Abstract:
:Hand, foot, and mouth disease (HFMD), predominantly occurs among infants and children. Previous studies have shown that suitable, stable temperatures favor HFMD virus reproduction; however, temperature fluctuations also affect virus transmission, and there are, so far, no studies concerning the association between such fluctuations and the incidence of HFMD. The objective of this study was to map the spatial-temporal distribution of HFMD incidence and quantify the long-term effects of temperature fluctuations on HFMD incidence in children. HFMD cases in children under five, from January 2009 to December 2013, in Beijing, Tianjin, and Hebei provinces of China, were used in this study. The GeoDetector and Bayesian space-time hierarchy models were employed to explore the spatial-temporal association between temperature fluctuations and HFMD incidence. The results indicate that HFMD incidence had significant spatial stratified heterogeneity (GeoDetector q-statistic = 0.83, p < 0.05), and that areas with higher risk mainly appeared in metropolises and their adjacent regions. HFMD transmission was negatively associated with temperature fluctuations. A 1 °C increase in the standard deviation of maximum and minimum temperatures was associated with decreases of 8.22% and 11.87% in the risk of HFMD incidence, respectively. The study suggests that large temperature fluctuations affect virus growth or multiplication, thereby inhibiting the activity of the virus and potentially even leading to its extinction, and consequently affecting the spatial-temporal distribution of HFMD. The findings can serve as a reference for the practical control of this disease and offer help in the rational allocation of medical resources.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Xu C,Zhang X,Wang L,Zhou Y,Xiao G,Liao Jdoi
10.1038/s41598-020-59265-zsubject
Has Abstractpub_date
2020-02-13 00:00:00pages
2541issue
1issn
2045-2322pii
10.1038/s41598-020-59265-zjournal_volume
10pub_type
杂志文章abstract::Sea surface temperature (SST) patterns can - as surface climate forcing - affect weather and climate at large distances. One example is El Niño-Southern Oscillation (ENSO) that causes climate anomalies around the globe via teleconnections. Although several studies identified and characterized these teleconnections, ou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45423-5
更新日期:2019-06-19 00:00:00
abstract::There is increasing evidence that extracellular cGMP modulates glutamatergic neurotransmission and some forms of learning. However, the underlying mechanisms remain unknown. We proposed the hypotheses that extracellular cGMP may regulate membrane expression of AMPA receptors. To do this extracellular cGMP should act o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18024-3
更新日期:2017-12-15 00:00:00
abstract::The health effects of the endocrine disruptor Bisphenol A (BPA) led to its partial replacement with Bisphenol S (BPS) in several products including food containers, toys, and thermal paper receipts. The acute effects of BPS on myocardial contractility are unknown. We perfused mouse hearts from both sexes for 15 min wi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52350-y
更新日期:2019-11-04 00:00:00
abstract::Post-infectious bronchiolitis obliterans (BO) could be diagnosed via spirometry and chest computed tomography (CT); however, these tests are limited in infants. We aimed to evaluate the utility of lung clearance index (LCI) and air-trapping lung volume from chest CT in infants. This prospective study included 20 infan...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15330-8
更新日期:2017-11-09 00:00:00
abstract::Molecular imaging is a powerful tool for investigating intracellular signalling, but it is difficult to acquire conventional fluorescence imaging from photoreceptive cells. Here we demonstrated that human opsin5 (OPN5) photoreceptor mediates light-induced Ca(2+) response in human embryonic kidney (HEK293) and mouse ne...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05352
更新日期:2014-06-19 00:00:00
abstract::If a cultural feature is transmitted over generations and exposed to stochastic selection when spreading in a population, its evolution may be governed by statistical laws and be partly predictable, as in the case of genetic evolution. Music exhibits steady changes of styles over time, with new characteristics develop...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52380-6
更新日期:2019-11-05 00:00:00
abstract::The present study evaluates the potential of Sar gassum muticum (Sar) and Jan ia rubens (Jan) seaweeds for enhancing growth and mitigating soil-salinity in chickpea (Cicer arietinum L.). Under control conditions, Sar and Jan extracts improved chickpea growth which was attributed to their potential for increasing photo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07692-w
