Retrieving transient conformational molecular structure information from inner-shell photoionization of laser-aligned molecules.

abstract：:Preventing the protein-protein interaction of the cellular chromatin binding protein Lens Epithelium-Derived Growth Factor (LEDGF) and human immunodeficiency virus (HIV) integrase is an important possible strategy for anti-viral treatment for AIDS. We have used Intracellular Antibody Capture technology to isolate a si...

journal_title：Scientific reports

authors： Bao L,Hannon C,Cruz-Mignoni A,Ptchelkine D,Sun MY,Miller A,Bunjobpol W,Quevedo CE,Derveni M,Chambers J,Simmons A,Phillips SEV,Rabbitts TH

更新日期：2017-12-04 00:00:00

abstract：:We demonstrate an ultrahigh-sensitivity gas pressure sensor based on the Fabry-Perot interferometer employing a fiber-tip diaphragm-sealed cavity. The cavity is comprised of a silica capillary and ultrathin silica diaphragm with a thickness of 170 nm, with represents the thinnest silica diaphragm fabricated thus far b...

journal_title：Scientific reports

authors： Liu S,Wang Y,Liao C,Wang Y,He J,Fu C,Yang K,Bai Z,Zhang F

更新日期：2017-04-11 00:00:00

abstract：:Azoles are antifungal drugs used to treat fungal infections such as candidiasis in humans. Their extensive use has led to the emergence of drug resistance, complicating antifungal therapy for yeast infections in critically ill patients. Combination therapy has become popular in clinical practice as a potential strateg...

journal_title：Scientific reports

authors： Shrestha SK,Fosso MY,Garneau-Tsodikova S

更新日期：2015-11-23 00:00:00

abstract：:Desertification due to climate change and increasing drought periods is a worldwide problem for both ecology and economy. Our ability to understand how vegetation manages to survive and propagate through arid and semiarid ecosystems may be useful in the development of future strategies to prevent desertification, pres...

journal_title：Scientific reports

authors： Bordeu I,Clerc MG,Couteron P,Lefever R,Tlidi M

更新日期：2016-09-21 00:00:00

abstract：:Printing techniques are becoming increasingly prevalent in modern manufacturing. However, its biggest drawback is the limit in printing resolution. In this paper, we present solvodynamic printing as a novel printing system which aims to improve print resolution by incorporating an additional immiscible carrier solvent...

journal_title：Scientific reports

authors： Liu WC,Watt AAR

更新日期：2019-07-24 00:00:00

abstract：:Stable isotopes in water (e.g., δ2H and δ18O) are important indicators of hydrological and ecological patterns and processes. Tap water can reflect integrated features of regional hydrological processes and human activities. China is a large country with significant meteorological and geographical variations. This rep...

journal_title：Scientific reports

authors： Zhao S,Hu H,Tian F,Tie Q,Wang L,Liu Y,Shi C

更新日期：2017-03-02 00:00:00

abstract：:The spirochete Leptospira spp. can move in liquid and on a solid surface using two periplasmic flagella (PFs), and its motility is an essential virulence factor for the pathogenic species. Mammals are infected with the spirochete through the wounded dermis, which implies the importance of behaviors on the boundary wit...

journal_title：Scientific reports

authors： Abe K,Kuribayashi T,Takabe K,Nakamura S

更新日期：2020-08-18 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Radeck J,Meyer D,Lautenschläger N,Mascher T

更新日期：2018-03-06 00:00:00

abstract：:Deficits in GABAergic inhibitory neurotransmission are a reliable finding in schizophrenia (SCZ) patients. Previous studies have reported that unaffected first-degree relatives of patients with SCZ demonstrate neurophysiological abnormalities that are intermediate between probands and healthy controls. In this study, ...

journal_title：Scientific reports

authors： Radhu N,Dominguez LG,Greenwood TA,Farzan F,Semeralul MO,Richter MA,Kennedy JL,Blumberger DM,Chen R,Fitzgerald PB,Daskalakis ZJ

更新日期：2017-02-27 00:00:00

abstract：:The growth of epitaxial Si nanowires by a metal-catalyst-free process has been investigated as an alternative to the more common metal-catalyzed vapor-liquid-solid process. The well-aligned Si nanowires are successfully grown on a (111)-oriented Si substrate without any metal catalysts by a thermal treatment using sil...

journal_title：Scientific reports

authors： Ishiyama T,Nakagawa S,Wakamatsu T

更新日期：2016-07-28 00:00:00

abstract：:A novel dinuclear Ir(III) complex 5 was discovered to be specific to G-quadruplex DNA, and was utilized in a label-free G-quadruplex-based detection platform for transcription factor activity. The principle of this assay was demonstrated by using HIF-1α as a model protein. Moreover, this HIF-1α detection assay exhibit...

