Abstract：
:Although lizards are often described as having robust neurogenic abilities, only a handful of the more than 6300 species have been explored. Here, we provide the first evidence of homeostatic neurogenesis in the leopard gecko (Eublepharis macularius). We focused our study on the medial cortex, homologue of the mammalian hippocampal formation. Using immunostaining, we identified proliferating pools of neural stem/progenitor cells within the sulcus septomedialis, the pseudostratified ventricular zone adjacent to the medial cortex. Consistent with their identification as radial glia, these cells expressed SOX2, glial fibrillary acidic protein, and Vimentin, and demonstrated a radial morphology. Using a 5-bromo-2'-deoxyuridine cell tracking strategy, we determined that neuroblast migration from the ventricular zone to the medial cortex takes ~30-days, and that newly generated neuronal cells survived for at least 140-days. We also found that cell proliferation within the medial cortex was not significantly altered following rupture of the tail spinal cord (as a result of the naturally evolved process of caudal autotomy). We conclude that the sulcus septomedialis of the leopard gecko demonstrates all the hallmarks of a neurogenic niche.
journal_name
Sci Repjournal_title
Scientific reportsauthors
McDonald RP,Vickaryous MKdoi
10.1038/s41598-018-27880-6subject
Has Abstractpub_date
2018-06-25 00:00:00pages
9648issue
1issn
2045-2322pii
10.1038/s41598-018-27880-6journal_volume
8pub_type
杂志文章abstract：:A new miniplate applied differently from conventional application method for bone fixation has been developed. The novel approach is the insertion of the screw into the bone before miniplate installation. This study aimed to assess the stress distribution of a newly designed Yang's Keyhole (YK)- plate for segmental-bo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27186-7
更新日期：2018-06-12 00:00:00
abstract：:Hand, foot, and mouth disease (HFMD), predominantly occurs among infants and children. Previous studies have shown that suitable, stable temperatures favor HFMD virus reproduction; however, temperature fluctuations also affect virus transmission, and there are, so far, no studies concerning the association between suc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59265-z
更新日期：2020-02-13 00:00:00
abstract：:Homogeneous target dose distribution in intensity-modulated radiotherapy (IMRT) for sinonasal cancer (SNC) is challenging to achieve. To solve this problem, we established and evaluated a basal-dose-compensation (BDC) optimization approach, in which the treatment plan is further optimized based on the initial plans. G...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15361
更新日期：2015-10-26 00:00:00
abstract：:Dendritic spines are the postsynaptic sites of most excitatory synapses in the brain, and spine enlargement and shrinkage give rise to long-term potentiation and depression of synapses, respectively. Because spine structural plasticity is accompanied by remodeling of actin scaffolds, we hypothesized that the filamento...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32897
更新日期：2016-09-06 00:00:00
abstract：:Breast cancer in young women is typically with higher proportion of adverse pathological features. Breast cancer with BRCA1 mutation is often early-onset, and is usually associated with triple negative phenotpe. In this study, we aim to analyze the clinicopathological characteristics and prognosis in young breast canc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05360
更新日期：2014-06-19 00:00:00
abstract：:Variability in the x-ray tube current used in computed tomography may affect quantitative features extracted from the images. To investigate these effects, we scanned the Credence Cartridge Radiomics phantom 12 times, varying the tube current from 25 to 300 mA∙s while keeping the other acquisition parameters constant....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20713-6
更新日期：2018-02-05 00:00:00
abstract：:We propose a homomorphic search protocol based on quantum homomorphic encryption, in which a client Alice with limited quantum ability can give her encrypted data to a powerful but untrusted quantum server and let the server search for her without decryption. By outsourcing the interactive key-update process to a trus...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61791-9
更新日期：2020-03-20 00:00:00
abstract：:The intensity of a nonlinear terahertz (THz) source is primarily given by its spectral density. In this letter, we introduce triangular Selinium (Se) as a novel THz emitter and show numerically its superior properties to the currently used crystals for intense THz generation. The excellent phase matching enables the a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08059
更新日期：2015-01-27 00:00:00
abstract：:Antimicrobial resistance (AMR) is a major public health threat. Plasmids are able to transfer AMR genes among bacterial isolates. Whole genome sequencing (WGS) is a powerful tool to monitor AMR determinants. However, plasmids are difficult to reconstruct from WGS data. This study aimed to improve the characterization,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61158-0
更新日期：2020-03-09 00:00:00
abstract：:This meta-analysis aims to evaluate whether the extant literature justifies any definitive conclusions about whether and how SITBs may be associated with brain differences. A total of 77 papers (N = 4,903) published through January 1, 2019 that compared individuals with and without SITBs were included, resulting in 88...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-020-59490-6
更新日期：2020-02-12 00:00:00
abstract：:Hallucinogens induce the head-twitch response (HTR), a rapid reciprocal head movement, in mice. Although head twitches are usually identified by direct observation, they can also be assessed using a head-mounted magnet and a magnetometer. Procedures have been developed to automate the analysis of magnetometer recordin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65264-x
更新日期：2020-05-20 00:00:00
abstract：:The mammalian Major Histocompatibility Complex (MHC) region contains several gene families characterized by highly polymorphic loci with extensive nucleotide diversity, copy number variation of paralogous genes, and long repetitive sequences. This structural complexity has made it difficult to construct a reliable ref...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45518
更新日期：2017-03-31 00:00:00
abstract：:We studied whether in patients with stable COPD blood gases (BG), especially oxygenated hemoglobin (OxyHem) as a novel biomarker confer information on disease burden and prognosis and how this adds to the information provided by the comorbidity pattern and systemic inflammation. Data from 2137 patients (GOLD grades 1-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67197-x
更新日期：2020-06-29 00:00:00