更新日期:2017-09-05 00:00:00
abstract::Next generation sequencing is transforming clinical medicine and genome research, providing a powerful route to establishing molecular diagnoses for genetic conditions; however, challenges remain given the volume and complexity of genetic variation. A number of methods integrate patient phenotype and genotypic data to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13841-y
更新日期:2017-10-18 00:00:00
abstract::Reactive oxygen and nitrogen species (RONS), e.g. generated by cold physical plasma (CPP) or photodynamic therapy, interfere with redox signaling pathways of mammalian cells, inducing downstream consequences spanning from migratory impairment to apoptotic cell death. However, the more austere impact of RONS on cancer ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75514-7
更新日期:2020-10-29 00:00:00
abstract::Sphingolipids are essential constituents of the plasma membrane (PM) and play an important role in signal transduction by modulating clustering and dynamics of membrane receptors. Changes in lipid composition are therefore likely to influence receptor organisation and function, but how this precisely occurs is difficu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20693
更新日期:2016-02-12 00:00:00
abstract::Developmental changes in salamander skulls, before and after metamorphosis, affect the feeding capabilities of these animals. How changes in cranial morphology and tissue properties affect the function of the skull are key to decipher the early evolutionary history of the crown-group of salamanders. Here, 3D cranial b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10553-1
更新日期:2017-08-31 00:00:00
abstract::Aerobic organisms evolved conserved mechanisms controlling the generation of reactive oxygen species (ROS) to maintain redox homeostasis signaling and modulate signal transduction, gene expression and cellular functional responses under physiological conditions. The production of ROS by mitochondria is essential in th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49766-x
更新日期:2019-09-13 00:00:00
abstract::Next Generation Sequencing is dramatically increasing the number of known protein sequences, with related experimentally determined protein structures lagging behind. Structural bioinformatics is attempting to close this gap by developing approaches that predict structure-level characteristics for uncharacterized prot...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36679
更新日期:2016-11-18 00:00:00
abstract::Free living nematodes (FLN) are microscopic worms found in all soils. While many FLN species are beneficial to crops, some species cause significant damage by feeding on roots and vectoring viruses. With the planned legislative removal of traditionally used chemical treatments, identification of new ways to manage FLN...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18797-7
更新日期:2018-01-23 00:00:00
abstract::Malaria surveillance data provide opportunity to develop forecasting models. Seasonal variability in environmental factors correlate with malaria transmission, thus the identification of transmission patterns is useful in developing prediction models. However, with changing seasonal transmission patterns, either due t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02560-z
更新日期:2017-06-01 00:00:00
abstract::Primary Sjögren's syndrome (pSS) is a complex autoimmune disease characterized by dysfunction of secretory epithelia with only palliative therapy. Patients present with a constellation of symptoms, and the diversity of symptomatic presentation has made it difficult to understand the underlying disease mechanisms. In t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71669-5
更新日期:2020-09-16 00:00:00
abstract::The diversity of DNA sequencing methods and algorithms for genome assemblies presents scientists with a bewildering array of choices. Here, we construct and compare eight candidate assemblies combining overlapping shotgun read data, mate-pair and Chicago libraries and four different genome assemblers to produce a high...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19430-x
更新日期:2018-01-24 00:00:00
abstract::Immunoproteasomes are known for their involvement in antigen presentation. However, their broad tissue presence and other evidence are indicative of nonimmune functions. We examined a role for immunoproteasomes in cellular responses to the endogenous and environmental carcinogen formaldehyde (FA) that binds to cytosol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00757-w
更新日期:2017-04-05 00:00:00