journal_title：Scientific reports

authors： Lu L,Wang M,Mao Z,Kang TS,Chen XP,Lu JJ,Leung CH,Ma DL

更新日期：2016-03-02 00:00:00

abstract：:Communication between neurons involves presynaptic neurotransmitter release which can be evoked by action potentials or occur spontaneously as a result of stochastic vesicle fusion. The Ca2+-binding double C2 proteins Doc2a and -b were implicated in spontaneous and asynchronous evoked release, but the mechanism remain...

journal_title：Scientific reports

authors： Bourgeois-Jaarsma Q,Verhage M,Groffen AJ

更新日期：2019-10-08 00:00:00

abstract：:The relationship between the cuprate pseudogap (Δ(p)) and superconducting gap (Δ(s)) remains an unsolved mystery. Here, we present a temperature- and doping-dependent tunneling study of submicron Bi(2)Sr(2)CaCu(2)O(8+δ) intrinsic Josephson junctions, which provides a clear evidence that Δ(s) closes at a temperature T(...

journal_title：Scientific reports

authors： Ren JK,Zhu XB,Yu HF,Tian Y,Yang HF,Gu CZ,Wang NL,Ren YF,Zhao SP

更新日期：2012-01-01 00:00:00

abstract：:Our data about pathogenesis of hepatic steatosis after liver transplantation is scarce. This study aimed to investigate the association between serum adipokines and insulin resistance with hepatic steatosis in liver transplant recipients. We investigated the association between insulin resistance, serum adiponectin, i...

journal_title：Scientific reports

authors： Eshraghian A,Nikeghbalian S,Shamsaeefar A,Kazemi K,Fattahi MR,Malek-Hosseini SA

更新日期：2020-07-29 00:00:00

abstract：:Swarming bacteria are an example of a complex, active biological system, where high cell density and super-diffusive cell mobility confer survival advantages to the group as a whole. Previous studies on the dynamics of the swarm have been limited to easily observable regions at the advancing edge of the swarm where ce...

journal_title：Scientific reports

authors： Partridge JD,Ariel G,Schvartz O,Harshey RM,Be'er A

更新日期：2018-10-25 00:00:00

abstract：:Pure iron has been confirmed as a promising biodegradable metal. However, the degradation rate of pure iron should be accelerated to meet the clinical requirements. In this work, two different designs of platinum disc arrays, including sizes of Φ20 μm × S5 μm and Φ4 μm × S4 μm, have been coated on the surface of pure ...

journal_title：Scientific reports

authors： Huang T,Zheng Y

更新日期：2016-04-01 00:00:00

abstract：:The late Ediacaran witnessed an increase in metazoan diversity and ecological complexity, marking the inception of the Cambrian Explosion. To constrain the drivers of this diversification, we combine redox and nutrient data for two shelf transects, with an inventory of biotic diversity and distribution from the Nama G...

journal_title：Scientific reports

authors： Bowyer FT,Shore AJ,Wood RA,Alcott LJ,Thomas AL,Butler IB,Curtis A,Hainanan S,Curtis-Walcott S,Penny AM,Poulton SW

更新日期：2020-02-10 00:00:00

abstract：:To what extent deep-time dispersal limitation shapes present-day biodiversity at broad spatial scales remains elusive. Here, we compiled a continental dataset on the distributions of African lizard species in the reptile subfamily Agaminae (a relatively young, Neogene radiation of agamid lizards which ancestors coloni...

journal_title：Scientific reports

authors： Kissling WD,Blach-Overgaard A,Zwaan RE,Wagner P

更新日期：2016-09-27 00:00:00

abstract：:Sub-gap density of states (DOS) is a key parameter to impact the electrical characteristics of semiconductor materials-based transistors in integrated circuits. Previously, spectroscopy methodologies for DOS extractions include the static methods, temperature dependent spectroscopy and photonic spectroscopy. However, ...

journal_title：Scientific reports

authors： Dai M,Khan K,Zhang S,Jiang K,Zhang X,Wang W,Liang L,Cao H,Wang P,Wang P,Miao L,Qin H,Jiang J,Xue L,Chu J

更新日期：2016-06-14 00:00:00

abstract：:This study was intended to determine the efficacy of nivolumab, we evaluated treatment response with respect to PD-1/PD-L1 SNPs among patients with NSCLC. A total of 50 patients with NSCLC were treated with nivolumab and were also evaluated for PD-1/PD-L1 single nucleotide polymorphisms (SNPs) from plasma DNA. We inve...

journal_title：Scientific reports

authors： Nomizo T,Ozasa H,Tsuji T,Funazo T,Yasuda Y,Yoshida H,Yagi Y,Sakamori Y,Nagai H,Hirai T,Kim YH

