Abstract：
:A versatile method based on Raman microscopy was developed to follow the degradation of iron carboxylate Metal Organic Framework (MOF) nano- or micro-particles in simulated body fluid (phosphate buffer). The analysis of both the morphology and chemical composition of individual particles, including observation at different regions on the same particle, evidenced the formation of a sharp erosion front during particle degradation. Interestingly, this front separated an intact non eroded crystalline core from an amorphous shell made of an inorganic network. According to Mössbauer spectrometry investigations, the shell consists essentially of iron phosphates. Noteworthy, neither drug loading nor surface modification affected the integrity of the tridimensional MOF network. These findings could be of interest in the further development of next generations of MOF drug carriers.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Li X,Lachmanski L,Safi S,Sene S,Serre C,Grenèche JM,Zhang J,Gref Rdoi
10.1038/s41598-017-13323-1subject
Has Abstractpub_date
2017-10-13 00:00:00pages
13142issue
1issn
2045-2322pii
10.1038/s41598-017-13323-1journal_volume
7pub_type
杂志文章abstract：:Hepatic fibrosis is caused by exaggerated wound healing response to chronic injury, which eventually leads to hepatic cirrhosis. Differentiation of hepatic stellate cells (HSCs) to myofibroblast-like cells by inflammatory cytokines is the critical step in fibrosis. This step is accompanied by enlargement of the endopl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08703-6
更新日期：2017-08-11 00:00:00
abstract：:Anxiety and depression are commonly found in patients with diabetes, but little is known about how the anxiety and depression symptoms of diabetes patients and the health-related quality of life (HRQoL) over time influence each other. Therefore, we conducted a survey among patients with diabetes (T1) and repeated the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57647-x
更新日期：2020-05-20 00:00:00
abstract：:A bioresorbable metallic helical stent was explored as a new device opportunity (magnesium scaffold), which can be absorbed by the body without leaving a trace and simultaneously allowing restoration of vasoreactivity with the potential for vessel remodeling. In this study, developed Mg-based helical stent was inserte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01214-4
更新日期：2017-04-26 00:00:00
abstract：:Microalgal harvesting and dewatering are the main bottlenecks that need to be overcome to tap the potential of microalgae for production of valuable compounds. Water surface-floating microalgae form robust biofilms, float on the water surface along with gas bubbles entrapped under the biofilms, and have great potentia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47612-8
更新日期：2019-08-01 00:00:00
abstract：:Visualization of the surgically operated tissues is vital to improve surgical model animals including mouse. Urological surgeries for urethra include series of fine manipulations to treat the increasing number of birth defects such as hypospadias. Hence visualization of the urethral status is vital. Inappropriate uret...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75184-5
更新日期：2020-10-26 00:00:00
abstract：:Anticarsia gemmatalis (velvetbean caterpillar) and Chrysodeixis includens (soybean looper) are two important defoliation pests of soybeans. In the present study, we have investigated the susceptibility and brush border membrane-binding properties of both species to Bacillus thuringiensis Cry1Ea toxin. Bioassays perfor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54850-3
更新日期：2019-12-03 00:00:00
abstract：:Online financial markets can be represented as complex systems where trading dynamics can be captured and characterized at different resolutions and time scales. In this work, we develop a methodology based on non-negative tensor factorization (NTF) aimed at extracting and revealing the multi-timescale trading dynamic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29537-w
更新日期：2018-07-25 00:00:00
abstract：:We evaluated changes in incidence, relative survival (RS), and conditional survival (CS) of head and neck squamous cell carcinoma (HNSCC), focusing on oral tongue squamous cell carcinoma (OTSCC). Data of 74 680 HNSCC patients from 1976 to 2015 were obtained from the Surveillance, Epidemiology, and End Results database...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64748-0
更新日期：2020-05-12 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-67129-9
更新日期：2020-06-17 00:00:00
abstract：:The temporal correspondence between two arbitrarily chosen pairs of alternating features can generally be reported for rates up to 3-4 Hz. This limit is however surpassed for specialised visual mechanisms that encode conjunctions of features. Here we show that this 3-4 Hz limit is exceeded for eye gaze and eyebrow pai...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27242-2
更新日期：2018-06-13 00:00:00
abstract：:Aortic stenosis (AS) is the most common form of valve disease. Once symptoms develop, there is an inexorable deterioration with a poor prognosis; currently there are no therapies capable of modifying disease progression, and aortic valve replacement is the only available treatment. Our goal is to study the progression...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27106
更新日期：2016-06-03 00:00:00
abstract：:High quality cadmium-free Zn-In-S:Ag doped-nanocrystals (d-NCs) were synthesized via a simple one-step noninjection route using silver nitrate, indium acetate, zinc acetate, oleylamine, S powder and 1-dodecanethiol as starting materials in an organic phase. The size and optical properties can be effectively tailored b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24459
更新日期：2016-04-14 00:00:00
abstract：:Individuals infected with hepatitis C virus (HCV) are at high risk of developing progressive liver disease, including cirrhosis and hepatocellular carcinoma (HCC). How HCV infection causes liver destruction has been of significant interest for many years, and apoptosis has been proposed as one operative mechanism. In ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37433
更新日期：2016-12-15 00:00:00
abstract：:While molecular-targeted drugs have demonstrated strong therapeutic efficacy against diverse diseases such as cancer and infection, the appearance of drug resistance associated with genetic variations in individual patients or pathogens has severely limited their clinical efficacy. Therefore, precision medicine approa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58877-9
更新日期：2020-02-07 00:00:00
