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Combined DNA, toxicological and heavy metal analyses provides an auditing toolkit to improve pharmacovigilance of traditional Chinese medicine (TCM).

Abstract：

:Globally, there has been an increase in the use of herbal remedies including traditional Chinese medicine (TCM). There is a perception that products are natural, safe and effectively regulated, however, regulatory agencies are hampered by a lack of a toolkit to audit ingredient lists, adulterants and constituent active compounds. Here, for the first time, a multidisciplinary approach to assessing the molecular content of 26 TCMs is described. Next generation DNA sequencing is combined with toxicological and heavy metal screening by separation techniques and mass spectrometry (MS) to provide a comprehensive audit. Genetic analysis revealed that 50% of samples contained DNA of undeclared plant or animal taxa, including an endangered species of Panthera (snow leopard). In 50% of the TCMs, an undeclared pharmaceutical agent was detected including warfarin, dexamethasone, diclofenac, cyproheptadine and paracetamol. Mass spectrometry revealed heavy metals including arsenic, lead and cadmium, one with a level of arsenic >10 times the acceptable limit. The study showed 92% of the TCMs examined were found to have some form of contamination and/or substitution. This study demonstrates that a combination of molecular methodologies can provide an effective means by which to audit complementary and alternative medicines.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Coghlan ML,Maker G,Crighton E,Haile J,Murray DC,White NE,Byard RW,Bellgard MI,Mullaney I,Trengove R,Allcock RJ,Nash C,Hoban C,Jarrett K,Edwards R,Musgrave IF,Bunce M

doi

10.1038/srep17475

subject

Has Abstract

pub_date

2015-12-10 00:00:00

pages

17475

issn

2045-2322

pii

srep17475

journal_volume

5

pub_type

杂志文章

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