abstract：:Obesity, often represented by higher body mass index (BMI), is not yet fully understood as a potential risk factor for poor clinical outcomes of prostate cancer (PCa) after radical prostatectomy (RP). This study aimed to evaluate the relationship between BMI and biochemical recurrence (BCR)-free survival in RP patient...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30473-y
更新日期：2018-08-10 00:00:00
abstract：:Amphibian skin is rich in mucous glands and poison glands, secreting substances important for gas exchange and playing a fundamental role in chemical defense against predators and microorganisms. In the caecilian Siphonops annulatus (Mikan, 1920) we observed a concentration of enlarged mucous glands in the head region...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22005-5
更新日期：2018-02-23 00:00:00
abstract：:Cell and animal studies have demonstrated that circadian rhythm is governed by autonomous rhythmicity of clock genes. Although disturbances in circadian rhythm have been implicated in metabolic disease development, it remains unknown whether muscle circadian rhythm is altered in human models of type 2 diabetes. Here w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35047
更新日期：2016-10-19 00:00:00
abstract：:Tobacco smoking is common in HIV-infected patients, and is prevalent among intravenous opiate abusers. Conversely, intravenous opiate abusers are more likely HIV-infected, and opiate abuse is associated with more severe neuroinflammation. Given the coincident use of tobacco smoking among HIV-infected intravenous drug ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70374-7
更新日期：2020-08-19 00:00:00
abstract：:Great Indian Bustard (GIB) is listed as Critically Endangered, with less than 250 individuals surviving in three fragmented populations. The species is under tremendous threat due to various anthropogenic pressures. Effective management and conservation of GIB requires a proper monitoring protocol, which we propose us...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48193-2
更新日期：2019-08-12 00:00:00
abstract：:Increasing evidence indicates that static magnetic fields (SMF) reduce cortical activity in both human and animal models. The aim of this work was to investigate the effect of SMF on epileptiform cortical activity, a condition related to an abnormal increase in neuronal excitability. The first experimental block inclu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33808-x
更新日期：2018-10-30 00:00:00
abstract：:This study was to assess the safety and efficacy of artificial ascitetes in assisting CT-guided cryoablation of hepatic tumors adjacent to the gastrointestinal (GI) tract. A total of 84 patients with peripheral hepatic tumors adjacent to the GI tract, who were treated cryoablation, were included in this retrospective ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17023-8
更新日期：2017-11-30 00:00:00
abstract：:Large-scale studies have not been conducted to assess whether serum hypobicarbonatemia increases the risk for kidney function deterioration and mortality among East-Asians. We aimed to determine the association between serum total CO2 (TCO2) concentrations measured at the first outpatient visit and clinical outcomes. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81332-2
更新日期：2021-01-18 00:00:00
abstract：:Modified constraint-induced movement therapy (mCIMT) improves upper limb (UL) motor execution in unilateral cerebral palsy (uCP). As these children also show motor planning deficits, action-observation training (AOT) might be of additional value. Here, we investigated the combined value of AOT to mCIMT on UL kinematic...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-67427-2
更新日期：2020-06-26 00:00:00
abstract：:Cytotoxic T lymphocyte (CTL) responses against the HIV Gag protein are associated with lowering viremia; however, immune control is undermined by viral escape mutations. The rapid viral mutation rate is a key factor, but recombination may also contribute. We hypothesized that CTL responses drive the outgrowth of uniqu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11253
更新日期：2015-06-17 00:00:00
abstract：:Next generation sequencing has disrupted genetic testing, allowing far more scope in the tests applied. The appropriate sections of the genome to be tested can now be readily selected, from single mutations to whole-genome sequencing. One product offering within this spectrum are focused exomes, targeting ~5,000 genes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60215-y
更新日期：2020-02-24 00:00:00
abstract：:Discs Large Homolog 5 (DLG5) plays an important role in the maintenance of epithelial cell polarity. Recent research showed that DLG5 is decreased in Yes-associated protein (YAP)-overexpressing cells. However, the exact relationship between DLG5 and YAP is not clear. In this study, we showed that loss of DLG5 promoted...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42125
更新日期：2017-02-07 00:00:00
abstract：:One of the key motivations in producing 3D structures has always been the realization of metamaterials with effective constituent properties that can be tuned in all propagation directions at various frequencies. Here, we report the investigation of spatially oriented "Nanograter" structures with orientation-dependent...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28764
更新日期：2016-06-30 00:00:00
abstract：:Despite a large body of evidence showing the pandemic of chronic kidney disease, the impact of pre-operative kidney function on the risk of post-operative pulmonary complications (PPCs) is not well known. We used multivariable logistic regression analyses with 3-level hierarchical adjustments to identify the associati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06842-4
更新日期：2017-07-26 00:00:00
abstract：:Efficient interventions to reduce blood triglycerides are few; newer and more tolerable intervention targets are needed. Understanding the molecular mechanisms underlying blood triglyceride levels variation is key to identifying new therapies. To explore the role of epigenetic mechanisms on triglyceride levels, a bloo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09552-z
更新日期：2017-09-11 00:00:00
abstract：:Around 350 million tonnes of plastics are annually produced worldwide. A remarkable percentage of these products is dispersed in the environment, finally reaching and dispersed in the marine environment. Recent field surveys detected microplastics' concentrations in the Mediterranean Sea. The most commonly polymers fo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74543-6
更新日期：2020-11-16 00:00:00
abstract：:Cesium (Cs) removal from nuclear liquid wastewater has become an emerging issue for safeguarding public health after the accident at the Fukushima Daiichi Nuclear Power Plant. A novel macrocyclic ligand of o-benzo-p-xylyl-22-crown-6-ether (OBPX22C6) was developed and successfully immobilized onto mesoporous silica for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19937
更新日期：2016-01-28 00:00:00
