新日期：2016-07-29 00:00:00

abstract：:In this work, lamellar MnFe2O4 was successfully planted on a wood surface through the association of hydrogen bonds via the one-pot hydrothermal method. Simultaneously, the fluoroalkylsilane (FAS-17) on the surface of the MnFe2O4 layer formed long-chain or network macromolecules through a poly-condensation process and...

journal_title：Scientific reports

authors： Wang H,Yao Q,Wang C,Fan B,Sun Q,Jin C,Xiong Y,Chen Y

更新日期：2016-10-17 00:00:00

abstract：:Dynamic optical imaging (e.g. time delay integration imaging) is troubled by the motion blur fundamentally arising from mismatching between photo-induced charge transfer and optical image movements. Motion aberrations from the forward dynamic imaging link impede the acquiring of high-quality images. Here, we propose a...

journal_title：Scientific reports

authors： Li J,Liu Z

更新日期：2019-08-05 00:00:00

abstract：:Triboelectric charging is common in desert sandstorms and dust devils on Earth; however, it remains poorly understood. Here we show a charging mechanism of sands with the adsorbed water on micro-porous surface in wind-blown sand based on the fact that water content is universal but usually a minor component in most pa...

journal_title：Scientific reports

authors： Gu Z,Wei W,Su J,Yu CW

更新日期：2013-01-01 00:00:00

abstract：:Long-term all-cause mortality and dependency after complex surgical procedures have not been assessed in the framework of value-based medicine. The aim of this study was to investigate the postoperative and long-term outcomes after surgical procedures lasting for more than six hours. Retrospective cohort study of pati...

journal_title：Scientific reports

authors： Cornellà N,Sancho J,Sitges-Serra A

更新日期：2017-08-23 00:00:00

abstract：:Intracellular ion channels are involved in multiple signaling processes, including such crucial ones as regulation of cellular motility and fate. With 95% of the cellular membrane belonging to intracellular organelles, it is hard to overestimate the importance of intracellular ion channels. Multiple studies have been ...

journal_title：Scientific reports

authors： Shapovalov G,Ritaine A,Bidaux G,Slomianny C,Borowiec AS,Gordienko D,Bultynck G,Skryma R,Prevarskaya N

更新日期：2017-10-26 00:00:00

abstract：:The receptor guanylate cyclases (rGCs) in animals serve as sensitive chemoreceptors to detect both chemical and environmental cues. In reproduction, rGCs were shown to be expressed on sperm and serve as receptors for egg-derived sperm-activating and sperm-attracting factors in some echinoderms and mammals. However, sp...

journal_title：Scientific reports

authors： Zhang Y,Chiu YL,Chen CJ,Ho YY,Shinzato C,Shikina S,Chang CF

更新日期：2019-10-10 00:00:00

abstract：:The most common surgical emergency is suspected acute appendicitis, the lifetime risk of acute appendicitis is estimated to be 8.6% for men and 6.7% for women, with a male to female ratio of 1.4:1; correct diagnosis can be made in 70-80% of patients after the operations about 32% of appendectomies revealed normal appe...

journal_title：Scientific reports

authors： Ahmed HO,Muhedin R,Boujan A,Aziz AHS,Abdulla AM,Hardi RA,Abdulla AA,Sidiq TA

更新日期：2020-02-06 00:00:00

abstract：:Little is known about the combined effects of stressors on social immunity of honey bees (Apis mellifera) and related gene expression. The interaction between sublethal doses of a neurotoxin, clothianidin, and the ectoparasite, Varroa destructor, was examined by measuring differentially expressed genes (DEGs) in brain...

journal_title：Scientific reports

authors： Morfin N,Goodwin PH,Hunt GJ,Guzman-Novoa E

更新日期：2019-03-26 00:00:00

abstract：:The transition from unicellular to multicellular organisms poses the question as to when genes that regulate cell-cell interactions emerged during evolution. The receptor and ligand pairing of plexins and semaphorins regulates cellular interactions in a wide range of developmental and physiological contexts. We survey...

journal_title：Scientific reports

authors： Junqueira Alves C,Yotoko K,Zou H,Friedel RH

更新日期：2019-02-13 00:00:00

abstract：:NF-κB signaling pathway has important roles in the regulation of growth and development of nervous system. This pathway has also been shown to participate in the pathogenesis of schizophrenia. Meanwhile, activity of NF-κB signaling pathway is regulated by several factors including non-coding RNAs (lncRNAs). In the cur...

