Abstract：
:Tumour tracking is an advanced radiotherapy technique for precise treatment of tumours subject to organ motion. In this work, we addressed crucial aspects of dose delivery for its realisation in pencil beam scanning proton therapy, exploring the momentum acceptance and global achromaticity of a Gantry beamline to perform continuous energy regulation with a standard upstream degrader. This novel approach is validated on simulation data from three geometric phantoms of increasing complexity and one liver cancer patient using 4D dose calculations. Results from a standard high-to-low beamline ramping scheme were compared to alternative energy meandering schemes including combinations with rescanning. Target coverage and dose conformity were generally well recovered with tumour tracking even though for particularly small targets, large variations are reported for the different approaches. Meandering in energy while rescanning has a positive impact on target homogeneity and similarly, hot spots outside the targets are mitigated with a relatively fast convergence rate for most tracking scenarios, halving the volume of hot spots after as little as 3 rescans. This work investigates the yet unexplored potential of having a large momentum acceptance in medical beam line, and provides an alternative to take tumour tracking with particle therapy closer to clinical translation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fattori G,Zhang Y,Meer D,Weber DC,Lomax AJ,Safai Sdoi
10.1038/s41598-020-71821-1subject
Has Abstractpub_date
2020-09-18 00:00:00pages
15325issue
1issn
2045-2322pii
10.1038/s41598-020-71821-1journal_volume
10pub_type
杂志文章abstract：:A multi-agent Parrondo's model based on complex networks is used in the current study. For Parrondo's game A, the individual interaction can be categorized into five types of behavioral patterns: the Matthew effect, harmony, cooperation, poor-competition-rich-cooperation and a random mode. The parameter space of Parro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37028
更新日期：2016-11-15 00:00:00
abstract：:The increased prevalence of childhood obesity is expected to translate in the near future into a concomitant soaring of multiple cardio-metabolic diseases. Obesity has a complex, multifactorial etiology, that includes multiple and multidomain potential risk factors: genetics, dietary and physical activity habits, soci...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81205-8
更新日期：2021-01-21 00:00:00
abstract：:Various folk remedies employ certain odorous compounds with analgesic effects. In fact, linalool, a monoterpene alcohol found in lavender extracts, has been found to attenuate pain responses via subcutaneous, intraperitoneal, intrathecal, and oral administration. However, the analgesic effects of odorous compounds med...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37129
更新日期：2016-11-15 00:00:00
abstract：:Gelatin-coupled cellulose (GCC) microgel with whisker-like structure is prepared and used to incorporate into casein (CA) matrix to construct reinforced CA-based composite films by solution casting. The GCC microgel has excellent dispersibility and stability in water, which contributes to the hydrophobicity and signif...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37848-1
更新日期：2019-02-04 00:00:00
abstract：:The leaf venation architecture is an ideal, highly structured and efficient irrigation system in plant leaves. Leaf vein density (LVD) and vein thickness are the two major properties of this system. Leaf laminae carry out photosynthesis to harvest the maximum biological yield. It is still unknown whether the LVD and/o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36894
更新日期：2016-11-16 00:00:00
abstract：:The ability to reprogram adult somatic cells into induced pluripotent stem cells (iPSCs) and the subsequent development of protocols for their differentiation into disease-relevant cell types have enabled in-depth molecular analyses of multiple disease states as hitherto impossible. Neurons differentiated from patient...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28420
更新日期：2016-06-24 00:00:00
abstract：:Although various surgical procedures have been developed for chronic rotator cuff tear repair, the re-tear rate remains high with severe fat infiltration. However, little is known about the molecular regulation of this process. Mesenchymal stem cells (MSCs) in the intra-muscular space are origin of ectopic fat cells i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28023-7
更新日期：2018-06-25 00:00:00
abstract：:Inflammatory and metabolic diseases can originate during early-life and have been correlated with shifts in intestinal microbial ecology. Here we demonstrate that minor environmental fluctuations during the early neonatal period had sustained effects on the developing porcine microbiota and host-microbe interface. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05689-z
更新日期：2017-07-13 00:00:00
abstract：:Goldlined spinefoot, Siganus guttatus, inhabits tropical and subtropical waters and synchronizes its spawning around the first quarter moon likely using an hourglass-like lunar timer. In previous studies, we have found that clock genes (Cryptochrome3 and Period1) could play the role of state variable in the diencephal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24538-1
更新日期：2018-04-18 00:00:00
abstract：:A versatile method based on Raman microscopy was developed to follow the degradation of iron carboxylate Metal Organic Framework (MOF) nano- or micro-particles in simulated body fluid (phosphate buffer). The analysis of both the morphology and chemical composition of individual particles, including observation at diff...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13323-1
更新日期：2017-10-13 00:00:00
abstract：:The psychrophilic (cold-loving) fungus Pseudogymnoascus destructans was discovered more than a decade ago to be the pathogen responsible for white-nose syndrome, an emerging disease of North American bats causing unprecedented population declines. The same species of fungus is found in Europe but without associated mo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70375-6
更新日期：2020-08-17 00:00:00
abstract：:The phase diagrams of continuous binary nanoalloys are important in providing guidance for material designs and industrial applications. However, experimental determination of the nano-phase diagram is scarce since calorimetric measurements remain quite challenging at the nanoscale. Based on the size-dependent cohesiv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41990
更新日期：2017-02-07 00:00:00
abstract：:The current flowing through a Mott spin junction depends on the relative spin orientation of the two ferromagnetic layers comprising the "source" and "drain" sides of the junction. The resulting current asymmetry is detected as giant or tunnelling magnetoresistance depending on whether the two ferromagnets are separat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13453-6
