AutoStitcher: An Automated Program for Efficient and Robust Reconstruction of Digitized Whole Histological Sections from Tissue Fragments.

abstract：:An increase of nucleolar number and size has made nucleoli essential markers for cytology and tumour development. However, the underlying basis for their structural integrity and abundance remains unclear. Protein phosphatase PPM1D was found to be up-regulated in different carcinomas including breast cancers. Here, we...

journal_title：Scientific reports

authors： Kozakai Y,Kamada R,Furuta J,Kiyota Y,Chuman Y,Sakaguchi K

更新日期：2016-09-13 00:00:00

abstract：:Duchenne muscular dystrophy, one of the most common lethal genetic disorders, is caused by mutations in the DMD gene and a lack of dystrophin protein. In most DMD patients and animal models, sporadic dystrophin-positive muscle fibres, called revertant fibres (RFs), are observed in otherwise dystrophin-negative backgro...

journal_title：Scientific reports

authors： Rodrigues M,Echigoya Y,Maruyama R,Lim KR,Fukada SI,Yokota T

更新日期：2016-12-07 00:00:00

abstract：:The newly designed fentanyl derivative [( ±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide] (NFEPP) was recently shown to produce analgesia selectively via peripheral mu-opioid receptors (MOR) at acidic pH in rat inflamed tissues. Here, we examined the pH-dependency of NFEPP binding to brain MOR and it...

journal_title：Scientific reports

authors： Baamonde A,Menéndez L,González-Rodríguez S,Lastra A,Seitz V,Stein C,Machelska H

更新日期：2020-10-29 00:00:00

abstract：:Doxorubicin (Dox) is a highly effective anticancer drug but cause acute ventricular dysfunction, and also induce late-onset cardiomyopathy and heart failure. Despite extensive studies, the pathogenic sequelae leading to the progression of Dox-associated cardiomyopathy remains unknown. We assessed temporal changes in a...

journal_title：Scientific reports

authors： Abdullah CS,Alam S,Aishwarya R,Miriyala S,Bhuiyan MAN,Panchatcharam M,Pattillo CB,Orr AW,Sadoshima J,Hill JA,Bhuiyan MS

更新日期：2019-02-14 00:00:00

abstract：:Humans, like all organisms, are subject to fundamental biophysical laws. Van Valen predicted that, because of zero-sum dynamics, all populations of all species in a given environment flux the same amount of energy on average. Damuth's 'energetic equivalence rule' supported Van Valen´s conjecture by showing a tradeoff ...

journal_title：Scientific reports

authors： Burger JR,Weinberger VP,Marquet PA

更新日期：2017-03-02 00:00:00

abstract：:DNA condensation is a ubiquitous phenomenon in biology, yet the physical basis for it has remained elusive. Here, we have explored the mechanism of DNA condensation through the protamine-DNA interaction, and by examining on it the influence of DNA binding drugs. We observed that the DNA condensation is accompanied by ...

journal_title：Scientific reports

authors： Gupta S,Tiwari N,Munde M

更新日期：2019-04-10 00:00:00

abstract：:Peripheral blood indices of systemic inflammation such as the neutrophil-lymphocyte ratio (NLR) have been shown to be prognostic in various cancers. We aim to investigate the clinical significance of these indices in patients with soft tissue sarcoma (STS). Seven hundred and twelve patients with available blood counts...

journal_title：Scientific reports

authors： Chan JY,Zhang Z,Chew W,Tan GF,Lim CL,Zhou L,Goh WL,Poon E,Somasundaram N,Selvarajan S,Sittampalam K,Chin F,Teh J,Tan MH,Soo KC,Teo M,Farid M,Quek R

更新日期：2018-08-10 00:00:00

abstract：:Most published sleep studies use three species: human, house mouse, or Norway rat. The degree to which data from these species captures variability in mammalian sleep remains unclear. To gain insight into mammalian sleep diversity, we examined sleep architecture in the spiny basal murid rodent Acomys cahirinus. First,...

journal_title：Scientific reports

authors： Wang C,Guerriero LE,Huffman DM,Ajwad AA,Brooks TC,Sunderam S,Seifert AW,O'Hara BF

更新日期：2020-07-02 00:00:00

abstract：:Increasingly, biofilms are being recognised for their causative role in persistent infections (like cystic fibrosis, otitis media, diabetic foot ulcers) and nosocomial diseases (biofilm-infected vascular catheters, implants and prosthetics). Given the clinical relevance of biofilms and their recalcitrance to conventio...

journal_title：Scientific reports

authors： Sharma A,Gupta P,Kumar R,Bhardwaj A

更新日期：2016-02-25 00:00:00

abstract：:Heating on the microscale using focused lasers gave rise to recent applications, e.g., in biomedicine, biology and microfluidics, especially using gold nanoparticles as efficient nanoabsorbers of light. However, such an approach naturally leads to nonuniform, Gaussian-like temperature distributions due to the diffusiv...