journal_title：Scientific reports

authors： Safa A,Badrlou E,Arsang-Jang S,Sayad A,Taheri M,Ghafouri-Fard S

更新日期：2020-10-22 00:00:00

abstract：:Diffuse myocardial fibrosis is a key pathophysiologic feature in heart failure and can be quantified by cardiac magnetic resonance (CMR) T1 mapping. However, increases in myocardial free water also prolong native T1 times and may impact fibrosis quantification. Thus far, the impact of systemic patient volume status re...

journal_title：Scientific reports

authors： Antlanger M,Aschauer S,Kammerlander AA,Duca F,Säemann MD,Bonderman D,Mascherbauer J

更新日期：2018-04-03 00:00:00

abstract：:The SW Japan arc built by subduction of the Philippine Sea (PHS) plate exhibits uneven distribution of volcanoes: thirteen Quaternary composite volcanoes form in the western half of this arc, Kyushu Island, while only two in the eastern half, Chugoku district. Reconstruction of the PHS plate back to 14 Ma, together wi...

journal_title：Scientific reports

authors： Tatsumi Y,Suenaga N,Yoshioka S,Kaneko K,Matsumoto T

更新日期：2020-09-14 00:00:00

abstract：:The synthetic Angiotensin Converting Enzyme (ACE) inhibitors have side effects and hence demands for natural ACE inhibitors have been rising. The aim of this study is to purify and introduce natural ACE inhibitors extracted from Zizyphus jujuba fruits. Proteins from Zizyphus jujuba were lysed by trypsin, papain and th...

journal_title：Scientific reports

authors： Memarpoor-Yazdi M,Zare-Zardini H,Mogharrab N,Navapour L

更新日期：2020-03-04 00:00:00

abstract：:We introduce a polarization-resolved terahertz time-domain spectrometer with a broadband (0.3-2.5 THz), rotatable THz polarization state, and which exhibits minimal change in the electric field amplitude and polarization state upon rotation. This was achieved by rotating an interdigitated photoconductive emitter, and ...

journal_title：Scientific reports

authors： Mosley CDW,Failla M,Prabhakaran D,Lloyd-Hughes J

更新日期：2017-09-26 00:00:00

abstract：:Competing phenomena in low dimensional systems can generate exotic electronic phases, either through symmetry breaking or a non-trivial topology. In two-dimensional (2D) systems, the interplay between superfluidity, disorder and repulsive interactions is especially fruitful in this respect although both the exact natu...

journal_title：Scientific reports

authors： Couëdo F,Crauste O,Drillien AA,Humbert V,Bergé L,Marrache-Kikuchi CA,Dumoulin L

更新日期：2016-10-27 00:00:00

abstract：:The essential cochaperone Sgt1 recruits Hsp90 chaperone activity to a range of cellular factors including SCF E3 ubiquitin ligases and the kinetochore in eukaryotes. In these pathways Sgt1 interacts with Skp1, a small protein that heterodimerizes with proteins containing the F-box motif. We have determined the crystal...

journal_title：Scientific reports

authors： Willhoft O,Kerr R,Patel D,Zhang W,Al-Jassar C,Daviter T,Millson SH,Thalassinos K,Vaughan CK

更新日期：2017-01-31 00:00:00

abstract：:Although collateral vessel growth is distinctly enhanced by elevated fluid shear stress (FSS), the underlying regulatory mechanism of this process remains incompletely understood. Recent studies have shown that microRNAs (miRNAs) play a pivotal role in vascular development, homeostasis and a variety of diseases. There...

journal_title：Scientific reports

authors： Guan Y,Cai B,Wu X,Peng S,Gan L,Huang D,Liu G,Dong L,Xiao L,Liu J,Zhang B,Cai WJ,Schaper J,Schaper W

更新日期：2017-07-27 00:00:00

abstract：:Invasive aspergillosis (IA) is a life-threatening complication among allogeneic hematopoietic stem cell transplant (alloSCT) recipients. Despite well known risk factors and different available assays, diagnosis of invasive aspergillosis remains challenging. 103 clinical variables from patients with hematological malig...

journal_title：Scientific reports

authors： Zoran T,Weber M,Springer J,White PL,Bauer J,Schober A,Löffler C,Seelbinder B,Hünniger K,Kurzai O,Scherag A,Schäuble S,Morton CO,Einsele H,Linde J,Löffler J

更新日期：2019-11-21 00:00:00

abstract：:The misuse of pharmaceutical opioids is a major public health issue. In Australia, codeine was re-scheduled on 1 February 2018 to restrict access; it is now only available on prescription. The aim of this study was to measure the change in dental opioid prescriptions, one year before and after the codeine re-schedulin...