abstract：:Enterococci are nosocomial pathogens that can form biofilms, which contribute to their virulence and antibiotic resistance. Although many genes involved in biofilm formation have been defined, their distribution among enterococci has not been comprehensively studied on a genome scale, and their diagnostic ability to p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05901-0
更新日期：2017-07-18 00:00:00
abstract：:This paper describes an origami-inspired self-folding method to form three-dimensional (3D) microstructures of co-cultured cells. After a confluent monolayer of fibroblasts (NIH/3T3 cells) with loaded hepatocytes (HepG2 cells) was cultured onto two-dimensional (2D) microplates, degradation of the alginate sacrificial ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22598-x
更新日期：2018-03-14 00:00:00
abstract：:In crystalline metals at small scales, the dislocation density will be increased by stochastic events of dislocation network, leading to a universal power law for various material structures. In this work, we develop a model obeyed by a probability distribution of dislocation density to describe the dislocation format...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39242
更新日期：2016-12-15 00:00:00
abstract：:Neurodegenerative processes are preceded by neuronal dysfunction and synaptic disconnection. Disconnection between spinal motoneuron (MN) soma and synaptic target leads either to a retrograde degenerative process or to a regenerative reaction, depending injury proximity among other factors. Distinguished key events as...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09185
更新日期：2015-03-18 00:00:00
abstract：:Although hepatitis B virus (HBV) infection is the leading cause of liver fibrosis (LF), the mechanisms underlying liver fibrotic progression remain unclear. Here, we investigated the gene expression profiles of HBV-related LF patients. Whole genome expression arrays were used to detect gene expression in liver biopsy ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43446
更新日期：2017-03-06 00:00:00
abstract：:Interfacial Dzyaloshinskii-Moriya interaction (IDMI) is important for its roles in stabilizing the skyrmionic lattice as well as soliton-like domain wall motion leading towards new generation spintronic devices. However, achievement and detection of IDMI is often hindered by various spurious effects. Here, we demonstr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32592
更新日期：2016-09-02 00:00:00
abstract：:Only few applications are currently dealing with personalized adverse drug reactions (ADRs) prediction in case of polypharmacy. The study aimed to develop a patient-tailored ADR web application, considering characteristics from 734 drugs and relevant patient related factors. The application was designed in Python usin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66611-8
更新日期：2020-06-12 00:00:00
abstract：:Evidence showed preventive impacts of the highly active antiretroviral therapy (HAART) on the Human Immunodeficiency Virus (HIV) transmission amomg heterosexual population, however, that is of deficit among men who have sex with men (MSM). The aim was to systematically examine the efficacy of HAART on HIV transmission...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-019-56530-8
更新日期：2020-01-23 00:00:00
abstract：:Morphological phylogenies stand in a major conflict with molecular hypotheses regarding the phylogeny of Cryptodira, the most diverse and widely distributed clade of extant turtles. However, molecular hypotheses are often considered a better estimate of phylogeny given that it is more consistent with the stratigraphic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16299
更新日期：2015-11-10 00:00:00
abstract：:TLR4 is implicated in diseases associated with chronic low-grade inflammation, yet homeostatic signaling mechanisms that prevent and/or are affected by chronic TLR4 activation are largely uncharacterized. We recently reported that LPS/TLR4 activates in human leukocytes signaling intermediates (SI), abbreviated TLR4-SI...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43347-8
更新日期：2019-05-07 00:00:00
abstract：:Accurately establishing the state of large-scale quantum systems is an important tool in quantum information science; however, the large number of unknown parameters hinders the rapid characterisation of such states, and reconstruction procedures can become prohibitively time-consuming. Compressive sensing, a procedur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06542
更新日期：2014-10-13 00:00:00
abstract：:From biomarkers to drug carriers, Extracellular Vesicles (EVs) are being used successfully in numerous applications. However, while the subject has been steadily rising in popularity, current methods of isolating EVs are lagging behind, incapable of isolating EVs at a high enough quantity or quality while also requiri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55477-0
更新日期：2019-12-16 00:00:00
abstract：:Tissue damage induces rapid recruitment of leukocytes and changes in the transcriptional landscape that influence wound healing. However, the cell-type specific transcriptional changes that influence leukocyte function and tissue repair have not been well characterized. Here, we employed translating ribosome affinity ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72750-9
更新日期：2020-09-24 00:00:00
abstract：:Asymmetric cell divisions are required for cellular diversity and defects can lead to altered daughter cell fates and numbers. In a genetic screen for C. elegans mutants with defects in dopaminergic head neuron specification or differentiation, we isolated a new allele of the transcription factor HAM-1 [HSN (Hermaphro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04375-4
更新日期：2017-06-28 00:00:00
abstract：:Unimolecular dual agonists for the glucagon-like peptide 1 receptor (GLP1R) and glucagon receptor (GCGR) are emerging as a potential new class of important therapeutics in type 2 diabetes (T2D). Reliable and quantitative assessments of in vivo occupancy on each receptor would improve the understanding of the efficacy ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73815-5
更新日期：2020-10-07 00:00:00
abstract：:Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2) are ligands for Tie2, an endothelial-specific receptor tyrosine kinase that is an essential regulator of angiogenesis. Here we report the identification, via expression cloning, of thrombomodulin (TM) as another receptor for Ang1 and Ang2. Thrombomodulin is an endothelia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18912-8
更新日期：2018-01-11 00:00:00
