Abstract：
:Although hepatitis B virus (HBV) infection is the leading cause of liver fibrosis (LF), the mechanisms underlying liver fibrotic progression remain unclear. Here, we investigated the gene expression profiles of HBV-related LF patients. Whole genome expression arrays were used to detect gene expression in liver biopsy samples from chronically HBV infected patients. Through integrative data analysis, we identified several pathways and key genes involved in the initiation and exacerbation of liver fibrosis. Weight gene co-expression analysis revealed that integrin subunit β-like 1 (ITGBL1) was a key regulator of fibrogenesis. Functional experiments demonstrated that ITGBL1 was an upstream regulator of LF via interactions with transforming growth factor β1. In summary, we investigated the gene expression profiles of HBV-related LF patients and identified a key regulator ITGBL1. Our findings provide a foundation for future studies of gene functions and promote the development of novel antifibrotic therapies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang M,Gong Q,Zhang J,Chen L,Zhang Z,Lu L,Yu D,Han Y,Zhang D,Chen P,Zhang X,Yuan Z,Huang J,Zhang Xdoi
10.1038/srep43446subject
Has Abstractpub_date
2017-03-06 00:00:00pages
43446issn
2045-2322pii
srep43446journal_volume
7pub_type
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