Impaired regenerative capacity and lower revertant fibre expansion in dystrophin-deficient mdx muscles on DBA/2 background.

abstract：:Inhibition of the androgen receptor (AR) by second-generation anti-androgens is a standard treatment for metastatic castration resistant prostate cancer (mCRPC), but it inevitably leads to the development of resistance. Since the introduction of highly efficient AR signalling inhibitors, approximately 20% of mCRPC pat...

journal_title：Scientific reports

authors： Handle F,Prekovic S,Helsen C,Van den Broeck T,Smeets E,Moris L,Eerlings R,Kharraz SE,Urbanucci A,Mills IG,Joniau S,Attard G,Claessens F

更新日期：2019-09-24 00:00:00

abstract：:Targeted antineoplastic agents show great promise in the treatment of cancer, having the ability to impart cytotoxicity only to specific tumor types. However, these therapies do not experience uniform uptake throughout tumors, leading to sub-lethal cell killing that can impart treatment resistance, and cause problemat...

journal_title：Scientific reports

authors： Klein OJ,Yuan H,Nowell NH,Kaittanis C,Josephson L,Evans CL

更新日期：2017-10-17 00:00:00

abstract：:Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease in which the abnormalities in alveolar surfactant accumulation are caused by impairments of GM-CSF pathway attributing to defects in a variety of genes. However, hereditary PAP is extremely uncommon and a detailed understanding in the genetic inheritance...

journal_title：Scientific reports

authors： Chiu CY,Su SC,Fan WL,Lai SH,Tsai MH,Chen SH,Wong KS,Chung WH

更新日期：2017-02-24 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are a potential therapy for many chronic inflammatory diseases due to their regenerative, immunologic and anti-inflammatory properties. The two-way dialogue between MSCs and macrophages is crucial to tissue regeneration and repair. Previous research demonstrated that murine adipose-der...

journal_title：Scientific reports

authors： Souza-Moreira L,Soares VC,Dias SDSG,Bozza PT

更新日期：2019-12-30 00:00:00

abstract：:Coexisting bacteria form various microbial communities in human body parts. In these ecosystems they interact in various ways and the properties of the interaction network can be related to the stability and functional diversity of the local bacterial community. In this study, we analyze the interaction network among ...

journal_title：Scientific reports

authors： Jordán F,Lauria M,Scotti M,Nguyen TP,Praveen P,Morine M,Priami C

更新日期：2015-10-30 00:00:00

abstract：:Maternal gene products deposited in the egg regulate early embryogenesis before activation of the embryonic genome in animals. While in higher plants, it is believed that genes of parental origin contribute to early embryogenesis. However, little is known regarding the particular processes in which genes of parental o...

journal_title：Scientific reports

authors： Luo A,Zhao P,Zhang LY,Sun MX

更新日期：2016-07-19 00:00:00

abstract：:To examine the influence on postoperative endothelial cell density (ECD) caused by preoperative temperature change from 4 °C to room temperature in donor corneas for Descemet stripping automated endothelial keratoplasty (DSAEK). This retrospective, case-controlled comparison of 100 eyes that underwent DSAEK using impo...

journal_title：Scientific reports

authors： Kakisu K,Yamaguchi T,Shimazaki J

更新日期：2020-01-20 00:00:00

abstract：:Hyperactivity of signal transducer and activity of transcription 3 (STAT3) plays a crucial role in melanoma invasion and metastasis. Gene therapy applying siRNA targeting STAT3 is a potential therapeutic strategy for melanoma. In this article, we first fabricated safe and novel dissolving microneedles (MNs) for topica...

journal_title：Scientific reports

authors： Pan J,Ruan W,Qin M,Long Y,Wan T,Yu K,Zhai Y,Wu C,Xu Y

更新日期：2018-01-18 00:00:00

abstract：:Using starch as the carbon precursor and different-sized ZnO naoparticles as the hard template, a series of porous carbon materials for electrochemical sensing were prepared. Experiments of scanning electron microscopy, transmission electron microscopy and Nitrogen adsorption-desorption isotherms reveal that the parti...

journal_title：Scientific reports

authors： Cheng Q,Ji L,Wu K,Zhang W

更新日期：2016-02-29 00:00:00

abstract：:An infinite three dimensional (3D) crystal can be constructed by an infinite number of parallel 2D (hkl) crystal planes (CPs) coupled to each other. Based on lattice model Hamiltonian with the hopping between the nearest neighbor (1NN) CPs and all possible neighbor hoppings within each CP, we analytically prove that a...

journal_title：Scientific reports

authors： Wang H,Gao T,Tao R

更新日期：2015-03-02 00:00:00

abstract：:Ti3+ species are highly unstable in air owing to their facile oxidation into Ti4+ species, and thus they cannot concentrate in the surface layer of TiO2 but are mainly present in its bulk. We report generation of abundant and stable Ti3+ species in the surface layer of TiO2 by boron doping for efficient utilization of...

