Transferrin-targeted porous silicon nanoparticles reduce glioblastoma cell migration across tight extracellular space.

Abstract:

:Mortality of glioblastoma multiforme (GBM) has not improved over the last two decades despite medical breakthroughs in the treatment of other types of cancers. Nanoparticles hold tremendous promise to overcome the pharmacokinetic challenges and off-target adverse effects. However, an inhibitory effect of nanoparticles by themselves on metastasis has not been explored. In this study, we developed transferrin-conjugated porous silicon nanoparticles (Tf@pSiNP) and studied their effect on inhibiting GBM migration by means of a microfluidic-based migration chip. This platform, designed to mimic the tight extracellular migration tracts in brain parenchyma, allowed high-content time-resolved imaging of cell migration. Tf@pSiNP were colloidally stable, biocompatible, and their uptake into GBM cells was enhanced by receptor-mediated internalisation. The migration of Tf@pSiNP-exposed cells across the confined microchannels was suppressed, but unconfined migration was unaffected. The pSiNP-induced destabilisation of focal adhesions at the leading front may partially explain the migration inhibition. More corroborating evidence suggests that pSiNP uptake reduced the plasticity of GBM cells in reducing cell volume, an effect that proved crucial in facilitating migration across the tight confined tracts. We believe that the inhibitory effect of Tf@pSiNP on cell migration, together with the drug-delivery capability of pSiNP, could potentially offer a disruptive strategy to treat GBM.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Sheykhzadeh S,Luo M,Peng B,White J,Abdalla Y,Tang T,Mäkilä E,Voelcker NH,Tong WY

doi

10.1038/s41598-020-59146-5

subject

Has Abstract

pub_date

2020-02-11 00:00:00

pages

2320

issue

1

issn

2045-2322

pii

10.1038/s41598-020-59146-5

journal_volume

10

pub_type

杂志文章
  • Communicative knowledge pervasively influences sensorimotor computations.

    abstract::Referential pointing is a characteristically human behavior, which involves moving a finger through space to direct an addressee towards a desired mental state. Planning this type of action requires an interface between sensorimotor and conceptual abilities. A simple interface could supplement spatially-guided motor r...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04442-w

    authors: Murillo Oosterwijk A,de Boer M,Stolk A,Hartmann F,Toni I,Verhagen L

    更新日期:2017-06-27 00:00:00

  • Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury.

    abstract::Successful tissue repair requires the activities of myeloid cells such as monocytes and macrophages that guide the progression of inflammation and healing outcome. Immunoregenerative materials leverage the function of endogenous immune cells to orchestrate complex mechanisms of repair; however, a deeper understanding ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00477-1

    authors: Olingy CE,San Emeterio CL,Ogle ME,Krieger JR,Bruce AC,Pfau DD,Jordan BT,Peirce SM,Botchwey EA

    更新日期:2017-03-27 00:00:00

  • Effect of Bacillus subtilis on corrosion behavior of 10MnNiCrCu steel in marine environment.

    abstract::Bacillus widely exists in wet natural environment such as soil, water and air, and is often studied as one of representative microorganisms for microbiologically influenced corrosion(MIC) research. In this paper, the growth curve of Bacillus subtilis isolated from marine environment was determined by turbidimetry and ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62809-y

    authors: Wang YS,Liu L,Fu Q,Sun J,An ZY,Ding R,Li Y,Zhao XD

    更新日期:2020-04-01 00:00:00

  • Gauss's law for networks directly reveals community boundaries.

    abstract::The study of network topology provides insight into the function and behavior of physical, social, and biological systems. A natural step towards discovering the organizing principles of these complex topologies is to identify a reduced network representation using cohesive subgroups or communities. This procedure oft...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-30401-0

    authors: Sinha A,Gleich DF,Ramani K

    更新日期:2018-08-09 00:00:00

  • Role of JAK-STAT signaling in maturation of phagosomes containing Staphylococcus aureus.

    abstract::Phagocytosis is a required mechanism for the defense against pathogens. Staphylococcus aureus, an important bacterial pathogen, can promptly escape from phagosomes and proliferate within the cytoplasm of host. However, the mechanism of phagocytosis against S. aureus has not been intensively investigated. In this study...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14854

    authors: Zhu F,Zhou Y,Jiang C,Zhang X

    更新日期:2015-10-07 00:00:00

  • Analysis of Breast Cancer Patients with T1-2 Tumors and 1-3 Positive Lymph Nodes Treated with or without Postmastectomy Radiation Therapy.