更新日期：2017-10-16 00:00:00
abstract：:A five-year swine manure application trial and a study of nitrate leaching losses have been conducted. There were three treatments: traditional without manure (CK), traditional matched manure 4500 kg ha-2 (T1) and traditional matched manure 9000 kg ha-2 (T2). Nitrate nitrogen leaching losses at the 30-, 60-, and 90-cm...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12953-9
更新日期：2017-10-20 00:00:00
abstract：:In this work, cerium-diethyldithiocarbamate (Ce-DEDTC) complex was synthesized as a novel anti-corrosion pigment. The structure of the synthesized pigment was characterized by employing Fourier transfer infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, inductively coupled plasma optical emission sp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61946-8
更新日期：2020-03-19 00:00:00
abstract：:Trophic variation in food web structure occurs among and within ecosystems. The magnitude of variation, however, differs from system to system. In ephemeral pond ecosystems, temporal dynamics are relatively more important than in many systems given that hydroperiod is the ultimate factor determining the presence of an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08026-6
更新日期：2017-08-08 00:00:00
abstract：:Stress variation induced bandgap tuning and surface wettability switching of spinel nickel ferrite (NiFe2O4, NFO) films were demonstrated and directly driven by phase transition via a post-annealing process. Firstly, the as-deposited NFO films showed hydrophilic surface with water contact angle (CA) value of 80 ± 1°. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19319-9
更新日期：2018-01-22 00:00:00
abstract：:Bone fracture repair is a multifaceted, coordinated physiological process that requires new bone formation and resorption, eventually returning the fractured bone to its original state. Currently, a variety of different approaches are pursued to accelerate the repair of defective bones, which include the use of 'gold ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67886-7
更新日期：2020-07-14 00:00:00
abstract：:This study aims to determine the prevalence of health personnel with normal weight central obesity and to investigate whether this group had higher cardiovascular disease (CVD) risk factors than those of the people with normal weight and without central obesity. A waist-to-height ratio was calculated as waist circumfe...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep37100
更新日期：2016-11-16 00:00:00
abstract：:Room-temperature ferromagnetism in Mn-doped chalcopyrites is a desire aspect when applying those materials to spin electronics. However, dominance of high Curie-temperatures due to cluster formation or inhomogeneities limited their consideration. Here we report how an external perturbation such as applied hydrostatic ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07720
更新日期：2015-01-12 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide. The use of alpha fetoprotein (AFP) alone was not an accurate biomarker for HCC despite its high specificity. Therefore, we assessed the possible role of serum biomarkers that have been mentioned briefly in previous studie...
journal_title：Scientific reports
pub_type： 杂志文章,评审
doi：10.1038/s41598-020-62051-6
更新日期：2020-03-20 00:00:00
abstract：:Thin layers of silicon nanocrystals (SiNC) in oxide matrix with optimized parameters are fabricated by the plasma-enhanced chemical vapor deposition. These materials with SiNC sizes of about 4.5 nm and the SiO2 barrier thickness of 3 nm reveal external quantum yield (QY) close to 50% which is near to the best chemical...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47825-x
更新日期：2019-08-02 00:00:00
abstract：:Semen fertilizing potential is dependent upon the morphological, functional and molecular attributes of sperm. Sperm microRNAs (miRNAs) were recently shown to hold promise regarding their association with different fertility phenotypes. However, their role in fertility regulation remains to be determined. We postulate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46775-8
更新日期：2019-07-17 00:00:00
abstract：:Little is known of how fungal distribution ranges vary with elevation. We studied fungal diversity and community composition from 740 to 2940 m above sea level on Mt. Norikura, Japan, sequencing the ITS2 region. There was a clear trend, repeated across each of the fungal phyla (Basidiomycota, Ascomycota, Zygomycota, C...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43025-9
更新日期：2019-04-25 00:00:00
abstract：:A neurogenic pathway, involving airway TRPV-1, has been implicated in acute cardiovascular events occurring after peaks of air pollution. We tested whether inhaled prostaglandin-E2 (PGE2) and bradykinin (BK) regulate TRPV-1 activity in vivo by changing cough response to capsaicin (CPS) and affecting heart rate variabi...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-72062-y
更新日期：2020-09-16 00:00:00
abstract：:Invasive plant species often form dense mono-dominant stands in areas they have invaded, while having only sparse distribution in their native ranges, and the reasons behind this phenomenon are a key point of research in invasive species biology. Differences in species composition between native and invasive ranges ma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16376-4
更新日期：2017-11-22 00:00:00
abstract：:Small amphipods (Halice sp. MT-2017) with body length <1 cm were collected from the Challenger Deep (~10,920 m below sea level). The divergence time of their lineage was approximately 109 Mya, making this group ancient compared to others under study. The mitochondrial genome of Halice sp. shared the usual gene compone...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38735-z
更新日期：2019-02-22 00:00:00
abstract：:Knowing when, where, and how seizures are initiated in large-scale epileptic brain networks remains a widely unsolved problem. Seizure precursors - changes in brain dynamics predictive of an impending seizure - can now be identified well ahead of clinical manifestations, but either the seizure onset zone or remote bra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47092-w
更新日期：2019-07-23 00:00:00
abstract：:The Great East Japan Earthquake on 11 March 2011, caused the release of radioactive materials from the Fukushima Daiichi Nuclear Power Plant (FDNPP), contaminating eastern Japan, particularly in part of Fukushima Prefecture. In 2012 and 2014, the radiocaesium concentration in brown rice did not exceed regulatory level...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20386
更新日期：2016-02-04 00:00:00
abstract：:Multi-junction solar cells made by assembling semiconductor materials with different bandgap energies have hold the record conversion efficiencies for many years and are currently approaching 50%. Theoretical efficiency limits make use of optimum designs with the right lattice constant-bandgap energy combination, whic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04321-4
更新日期：2017-06-21 00:00:00