journal_title：Scientific reports

authors： Feng N,Liu F,Huang M,Zheng A,Wang Q,Chen T,Cao G,Xu J,Fan J,Deng F

更新日期：2016-10-06 00:00:00

abstract：:Hepatic steatosis (HS) can exacerbate acute pancreatitis (AP). This study aimed to investigate the relation between α1-antitrypsin (AAT) and acute pancreatitis when patients have HS. Using proteomic profiling, we identified 18 differently expressed proteins pots in the serum of rats with or without HS after surgical e...

journal_title：Scientific reports

authors： Wang Q,Du J,Yu P,Bai B,Zhao Z,Wang S,Zhu J,Feng Q,Gao Y,Zhao Q,Liu C

更新日期：2015-12-04 00:00:00

abstract：:Brain µ-opioid receptors (MOR) mediate reward and help coping with pain, social rejection, anxiety and depression. The dorsal midline thalamus (dMT) integrates visceral/emotional signals and biases behavior towards aversive or defensive states through projections to the amygdala. While a dense MOR expression in the dM...

journal_title：Scientific reports

authors： Goedecke L,Bengoetxea X,Blaesse P,Pape HC,Jüngling K

更新日期：2019-11-28 00:00:00

abstract：:Human NAD-dependent isocitrate dehydrogenase catalyzes the decarboxylation of isocitrate (ICT) into α-ketoglutarate in the Krebs cycle. It exists as the α2βγ heterotetramer composed of the αβ and αγ heterodimers. Previously, we have demonstrated biochemically that the α2βγ heterotetramer and αγ heterodimer can be allo...

journal_title：Scientific reports

authors： Ma T,Peng Y,Huang W,Ding J

更新日期：2017-01-18 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an incurable and fatal neurodegenerative disease. Increasing the chances of success for future clinical strategies requires more in-depth knowledge of the molecular basis underlying disease heterogeneity. We recently laid the foundation for a molecular taxonomy of ALS by whole-ge...

journal_title：Scientific reports

authors： Morello G,Guarnaccia M,Spampinato AG,Salomone S,D'Agata V,Conforti FL,Aronica E,Cavallaro S

更新日期：2019-07-10 00:00:00

abstract：:Ossification of the posterior longitudinal ligament (OPLL) can occur throughout the entire spine and can sometimes lead to spinal disorder. Although patients with OPLL sometimes develop physical limitations because of pain, the characteristics of pain and effects on activities of daily living (ADL) have not been preci...

journal_title：Scientific reports

authors： Hirai T,Yoshii T,Ushio S,Mori K,Maki S,Katsumi K,Nagoshi N,Takeuchi K,Furuya T,Watanabe K,Nishida N,Watanabe K,Kaito T,Kato S,Nagashima K,Koda M,Ito K,Imagama S,Matsuoka Y,Wada K,Kimura A,Ohba T,Katoh H,Mats

更新日期：2020-03-26 00:00:00

abstract：:Anthropometric indices determine important risk factors for many chronic diseases. However, to date, no study has simultaneously analyzed the capabilities of trunk circumference and width indices to identify hypertension and type 2 diabetes in a large-scale screening study. The objectives of this study were to examine...

journal_title：Scientific reports

authors： Lee BJ,Ku B

更新日期：2018-09-05 00:00:00

abstract：:The effect on the reproductive system and fertility of living in a space environment remains unclear. Here, we caged 12 male mice under artificial gravity (≈1 gravity) (AG) or microgravity (MG) in the International Space Station (ISS) for 35 days, and characterized the male reproductive organs (testes, epididymides, a...

journal_title：Scientific reports

authors： Matsumura T,Noda T,Muratani M,Okada R,Yamane M,Isotani A,Kudo T,Takahashi S,Ikawa M

更新日期：2019-09-24 00:00:00

abstract：:Sclerotinia sclerotiorum, the causal agent of white stem rot, is responsible for significant losses in crop yields around the globe. While our understanding of S. sclerotiorum infection is becoming clearer, genetic control of the pathogen has been elusive and effective control of pathogen colonization using traditiona...

journal_title：Scientific reports

authors： McLoughlin AG,Wytinck N,Walker PL,Girard IJ,Rashid KY,de Kievit T,Fernando WGD,Whyard S,Belmonte MF

更新日期：2018-05-09 00:00:00

abstract：:Validation of imaging contrast agents, such as fluorescently labeled imaging antibodies, has been recognized as a critical challenge in clinical and preclinical studies. As the number of applications for imaging antibodies grows, these materials are increasingly being subjected to careful scrutiny. Antibody fluorescen...