    abstract::The use of postmastectomy radiation therapy (PMRT) has been recommended for patients with 4 or more positive lymph nodes, however, its role in patients with 1-3 positive lymph nodes remains unclear. The purpose of this study is to evaluate oncological outcomes for breast cancer patients with T1-2 tumors and 1-3 positi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66495-8

    authors: Gilmore RC,Sebai ME,Psoter KJ,Prasath V,Siotos C,Broderick KP,Jacobs LK,Harvey SC,Habibi M

    更新日期:2020-06-18 00:00:00

  • Transcriptome and gene expression analysis of DHA producer Aurantiochytrium under low temperature conditions.

    abstract::Aurantiochytrium is a promising docosahexaenoic acid (DHA) production candidate due to its fast growth rate and high proportions of lipid and DHA content. In this study, high-throughput RNA sequencing technology was employed to explore the acclimatization of this DHA producer under cold stress at the transcriptional l...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14446

    authors: Ma Z,Tan Y,Cui G,Feng Y,Cui Q,Song X

    更新日期:2015-09-25 00:00:00

  • Load partitioning between the bcc-iron matrix and NiAl-type precipitates in a ferritic alloy on multiple length scales.

    abstract::An understanding of load sharing among constituent phases aids in designing mechanical properties of multiphase materials. Here we investigate load partitioning between the body-centered-cubic iron matrix and NiAl-type precipitates in a ferritic alloy during uniaxial tensile tests at 364 and 506 °C on multiple length ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep23137

    authors: Sun Z,Song G,Sisneros TA,Clausen B,Pu C,Li L,Gao Y,Liaw PK

    更新日期:2016-03-16 00:00:00

  • Synergetic effect of metal nickel and graphene as a cocatalyst for enhanced photocatalytic hydrogen evolution via dye sensitization.

    abstract::Exploiting new, low-cost and efficient electrocatalysts for hydrogen evolution reaction (HER) is important to resolve the energy crisis and environment pollution. In this work, graphene decorated with Ni nanoparticles (NPs) were synthesized via one-pot reduction using graphene oxide (GO, the obtained composite was den...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10589

    authors: Zhang W,Li Y,Zeng X,Peng S

    更新日期:2015-06-12 00:00:00

  • Population history and ecology, in addition to climate, influence human stature and body proportions.

    abstract::Worldwide variation in human stature and limb proportions is widely accepted to reflect thermal adaptation, but the contribution of population history to this variation is unknown. Furthermore, stature and relative lower limb length (LLL) show substantial plastic responses to environmental stressors, e.g., nutrition, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79501-w

    authors: Pomeroy E,Stock JT,Wells JCK

    更新日期:2021-01-11 00:00:00

  • Effects of Black Raspberries and Their Ellagic Acid and Anthocyanin Constituents on Taxane Chemotherapy of Castration-Resistant Prostate Cancer Cells.

    abstract::Cancer patients often use dietary supplements while on therapy, but little is known about interactions of supplements with cancer chemotherapy. Black raspberries (BRB) have anti-cancer effects, but have not been evaluated for interference with chemotherapy for castrate-resistant prostate cancer (CRPC). Here we studied...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39589-1

    authors: Eskra JN,Schlicht MJ,Bosland MC

    更新日期:2019-03-13 00:00:00

  • Chemical transfer of dissolved organic matter from surface seawater to sea spray water-soluble organic aerosol in the marine atmosphere.

    abstract::It is critical to understand how variations in chemical composition in surface seawater (SSW) affect the chemistry of marine atmospheric aerosols. We investigated the sea-to-air transfer of dissolved organic carbon (DOC) via cruise measurements of both ambient aerosols and SSW in the Oyashio and its coastal regions, t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32864-7

    authors: Miyazaki Y,Yamashita Y,Kawana K,Tachibana E,Kagami S,Mochida M,Suzuki K,Nishioka J

    更新日期:2018-10-05 00:00:00

  • Hyperspectral Imaging for Determining Pigment Contents in Cucumber Leaves in Response to Angular Leaf Spot Disease.