journal_title：Scientific reports

authors： Teoh L,Hollingworth S,Marino R,McCullough MJ

更新日期：2020-05-21 00:00:00

abstract：:Protein S-sulfenylation, which results from oxidation of free thiols on cysteine residues, has recently emerged as an important post-translational modification that regulates the structure and function of proteins involved in a variety of physiological and pathological processes. By altering the size and physiochemica...

journal_title：Scientific reports

authors： Al-Barakati HJ,McConnell EW,Hicks LM,Poole LB,Newman RH,Kc DB

更新日期：2018-07-26 00:00:00

abstract：:Virus pseudotyping is a useful and safe technique for studying entry of emerging strains of influenza virus. However, few studies have compared different reassortant combinations in pseudoparticle systems, or compared entry kinetics of native viruses and their pseudotyped analogs. Here, vesicular stomatitis virus (VSV...

journal_title：Scientific reports

authors： Hsu HL,Millet JK,Costello DA,Whittaker GR,Daniel S

更新日期：2016-10-18 00:00:00

abstract：:Paeonia ostii, a member of tree peony, is an emerging oil crop with important medical and oil uses and widely cultivated in China. Dissolving the genetic diversity and domestication history of this species is important for further genetic improvements and deployments. We firstly selected 29 simple sequence repeats (SS...

journal_title：Scientific reports

authors： Peng LP,Cai CF,Zhong Y,Xu XX,Xian HL,Cheng FY,Mao JF

更新日期：2017-07-13 00:00:00

abstract：:Bisphosphonates have benefits in breast cancer and multiple myeloma patients and have been used with adoptive immunotherapy with γδ T cells expressing Vγ2 Vδ2 TCRs. Although treatment with γδ T cells is safe, it has shown limited efficacy. Present bisphosphonates stimulate γδ T cells but were designed to inhibit bone ...

journal_title：Scientific reports

authors： Tanaka Y,Iwasaki M,Murata-Hirai K,Matsumoto K,Hayashi K,Okamura H,Sugie T,Minato N,Morita CT,Toi M

更新日期：2017-07-20 00:00:00

abstract：:Sense of touch is a major part of man's communication with their environment. Artificial skins can help robots to have the same sense of touch, especially for their social interactions. This paper presents a pressure mapping sensing using piezo-resistive fabric to represent aspects of the sense of touch. In past few y...

journal_title：Scientific reports

authors： Duan X,Taurand S,Soleimani M

更新日期：2019-06-20 00:00:00

abstract：:Spotted seal (Phoca largha) is a critically endangered pinniped in China and South Korea. The conventional method to protect and maintain the P. largha population is to keep them captive in artificially controlled environments. However, little is known about the physiological differences between wild and captive P. la...

journal_title：Scientific reports

authors： Tian J,Du J,Han J,Bao X,Song X,Lu Z

更新日期：2020-10-30 00:00:00

abstract：:Epigenetic mechanisms are known to exert control over gene expression and determine cell fate. Genetic mutations in epigenetic regulators are responsible for several neurologic disorders. Mutations of the chromatin remodeling protein Lsh/HELLS can cause the human Immunodeficiency, Centromere instability and Facial ano...

journal_title：Scientific reports

authors： Han Y,Ren J,Lee E,Xu X,Yu W,Muegge K

更新日期：2017-04-25 00:00:00

abstract：:The κ opioid receptor (κOR) is a member of G-protein-coupled receptors, and is considered as a promising drug target for treating neurological diseases. κOR selective 6'-GNTI was proved to be a G-protein biased agonist, whereas 5'-GNTI acts as an antagonist. To investigate the molecular mechanism of how these two liga...

journal_title：Scientific reports

authors： Cheng J,Sun X,Li W,Liu G,Tu Y,Tang Y

更新日期：2016-01-08 00:00:00

abstract：:The newly sequenced mitochondrial genomes of 107 Asian swamp buffalo (Bubalus bubalis carabensis) allowed the reconstruction of the matrilineal divergence since ~900 Kya. Phylogenetic trees and Bayesian skyline plots suggest a role of the glacial periods in the demographic history of swamp buffalo. The ancestral swamp...

journal_title：Scientific reports

authors： Wang S,Chen N,Capodiferro MR,Zhang T,Lancioni H,Zhang H,Miao Y,Chanthakhoun V,Wanapat M,Yindee M,Zhang Y,Lu H,Caporali L,Dang R,Huang Y,Lan X,Plath M,Chen H,Lenstra JA,Achilli A,Lei C

更新日期：2017-07-05 00:00:00