Hypermethylated Epidermal growth factor receptor (EGFR) promoter is associated with gastric cancer.


:Epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinases ErbB family and it is found to be overexpressed in gastric cancer. However, the mechanism of the regulation of the EGFR expression is still unknown. We used the Sequenom EpiTYPER assay to detect the methylation status of the EGFR promoter in normal and tumour tissues of 30 patients with gastric cancer. We also carried out quantitative real time PCR (qPCR) to detect the expression level of EGFR in our 30 patients. Notably, increased methylation level at EGFR promoter was found in tumour tissues than the corresponding adjacent noncancerous. In both Region I DMR and Region II DMR detected in our study, tumor tissues were significantly hypermethylated (P=2.7743E-10 and 2.1703E-05, respectively). Region I_⊿CpG_2 was also found to be associated with the presence of distant metastasis (P=0.0323). Furthermore, the results showed a strongly significant association between the relative EGFR expression and the EGFR methylation changes in both Region I and Region II (P=0.0004 and 0.0001, respectively). Our findings help to indicate the hypermethylation at EGFR promoter in gastric cancer and it could be a potential epigenetic biomarker for gastric cancer status and progression.


Sci Rep


Scientific reports


Weng X,Zhang H,Ye J,Kan M,Liu F,Wang T,Deng J,Tan Y,He L,Liu Y




Has Abstract


2015-05-11 00:00:00










  • Visualization of a Mammalian Mitochondrion by Coherent X-ray Diffractive Imaging.

    abstract::We report a three dimensional (3D) quantitative visualization of a mammalian mitochondrion by coherent x-ray diffractive imaging (CXDI) using synchrotron radiation. The internal structures of a mitochondrion from a mouse embryonic fibroblast cell line (NIH3T3) were visualized by tomographic imaging at approximately 60...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kim Y,Kim C,Kwon OY,Nam D,Kim SS,Park JH,Kim S,Gallagher-Jones M,Kohmura Y,Ishikawa T,Song C,Tae G,Noh DY

    更新日期:2017-05-12 00:00:00

  • VEGF/Flk1 Mechanism is Involved in Roxarsone Promotion of Rat Endothelial Cell Growth and B16F10 Xenograft Tumor Angiogenesis.

    abstract::The potential angiogenic effect of roxarsone, a feed additive widely used to promote animal growth worldwide, was demonstrated recently. We explored the mechanism of vascular endothelial growth factor (VEGF) and its receptor (VEGFR) in roxarsone promotion of rat vascular endothelial cells (ECs) and B16F10 mouse xenogr...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Chen S,Xu J,Wei Q,Zhao Z,Chen X,Cui H,Zhang Y

    更新日期:2019-11-22 00:00:00

  • Contactless transient carrier spectroscopy and imaging technique using lock-in free carrier emission and absorption.

    abstract::In this paper we present a contactless transient carrier spectroscopy and imaging technique for traps in silicon. At each pixel, we fit the transient decay of the trap emission which allows us to obtain both the trap time constant and trap concentration. Here we show that this technique allows for high-resolution imag...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Rougieux FE,Kwapil W,Heinz F,Siriwardhana M,Schubert MC

    更新日期:2019-10-03 00:00:00

  • Short-term changes in frequencies of circulating leukocytes associated with narrowband UVB phototherapy in people with clinically isolated syndrome.

    abstract::Clinically isolated syndrome (CIS) is the earliest clinical episode in multiple sclerosis (MS). Low environmental exposure to UV radiation is implicated in risk of developing MS, and therefore, narrowband UVB phototherapy might delay progression to MS in people with CIS. Twenty individuals with CIS were recruited, and...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Trend S,Jones AP,Cha L,Cooper MN,Geldenhuys S,Fabis-Pedrini MJ,Carroll WM,Cole JM,Booth DR,Lucas RM,French MA,Byrne SN,Kermode AG,Hart PH

    更新日期:2019-05-28 00:00:00

  • Biofilm may not be Necessary for the Epidemic Spread of Acinetobacter baumannii.

    abstract::Biofilm is recognized as a contributing factor to the capacity of Acinetobacter baumannii to persist and prosper in medical settings, but it is still unknown whether biofilms contribute to the spread of A. baumannii. In this study, the biofilm formation of 114 clinical A. baumannii isolates and 32 non-baumannii Acinet...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Hu Y,He L,Tao X,Meng F,Zhang J

