Abstract:
:High-risk human papillomavirus (HPV) type 16, which is responsible for greater than 50% of cervical cancer cases, is the most prevalent and lethal HPV type. However, the molecular mechanisms of cervical carcinogenesis remain elusive, particularly the early steps of HPV infection that may transform normal cervical epithelium into a pre-neoplastic state. Here, we report that a group of microRNAs (microRNAs) were aberrantly decreased in HPV16-positive normal cervical tissues, and these groups of microRNAs are further reduced in cervical carcinoma. Among these miRNAs, miR196a expression is the most reduced in HPV16-infected tissues. Interestingly, miR196a expression is low in HPV16-positive cervical cancer cell lines but high in HPV16-negative cervical cancer cell lines. Furthermore, we found that only HPV16 early gene E5 specifically down-regulated miRNA196a in the cervical cancer cell lines. In addition, HoxB8, a known miR196a target gene, is up-regulated in the HPV16 cervical carcinoma cell line but not in HPV18 cervical cancer cell lines. Various doses of miR196a affected cervical cancer cell proliferation and apoptosis. Altogether, these results suggested that HPV16 E5 specifically down-regulates miR196a upon infection of the human cervix and initiates the transformation of normal cervix cells to cervical carcinoma.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu C,Lin J,Li L,Zhang Y,Chen W,Cao Z,Zuo H,Chen C,Kee Kdoi
10.1038/srep07653subject
Has Abstractpub_date
2015-01-07 00:00:00pages
7653issn
2045-2322pii
srep07653journal_volume
5pub_type
杂志文章abstract::α-synuclein plays a key role in the pathogenesis of Parkinson's disease (PD); its deposits are found as amyloid fibrils in Lewy bodies and Lewy neurites, the histopathological hallmarks of PD. Amyloid fibrillation is a progressive polymerization path starting from peptide/protein misfolding and proceeding through the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26645-5
更新日期:2018-05-29 00:00:00
abstract::Negative diagonal magneto-conductivity/resistivity is a spectacular- and thought provoking-property of driven, far-from-equilibrium, low dimensional electronic systems. The physical response of this exotic electronic state is not yet fully understood since it is rarely encountered in experiment. The microwave-radiatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03478
更新日期:2013-12-11 00:00:00
abstract::Improving dewaterability of sludge is important for the disposal of sludge in wastewater treatment plants (WWTPs). This study, for the first time, investigated the Fe(II) activated oxidization processes in improving anaerobically digested sludge (ADS) dewaterability. The combination of Fe(II) (0-100 mg/g total solids ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24800
更新日期:2016-04-25 00:00:00
abstract::Quick inhibition of approach tendencies in response to signals of potential threats is thought to promote survival. However, little is known about the effect of viewing fearful expressions on the early dynamics of the human motor system. We used the high temporal resolution of single-pulse and paired-pulse transcrania...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14122
更新日期:2015-09-21 00:00:00
abstract::The design of active and stable semiconducting composites with enhanced photoresponse from visible light to near infrared (NIR) is a key to improve solar energy harvesting for photolysis of water in photoelectrochemical cell. In this study, we prepared earth abundant semiconducting composites consisting of iron pyrite...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20397
更新日期:2016-02-08 00:00:00
abstract::Dark-operative protochlorophyllide oxidoreductase (DPOR) is a key enzyme to produce chlorophyll in the dark. Among photosynthetic eukaryotes, all three subunits chlL, chlN, and chlB are encoded by plastid genomes. In some gymnosperms, two codons of chlB mRNA are changed by RNA editing to codons encoding evolutionarily...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02630-2
更新日期:2017-05-24 00:00:00
abstract::Incorporation of Zn atoms into a nanosize Cu lattice is known to alter the electronic properties of Cu, improving catalytic performance in a number of industrially important reactions. However the structural influence of Zn on the Cu phase is not well studied. Here, we show that Cu nano-clusters modified with increasi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20527
更新日期:2016-02-09 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-67920-8
更新日期:2020-06-26 00:00:00
abstract::Early cow-calf separation prevents much of cows' natural maternal behaviour. Early separation is thought to prevent the development of a cow-calf bond. To assess this bond, we measured motivation of dairy cows to reunite with their calf. To vary the degree of bonding, some cows were allowed continued contact with thei...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70927-w
更新日期:2020-08-28 00:00:00
abstract::PDA is a major cause of US cancer-related deaths. Oncogenic Kras presents in 90% of human PDAs. Kras mutations occur early in pre-neoplastic lesions but are insufficient to cause PDA. Other contributing factors early in disease progression include chronic pancreatitis, alterations in epigenetic regulators, and tumor s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77373-8
更新日期:2020-11-26 00:00:00
abstract::Wolfram syndrome (WS) is a rare neurodegenerative disorder that is mainly characterized by diabetes mellitus, optic nerve atrophy, deafness, and progressive brainstem degeneration. Treatment with GLP-1 receptor agonists has shown a promising anti-diabetic effect in WS treatment in both animal models and in human patie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52295-2
更新日期:2019-10-31 00:00:00
abstract::Crystal and electronic structures of ~380 nm BiFeO3 film grown on LaAlO3 substrate are comprehensively studied using advanced transmission electron microscopy (TEM) technique combined with first-principles theory. Cross-sectional TEM images reveal the BiFeO3 film consists of two zones with different crystal structures...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46498
更新日期:2017-04-19 00:00:00
abstract::Burgeoning availability of genome-wide association study (GWAS) results and national biobank data has led to growing interest in performing multi-trait genetic analyses. Numerous multi-trait GWAS methods that exploit either summary statistics or individual-level data have been developed, but their relative performance...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38837