abstract::The patterns of life exhibited by large populations have been described and modeled both as a basic science exercise and for a range of applied goals such as reducing automotive congestion, improving disaster response, and even predicting the location of individuals. However, these studies have had limited access to c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02625
更新日期:2013-01-01 00:00:00
abstract::Platelet aggregation and adhesion are critically involved in both normal hemostasis and thrombosis during vascular injury. Before any surgery, it is important to identify the number of platelets and their functionality to reduce the risk of bleeding; therefore, platelet function testing is a requirement. We introduce ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52953-5
更新日期:2019-11-11 00:00:00
abstract::Canine distemper virus (CDV) is the cause of a multisystem disease in domestic dogs and wild animals, infecting more than 20 carnivore and non-carnivore families and even infecting human cell lines in in vitro conditions. Phylogenetic classification based on the hemagglutinin gene shows 17 lineages with a phylogeograp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52345-9
更新日期:2019-10-31 00:00:00
abstract::Free-living amoebae are well known for their role in controlling microbial community composition through grazing, but some groups, namely Acanthamoeba species, also frequently serve as hosts for bacterial symbionts. Here we report the first identification of a bacterial symbiont in the testate amoeba Cochliopodium. Th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03642-8
更新日期:2017-06-13 00:00:00
abstract::Plutonium isotopes have primarily been injected to the stratosphere by the atmospheric nuclear weapon tests and the burn-up of the SNAP-9A satellite. Here we show by using published data that the stratospheric plutonium exponentially decreased with apparent residence time of 1.5 ± 0.5 years, and that the temporal vari...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15707
更新日期:2015-10-28 00:00:00
abstract::The prevalence of a macrophage phenotype in atherosclerotic plaque may drive its progression and/or instability. Macrophages from coronary plaques are not available, and monocyte-derived macrophages (MDMs) are usually considered as a surrogate. We compared the MDM profile obtained from coronary artery disease (CAD) pa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44847-3
更新日期:2019-06-18 00:00:00
abstract::The Gram-negative bacterium B. pertussis is the causative agent of whooping cough. This infection is re-emerging and new features related to Bordetella pathogenesis and microbiology could be relevant to defeat it. Therefore, we focused our attention on BP1253, a predicted exported protein from B. pertussis erroneously...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53171-9
更新日期:2019-11-19 00:00:00
abstract::Nanoporous structures have proven as an effective way for enhanced electrochromic performance by providing a large surface area can get fast ion/electron transfer path, leading to larger optical modulation and fast response time. Herein, for the first time, application of vacuum cathodic arc plasma (CAP) deposition te...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65191-x
更新日期:2020-05-21 00:00:00
abstract::Intrahepatic cholangiocarcinoma (IHCC) is a highly aggressive malignancy with a poor prognosis. It is thought to originate from cholangiocytes, which are the component cells of intrahepatic bile ducts. However, as patients with viral hepatitis often develop IHCC, it has been suggested that transformed hepatocytes may ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21121-6
更新日期:2018-02-12 00:00:00
abstract::In this study, an interval optimization model is developed to maximize the benefits of a water rights transfer system that comprises industry and agriculture sectors in the Ningxia Hui Autonomous Region in China. The model is subjected to a number of constraints including water saving potential from agriculture and ec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02734-9
更新日期:2017-06-14 00:00:00
abstract::Visual field testing is an important endpoint in glaucoma clinical trials, and the testing paradigm used can have a significant impact on the sample size requirements. To investigate this, this study included 353 eyes of 247 glaucoma patients seen over a 3-year period to extract real-world visual field rates of change...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23220-w
更新日期:2018-03-20 00:00:00
abstract::Parkinson's disease (PD) is a degenerative disorder that affects the central nervous system. PD-related alterations in structural and functional neuroimaging have not been fully explored. This study explored multi-modal PD neuroimaging and its application for predicting clinical scores on the Movement Disorder Society...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/srep38070
更新日期:2016-11-30 00:00:00