Abstract：
:Stress is one of major factors that cause sleep problems. Hypocretin represents a stress-related neuropeptide and is well known in maintaining physiological wakefulness. The hypocretinergic neurons originate in the lateral hypothalamic area (LHA) and transmit to several brain regions, including the median raphe nuclei (MRNs). The MRNs modulate both fear responses and sleep-wake activity; however, it remains unclear whether stress alters the levels of hypocretin to regulate MRNs and consequently disrupt sleep. In this paper, we employed the inescapable footshock stimuli (IFS) as a stressor and hypothesized that the IFS-induced sleep disruption is mediated by increased hypocretins in the MRNs. Our results demonstrate that the concentrations of hypocretin in the hypothalamus increased after IFS. Rapid eye movement (REM) sleep was reduced after footshock, and microinjection of non-selective hypocretin receptor antagonist TCS-1102 into the MRNs blocked the IFS-induced decrease of REM sleep. Furthermore, administration of hypocretins into the MRNs mimicked the IFS-induced REM sleep reduction. These results conclude that the increased levels of hypocretins in the MRNs mediate the IFS-induced REM sleep reduction.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hsiao YT,Lo Y,Yi PL,Chang FCdoi
10.1038/s41598-019-44731-0subject
Has Abstractpub_date
2019-06-03 00:00:00pages
8198issue
1issn
2045-2322pii
10.1038/s41598-019-44731-0journal_volume
9pub_type
杂志文章abstract：:Platelet-derived growth factor receptor beta (PDGFRβ) affects in numerous human cancers and has been recognized as a promising molecular target for cancer therapies. The overexpression of PDGFRβ could be a biomarker for cancer diagnosis. Radiolabeled ligands having high affinity for the molecular target could be usefu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28529-0
更新日期：2018-07-10 00:00:00
abstract：:The manuscript highlights the efficacy of silver ions to act as a unique probe for the detection of bacterial contamination in water samples. The bacterial cell membrane adherence property of the silver ions was employed to develop two different bacterial detection assays employing colorimetric and electrochemical tec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68803-8
更新日期：2020-07-20 00:00:00
abstract：:Mitochondrial dysfunction and significant changes in metabolic pathways accompany cancer development and are responsible for maintaining the tumor microenvironment. Normal mitochondria can trigger intrinsic apoptosis by releasing cytochrome c into the cytosol. The survival of malignant cells highly depends on the supp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71118-3
更新日期：2020-08-25 00:00:00
abstract：:Uncertainty in the form of risk or ambiguity can arise from the interaction with nature and other players, while strategic uncertainty arises only in interactions with others. Here, we systematically compare binary decisions between a safe option and a potentially higher paying but uncertain option in four experimenta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21962-1
更新日期：2018-02-23 00:00:00
abstract：:Although habitat transformation is one of the main causes of biodiversity loss, there are many examples of species successfully occupying and even proliferating in highly human-modified habitats such are the cities. Thus, there is an increasing interest in understanding the drivers favoring urban life for some species...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03853-z
更新日期：2017-06-14 00:00:00
abstract：:Plasmonic nanostructures can significantly advance broadband visible-light absorption, with absorber thicknesses in the sub-wavelength regime, much thinner than conventional broadband coatings. Such absorbers have inherently very small heat capacity, hence a very rapid response time, and high light power-to-temperatur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07181
更新日期：2014-11-24 00:00:00
abstract：:Corticosteroids have been proved to be ineffective for Guillain-Barré syndrome, but the mechanism remains unknown. In a rabbit model of axonal Guillain-Barré syndrome, treatment with corticosteroids significantly reduced macrophage infiltration in the spinal ventral roots and the survival rate as well as clinical impr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13931
更新日期：2015-09-10 00:00:00
abstract：:Sex hormones fluctuate during the menstrual cycle. Evidence from animal studies suggests similar subtle fluctuations in hippocampal structure, predominantly linked to estrogen. Hippocampal abnormalities have been observed in several neuropsychiatric pathologies with prominent sexual dimorphism. Yet, the potential impa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32833
更新日期：2016-10-07 00:00:00
abstract：:Coffee is a major tropical commodity crop that can provide supplementary habitat for native wildlife. In Asia, coffee production is an increasingly important driver of landscape transformation and shifts between different coffee species is a major dimension of agroforestry trends. Yet few studies have compared the eco...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21401-1
更新日期：2018-02-16 00:00:00
abstract：:Clostridium difficile is a gastrointestinal pathogen but how the bacterium colonises this niche is still little understood. Sortase enzymes covalently attach specific bacterial proteins to the peptidoglycan cell wall and are often involved in colonisation by pathogens. Here we show C. difficile proteins CD2537 and CD3...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08322-1
更新日期：2017-08-23 00:00:00
abstract：:The mammalian central nervous system (CNS) contains various types of neurons with different neuronal functions. In contrast to established roles of cell type-specific transcription factors on neuronal specification and maintenance, whether ubiquitous transcription factors have conserved or differential neuronal functi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34575
更新日期：2016-09-30 00:00:00
abstract：:Compared with the commercially available single nucleotide polymorphism (SNP) chip based on the Bead Chip technology, the solution hybrid selection (SHS)-based target enrichment SNP chip is not only design-flexible, but also cost-effective for genotype sequencing. In this study, we propose to design an animal SNP chip...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09285-z
更新日期：2017-08-17 00:00:00
