Impact of Systemic Volume Status on Cardiac Magnetic Resonance T1 Mapping.

abstract：:Human populations worldwide are increasingly confronted with infectious diseases and antimicrobial resistance spreading faster and appearing more frequently. Knowledge regarding their occurrence and worldwide transmission is important to control outbreaks and prevent epidemics. Here, we performed shotgun sequencing of...

journal_title：Scientific reports

authors： Nordahl Petersen T,Rasmussen S,Hasman H,Carøe C,Bælum J,Schultz AC,Bergmark L,Svendsen CA,Lund O,Sicheritz-Pontén T,Aarestrup FM

更新日期：2015-07-10 00:00:00

abstract：:Interleukin-10 (IL-10) plays a central role in regulation of intestinal mucosal homeostasis and prevention of inflammatory bowel disease (IBD). We previously reported that CD11b(hi) regulatory dendritic cells (DCs) can produce more IL-10, and CD11b can negatively regulate Toll-like receptors (TLRs)-induced inflammator...

journal_title：Scientific reports

authors： Hu X,Han C,Jin J,Qin K,Zhang H,Li T,Li N,Cao X

更新日期：2016-05-18 00:00:00

abstract：:Microglial activation is associated with glaucoma. In the model of unilateral laser-induced ocular hypertension (OHT), the time point at which the inflammatory process peaks remains unknown. Different time points (1, 3, 5, 8, and 15 d) were compared to analyze signs of microglial activation both in OHT and contralater...

journal_title：Scientific reports

authors： Ramírez AI,de Hoz R,Fernández-Albarral JA,Salobrar-Garcia E,Rojas B,Valiente-Soriano FJ,Avilés-Trigueros M,Villegas-Pérez MP,Vidal-Sanz M,Triviño A,Ramírez JM,Salazar JJ

更新日期：2020-03-17 00:00:00

abstract：:Biomarkers suitable for early diagnosis and monitoring disease progression are the cornerstone of developing disease-modifying treatments for neurodegenerative diseases such as Parkinson's disease (PD). Besides motor complications, PD is also characterized by deficits in visual processing. Here, we investigate how vir...

journal_title：Scientific reports

authors： Østergaard FG,Himmelberg MM,Laursen B,Siebner HR,Wade AR,Christensen KV

更新日期：2020-07-17 00:00:00

abstract：:Anti-cytokine therapeutic antibodies have been demonstrated to be effective in the treatment of several auto-immune disorders. However, The problems in antibody manufacture and the immunogenicity caused by multiple doses of antibodies inspire people to use auto-cytokine as immunogen to induce anti-cytokine antibodies....

journal_title：Scientific reports

authors： Liu C,Zhao Y,He W,Wang W,Chen Y,Zhang S,Ma Y,Gohda J,Ishida T,Walter TS,Owens RJ,Stuart DI,Ren J,Gao B

更新日期：2015-09-28 00:00:00

abstract：:Two-dimensional (2D) transition metal dichalcogenides MX2 (M = Mo, W, X = S, Se, Te) attracts enormous research interests in recent years. Its 2H phase possesses an indirect to direct bandgap transition in 2D limit, and thus shows great application potentials in optoelectronic devices. The 1T' crystalline phase transi...

journal_title：Scientific reports

authors： Chen W,Xie X,Zong J,Chen T,Lin D,Yu F,Jin S,Zhou L,Zou J,Sun J,Xi X,Zhang Y

更新日期：2019-02-25 00:00:00

abstract：:Due to the increasing concern of using smallpox virus as biological weapons for terrorist attack, there is renewed interest in studying the pathogenesis of human smallpox and development of new therapies. Animal models are highly demanded for efficacy and safety examination of new vaccines and therapeutic drugs. Here,...

journal_title：Scientific reports

authors： Liu Q,Fan C,Zhou S,Guo Y,Zuo Q,Ma J,Liu S,Wu X,Peng Z,Fan T,Guo C,Shen Y,Huang W,Li B,He Z,Wang Y

