HIV-infected sex workers with beneficial HLA-variants are potential hubs for selection of HIV-1 recombinants that may affect disease progression.

abstract：:We describe a technique for imaging single mRNAs in living cells based on fluorescent protein (FP) complementation. We employ the high affinity interaction between the bacterial phage MS2/PP7 coat proteins and their respective RNA binding motifs as an RNA scaffold to bring two halves of a split-FP together to image si...

journal_title：Scientific reports

authors： Wu B,Chen J,Singer RH

更新日期：2014-01-09 00:00:00

abstract：:Two related models for T cell signalling initiation suggest either that T cell receptor (TCR) engagement leads to its recruitment to ordered membrane domains, often referred to as lipid rafts, where signalling molecules are enriched or that ordered TCR-containing membrane nanodomains coalesce upon TCR engagement. That...

journal_title：Scientific reports

authors： Dinic J,Riehl A,Adler J,Parmryd I

更新日期：2015-05-08 00:00:00

abstract：:In applications involving large tissue specimens that have been sectioned into smaller tissue fragments, manual reconstruction of a "pseudo whole-mount" histological section (PWMHS) can facilitate (a) pathological disease annotation, and (b) image registration and correlation with radiological images. We have previous...

journal_title：Scientific reports

authors： Penzias G,Janowczyk A,Singanamalli A,Rusu M,Shih N,Feldman M,Stricker PD,Delprado W,Tiwari S,Böhm M,Haynes AM,Ponsky L,Viswanath S,Madabhushi A

更新日期：2016-07-26 00:00:00

abstract：:The first instar larva of a species of the Australian endemic genus Aenigmetopia Malloch is described for the first time, along with the first instar larvae of three other Australian species representing the genera Amobia Robineau-Desvoidy and Protomiltogramma Townsend. Larval morphology was analysed using a combinati...

journal_title：Scientific reports

authors： Szpila K,Walczak K,Johnston NP,Pape T,Wallman JF

更新日期：2021-01-29 00:00:00

abstract：:A key to the success of chimeric antigen receptor (CAR) T-cell based therapies greatly rely on the capacity to identify and target antigens with expression restrained to tumor cells. Here we present a strategy to generate CAR T-cells that are only effective locally (tumor tissue), potentially also increasing the choic...

journal_title：Scientific reports

authors： Juillerat A,Marechal A,Filhol JM,Valogne Y,Valton J,Duclert A,Duchateau P,Poirot L

更新日期：2017-01-20 00:00:00

abstract：:Galvanic vestibular stimulation (GVS) can be applied to induce the feeling of directional virtual head motion by stimulating the vestibular organs electrically. Conventional studies used a two-pole GVS, in which electrodes are placed behind each ear, or a three-pole GVS, in which an additional electrode is placed on t...

journal_title：Scientific reports

authors： Aoyama K,Iizuka H,Ando H,Maeda T

更新日期：2015-05-11 00:00:00

abstract：:Bone metastasis of breast cancer cells is a major concern, as it causes increased morbidity and mortality in patients. Bone tissue-derived CXCL12 preferentially recruits breast cancer cells expressing CXCR4 to bone metastatic sites. Thus, understanding how CXCR4 expression is regulated in breast cancer cells could sug...

journal_title：Scientific reports

authors： Masuda T,Endo M,Yamamoto Y,Odagiri H,Kadomatsu T,Nakamura T,Tanoue H,Ito H,Yugami M,Miyata K,Morinaga J,Horiguchi H,Motokawa I,Terada K,Morioka MS,Manabe I,Iwase H,Mizuta H,Oike Y

更新日期：2015-03-16 00:00:00

abstract：:Climate-driven environmental change and land-use change often interact in their impact on biodiversity, but these interactions have received little scientific attention. Here we study the effects of climate-driven environmental variation (i.e. vegetation greenness) and land-use (protected versus unprotected areas) on ...

journal_title：Scientific reports

authors： Santangeli A,Spiegel O,Bridgeford P,Girardello M

更新日期：2018-08-29 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Khalid MW,Ahmed R,Yetisen AK,AlQattan B,Butt H

更新日期：2018-04-18 00:00:00

abstract：:The digit ratio has been used as a retrospective noninvasive biomarker to investigate the putative effects of prenatal exposure to androgens. In recent years, many scholars have paid attention to the association between 2D:4D (the second and fourth digits) and prostatic cancer. This study explored the prognostic signi...

journal_title：Scientific reports

authors： Li G,Sun K,Guo J,Li S,Li B,Cao J,Lu P,Yang J,Zhang Y,Yang X,Gao L,He Y,Cui T,Ma B

