Abstract：
:Amyloid-beta (Aβ)-induced neurotoxicity is a major contributor to the pathologies associated with Alzheimer's disease (AD). The formation of reactive oxygen species (ROS), an early response induced by the peptide and oligomeric derivatives of Aβ, plays a significant role in effecting cellular pathogenesis. Here we employ particularly toxic forms of Aβ with cultured primary cortical/hippocampal neurons to elicit ROS and drive cellular dysfunction. To prevent and even reverse such effects, we utilized a cell-penetrating, peroxisome-targeted, protein biologic--called CAT-SKL. We show the recombinant enzyme enters neurons, reverses Aβ-induced oxidative stress, and increases cell viability. Dramatic restorative effects on damaged neuronal processes were also observed. In addition, we used DNA microarrays to determine Aβ's effects on gene expression in neurons, as well as the ability of CAT-SKL to modify such Aβ-induced expression profiles. Our results suggest that CAT-SKL, a targeted antioxidant, may represent a new therapeutic approach for treatment of disorders, like Alzheimer's disease, that are driven through oxidative stress. Preclinical testing is ongoing.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Giordano CR,Terlecky LJ,Bollig-Fischer A,Walton PA,Terlecky SRdoi
10.1038/srep04983subject
Has Abstractpub_date
2014-05-15 00:00:00pages
4983issn
2045-2322pii
srep04983journal_volume
4pub_type
杂志文章abstract：:Archaea are unique microorganisms that are present in ecological niches of high temperature, pH and salinity. A total of 157 archaea were obtained from thirteen sediment, water and rhizospheric soil samples collected from Rann of Kutch, Gujarat, India. With an aim to screen phosphate solubilizing archaea, a new medium...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-07-28 00:00:00
abstract：:Although there is evidence that non-steroidal anti-inflammatory drugs (NSAIDs) might be able to prevent pancreatic cancer, the findings from epidemiological studies have been inconsistent. In this paper, we conducted a meta-analysis of observational studies to examine this possibility. We searched PubMed and Embase fo...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
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更新日期：2015-10-21 00:00:00
abstract：:Mustard aphid, also known as turnip aphid (Lipaphis erysimi) is a major insect pest of rapeseed-mustard group of crops. Tremendous economic significance has led to substantial basic research involving gene-expression studies in this insect species. In qRT-PCR analysis of gene-expression, normalization of data against ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25883
更新日期：2016-05-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-41923-6
更新日期：2019-04-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-06-18 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2018-05-16 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2016-08-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-06-17 00:00:00
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pub_type： 杂志文章
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更新日期：2017-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-10-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-01-10 00:00:00
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pub_type： 已发布勘误
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-06-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-11-08 00:00:00
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