White matter microstructural changes are related to cognitive dysfunction in essential tremor.

Abstract:

:Diffusion tensor imaging (DTI) studies have detected white matter microstructural changes in essential tremor (ET). However, it is still unclear whether these changes are related to cognitive deficits, which have been described in ET patients. DTI-derived fractional anisotropy, mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity measures were compared between 23 ET patients and 23 age-, gender-, and education-matched healthy individuals, using whole-brain tract-based spatial statistics. Correlations of white matter changes with scores obtained from a detailed neuropsychological assessment were subsequently examined. ET patients demonstrated increases in MD in the bilateral posterior corona radiata, bilateral superior longitudinal fasciculus, bilateral fornix (cres)/stria terminalis, genu and splenium of the corpus callosum, bilateral anterior and posterior limbs of internal capsule, bilateral retrolenticular region part of internal capsule, and left posterior thalamic radiation. Except for the genu of the corpus callosum, an increase in AD values was also found in these same tracts. Furthermore, increased MD and AD values in different white matter areas was negatively correlated with performance on language and verbal memory and positively with visuospatial ability. These correlations suggest that white matter changes might be involved in the pathogenesis of cognitive deficits in ET.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Benito-León J,Mato-Abad V,Louis ED,Hernández-Tamames JA,Álvarez-Linera J,Bermejo-Pareja F,Domingo-Santos Á,Collado L,Romero JP

doi

10.1038/s41598-017-02596-1

subject

Has Abstract

pub_date

2017-06-07 00:00:00

pages

2978

issue

1

issn

2045-2322

pii

10.1038/s41598-017-02596-1

journal_volume

7

pub_type

杂志文章
  • Morphology-dependent Electrochemical Enhancements of Porous Carbon as Sensitive Determination Platform for Ascorbic Acid, Dopamine and Uric Acid.

    abstract::Using starch as the carbon precursor and different-sized ZnO naoparticles as the hard template, a series of porous carbon materials for electrochemical sensing were prepared. Experiments of scanning electron microscopy, transmission electron microscopy and Nitrogen adsorption-desorption isotherms reveal that the parti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep22309

    authors: Cheng Q,Ji L,Wu K,Zhang W

    更新日期:2016-02-29 00:00:00

  • Evidence of Cardiovascular Calcification and Fibrosis in Pseudoxanthoma Elasticum Mouse Models Subjected to DOCA-Salt Hypertension.

    abstract::Pseudoxanthoma Elasticum (PXE) is a rare disorder characterized by fragmentation and progressive calcification of elastic fibres in connective tissues. Although arterial hypertension (AHT) has been reported in PXE patients, its impact on pathological manifestations has as yet been unexplored. We investigated the conse...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52808-z

    authors: Omarjee L,Roy C,Leboeuf C,Favre J,Henrion D,Mahe G,Leftheriotis G,Martin L,Janin A,Kauffenstein G

    更新日期:2019-11-08 00:00:00

  • Numerical analysis of wide-field optical imaging with a sub-20 nm resolution based on a meta-sandwich structure.

    abstract::Biological research requires wide-field optical imaging techniques with resolution down to the nanometer scale to study the biological process in a sub-cell or single molecular level. To meet this requirement, wide-field structured illumination method (WFSIM) has been extensively studied. The resolution of WFSIM is de...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01521-w

    authors: Cao S,Wang T,Yang J,Hu B,Levy U,Yu W

    更新日期:2017-05-02 00:00:00

  • On the molecular and cellular effects of omeprazole to further support its effectiveness as an antigiardial drug.

    abstract::Research on Giardia lamblia has accumulated large information about its molecular cell biology and infection biology. However, giardiasis is still one of the commonest parasitic diarrheal diseases affecting humans. Additionally, an alarming increase in cases refractory to conventional treatment has been reported in lo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45529-w

    authors: López-Velázquez G,Fernández-Lainez C,de la Mora-de la Mora JI,Caudillo de la Portilla D,Reynoso-Robles R,González-Maciel A,Ridaura C,García-Torres I,Gutiérrez-Castrellón P,Olivos-García A,Flores-López LA,Enríquez-Flores S

    更新日期:2019-06-20 00:00:00

  • Volcanic glass properties from 1459 C.E. volcanic event in South Pole ice core dismiss Kuwae caldera as a potential source.

    abstract::A large volcanic sulfate increase observed in ice core records around 1450 C.E. has been attributed in previous studies to a volcanic eruption from the submarine Kuwae caldera in Vanuatu. Both EPMA-WDS (electron microprobe analysis using a wavelength dispersive spectrometer) and SEM-EDS (scanning electron microscopy a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50939-x

    authors: Hartman LH,Kurbatov AV,Winski DA,Cruz-Uribe AM,Davies SM,Dunbar NW,Iverson NA,Aydin M,Fegyveresi JM,Ferris DG,Fudge TJ,Osterberg EC,Hargreaves GM,Yates MG