abstract：:The structure and function of cellular membranes were sustained by redox-enzymes. We studied the interaction between the oxidative stress caused by excessive accumulation of ZnO-nanoparticles (ZnO-NPs) in plants and the role of redox-enzymes that can alleviate this stress. The crude callus extract from pomegranate, wh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76664-4
更新日期：2020-11-12 00:00:00
abstract：:We have developed a plasma cell treatment device called Plasma-on-Chip that enables the real-time monitoring of a single cell culture during plasma treatment. The device consists of three parts: 1) microwells for cell culture, 2) a microplasma device for generating reactive oxygen and nitrogen species (RONS) for use i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41953
更新日期：2017-02-08 00:00:00
abstract：:Several proteins and peptides in saliva were shown to stimulate gingival wound repair, but the role of salivary metabolites in this process remains unexplored. In vitro gingival re-epithelialization kinetics were determined using unstimulated saliva samples from healthy individuals collected during an experimental gin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59988-z
更新日期：2020-02-20 00:00:00
abstract：:Observational studies suggest associations of triglyceride levels with longevity and frailty. This study aimed to test whether the associations are causal. We used data from the Rugao Longevity and Ageing Study, a population-based cohort study performed in Rugao, China. A variant in the APOA5 gene region (rs662799) wa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41579
更新日期：2017-01-30 00:00:00
abstract：:A functional genetic switch from the lactococcal bacteriophage TP901-1, deciding which of two divergently transcribing promoters becomes most active and allows this bi-stable decision to be inherited in future generations requires a DNA region of less than 1 kb. The fragment encodes two repressors, CI and MOR, transcr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65493-0
更新日期：2020-05-26 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-017-15019-y
更新日期：2017-11-10 00:00:00
abstract：:Compared with natural materials, chiral metamaterials have been demonstrated with orders of magnitude stronger chiroptical response, which provides the basis for applications such as ultracompact polarization components and plasmonic-enhanced biosensing. Terahertz chiral metamaterials that allow dynamic polarization c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18472-x
更新日期：2018-01-09 00:00:00
abstract：:The development of a miniaturised device that provides efficient beam manipulation with high transmittance is extremely desirable for the broad range of applications including holography, metalens, and imaging. Recently, the potential of dielectric metasurfaces has been unleashed to efficiently manipulate the beam wit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42444-y
更新日期：2019-04-24 00:00:00
abstract：:The concept of entropy connects the number of possible configurations with the number of variables in large stochastic systems. Independent or weakly interacting variables render the number of configurations scale exponentially with the number of variables, making the Boltzmann-Gibbs-Shannon entropy extensive. In syst...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72422-8
更新日期：2020-09-23 00:00:00
abstract：:Monochamus beetles are the dispersing vectors of the nematode Bursaphelenchus xylophilus, the causative agent of pine wilt disease (PWD). PWD inflicts significant damages in Eurasian pine forests. Symbiotic microorganisms have a large influence in insect survival. The aim of this study was to characterize the bacteria...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23908
更新日期：2016-04-05 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-70343-0
更新日期：2020-08-11 00:00:00
abstract：:Salinization is having a major impact on wetlands and its biota worldwide. Specifically, many migratory animals that rely on wetlands are increasingly exposed to elevated salinity on their nonbreeding grounds. Experimental evidence suggests that physiological challenges associated with increasing salinity may disrupt ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07258-w
更新日期：2017-07-31 00:00:00
abstract：:Amyloid-beta (Aβ)-induced neurotoxicity is a major contributor to the pathologies associated with Alzheimer's disease (AD). The formation of reactive oxygen species (ROS), an early response induced by the peptide and oligomeric derivatives of Aβ, plays a significant role in effecting cellular pathogenesis. Here we emp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04983
更新日期：2014-05-15 00:00:00
abstract：:Resistance to 157 different herbicides and 88% of known sites of action has been observed, with many weeds resistant to two or more modes. Coupled with tighter environmental regulation, this demonstrates the need to identify new modes of action and novel herbicides. The plant sphingolipid biosynthetic enzyme, inositol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44544-1
更新日期：2019-05-30 00:00:00
abstract：:The inhibitory behaviour of non-ionic sugar based N,N'-didodecyl-N,N'-digluconamideethylenediamine gemini surfactant, designated as Glu(12)-2-Glu(12) on mild steel (MS) corrosion in 3.5% NaCl at 30-60 °C was explored using weight loss, PDP, EIS and SEM/EDAX/AFM techniques. The compound inhibited the corrosion of mild ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21175-6
更新日期：2018-02-27 00:00:00
abstract：:Although lizards are often described as having robust neurogenic abilities, only a handful of the more than 6300 species have been explored. Here, we provide the first evidence of homeostatic neurogenesis in the leopard gecko (Eublepharis macularius). We focused our study on the medial cortex, homologue of the mammali...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27880-6
更新日期：2018-06-25 00:00:00
abstract：:The mechanism by which enzymes arose from both abiotic and biological worlds remains an unsolved natural mystery. We postulate that an enzyme can emerge from any sequence of any functional polymer under permissive evolutionary conditions. To support this premise, we have arbitrarily chosen a 50-nucleotide DNA fragment...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11405
更新日期：2015-06-19 00:00:00
abstract：:In Eastern Boundary Current systems, wind-driven upwelling drives nutrient-rich water to the ocean surface, making these regions among the most productive on Earth. Regulation of productivity by changing wind and/or nutrient conditions can dramatically impact ecosystem functioning, though the mechanisms are not well u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27612
更新日期：2016-06-09 00:00:00
