Abstract:
:Due to the obesity epidemic, non-alcoholic steatohepatitis (NASH) is a prevalent liver disease, characterized by fat accumulation and inflammation of the liver. However, due to a lack of mechanistic insight, diagnostic and therapeutic options for NASH are poor. Recent evidence has indicated cathepsin D (CTSD), a lysosomal enzyme, as a marker for NASH. Here, we investigated the function of CTSD in NASH by using an in vivo and in vitro model. In addition to diminished hepatic inflammation, inhibition of CTSD activity dramatically improved lipid metabolism, as demonstrated by decreased plasma and liver levels of both cholesterol and triglycerides. Mechanistically, CTSD inhibition resulted in an increased conversion of cholesterol into bile acids and an elevated excretion of bile acids via the feces, indicating that CTSD influences lipid metabolism. Consistent with these findings, treating Wt BMDMs with PepA in vitro showed a similar decrease in inflammation and an analogous effect on cholesterol metabolism. CONCLUSION:CTSD is a key player in the development of hepatic inflammation and dyslipidemia. Therefore, aiming at the inhibition of the activity of CTSD may lead to novel treatments to combat NASH.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Houben T,Oligschlaeger Y,Hendrikx T,Bitorina AV,Walenbergh SMA,van Gorp PJ,Gijbels MJJ,Friedrichs S,Plat J,Schaap FG,Lütjohann D,Hofker MH,Shiri-Sverdlov Rdoi
10.1038/s41598-017-03796-5subject
Has Abstractpub_date
2017-06-14 00:00:00pages
3494issue
1issn
2045-2322pii
10.1038/s41598-017-03796-5journal_volume
7pub_type
杂志文章abstract::Multiferroics, where two or more ferroic order parameters coexist, is one of the hottest fields in condensed matter physics and materials science. To search multiferroics, currently most researches are focused on frustrated magnets, which usually have complicated magnetic structure and low magnetic ordering temperatur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22743
更新日期:2016-03-09 00:00:00
abstract::Ambient seismic noise is characterized by randomness incurred by the random position and strength of the noise sources as well as the heterogeneous properties of the medium through which it propagates. Here we use ambient noise data recorded prior to the 1996 Gjálp eruption in Iceland in order to show that a reduction...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37733
更新日期:2016-11-24 00:00:00
abstract::The foregut endoderm gives rise to several organs including liver, pancreas, lung and thyroid with important roles in human physiology. Understanding which genes and signalling pathways regulate their development is crucial for understanding developmental disorders as well as diseases in adulthood. We exploited unique...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24036-4
更新日期:2018-04-04 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is a chronic disease, and dietary modification is a crucial part of disease management. Okara is a sustainable source of fibre-rich food. Most of the valorization research on okara focused more on the physical attributes instead of the possible health attributes. The fermentation of oka...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54021-4
更新日期:2019-11-26 00:00:00
abstract::Accumulating evidence suggests that neuroinflammatory processes are implicated in the initiation and progression of amyotrophic lateral sclerosis (ALS). Previous reports have demonstrated an increase in microgliosis and astrogliosis in the lumbar spinal cord of SOD1G93A transgenic mice before the onset of symptoms, a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53982-w
更新日期:2019-11-27 00:00:00
abstract::By combining the two basic deformation mechanisms for auxetic open-cell metamaterials, re-entrant angle and chirality, new hybrid chiral mechanical metamaterials are designed and fabricated via a multi-material 3D printer. Results from mechanical experiments on the 3D printed prototypes and systematic Finite Element (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20795-2
更新日期:2018-02-05 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-60882-x
更新日期:2020-03-02 00:00:00
abstract::Circular RNAs (circRNAs) are covalently closed circular non-coding RNAs. Due to their structure, circRNAs are more stable and have longer half-lives than linear RNAs making them good candidates for disease biomarkers. Despite the scientific relevance of these molecules, the study of circRNAs in non-model organisms is ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79781-2
更新日期:2021-01-11 00:00:00
abstract::We study the spreading of cell aggregates deposited on adhesive substrates decorated with microparticles (MPs). A cell monolayer expands around the aggregate. The cells on the periphery of the monolayer take up the MPs, clearing the substrate as they progress and forming an aureole of cells filled with MPs. We study t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15665-2
更新日期:2017-11-16 00:00:00
abstract::The aim of the study was to compare background characteristics, microbiology and outcome of patients with right-sided and left-sided intravenous drug use (IDU) associated infective endocarditis (IE). A nationwide retrospective study using the Swedish Registry on Infective Endocarditis between 2008 and 2019 was conduct...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80869-y
更新日期:2021-01-13 00:00:00
abstract::Epigenetic mechanisms are known to exert control over gene expression and determine cell fate. Genetic mutations in epigenetic regulators are responsible for several neurologic disorders. Mutations of the chromatin remodeling protein Lsh/HELLS can cause the human Immunodeficiency, Centromere instability and Facial ano...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00804-6
更新日期:2017-04-25 00:00:00
abstract::1-aminoperylene diimide/TiO2/MoS2 composite (NH2-PDI/TiO2/MoS2) with ordered structure was prepared by hydrothermal synthesis method. The composite was characterized by XRD, SEM, FTIR, XPS, BET, DRS, PL, EIS, Raman, photocurrent, and Mott-Schottky plots spectroscopy. The potential positions of the conduction and valen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78894-y
更新日期:2020-12-15 00:00:00
abstract::WO3 is widely used as industrial catalyst. Intrinsic and/or extrinsic defects can tune the electronic properties and extend applications to gas sensors and optoelectonics. However, H doping is a challenge to WO3, the relevant mechanisms being hardly understood. In this context, we investigate intrinsic defects and H d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40882