更新日期：2015-08-03 00:00:00

abstract：:Adenosine receptors (ARs) are potential therapeutic targets for Parkinson's disease, diabetes, pain, stroke and cancers. Prediction of subtype selectivity is therefore important from both therapeutic and mechanistic perspectives. In this paper, we introduced a shape similarity profile as molecular descriptor, namely t...

journal_title：Scientific reports

authors： He SB,Ben Hu,Kuang ZK,Wang D,Kong DX

更新日期：2016-11-04 00:00:00

abstract：:Accumulating evidence suggests that neuroinflammatory processes are implicated in the initiation and progression of amyotrophic lateral sclerosis (ALS). Previous reports have demonstrated an increase in microgliosis and astrogliosis in the lumbar spinal cord of SOD1G93A transgenic mice before the onset of symptoms, a ...

journal_title：Scientific reports

authors： Granucci EJ,Griciuc A,Mueller KA,Mills AN,Le H,Dios AM,McGinty D,Pereira J,Elmaleh D,Berry JD,Paganoni S,Cudkowicz ME,Tanzi RE,Sadri-Vakili G

更新日期：2019-11-27 00:00:00

abstract：:Sharp increase in macromolecular crowding induces abnormal chromatin compaction in the cell nucleus, suggesting its non-negligible impact on chromatin structure and function. However, the details of the crowding-induced chromatin compaction remain poorly understood. In this work, we present a computer simulation study...

journal_title：Scientific reports

authors： Oh I,Choi S,Jung Y,Kim JS

更新日期：2018-04-03 00:00:00

abstract：:Several epidemiological studies have found a positive association between diabetic retinopathy (DR) and subclinical hypothyroidism (SCH), but the findings are varied or even contradictory. In the work, we performed a meta-analysis to ascertain the relationship between DR and SCH. We searched relevant studies on the re...

journal_title：Scientific reports

authors： Wu J,Yue S,Geng J,Liu L,Teng W,Liu L,Chen L

更新日期：2015-07-20 00:00:00

abstract：:Drug resistance is one of the leading causes of failed cancer therapy in the treatment of acute myeloid leukemia. Although the mechanisms of resistance are poorly understood, they may be related to the presence of leukemia stem cells (LSCs). Down-regulation of the miR-203 reportedly contributes to oncogenesis and chem...

journal_title：Scientific reports

authors： Zhang Y,Zhou SY,Yan HZ,Xu DD,Chen HX,Wang XY,Wang X,Liu YT,Zhang L,Wang S,Zhou PJ,Fu WY,Ruan BB,Ma DL,Wang Y,Liu QY,Ren Z,Liu Z,Zhang R,Wang YF

更新日期：2016-02-05 00:00:00

abstract：:When searching for food, foraging fishes expose themselves to hidden predators. The strategies that maximize the survival of foraging fishes are not well understood. Here, we describe a novel type of mobbing behaviour displayed by foraging Scolopsis affinis. The fish direct sharp water jets towards the hidden sessile ...

journal_title：Scientific reports

authors： Lachat J,Haag-Wackernagel D

更新日期：2016-09-12 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) are promising candidate cells for cardiomyogenesis in the failing heart. However, teratoma/tumour formation originating from undifferentiated iPSCs contaminating the graft is a critical concern for clinical application. Here, we hypothesized that brentuximab vedotin, which target...

journal_title：Scientific reports

authors： Sougawa N,Miyagawa S,Fukushima S,Kawamura A,Yokoyama J,Ito E,Harada A,Okimoto K,Mochizuki-Oda N,Saito A,Sawa Y

更新日期：2018-02-27 00:00:00

abstract：:Although the reversible wettability transition between hydrophobic and hydrophilic graphene under ultraviolet (UV) irradiation has been observed, the mechanism for this phenomenon remains unclear. In this work, experimental and theoretical investigations demonstrate that the H2O molecules are split into hydrogen and h...