更新日期：2017-03-23 00:00:00

abstract：:A novel eco-friendly procedure was developed to produce safer, stable and highly pure zinc oxide nanoparticles (ZnO NPs) using microalgae Chlorella extract. The ZnO NPs were synthesized simply using zinc nitrate and microalgae Chlorella extract which conducted at ambient conditions. In this recipe, microalgae Chlorell...

journal_title：Scientific reports

authors： Khalafi T,Buazar F,Ghanemi K

更新日期：2019-05-03 00:00:00

abstract：:Endothelial plasticity enables the cells to switch their phenotype according to the surrounding vascular microenvironment. MicroRNAs (miRNAs) are small noncoding RNAs that control endothelial plasticity. The objective of this study was to investigate the differences in miRNA profiles of tissue-derived cells and cultur...

journal_title：Scientific reports

authors： Kuosmanen SM,Kansanen E,Sihvola V,Levonen AL

更新日期：2017-09-08 00:00:00

abstract：:Ice-albedo feedback due to the albedo contrast between water and ice is a major factor in seasonal sea ice retreat, and has received increasing attention with the Arctic Ocean shifting to a seasonal ice cover. However, quantitative evaluation of such feedbacks is still insufficient. Here we provide quantitative eviden...

journal_title：Scientific reports

authors： Kashiwase H,Ohshima KI,Nihashi S,Eicken H

更新日期：2017-08-15 00:00:00

abstract：:The precise manner in which physical changes to the breast cancer susceptibility protein (BRCA1) affect its role in DNA repair events remain unclear. Indeed, cancer cells harboring mutations in BRCA1 suffer from genomic instability and increased DNA lesions. Here, we used a combination of molecular imaging and biochem...

journal_title：Scientific reports

authors： Gilmore BL,Liang Y,Winton CE,Patel K,Karageorge V,Varano AC,Dearnaley W,Sheng Z,Kelly DF

更新日期：2017-03-06 00:00:00

abstract：:Metastable ω phase is common in body-centred cubic (bcc) metals and alloys, including high-alloying steels. Recent theoretical calculations also suggest that the ω structure may act as an intermediate phase for face-centred cubic (fcc)-to-bcc transformation. Thus far, the role of the ω phase played in fcc-bcc martensi...

journal_title：Scientific reports

authors： Liu T,Zhang D,Liu Q,Zheng Y,Su Y,Zhao X,Yin J,Song M,Ping D

更新日期：2015-10-27 00:00:00

abstract：:Moderate alcohol consumption is generally associated with reduced risk of type 2 diabetes. However, this beneficial effects of alcohol intake remains controversial due to inconsistent results across studies. The analysis was performed using data from the Ansung-Ansan cohort study. We categorized the participants into ...

journal_title：Scientific reports

authors： Lee DY,Yoo MG,Kim HJ,Jang HB,Kim JH,Lee HJ,Park SI

更新日期：2017-08-04 00:00:00

abstract：:Hepatocellular carcinoma is a common type of malignancy with a poor prognosis. Identification and utilisation of markers for monitoring and diagnosis are urgently needed. Alpha-fetoprotein (AFP) and Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) have been proved to be efficient biomarkers for hepatit...

journal_title：Scientific reports

authors： Wang G,Lu X,Du Q,Zhang G,Wang D,Wang Q,Guo X

更新日期：2020-08-11 00:00:00

abstract：:The role of non-bilayer lipids and non-lamellar lipid phases in biological membranes is an enigmatic problem of membrane biology. Non-bilayer lipids are present in large amounts in all membranes; in energy-converting membranes they constitute about half of their total lipid content-yet their functional state is a bila...

journal_title：Scientific reports

authors： Dlouhý O,Kurasová I,Karlický V,Javornik U,Šket P,Petrova NZ,Krumova SB,Plavec J,Ughy B,Špunda V,Garab G

更新日期：2020-07-20 00:00:00

abstract：:In recent decades Madagascar has experienced significant habitat loss and modification, with minimal understanding of how human land use practices have impacted the evolution of its flora and fauna. In light of ongoing and intensifying anthropogenic pressures, we seek new insight into mechanisms driving genetic variab...

journal_title：Scientific reports

authors： Baden AL,Mancini AN,Federman S,Holmes SM,Johnson SE,Kamilar J,Louis EE Jr,Bradley BJ

更新日期：2019-11-07 00:00:00

abstract：:Even after years of experiencing malaria, caused by infection with Plasmodium species, individuals still have incomplete immunity and develop low-density parasitemia on re-infection. Previous studies using the P. chabaudi (Pch) mouse model to understand the reason for chronic malaria, found that mice with a deletion o...

journal_title：Scientific reports

authors： Horne-Debets JM,Karunarathne DS,Faleiro RJ,Poh CM,Renia L,Wykes MN

更新日期：2016-05-24 00:00:00