journal_title：Scientific reports

authors： Zhou H,Tourkakis G,Shi D,Kim DM,Zhang H,Du T,Eades WC,Berezin MY

更新日期：2017-02-02 00:00:00

abstract：:Precise mitotic spindle orientation is essential for both cell fate and tissue organization while defects in this process are associated with tumorigenesis and other diseases. In most animal cell types, the dynein motor complex is anchored at the cell cortex and exerts pulling forces on astral microtubules to position...

journal_title：Scientific reports

authors： Vodicska B,Cerikan B,Schiebel E,Hoffmann I

更新日期：2018-04-20 00:00:00

abstract：:Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown. Here we show that Cic hypomorphic (Cic-L(-/-)) mice have impaired bile acid (BA) homeostasis associated with induction of proinflammatory...

journal_title：Scientific reports

authors： Kim E,Park S,Choi N,Lee J,Yoe J,Kim S,Jung HY,Kim KT,Kang H,Fryer JD,Zoghbi HY,Hwang D,Lee Y

更新日期：2015-02-05 00:00:00

abstract：:Flux balance analysis is the only modelling approach that is capable of producing genome-wide predictions of gene essentiality that may aid to unveil metabolic liabilities in cancer. Nevertheless, a systemic validation of gene essentiality predictions by flux balance analysis is currently missing. Here, we critically ...

journal_title：Scientific reports

authors： Gatto F,Miess H,Schulze A,Nielsen J

更新日期：2015-06-04 00:00:00

abstract：:We evaluated the performance of CSF biomarkers for predicting risk of clinical decline and conversion to dementia in non-demented patients with cognitive symptoms. CSF samples from patients in two multicentre longitudinal studies (ADNI, n = 619; BioFINDER, n = 431) were analysed. Aβ(1-42), tTau and pTau CSF concentrat...

journal_title：Scientific reports

authors： Blennow K,Shaw LM,Stomrud E,Mattsson N,Toledo JB,Buck K,Wahl S,Eichenlaub U,Lifke V,Simon M,Trojanowski JQ,Hansson O

更新日期：2019-12-13 00:00:00

abstract：:The role of isochrony in speech-the hypothetical division of speech units into equal duration intervals-has been the subject of a long-standing debate. Current approaches in neurosciences have brought new perspectives in that debate through the theoretical framework of predictive coding and cortical oscillations. Here...

journal_title：Scientific reports

authors： Aubanel V,Schwartz JL

更新日期：2020-11-11 00:00:00

abstract：:Ancestor microbes started colonizing inland habitats approximately 2.7 to 3.5 billion years ago. With some exceptions, the key physiological adaptations of microbiomes associated with marine-to-land transitions have remained elusive. This is essentially caused by the lack of suitable systems that depict changes in mic...

journal_title：Scientific reports

authors： Dini-Andreote F,van Elsas JD,Olff H,Salles JF

更新日期：2018-06-21 00:00:00

abstract：:The immunomodulatory properties of human endometrial mesenchymal stem cells (eMSC) have not been well characterised. Initial studies showed that eMSC modulated the chronic inflammatory response to a non-degradable polyamide/gelatin mesh in a xenogeneic rat skin wound repair model, but the mechanism remains unclear. In...

journal_title：Scientific reports

authors： Darzi S,Deane JA,Nold CA,Edwards SE,Gough DJ,Mukherjee S,Gurung S,Tan KS,Vashi AV,Werkmeister JA,Gargett CE

更新日期：2018-04-26 00:00:00

abstract：:We report a theoretical and experimental study of the aggregation kinetics of oppositely charged nanoparticles. Kinetic Monte Carlo simulations are performed for symmetric, charge-asymmetric and size-asymmetric systems of oppositely charged nanoparticles. Simulation results show that both the weight and number average...

journal_title：Scientific reports

authors： Singh K,Raghav A,Jha PK,Satapathi S

更新日期：2019-03-06 00:00:00

abstract：:Globally, there has been an increase in the use of herbal remedies including traditional Chinese medicine (TCM). There is a perception that products are natural, safe and effectively regulated, however, regulatory agencies are hampered by a lack of a toolkit to audit ingredient lists, adulterants and constituent activ...

journal_title：Scientific reports

authors： Coghlan ML,Maker G,Crighton E,Haile J,Murray DC,White NE,Byard RW,Bellgard MI,Mullaney I,Trengove R,Allcock RJ,Nash C,Hoban C,Jarrett K,Edwards R,Musgrave IF,Bunce M

更新日期：2015-12-10 00:00:00

abstract：:Visible indication based on the aggregation of colloidal nanoparticles (NPs) is highly advantageous for rapid on-site detection of biological entities, which even untrained persons can perform without specialized instrumentation. However, since the extent of aggregation should exceed a certain minimum threshold to pro...

journal_title：Scientific reports

authors： Lim S,Koo OK,You YS,Lee YE,Kim MS,Chang PS,Kang DH,Yu JH,Choi YJ,Gunasekaran S

更新日期：2012-01-01 00:00:00