更新日期：2017-07-12 00:00:00

abstract：:Stroke is a leading cause of death and the leading cause of long-term disability, but its electrophysiological basis is poorly understood. Characterizing acute ischemic neuronal activity dynamics is important for understanding the temporal and spatial development of ischemic pathophysiology and determining neuronal ac...

journal_title：Scientific reports

authors： Wann EG,Wodeyar A,Srinivasan R,Frostig RD

更新日期：2020-12-08 00:00:00

abstract：:The p38 MAPKs play important roles in the regulation of balance between cell survival and cell death on the development of various cancers. However, the roles of p38 MAPKs regulating apoptotic effects on Leydig tumor cells remain unclear. In the present study, we showed that cordycepin (3'-deoxyadenosine) selectively ...

journal_title：Scientific reports

authors： Pan BS,Wang YK,Lai MS,Mu YF,Huang BM

更新日期：2015-08-25 00:00:00

abstract：:Bezafibrate (BzF) is eliminated by renal excretion and dosage must be reduced in patients with chronic kidney disease (CKD). There is a concern that BzF causes a further deterioration in renal function in patients with CKD. This study assessed whether BzF discontinuation or dose reduction in CKD patients improves rena...

journal_title：Scientific reports

authors： Zingerman B,Ziv D,Feder Krengel N,Korzets A,Matok I

更新日期：2020-11-13 00:00:00

abstract：:Recent clinical trials have investigated the benefit of combining tyrosine kinase inhibitors (TKIs) and cytoreductive nephrectomy (CN) in patients with metastatic renal cell carcinoma. Our goal is to determine whether the perioperative use of TKIs increases the postoperative morbidity following CN in renal cell carcin...

journal_title：Scientific reports

authors： Carvalho FLF,Zheng C,Witmer K,O'neill J,Lynch JH,Kowalczyk KJ

更新日期：2019-10-24 00:00:00

abstract：:Biological sulfate-reducing bacteria (SRB) may be effective in removing toxic lead and mercury ions (Pb(II) and Hg(II)) from wet flue gas desulfurization (FGD) wastewater through anaerobic sulfite reduction. To confirm this hypothesis, a sulfite-reducing up-flow anaerobic sludge blanket reactor was set up to treat FGD...

journal_title：Scientific reports

authors： Zhang L,Lin X,Wang J,Jiang F,Wei L,Chen G,Hao X

更新日期：2016-07-26 00:00:00

abstract：:Recent studies have shown that cellular metabolism plays an important role in regulating immune cell functions. In immune cell differentiation, both interleukin-17-producing T (Th17) cells and dendritic cells (DCs) exhibit increased glycolysis through the upregulation of glycolytic enzymes, such as hexokinase-2 (HK2)....

journal_title：Scientific reports

authors： Okano T,Saegusa J,Nishimura K,Takahashi S,Sendo S,Ueda Y,Morinobu A

更新日期：2017-02-10 00:00:00

abstract：:Antibody humanization is a key step in the preclinical phase of the development of therapeutic antibodies, originally developed and tested in non-human models (most typically, in mouse). The standard technique of Complementarity-Determining Regions (CDR) grafting into human Framework Regions of germline sequences has ...

journal_title：Scientific reports

authors： Clavero-Álvarez A,Di Mambro T,Perez-Gaviro S,Magnani M,Bruscolini P

更新日期：2018-10-04 00:00:00

abstract：:Traditional radiomics models mainly rely on explicitly-designed handcrafted features from medical images. This paper aimed to investigate if deep features extracted via transfer learning can generate radiomics signatures for prediction of overall survival (OS) in patients with Glioblastoma Multiforme (GBM). This study...

journal_title：Scientific reports

authors： Lao J,Chen Y,Li ZC,Li Q,Zhang J,Liu J,Zhai G

更新日期：2017-09-04 00:00:00

abstract：:Lactobacillus species are the predominant vaginal microbiota found in healthy women of reproductive age and help to prevent pathogen infection by producing lactic acid, H2O2 and anti-microbial compounds. Identification of novel vaginal Lactobacillus isolates that exhibit efficient colonisation and secrete anti-Candida...

journal_title：Scientific reports

authors： Jang SJ,Lee K,Kwon B,You HJ,Ko G

更新日期：2019-05-31 00:00:00

abstract：:Despite the efficacy of synthetic fungicides in controlling postharvest diseases, public concerns regarding chemical residues in food and an increase in drug-resistant strains of pathogens have led to a need for new agents to control postharvest diseases. The current study was performed to find control agents of micro...