更新日期:2017-01-18 00:00:00
abstract::Stem and progenitor cells of the submandibular salivary gland (SMG) give rise to, maintain, and regenerate the multiple lineages of mature epithelial cells including those belonging to the ductal, acinar, basal and myoepithelial subtypes. Here we have exploited single cell RNA-sequencing and in vivo genetic lineage tr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32343-z
更新日期:2018-09-19 00:00:00
abstract::Glucagon is a pancreatic hormone and increases the blood glucose levels. It may be incorporated in a dual hormone artificial pancreas, a device to automatically and continuously control blood glucose levels of individuals with diabetes. Artificial pancreas systems have been developed for use in the subcutaneous tissue...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70813-5
更新日期:2020-08-13 00:00:00
abstract::Energy plants are the main source of bioenergy which will play an increasingly important role in future energy supplies. With limited cultivated land resources in China, the development of energy plants may primarily rely on the marginal land. In this study, based on the land use data from 1990 to 2010(every 5 years i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05816
更新日期:2014-07-24 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-60629-8
更新日期:2020-02-25 00:00:00
abstract::The human sweet taste receptor (T1R2) monomer-a member of the G-protein coupled receptor family that detects a wide variety of chemically and structurally diverse sweet tasting molecules, is known to pose a significant threat to human health. Protein that lack crystal structure is a challenge in structure-based protei...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75123-4
更新日期:2020-10-27 00:00:00
abstract::Estimating regional nutrient criteria for streams and rivers is a key step toward protecting river water quality and restoring the health of aquatic ecosystems. Using a multivariable statistical analysis technique, nutrients were identified as the main factor influencing the degradation of the benthic macroinvertebrat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22128-9
更新日期:2018-02-28 00:00:00
abstract::Gold nanoparticle radiosensitization represents a novel technique in enhancement of ionising radiation dose and its effect on biological systems. Variation between theoretical predictions and experimental measurement is significant enough that the mechanism leading to an increase in cell killing and DNA damage is stil...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19442
更新日期:2016-01-20 00:00:00
abstract::The main feature of the present numerical model is to explore the behavior of Maxwell nanoliquid moving within two horizontal rotating disks. The disks are stretchable and subjected to a magnetic field in axial direction. The time dependent characteristics of thermal conductivity have been considered to scrutinize the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74096-8
更新日期:2020-10-13 00:00:00
abstract::Biological research requires wide-field optical imaging techniques with resolution down to the nanometer scale to study the biological process in a sub-cell or single molecular level. To meet this requirement, wide-field structured illumination method (WFSIM) has been extensively studied. The resolution of WFSIM is de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01521-w
更新日期:2017-05-02 00:00:00
abstract::8-band k · p Hamiltonian together with envelope function approximation and planewave expansion method are applied to calculate the electronic band structure and material gain for Ge1-wSnw/SiyGe1-x-ySnx/Ge1-wSnw quantum wells (QWs) grown on virtual Ge1-zSnz substrates integrated with Si platform. It is clearly shown ho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40146-z
更新日期:2019-03-01 00:00:00
abstract::The development of novel small molecule inhibitors of the cancer-associated tropomyosin 3.1 (Tpm3.1) provides the ability to examine the metabolic function of specific actin filament populations. We have determined the ability of these anti-Tpm (ATM) compounds to regulate glucose metabolism in mice. Acute treatment (1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22946-x
更新日期:2018-03-15 00:00:00
abstract::This study assessed cortical tracking of temporal information in incoming natural speech in seven-month-old infants. Cortical tracking refers to the process by which neural activity follows the dynamic patterns of the speech input. In adults, it has been shown to involve attentional mechanisms and to facilitate effect...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32150-6
更新日期:2018-09-13 00:00:00
abstract::The number of patients with dry eye disease (DED) is increasing, and DED has become an urgent public health problem. A comorbidity of mental disorders has been reported in DED patients. We hypothesized that physical and psychological stressors impair tear secretion. To examine the relationship between stress loading a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39467-w
更新日期:2019-03-04 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-62439-4
更新日期:2020-03-24 00:00:00
abstract::Bitter taste receptors (TAS2Rs) are present in extra-oral tissues, including gut endocrine cells. This study explored the presence and mechanism of action of TAS2R agonists on gut smooth muscle in vitro and investigated functional effects of intra-gastric administration of TAS2R agonists on gastric motility and satiat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15985
更新日期:2015-11-06 00:00:00
abstract::This study aims to examine the long-term effect of adjuvant treatment in Korean Medicine (KM) clinics in ischemic stroke patients, using a national sample cohort from the National Health Insurance Service in Korea between 2010 and 2013. The National Health Insurance Service - National Sample Cohort database from 2002 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19841-w
更新日期:2018-01-26 00:00:00
abstract::BNip1, which functions as a t-SNARE component of the syntaxin18 complex, is localized on the ER membrane and regulates retrograde transport from Golgi to the ER. BNip1 also has a BH3 domain, which generally releases pro-apoptotic proteins from Bcl2-mediated inhibition. Previously we reported that retinal photoreceptor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74360-x
更新日期:2020-10-15 00:00:00