    更新日期:2016-08-25 00:00:00

  • YebC, a putative transcriptional factor involved in the regulation of the proteolytic system of Lactobacillus.

    abstract::The proteolytic system of Lactobacillus plays an essential role in bacterial growth, contributes to the flavor development of fermented products, and can release bioactive health-beneficial peptides during milk fermentation. In this work, a genomic analysis of all genes involved in the proteolytic system of L. delbrue...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Brown L,Villegas JM,Elean M,Fadda S,Mozzi F,Saavedra L,Hebert EM

    更新日期:2017-08-17 00:00:00

  • Heterogeneity of a landscape influences size of home range in a North American cervid.

    abstract::In the northeastern United States, chronic wasting disease has recently been detected in white-tailed deer (Odocoileus virginianus) populations, and understanding the relationship between landscape configuration and home range may improve disease surveillance and containment efforts. The objectives of our study were t...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Walter WD,Evans TS,Stainbrook D,Wallingford BD,Rosenberry CS,Diefenbach DR

    更新日期:2018-10-02 00:00:00

  • Non-invasive spinal vibration testing using ultrafast ultrasound imaging: A new way to measure spine function.

    abstract::Ultrafast ultrasound imaging is used to capture driven spinal vibrations as a new method for non-invasive spinal testing in living subjects. Previously, it has been shown that accelerometer-based vibration testing in cadaveric models can reveal the presence, location and magnitude of spinal pathology. However, this pr...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kaddoura T,Au A,Kawchuk G,Uwiera R,Fox R,Zemp R

    更新日期:2018-06-25 00:00:00

  • Network-based Responses to the Psychomotor Vigilance Task during Lapses in Adolescents after Short and Extended Sleep.

    abstract::Neuroimaging studies of the Psychomotor Vigilance Task (PVT) have revealed brain regions involved in attention lapses in sleep-deprived and well-rested adults. Those studies have focused on individual brain regions, rather than integrated brain networks, and have overlooked adolescence, a period of ongoing brain devel...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: DiFrancesco MW,Van Dyk T,Altaye M,Drummond SPA,Beebe DW

    更新日期:2019-09-26 00:00:00

  • A model of the PI cycle reveals the regulating roles of lipid-binding proteins and pitfalls of using mosaic biological data.

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    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Mazet F,Tindall MJ,Gibbins JM,Fry MJ

    更新日期:2020-08-06 00:00:00

  • IκBζ facilitates protective immunity against Salmonella infection via Th1 differentiation and IgG production.

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    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ahn JH,Cho J,Kwon BE,Lee GS,Yoon SI,Kang SG,Kim PH,Kweon MN,Yang H,Vallance BA,Kim YI,Chang SY,Ko HJ

    更新日期:2019-06-10 00:00:00

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    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Callegaro S,Perrone R,Scalabrin M,Doria F,Palù G,Richter SN

    更新日期:2017-05-24 00:00:00

  • Pathogenic lineage of Perkinsea associated with mass mortality of frogs across the United States.

    abstract::Emerging infectious diseases such as chytridiomycosis and ranavirus infections are important contributors to the worldwide decline of amphibian populations. We reviewed data on 247 anuran mortality events in 43 States of the United States from 1999-2015. Our findings suggest that a severe infectious disease of tadpole...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Isidoro-Ayza M,Lorch JM,Grear DA,Winzeler M,Calhoun DL,Barichivich WJ

    更新日期:2017-08-31 00:00:00

  • A new mass spectrometry-based method for the quantification of histones in plasma from septic shock patients.

    abstract::The aim of this study was to develop a novel method to detect circulating histones H3 and H2B in plasma based on multiple reaction monitoring targeted mass spectrometry and a multiple reaction monitoring approach (MRM-MS) for its clinical application in critical bacteriaemic septic shock patients. Plasma samples from ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: García-Giménez JL,Romá-Mateo C,Carbonell N,Palacios L,Peiró-Chova L,García-López E,García-Simón M,Lahuerta R,Gimenez-Garzó C,Berenguer-Pascual E,Mora MI,Valero ML,Alpízar A,Corrales FJ,Blanquer J,Pallardó FV

    更新日期:2017-09-06 00:00:00

  • Genetic effects of BDKRB2 and KNG1 on deep venous thrombosis after orthopedic surgery and the potential mediator.

