Abstract：
:Microglial activation is associated with glaucoma. In the model of unilateral laser-induced ocular hypertension (OHT), the time point at which the inflammatory process peaks remains unknown. Different time points (1, 3, 5, 8, and 15 d) were compared to analyze signs of microglial activation both in OHT and contralateral eyes. In both eyes, microglial activation was detected in all retinal layers at all time points analyzed, including: i) increase in the cell number in the outer segment photoreceptor layer and plexiform layers (only in OHT eyes) from 3 d onward; ii) increase in soma size from 1 d onward; iii) retraction of the processes from 1 d in OHT eyes and 3 d in contralateral eyes; iv) increase in the area of the retina occupied by Iba-1+ cells in the nerve fiber layer/ganglion cell layer from 1 d onward; v) increase in the number of vertical processes from 1 d in contralateral eyes and 3 d in OHT eyes. In OHT eyes at 24 h and 15 d, most Iba-1+ cells were P2RY12+ and were down-regulated at 3 and 5 d. In both eyes, microglial activation was stronger at 3 and 5 d (inflammation peaked in this model). These time points could be useful to identify factors implicated in the inflammatory process.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ramírez AI,de Hoz R,Fernández-Albarral JA,Salobrar-Garcia E,Rojas B,Valiente-Soriano FJ,Avilés-Trigueros M,Villegas-Pérez MP,Vidal-Sanz M,Triviño A,Ramírez JM,Salazar JJdoi
10.1038/s41598-020-61848-9subject
Has Abstractpub_date
2020-03-17 00:00:00pages
4890issue
1issn
2045-2322pii
10.1038/s41598-020-61848-9journal_volume
10pub_type
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