    更新日期:2019-10-08 00:00:00

  • Spectroscopic observation of oxygen dissociation on nitrogen-doped graphene.

    abstract::Carbon nanomaterials' reactivity towards oxygen is very poor, limiting their potential applications. However, nitrogen doping is an established way to introduce active sites that facilitate interaction with gases. This boosts the materials' reactivity for bio-/gas sensing and enhances their catalytic performance for t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08651-1

    authors: Scardamaglia M,Susi T,Struzzi C,Snyders R,Di Santo G,Petaccia L,Bittencourt C

    更新日期:2017-08-11 00:00:00

  • Probing of carotenoid-tryptophan hydrogen bonding dynamics in the single-tryptophan photoactive Orange Carotenoid Protein.

    abstract::The photoactive Orange Carotenoid Protein (OCP) plays a key role in cyanobacterial photoprotection. In OCP, a single non-covalently bound keto-carotenoid molecule acts as a light intensity sensor, while the protein is responsible for forming molecular contacts with the light-harvesting antenna, the fluorescence of whi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68463-8

    authors: Maksimov EG,Protasova EA,Tsoraev GV,Yaroshevich IA,Maydykovskiy AI,Shirshin EA,Gostev TS,Jelzow A,Moldenhauer M,Slonimskiy YB,Sluchanko NN,Friedrich T

    更新日期:2020-07-16 00:00:00

  • Fast response of complementary electrochromic device based on WO3/NiO electrodes.

    abstract::Nanoporous structures have proven as an effective way for enhanced electrochromic performance by providing a large surface area can get fast ion/electron transfer path, leading to larger optical modulation and fast response time. Herein, for the first time, application of vacuum cathodic arc plasma (CAP) deposition te...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65191-x

    authors: Chen PW,Chang CT,Ko TF,Hsu SC,Li KD,Wu JY

    更新日期:2020-05-21 00:00:00

  • Floating photocatalyst of B-N-TiO2/expanded perlite: a sol-gel synthesis with optimized mesoporous and high photocatalytic activity.

    abstract::Optimized mesoporous photocatalyst endowed with high specific surface area and large pore size was synthesized by sol-gel method. These large pore mesoporous materials (33.39 nm) were conducive to the movement of larger molecules or groups in pore path and for effective use of active sites. The high specific surface a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29902

    authors: Xue H,Jiang Y,Yuan K,Yang T,Hou J,Cao C,Feng K,Wang X

    更新日期:2016-07-19 00:00:00

  • Author Correction: A novel perspective on MOL-PCR optimization and MAGPIX analysis of in-house multiplex foodborne pathogens detection assay.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-019-42194-x

    authors: Reslova N,Huvarova V,Hrdy J,Kasny M,Kralik P

    更新日期:2019-04-04 00:00:00

  • The effect of particle properties on the depth profile of buoyant plastics in the ocean.

    abstract::Most studies on buoyant microplastics in the marine environment rely on sea surface sampling. Consequently, microplastic amounts can be underestimated, as turbulence leads to vertical mixing. Models that correct for vertical mixing are based on limited data. In this study we report measurements of the depth profile of...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33882

    authors: Kooi M,Reisser J,Slat B,Ferrari FF,Schmid MS,Cunsolo S,Brambini R,Noble K,Sirks LA,Linders TE,Schoeneich-Argent RI,Koelmans AA

    更新日期:2016-10-10 00:00:00

  • SLIME: robust, high-speed 3D microvascular mapping.

    abstract::Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37313-z

    authors: Liu Y,Broberg MCG,Watanabe M,Rollins AM,Jenkins MW

    更新日期:2019-01-29 00:00:00

  • Ultra-purification of Lipopolysaccharides reveals species-specific signalling bias of TLR4: importance in macrophage function.

    abstract::TLR4 location, and bacterial species-derived lipopolysaccharides, play a significant role in the downstream activation of transcription factors, accessory molecules, and products. Here, this is demonstrated through the use of classically-activated and alternatively-activated macrophages. We show that, when polarized, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79145-w

    authors: Stephens M,Liao S,von der Weid PY

    更新日期:2021-01-14 00:00:00

  • Security of six-state quantum key distribution protocol with threshold detectors.

    abstract::The security of quantum key distribution (QKD) is established by a security proof, and the security proof puts some assumptions on the devices consisting of a QKD system. Among such assumptions, security proofs of the six-state protocol assume the use of photon number resolving (PNR) detector, and as a result the bit ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30044

    authors: Kato G,Tamaki K

    更新日期:2016-07-22 00:00:00

  • Data-driven spectral analysis for coordinative structures in periodic human locomotion.