journal_title：Scientific reports

authors： Kim JD,Park MY,Jeon BJ,Kim BS

更新日期：2019-09-19 00:00:00

abstract：:Variations in isotopic composition of water vapor in the atmosphere is an important indicator of the processes within the hydrological cycle. Isotopic signature of water vapor and precipitation can be helpful in partitioning evaporation and transpiration fluxes. It is well known that transpiration from forested region...

journal_title：Scientific reports

authors： Pradhan R,Singh N,Singh RP

更新日期：2019-12-09 00:00:00

abstract：:Night-workers, transcontinental travelers and individuals that regularly shift their sleep timing, suffer from circadian desynchrony and are at risk to develop metabolic disease, cancer, and mood disorders, among others. Experimental and clinical studies provide evidence that food intake restricted to the normal activ...

journal_title：Scientific reports

authors： Escobar C,Espitia-Bautista E,Guzmán-Ruiz MA,Guerrero-Vargas NN,Hernández-Navarrete MÁ,Ángeles-Castellanos M,Morales-Pérez B,Buijs RM

更新日期：2020-04-10 00:00:00

abstract：:Multi-drug resistant Pseudomonas aeruginosa has increased progressively and impedes further regression in mortality in burn patients. Such wound infections serve as bacterial reservoir for nosocomial infections and are associated with significant morbidity and costs. Anti-microbial polycationic dendrimers G3KL and G3R...

journal_title：Scientific reports

authors： Abdel-Sayed P,Kaeppeli A,Siriwardena T,Darbre T,Perron K,Jafari P,Reymond JL,Pioletti DP,Applegate LA

更新日期：2016-02-25 00:00:00

abstract：:Here we show that electrical tuning of the sensitivity of chemitransistor sensors, namely field-effect-transistors (FETs) exploiting nano/mesostructured sensing materials, can be used to effectively address two chief problems of state-of-the-art gas sensors, specifically fabrication reliability and degradation by agin...

journal_title：Scientific reports

authors： Lazzerini GM,Strambini LM,Barillaro G

更新日期：2013-01-01 00:00:00

abstract：:The goal of this study was to develop a cheap and simple medium and to optimize fermentation parameters for fibrinolytic enzyme production by Bacillus subtilis WR350. A low-cost medium containing 35 g/L sucrose, 20 g/L corn steep powder and 2 g/L MgSO4·7H2O was developed via single-factor and orthogonal experiments. A...

journal_title：Scientific reports

authors： Wu R,Chen G,Pan S,Zeng J,Liang Z

更新日期：2019-05-02 00:00:00

abstract：:Marigold (Tagetes erecta L.) is an important ornamental plant with a wide variety of flower colors. Despite its economic value, few biochemical and molecular studies have explored the generation of flower color in this species. To study the mechanism underlying marigold petal color, we performed a metabolite analysis ...

journal_title：Scientific reports

authors： Zhang H,Zhang S,Zhang H,Chen X,Liang F,Qin H,Zhang Y,Cong R,Xin H,Zhang Z

更新日期：2020-10-08 00:00:00

abstract：:The FDA-approved prophylactic antimalarial drug atovaquone (ATO) recently was repurposed as an antitumor drug. Studies show that ATO exerts a profound antiproliferative effect in several cancer cells, including breast, ovarian, and glioma. Analogous to the mechanism of action proposed in parasites, ATO inhibits mitoch...

journal_title：Scientific reports

authors： Cheng G,Hardy M,Topchyan P,Zander R,Volberding P,Cui W,Kalyanaraman B

更新日期：2020-10-21 00:00:00

abstract：:Rabi splitting and Fano resonance are well-known physical phenomena in conventional quantum systems as atoms and quantum dots, arising from strong interaction between two quantum states. In recent years similar features have been observed in various nanophotonic and nanoplasmonic systems. Yet, realization of strong in...

journal_title：Scientific reports

authors： Liu Z,Li J,Liu Z,Li W,Li J,Gu C,Li ZY

更新日期：2017-08-14 00:00:00

abstract：:Network alignment (NA) compares networks with the goal of finding a node mapping that uncovers highly similar (conserved) network regions. Existing NA methods are homogeneous, i.e., they can deal only with networks containing nodes and edges of one type. Due to increasing amounts of heterogeneous network data with nod...

journal_title：Scientific reports

authors： Gu S,Johnson J,Faisal FE,Milenković T

更新日期：2018-08-21 00:00:00

abstract：:Maternal obesity and overnutrition during pregnancy and lactation can program an increased risk of obesity in offspring. In this context, improving maternal metabolism may help reduce the intergenerational transmission of obesity. Here we show that, in Sprague-Dawley rats, selectively altering obese maternal gut micro...

journal_title：Scientific reports

authors： Paul HA,Bomhof MR,Vogel HJ,Reimer RA

更新日期：2016-02-12 00:00:00