journal_title：Scientific reports

authors： Xu Z,Ao Z,Chu D,Younis A,Li CM,Li S

更新日期：2014-09-23 00:00:00

abstract：:Risk of hospital readmission and cardiac mortality increases with atmospheric pollution for patients with heart failure. The underlying mechanisms are unclear. Carbon monoxide (CO) a ubiquitous environmental pollutant could be involved. We explored the effect of daily exposure of CO relevant to urban pollution on post...

journal_title：Scientific reports

authors： Reboul C,Boissière J,André L,Meyer G,Bideaux P,Fouret G,Feillet-Coudray C,Obert P,Lacampagne A,Thireau J,Cazorla O,Richard S

更新日期：2017-01-03 00:00:00

abstract：:Chronic myeloid leukemia (CML) is characterized in the majority of cases by a t(9;22)(q34;q11) translocation, also called the Philadelphia chromosome, giving rise to the BCR-ABL1 fusion protein. Current treatment with tyrosine kinase inhibitors is directed against the constitutively active ABL1 domain of the fusion pr...

journal_title：Scientific reports

authors： Löf L,Arngården L,Olsson-Strömberg U,Siart B,Jansson M,Dahlin JS,Thörn I,Christiansson L,Hermansson M,Larsson A,Ahlstrand E,Wålinder G,Söderberg O,Rosenquist R,Landegren U,Kamali-Moghaddam M

更新日期：2017-04-04 00:00:00

abstract：:A child with Down syndrome, like any other child, may benefit from interacting with memory stimuli, but needs additional support and help. The use of special teaching methods, which add playfulness and use of the computer, can enhance the memory processes of these children. In this work, we present the virtual environ...

journal_title：Scientific reports

authors： da Cruz Netto OL,Rodrigues SCM,de Castro MV,da Silva DP,da Silva RR,de Souza RRB,de Souza AAF,Bissaco MAS

更新日期：2020-02-21 00:00:00

abstract：:Various sea foods including fish, shellfish and shrimp were collected from different coastal areas of Fujian in China, and their Pb species characteristics were investigated in detail. The results indicated that there are two different species characteristics of Pb existing in sea food samples. About half of samples w...

journal_title：Scientific reports

authors： He Y,Chen Z,Mo F,Huang L,Xu L,Wu Y,Xue Z,Fu F

更新日期：2016-09-14 00:00:00

abstract：:Genetically encoded calcium indicators and optogenetic actuators can report and manipulate the activity of specific neuronal populations. However, applying imaging and optogenetics simultaneously has been difficult to establish in the mammalian brain, even though combining the techniques would provide a powerful appro...

journal_title：Scientific reports

authors： Bovetti S,Moretti C,Zucca S,Dal Maschio M,Bonifazi P,Fellin T

更新日期：2017-01-05 00:00:00

abstract：:Recently, quantum Hall state analogs in classical mechanics attract much attention from topological points of view. Topology is not only for mathematicians but also quite useful in a quantum world. Further it even governs the Newton's law of motion. One of the advantages of classical systems over solid state materials...

journal_title：Scientific reports

authors： Kariyado T,Hatsugai Y

更新日期：2015-12-15 00:00:00

abstract：:Sodium butyrate (NaBu), a form of short-chain fatty acid (SCFA), acts classically as a potent anti-angiogenic agent in tumour angiogenesis models, some authors demonstrated that low concentrations of NaBu may contribute to healing of tendon-bone injury in part at least through promotion of tissue remodelling. Here, we...

journal_title：Scientific reports

authors： Liu D,Andrade SP,Castro PR,Treacy J,Ashworth J,Slevin M

更新日期：2016-10-03 00:00:00

abstract：:We introduce a setup which realises a tunable engineered environment for experiments in circuit quantum electrodynamics. We illustrate this concept with the specific example of a quantum bit, qubit, in a high-quality-factor cavity which is capacitively coupled to another cavity including a resistor. The temperature of...