journal_title：Scientific reports

authors： Durdevic L,Robert HML,Wattellier B,Monneret S,Baffou G

更新日期：2019-03-15 00:00:00

abstract：:The endogenous circadian clock drives oscillations that are completely synchronized with the environmental day-night rhythms with a period of approximately 24 hours. Temporal misalignment between one's internal circadian clock and the external solar time often occurs in shift workers and long-distance travelers; such ...

journal_title：Scientific reports

authors： Kori H,Yamaguchi Y,Okamura H

更新日期：2017-04-26 00:00:00

abstract：:Solitons, defined as nonlinear waves which can reflect from boundaries or transmit through each other, are found in conservative, fully integrable systems. Similar phenomena, dubbed quasi-solitons, have been observed also in dissipative, "excitable" systems, either at finely tuned parameters (near a bifurcation) or in...

journal_title：Scientific reports

authors： Biktashev VN,Tsyganov MA

更新日期：2016-08-05 00:00:00

abstract：:In a previous study, we proposed that age-related mitochondrial respiration defects observed in elderly subjects are partially due to age-associated downregulation of nuclear-encoded genes, including serine hydroxymethyltransferase 2 (SHMT2), which is involved in mitochondrial one-carbon (1C) metabolism. This assertio...

journal_title：Scientific reports

authors： Tani H,Mito T,Velagapudi V,Ishikawa K,Umehara M,Nakada K,Suomalainen A,Hayashi JI

更新日期：2019-11-05 00:00:00

abstract：:The global problem of unowned domestic cats, driven by their phenomenal reproductive success, carries significant economic, animal welfare and biodiversity costs. Desexing owned cats prior to puberty prevents unwanted litters that contribute to unowned cat populations. The prevalence and predictors of desexing, and th...

journal_title：Scientific reports

authors： Mazeau L,Wylie C,Boland L,Beatty JA

更新日期：2021-01-18 00:00:00

abstract：:Rickettsiales are important zoonotic pathogens, causing severe disease in humans globally. Although mosquitoes are an important vector for diverse pathogens, with the exception of members of the genus Wolbachia little is known about their role in the transmission of Rickettsiales. Herein, Rickettsiales were identified...

journal_title：Scientific reports

authors： Guo WP,Tian JH,Lin XD,Ni XB,Chen XP,Liao Y,Yang SY,Dumler JS,Holmes EC,Zhang YZ

更新日期：2016-12-09 00:00:00

abstract：:Long-term all-cause mortality and dependency after complex surgical procedures have not been assessed in the framework of value-based medicine. The aim of this study was to investigate the postoperative and long-term outcomes after surgical procedures lasting for more than six hours. Retrospective cohort study of pati...

journal_title：Scientific reports

authors： Cornellà N,Sancho J,Sitges-Serra A

更新日期：2017-08-23 00:00:00

abstract：:The Sansha Yongle Blue Hole (SYBH) is the deepest blue hole found anywhere to date. Study of the SYBH can provide insight into the interactions between hole wall morphology and many geological/hydrological mechanisms. A comprehensive investigation of the SYBH was carried out for the first time in 2017 using a professi...

journal_title：Scientific reports

authors： Li T,Feng A,Liu Y,Li Z,Guo K,Jiang W,Du J,Tian Z,Xu W,Liu Y,Wang Y

更新日期：2018-11-20 00:00:00

abstract：:Photoluminescence and photomodulated reflectivity measurements of ZnOSe alloys are used to demonstrate a splitting of the valence band due to the band anticrossing interaction between localized Se states and the extended valence band states of the host ZnO matrix. A strong multiband emission associated with optical tr...

journal_title：Scientific reports

authors： Welna M,Baranowski M,Linhart WM,Kudrawiec R,Yu KM,Mayer M,Walukiewicz W

更新日期：2017-03-13 00:00:00

abstract：:Near-surface ozone is enhanced under particular chemical reactions and physical processes. This study showed the seasonal variation of near-surface ozone in Nicosia, Cyprus and focused in summers when the highest ozone levels were noted using a seven year hourly dataset from 2007 to 2014. The originality of this study...

journal_title：Scientific reports

authors： Pyrgou A,Hadjinicolaou P,Santamouris M

更新日期：2018-06-15 00:00:00

abstract：:Method for production of alpha emitter 149Tb by irradiation of 151Eu with 70 MeV 3He nuclei is proposed. For the first time, the cross sections for the formation of isotopes 149,150,151,152Tb were measured experimentally using a stack foil technique in the 3He particles energy range 70 → 12 MeV. The thick target yield...

