Abstract:
:The association between gene polymorphisms and plasma virus load at the set point (SP-PVL) was investigated in Mauritian macaques inoculated with SIV. Among 44 macaques inoculated with 50 AID50, six individuals were selected: three with SP-PVL among the highest and three with SP-PVL among the lowest. The exons of 390 candidate genes of these six animals were sequenced. Twelve non-synonymous single nucleotide polymorphisms (NS-SNPs) lying in nine genes potentially associated with PVL were genotyped in 23 animals. Three NS-SNPs with probabilities of association with PVL less than 0.05 were genotyped in a total of 44 animals. One NS-SNP lying in exon 1 of the IL37 gene displayed a significant association (p = 3.33 × 10-4) and a strong odds ratio (19.52). Multiple linear regression modeling revealed three significant predictors of SP-PVL, including the IL37 exon 1 NS-SNP (p = 0.0004) and the MHC Class IB haplotypes M2 (p = 0.0007) and M6 (p = 0.0013). These three factors in conjunction explained 48% of the PVL variance (p = 4.8 × 10-6). The potential role of IL37 in the control of SIV infection is discussed.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Shiina T,Suzuki S,Congy-Jolivet N,Aarnink A,Garchon HJ,Dereuddre-Bosquet N,Vaslin B,Tchitchek N,Desjardins D,Autran B,Lambotte O,Theodorou I,Le Grand R,Blancher Adoi
10.1038/s41598-019-44235-xsubject
Has Abstractpub_date
2019-05-28 00:00:00pages
7981issue
1issn
2045-2322pii
10.1038/s41598-019-44235-xjournal_volume
9pub_type
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