    abstract::Living organisms dynamically and flexibly operate a great number of components. As one of such redundant control mechanisms, low-dimensional coordinative structures among multiple components have been investigated. However, structures extracted from the conventional statistical dimensionality reduction methods do not ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53187-1

    authors: Fujii K,Takeishi N,Kibushi B,Kouzaki M,Kawahara Y

    更新日期:2019-11-14 00:00:00

  • Evolution of an Enzyme from a Noncatalytic Nucleic Acid Sequence.

    abstract::The mechanism by which enzymes arose from both abiotic and biological worlds remains an unsolved natural mystery. We postulate that an enzyme can emerge from any sequence of any functional polymer under permissive evolutionary conditions. To support this premise, we have arbitrarily chosen a 50-nucleotide DNA fragment...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11405

    authors: Gysbers R,Tram K,Gu J,Li Y

    更新日期:2015-06-19 00:00:00

  • Genetic and Neurobiological Analyses of the Noradrenergic-like System in Vulnerability to Sugar Overconsumption Using a Drosophila Model.

    abstract::Regular overconsumption of sugar is associated with obesity and type-2 diabetes, but how genetic factors contribute to variable sugar preferences and intake levels remains mostly unclear. Here we provide evidence for the usefulness of a Drosophila larva model to investigate genetic influence on vulnerability to sugar ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17760-w

    authors: Branch A,Zhang Y,Shen P

    更新日期:2017-12-15 00:00:00

  • Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A.

    abstract::Hepatitis C virus (HCV) uses components of the very-low-density lipoprotein (VLDL) pathway for assembly/release. We previously reported that hepatocyte nuclear factor 4α (HNF4α) participates in HCV assembly/release through downstream factors those participate in VLDL assembly/secretion. Cell-death-inducing DFFA-like e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27778

    authors: Cai H,Yao W,Li L,Li X,Hu L,Mai R,Peng T

    更新日期:2016-06-10 00:00:00

  • Metabolomic effects of the colonization of Medicago truncatula by the facultative endophyte Arthrobacter agilis UMCV2 in a foliar inoculation system.

    abstract::Biofertilizer production and application for sustainable agriculture is already a reality. The methods for biofertilizers delivery in crop fields are diverse. Although foliar spray is gaining wide acceptance, little is known about the influence that the biochemical features of leaves have on the microbial colonization...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65314-4

    authors: Ramírez-Ordorica A,Valencia-Cantero E,Flores-Cortez I,Carrillo-Rayas MT,Elizarraraz-Anaya MIC,Montero-Vargas J,Winkler R,Macías-Rodríguez L

    更新日期:2020-05-21 00:00:00

  • Clinical Utility of Intraoperative Tympanomastoidectomy Assessment Using a Surgical Microscope Integrated with an Optical Coherence Tomography.

    abstract::Significant technical and optical advances are required for intraoperative optical coherence tomography (OCT) to be utilized during otological surgeries. Integrating OCT with surgical microscopy makes it possible to evaluate soft tissue in real-time and at a high resolution. Herein, we describe an augmented-reality, i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35563-5

    authors: Lee J,Wijesinghe RE,Jeon D,Kim P,Choung YH,Jang JH,Jeon M,Kim J

    更新日期:2018-11-27 00:00:00

  • Differential landscape of non-CpG methylation in embryonic stem cells and neurons caused by DNMT3s.

    abstract::Methylated non-CpGs (mCpH; H means A, C, and T) have emerged as key epigenetic marks in mammalian embryonic stem cells (ESCs) and neurons, regulating cell type-specific functions. In these two cell types, mCpHs show distinct motifs and correlations to transcription that could be a key in understanding the cell type-sp...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-11800-1

    authors: Lee JH,Park SJ,Nakai K

    更新日期:2017-09-12 00:00:00

  • Hierarchically structured activated carbon for ultracapacitors.

    abstract::To resolve the pore-associated bottleneck problem observed in the electrode materials used for ultracapacitors, which inhibits the transport of the electrolyte ions, we designed hierarchically structured activated carbon (HAC) by synthesizing a mesoporous silica template/carbon composite and chemically activating it t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep21182

    authors: Kim MH,Kim KB,Park SM,Roh KC

    更新日期:2016-02-16 00:00:00

  • Recombinant Thrombomodulin Exerts Anti-autophagic Action in Endothelial Cells and Provides Anti-atherosclerosis Effect in Apolipoprotein E Deficient Mice.