journal_title：Scientific reports

authors： Moiseeva AN,Aliev RA,Unezhev VN,Zagryadskiy VA,Latushkin ST,Aksenov NV,Gustova NS,Voronuk MG,Starodub GY,Ogloblin AA

更新日期：2020-01-16 00:00:00

abstract：:A visible light active Bi0.9Ho0.1FeO3 nanoparticles/TiO2 composite thin films with different mol.% of Bi0.9Ho0.1FeO3 were successfully prepared via non-aqueous sol-gel method. The incorporation of 5, 10 and 20 mol.% Bi0.9Ho0.1FeO3 nanoparticles in the precursor solution of TiO2 brings modifications in the functional p...

journal_title：Scientific reports

authors： Islam MR,Zubair MA,Bashar MS,Rashid AKMB

更新日期：2019-03-26 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer that is consistently associated with Epstein-Barr virus (EBV) infection. In this study, we identify for the first time a role for monoamine oxidase A (MAOA) in NPC. MAOA is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and ...

journal_title：Scientific reports

authors： Lee HM,Sia APE,Li L,Sathasivam HP,Chan MSA,Rajadurai P,Tsang CM,Tsao SW,Murray PG,Tao Q,Paterson IC,Yap LF

更新日期：2020-04-09 00:00:00

abstract：:Continuous, as opposed to pulsatile, delivery of hypothalamic gonadotropin-releasing hormone (GnRH) leads to a marked decrease in secretion of pituitary gonadotropins LH and FSH and impairment of reproductive function. Here we studied the expression profile of gonadotropin subunit and GnRH receptor genes in rat pituit...

journal_title：Scientific reports

authors： Janjic MM,Prévide RM,Fletcher PA,Sherman A,Smiljanic K,Abebe D,Bjelobaba I,Stojilkovic SS

更新日期：2019-12-27 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinases ErbB family and it is found to be overexpressed in gastric cancer. However, the mechanism of the regulation of the EGFR expression is still unknown. We used the Sequenom EpiTYPER assay to detect the methylation status of the EGFR prom...

journal_title：Scientific reports

authors： Weng X,Zhang H,Ye J,Kan M,Liu F,Wang T,Deng J,Tan Y,He L,Liu Y

更新日期：2015-05-11 00:00:00

abstract：:Three kinds of Al-TiO2 samples and pure TiO2 samples were synthesized via a modified polyacrylamide gel route using different aluminum salts, including Al2(SO4)3∙18H2O, AlCl3, and Al(NO3)3∙9H2O under identical conditions. The influence of different aluminum salts on the phase purity, morphologies, thermal stability of...

journal_title：Scientific reports

authors： Luo JL,Wang SF,Liu W,Tian CX,Wu JW,Zu XT,Zhou WL,Yuan XD,Xiang X

更新日期：2017-08-14 00:00:00

abstract：:Transcript levels are the primary factor determining protein levels, but for the majority of genes, fold changes in transcript levels are larger than the corresponding changes in protein levels, a phenomenon that is termed "protein homeostasis". However, this phenomenon is not well characterized in the context of envi...

journal_title：Scientific reports

authors： Sun Y,Wen J,Chen R,Deng Y

更新日期：2019-05-24 00:00:00

abstract：:Identifying communities in complex networks is an effective means for analyzing complex systems, with applications in diverse areas such as social science, engineering, biology and medicine. Finding communities of nodes and finding communities of links are two popular schemes for network analysis. These schemes, howev...

journal_title：Scientific reports

authors： He D,Jin D,Chen Z,Zhang W

更新日期：2015-03-02 00:00:00

abstract：:In this paper we present a detailed theoretical investigation of the electric field induced mixing effect, in which the up and down frequency-conversion processes are obtained by inducing an effective second order susceptibility via the periodic spatial distribution of reversed biased p-i-n junctions. The possibility ...

journal_title：Scientific reports

authors： De Leonardis F,Soref RA,Passaro VMN

更新日期：2017-06-13 00:00:00

abstract：:Toxin-antitoxin (TA) systems were initially discovered as plasmid addiction systems on low-copy-number plasmids. Thousands of TA loci have since been identified on chromosomes, plasmids and mobile elements in bacteria and archaea with diverse roles in bacterial physiology and in maintenance of genetic elements. Here, ...

journal_title：Scientific reports

authors： Kamruzzaman M,Iredell J

更新日期：2019-07-08 00:00:00

abstract：:Delay embedding-a method for reconstructing dynamical systems by delay coordinates-is widely used to forecast nonlinear time series as a model-free approach. When multivariate time series are observed, several existing frameworks can be applied to yield a single forecast combining multiple forecasts derived from vario...

journal_title：Scientific reports

authors： Okuno S,Aihara K,Hirata Y

更新日期：2020-01-20 00:00:00