更新日期:2017-03-13 00:00:00
abstract::The insect membrane-protein, Torso, is a member of the receptor-tyrosine-kinase family, and is activated by its ligand, prothoracicotropic hormone (PTTH). Although PTTH is one of the most important regulators of insect development, the mechanism of Torso activation by the hormone has remained elusive. In this study, u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22437
更新日期:2016-03-01 00:00:00
abstract::Myelination is critical for transduction of neuronal signals, neuron survival and normal function of the nervous system. Myelin disorders account for many debilitating neurological diseases such as multiple sclerosis and leukodystrophies. The lack of experimental models and tools to observe and manipulate this process...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18744-6
更新日期:2018-01-11 00:00:00
abstract::Respiratory syncytial virus (RSV) is a significant cause of lower respiratory tract infection in infants and elderly. To understand the evolution of neutralizing epitopes on the RSV glycoprotein (G) and fusion (F) proteins, we conducted a multi-year surveillance program (OUTSMART-RSV) in the US. Analysis of 1,146 RSV ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40387-y
更新日期:2019-03-07 00:00:00
abstract::We measured the interleukin-34 (IL-34) level in sera from patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) using an enzyme-linked immunosorbent assay (ELISA). Blood tests, including assays to determine C-reactive protein (CRP), complement (C) 3, C4, immunoglobulin (Ig) A, IgG, IgM...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21859-z
更新日期:2018-02-22 00:00:00
abstract::Understanding the processes that shaped contemporary pathogen populations in agricultural landscapes is quite important to define appropriate management strategies and to support crop improvement efforts. Here, we took advantage of an historical record to examine the adaptation pathway of the rice pathogen Xanthomonas...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34137
更新日期:2016-09-26 00:00:00
abstract::Glioblastoma (GBM) is the most prevalent and lethal type of primary malignant brain tumour. Recent studies suggest that the discovery of human cytomegalovirus (HCMV)-encoded microRNAs (miRNAs) might play a role in the pathogenesis of diseases, including GBM. In this study, we aimed to analyse the expression and functi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44705
更新日期:2017-03-17 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-56287-0
更新日期:2019-12-19 00:00:00
abstract::Our understanding of a variety of phenomena in physics, biology and economics crucially depends on the analysis of multivariate time series. While a wide range tools and techniques for time series analysis already exist, the increasing availability of massive data structures calls for new approaches for multidimension...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15508
更新日期:2015-10-21 00:00:00
abstract::Horizontal gene transfer (HGT) is a main mechanism of bacterial evolution endowing bacteria with new genetic traits. The transfer of mobile genetic elements such as plasmids (conjugation) requires the close proximity of cells. HGT between genetically distinct bacteria largely depends on cell movement in water films, w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36390
更新日期:2016-11-04 00:00:00
abstract::The group-IV tin has been hypothesized to possess intriguing electronic properties in an atom-thick hexagonal form. An attractive pathway of producing sizable 2D crystallites of tin is based on deintercalation of bulk compounds with suitable tin frameworks. Here, we have identified a new synthesizable metal distannide...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28369
更新日期:2016-07-08 00:00:00
abstract::It is notable that the adoption of GM glyphosate-tolerant crops increases glyphosate use but reduces non-glyphosate herbicide use; and adoption of GM insect-resistant crops significantly reduces insecticide use. While the health hazard of pesticide use has been well documented, little literature evaluates the health e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34918
更新日期:2016-10-10 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-54657-2
更新日期:2019-11-25 00:00:00
abstract::Fine particulate matter 2.5 (PM2.5) induces free radicals and oxidative stress in animals, leading to a range of illnesses. In this study, Ganoderma Microsporum immunomodulatory (GMI) proteins were administered to alleviate PM2.5-induced inflammatory responses in mother rats, and PM2.5-induced inflammatory responses a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38810-5
更新日期:2019-05-02 00:00:00
abstract::The mechanical behavior of a single phase (fcc) Al0.3CoCrFeNi high-entropy alloy (HEA) was studied in the low and high strain-rate regimes. The combination of multiple strengthening mechanisms such as solid solution hardening, forest dislocation hardening, as well as mechanical twinning leads to a high work hardening ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42742
更新日期:2017-02-17 00:00:00
abstract::Only few applications are currently dealing with personalized adverse drug reactions (ADRs) prediction in case of polypharmacy. The study aimed to develop a patient-tailored ADR web application, considering characteristics from 734 drugs and relevant patient related factors. The application was designed in Python usin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66611-8
更新日期:2020-06-12 00:00:00
abstract::Despite advances in renovascular disease (RVD) research, gaps remain between experimental and clinical outcomes, translation of results, and the understanding of pathophysiological mechanisms. A predictive tool to indicate support (or lack of) for biological findings may aid clinical translation of therapies. We creat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57386-8
更新日期:2020-01-16 00:00:00
abstract::Bivalent (poised or paused) chromatin comprises activating and repressing histone modifications at the same location. This combination of epigenetic marks at promoter or enhancer regions keeps genes expressed at low levels but poised for rapid activation. Typically, DNA at bivalent promoters is only lowly methylated i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37393
更新日期:2016-11-23 00:00:00