    abstract::Stress-induced alteration in endothelial cells (ECs) integrity precedes the development of atherosclerosis. Previous studies showed that the soluble recombinant thrombomodulin (rTM) not only increases ECs proliferation but also exerts anti-apoptotic activity in ECs. However, the functional significance of soluble rTM ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03443-z

    authors: Chen PS,Wang KC,Chao TH,Chung HC,Tseng SY,Luo CY,Shi GY,Wu HL,Li YH

    更新日期:2017-06-12 00:00:00

  • Drivers of Cape Verde archipelagic endemism in keyhole limpets.

    abstract::Oceanic archipelagos are the ideal setting for investigating processes that shape species assemblages. Focusing on keyhole limpets, genera Fissurella and Diodora from Cape Verde Islands, we used an integrative approach combining molecular phylogenetics with ocean transport simulations to infer species distribution pat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41817

    authors: Cunha RL,Assis JM,Madeira C,Seabra R,Lima FP,Lopes EP,Williams ST,Castilho R

    更新日期:2017-02-02 00:00:00

  • Identification and Prediction of Tuberculosis in Eastern China: Analyses from 10-year Population-based Notification Data in Zhejiang Province, China.

    abstract::Tuberculosis, a severe infectious disease caused by the Mycobacterium tuberculosis, arouses huge concerns globally. In this study, a total of 331,594 TB cases in Zhejiang Province were notified during the period of 2009-2018 with the gender ratio of male to female 2.16:1. The notified TB incidences demonstrated a cont...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64387-5

    authors: Liu K,Li T,Vongpradith A,Wang F,Peng Y,Wang W,Chai C,Chen S,Zhang Y,Zhou L,Chen X,Bian Q,Chen B,Wang X,Jiang J

    更新日期:2020-05-04 00:00:00

  • hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells.

    abstract::c-FLIP (cellular FLICE-inhibitory protein) is the pivotal regulator of TRAIL resistance in cancer cells, It is a short-lived protein degraded through the ubiquitin/proteasome pathway. The discovery of factors and mechanisms regulating its protein stability is important for the comprehension of TRAIL resistance by tumo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep22999

    authors: Gao X,Feng J,He Y,Xu F,Fan X,Huang W,Xiong H,Liu Q,Liu W,Liu X,Sun X,He QY,Zhang Q,Liu L

    更新日期:2016-03-14 00:00:00

  • Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection.

    abstract::Peptides derived from the N-terminal heptad repeat (NHR) of HIV-1 gp41 can be potent inhibitors against viral entry when presented in a nonaggregating trimeric coiled-coil conformation via the introduction of exogenous trimerization motifs and intermolecular disulfide bonds. We recently discovered that crosslinking is...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32161

    authors: Wang C,Li X,Yu F,Lu L,Jiang X,Xu X,Wang H,Lai W,Zhang T,Zhang Z,Ye L,Jiang S,Liu K

    更新日期:2016-08-26 00:00:00

  • Enhanced Wave Absorption and Mechanical Properties of Cobalt Sulfide/PVDF Composite Materials.

    abstract::A cobalt sulfide/PVDF(Polyvinylidene Fluoride) composite was prepared by a simple blending method, and the microstructure of the composite was investigated through X-ray diffraction, scanning electron microscopy, and field emission scanning electron microscopy. Increased absorption properties at frequencies ranging fr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47037-3

    authors: Wu Q,Wu J,Wang GS,Zhang HZ,Gao HJ,Shui WJ

    更新日期:2019-07-19 00:00:00

  • Notch signaling facilitates hepatitis B virus covalently closed circular DNA transcription via cAMP response element-binding protein with E3 ubiquitin ligase-modulation.

    abstract::Notch1 is regulated by E3 ubiquitin ligases, with proteasomal degradation of the Notch intracellular domain affecting the transcription of target genes. cAMP response element-binding protein (CREB) mediates the transcription of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA). We assessed the relationsh...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-38139-5

    authors: Wang Z,Kawaguchi K,Honda M,Hashimoto S,Shirasaki T,Okada H,Orita N,Shimakami T,Yamashita T,Sakai Y,Mizukoshi E,Murakami S,Kaneko S

    更新日期:2019-02-07 00:00:00

  • Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue.

    abstract::In comparison to genome-wide association studies (GWAS), there has been poor replication of gene expression studies in chronic obstructive pulmonary disease (COPD). We performed microarray gene expression profiling on a large sample of resected lung tissues from subjects with severe COPD. Comparing 111 COPD cases and ...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1038/srep44232

    authors: Morrow JD,Zhou X,Lao T,Jiang Z,DeMeo DL,Cho MH,Qiu W,Cloonan S,Pinto-Plata V,Celli B,Marchetti N,Criner GJ,Bueno R,Washko GR,Glass K,Quackenbush J,Choi AM,Silverman EK,Hersh CP

    更新日期:2017-03-13 00:00:00