    abstract::Deep venous thrombosis (DVT) is a common complication of orthopedic surgery. Genetic risk factors and high heritability carried a substantial risk of DVT. In this study, we aimed to investigate the potential association in the Han Chinese population between the polymorphisms of BDKRB2 and KNG1 and DVT after orthopedic...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang Q,Cheng G,Wang X,Wang D,Yang Y,Chen K,Ye J,Qing Z

    更新日期:2018-11-26 00:00:00

  • A Semi-Continuous Process For Polyphenols Extraction From Sea Buckthorn Leaves.

    abstract::Sea buckthorn (Hippophae Rhamnoides L.) is an important source of bioactive compounds such as: antioxidants, vitamins, fatty acids, amino acids, and minerals. Sea buckthorn leaves extracts have been proved to have anti-microbial, antioxidant, anti-inflammatory, and anti-viral properties. In this paper, the extraction ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Asofiei I,Calinescu I,Trifan A,Gavrila AI

    更新日期:2019-08-19 00:00:00

  • Direct incorporation of mesenchymal stem cells into a Nanofiber scaffold - in vitro and in vivo analysis.

    abstract::Bony defects are a common problem in musculoskeletal surgery. Replacement with autologous bone grafts is limited by availability of transplant material. Sterilized cancellous bone, while being osteoconductive, has limited osteoinductivity. Nanofiber scaffolds are currently used for several purposes due to their capabi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Schüttler KF,Bauhofer MW,Ketter V,Giese K,Eschbach DA,Yenigün M,Fuchs-Winkelmann S,Paletta JRJ

    更新日期:2020-06-12 00:00:00

  • Sustainability of soil organic carbon in consolidated gully land in China's Loess Plateau.

    abstract::Massive gully land consolidation projects, launched in China's Loess Plateau, aim to restore 2667 [Formula: see text] agricultural lands in total by consolidating 2026 highly eroded gullies. This effort represents a social engineering project where the economic development and livelihood of the farming families are cl...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yan Q,Kumar P,Wang Y,Zhao Y,Lin H,Ran Q,An Z,Zhou W

    更新日期:2020-10-09 00:00:00

  • Consequences of Nosema apis infection for male honey bees and their fertility.

    abstract::The queens of eusocial bees, ants and wasps mate only during a very short period early in life and males therefore produce ejaculates consisting of large numbers of high quality sperm. Such extreme selection for high fecundity resulted in males investing minimally into their somatic survival, including their immune sy...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Peng Y,Baer-Imhoof B,Millar AH,Baer B

    更新日期:2015-06-30 00:00:00

  • Bundles of Brain Microtubules Generate Electrical Oscillations.

    abstract::Microtubules (MTs) are long cylindrical structures of the cytoskeleton that control cell division, intracellular transport, and the shape of cells. MTs also form bundles, which are particularly prominent in neurons, where they help define axons and dendrites. MTs are bio-electrochemical transistors that form nonlinear...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Cantero MDR,Villa Etchegoyen C,Perez PL,Scarinci N,Cantiello HF

    更新日期:2018-08-09 00:00:00

  • High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease.

    abstract::Peri-implant disease is a chronic inflammation of the soft and hard tissues around a dental implant, resulting from bacterial infection. Recent evidence indicates that some pro-inflammatory cytokines and chemokines released by immunocytes are substantially responsible for the progress and consequence of inflammation. ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Liu J,Li R,Liu T,Rausch-Fan X,Wang M

    更新日期:2017-08-01 00:00:00

  • Dimensionality Effects in FeGe2 Nanowires: Enhanced Anisotropic Magnetization and Anomalous Electrical Transport.

    abstract::We report the synthesis of single-crystal iron germanium nanowires via chemical vapor deposition without the assistance of any catalysts. The assembly of single-crystal FeGe2 nanowires with tetragonal C16 crystal structure shows anisotropic magnetic behavior along the radial direction or the growth axial direction, wi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Tang S,Kravchenko I,Ward TZ,Zou Q,Yi J,Ma C,Chi M,Cao G,Li AP,Mandrus D,Gai Z

    更新日期:2017-08-02 00:00:00

  • Surface-modified Ba(Zr0.3Ti0.7)O3 nanofibers by polyvinylpyrrolidone filler for poly(vinylidene fluoride) composites with enhanced dielectric constant and energy storage density.