journal_title：Scientific reports

authors： Jones PJ,Huhtamäki JA,Salmilehto J,Tan KY,Möttönen M

更新日期：2013-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is the leading cause of cancer-related mortality worldwide. Although the role of tumor programmed cell death 1 ligand 1 (PD-L1) in suppressing antitumor immunity has been validated in various malignances, the impact of PD-L2 (PD-L2/PDCD1LG2) within tumors remains elusive. Here, we examined tumo...

journal_title：Scientific reports

authors： Huang KC,Chiang SF,Chen TW,Chen WT,Yang PC,Ke TW,Chao KSC

更新日期：2020-12-18 00:00:00

abstract：:Fruit ripening is a complex and genetically programmed process. Brassinosteroids (BRs) play an essential role in plant growth and development, including fruit ripening. As a central component of BR signaling, the transcription factor BZR1 is involved in fruit development in tomato. However, the transcriptional network...

journal_title：Scientific reports

authors： Liu L,Liu H,Li S,Zhang X,Zhang M,Zhu N,Dufresne CP,Chen S,Wang Q

更新日期：2016-09-29 00:00:00

abstract：:For patients with amyotrophic lateral sclerosis (ALS), the primary therapeutic goal is to minimize morbidity. Non-invasive ventilation improves survival. We aim to assess whether Magnetic Resonance Imaging (MRI) of the cervical spinal cord predicts the progression of respiratory disorders in ALS. Brain and spinal MRI ...

journal_title：Scientific reports

authors： Grolez G,Kyheng M,Lopes R,Moreau C,Timmerman K,Auger F,Kuchcinski G,Duhamel A,Jissendi-Tchofo P,Besson P,Laloux C,Petrault M,Devedjian JC,Pérez T,Pradat PF,Defebvre L,Bordet R,Danel-Brunaud V,Devos D

更新日期：2018-01-29 00:00:00

abstract：:Prediction of infection trends, estimating the efficacy of contact tracing, testing or impact of influx of infected are of vital importance for administration during an ongoing epidemic. Most effective methods currently are empirical in nature and their relation to parameters of interest to administrators are not evid...

journal_title：Scientific reports

authors： Raghavan M,Sridharan KS,Mandayam Rangayyan Y

更新日期：2020-10-06 00:00:00

abstract：:Actinobacillus pleuropneumoniae (App) is the causative agent of porcine pleuropneumonia. Although App produces several virulence factors, Apx toxins, the primary App virulence factors, have been the focus of numerous studies. However, the host response against the Apx toxins has not been elucidated at the transcriptom...

journal_title：Scientific reports

authors： Kim S,Oh MW,Bin Park W,Yoo HS

更新日期：2019-03-27 00:00:00

abstract：:Transgenic sheep can be used to achieve genetic improvements in breeds and as an important large-animal model for biomedical research. In this study, we generated a TALEN plasmid specific for ovine MSTN and transfected it into fetal fibroblast cells of STH sheep. MSTN biallelic-KO somatic cells were selected as nuclea...

journal_title：Scientific reports

authors： Li H,Wang G,Hao Z,Zhang G,Qing Y,Liu S,Qing L,Pan W,Chen L,Liu G,Zhao R,Jia B,Zeng L,Guo J,Zhao L,Zhao H,Lv C,Xu K,Cheng W,Li H,Zhao HY,Wang W,Wei HJ

更新日期：2016-09-22 00:00:00

abstract：:Although Heme Oxygenase-1 (HO-1) induction in various forms of kidney injury is protective, its role in age-related renal pathology is unknown. In the ageing kidney there is nephron loss and lesions of focal glomerulosclerosis, interstitial fibrosis, tubular atrophy and arteriolosclerosis. Underlying mechanisms includ...

journal_title：Scientific reports

authors： Poulaki E,Detsika MG,Fourtziala E,Lianos EA,Gakiopoulou H

更新日期：2020-03-31 00:00:00