    abstract::Ferroelectric-relaxor behavior of Ba(Zr0.3Ti0.7)O3 nanofibers (BZT NF) with a large aspect ratio were prepared via electrospinning and surface modified by PVP as dielectric fillers. The nanocomposite flexible films based on surface modified BZT NF and polyvinylidene fluoride (PVDF) were fabricated via a solution casti...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Liu S,Xue S,Xiu S,Shen B,Zhai J

    更新日期:2016-05-17 00:00:00

  • Author Correction: Low dose of chlorine exposure exacerbates nasal and pulmonary allergic inflammation in mice.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误


    authors: de Genaro IS,de Almeida FM,Hizume-Kunzler DC,Moriya HT,Silva RA,Cruz JCG,Lopes RB,Righetti RF,de Paula Vieira R,Saiki M,Martins MA,Tibério IFLC,Arantes-Costa FM,Saraiva-Romanholo BM

    更新日期:2018-12-12 00:00:00

  • NMDA receptors in mouse anterior piriform cortex initialize early odor preference learning and L-type calcium channels engage for long-term memory.

    abstract::The interactions of L-type calcium channels (LTCCs) and NMDA receptors (NMDARs) in memories are poorly understood. Here we investigated the specific roles of anterior piriform cortex (aPC) LTCCs and NMDARs in early odor preference memory in mice. Using calcium imaging in aPC slices, LTCC activation was shown to be dep...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Mukherjee B,Yuan Q

    更新日期:2016-10-14 00:00:00

  • Enigmatic incongruence between mtDNA and nDNA revealed by multi-locus phylogenomic analyses in freshwater snails.

    abstract::Phylogenetic incongruence has frequently been encountered among different molecular markers. Recent progress in molecular phylogenomics has provided detailed and important information for evolutionary biology and taxonomy. Here we focused on the freshwater viviparid snails (Cipangopaludina chinensis chinensis and C. c...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Hirano T,Saito T,Tsunamoto Y,Koseki J,Ye B,Do VT,Miura O,Suyama Y,Chiba S

    更新日期:2019-04-17 00:00:00

  • Classification of skin phenotypes caused by diabetes mellitus using complex scattering parameters in the millimeter-wave frequency range.

    abstract::The pathological skin phenotype caused by hyperglycemia is an important indicator for the progress of diabetes mellitus. An early detection of diabetes assures an early intervention to regulate the carbohydrate metabolism. In this publication a non-invasive detection principle based on the measurement of complex scatt...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Dornuf F,Martín-Mateos P,Duarte B,Hils B,Bonilla-Manrique OE,Larcher F,Acedo P,Krozer V

    更新日期:2017-07-19 00:00:00

  • On the importance of full-dimensionality in low-energy molecular scattering calculations.

    abstract::Scattering of H2 on CO is of great importance in astrophysics and also is a benchmark system for comparing theory to experiment. We present here a new 6-dimensional potential energy surface for the ground electronic state of H2-CO with an estimated uncertainty of about 0.6 cm(-1) in the global minimum region, several ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Faure A,Jankowski P,Stoecklin T,Szalewicz K

    更新日期:2016-06-23 00:00:00

  • Cotransfection of Pax2 and Math1 promote in situ cochlear hair cell regeneration after neomycin insult.

    abstract::The ideal strategy for hair cell regeneration is promoting residual supporting cell proliferation followed by induction of hair cell differentiation. In this study, cultured neonatal mouse organs of Corti were treated with neomycin to eliminate hair cells followed by incubation with recombined adenovirus expressing Pa...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Chen Y,Yu H,Zhang Y,Li W,Lu N,Ni W,He Y,Li J,Sun S,Wang Z,Li H

    更新日期:2013-10-21 00:00:00

  • The Gatekeepers in the Mouse Ophthalmic Artery: Endothelium-Dependent Mechanisms of Cholinergic Vasodilation.

    abstract::Cholinergic regulation of arterial luminal diameter involves intricate network of intercellular communication between the endothelial and smooth muscle cells that is highly dependent on the molecular mediators released by the endothelium. Albeit the well-recognized contribution of nitric oxide (NO) towards vasodilatio...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Manicam C,Staubitz J,Brochhausen C,Grus FH,Pfeiffer N,Gericke A

    更新日期:2016-02-02 00:00:00