    abstract::Hyperspectral imaging technique was employed to determine spatial distributions of chlorophyll (Chl), and carotenoid (Car) contents in cucumber leaves in response to angular leaf spot (ALS). Altogether, 196 hyperspectral images of cucumber leaves with five infection severities of ALS were captured by a hyperspectral i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27790

    authors: Zhao YR,Li X,Yu KQ,Cheng F,He Y

    更新日期:2016-06-10 00:00:00

  • Author Correction: Giant beaver palaeoecology inferred from stable isotopes.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-61338-y

    authors: Plint T,Longstaffe FJ,Zazula G

    更新日期:2020-03-06 00:00:00

  • Organic carbon budget for the eastern boundary of the North Atlantic subtropical gyre: major role of DOC in mesopelagic respiration.

    abstract::Transports of suspended particulate (POCsusp) and dissolved (DOC) organic carbon are inferred from a box-model covering the eastern boundary of the North Atlantic subtropical gyre. Corresponding net respiration rates (R) are obtained from a net organic carbon budget that is based on the transport estimates, and includ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10974-y

    authors: Santana-Falcón Y,Álvarez-Salgado XA,Pérez-Hernández MD,Hernández-Guerra A,Mason E,Arístegui J

    更新日期:2017-08-31 00:00:00

  • Altered spontaneous calcium signaling of in situ chondrocytes in human osteoarthritic cartilage.

    abstract::Intracellular calcium ([Ca2+]i) signaling is an essential universal secondary messenger in articular chondrocytes. However, little is known about its spatiotemporal features in the context of osteoarthritis (OA). Herein, by examining the cartilage samples collected from patients undergoing knee arthroscopic surgery, w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17172-w

    authors: Gong X,Xie W,Wang B,Gu L,Wang F,Ren X,Chen C,Yang L

    更新日期:2017-12-06 00:00:00

  • Asymmetric air-sea heat flux response and ocean impact to synoptic-scale atmospheric disturbances observed at JKEO and KEO buoys.

    abstract::This study aims to identify patterns of surface heat fluxes, and corresponding surface ocean responses, associated with synoptic-scale atmospheric events and their modulation on seasonal time scales. In particular, northerly and southerly wind events associated with atmospheric disturbances were analyzed using high-te...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-80665-8

    authors: Tomita H,Cronin MF,Ohishi S

    更新日期:2021-01-11 00:00:00

  • The dynamic interplay between acute psychosocial stress, emotion and autobiographical memory.

    abstract::Although acute psychosocial stress can impact autobiographical memory retrieval, the nature of this effect is not entirely clear. One reason for this ambiguity is because stress can have opposing effects on the different stages of autobiographical memory retrieval. We addressed this issue by testing how acute stress a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26890-8

    authors: Sheldon S,Chu S,Nitschke JP,Pruessner JC,Bartz JA

    更新日期:2018-06-06 00:00:00

  • Tidally disrupted stars as a possible origin of both cosmic rays and neutrinos at the highest energies.

    abstract::Tidal Disruption Events (TDEs) are processes where stars are torn apart by the strong gravitational force near to a massive or supermassive black hole. If a jet is launched in such a process, particle acceleration may take place in internal shocks. We demonstrate that jetted TDEs can simultaneously describe the observ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29022-4

    authors: Biehl D,Boncioli D,Lunardini C,Winter W

    更新日期:2018-07-17 00:00:00

  • Detection-dependent six-photon Holland-Burnett state interference.

    abstract::The NOON state, and its experimental approximation the Holland-Burnett state, have important applications in phase sensing measurement with enhanced sensitivity. However, most of the previous Holland-Burnett state interference (HBSI) experiments only investigated the area of the interference pattern in the region imme...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep36914

    authors: Jin RB,Fujiwara M,Shimizu R,Collins RJ,Buller GS,Yamashita T,Miki S,Terai H,Takeoka M,Sasaki M

    更新日期:2016-11-14 00:00:00

  • Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage.

    abstract::In non-growing teeth, such as mouse and human molars, primary odontoblasts are long-lived post-mitotic cells that secrete dentine throughout the life of the tooth. New odontoblast-like cells are only produced in response to a damage or trauma. Little is known about the molecular events that initiate mesenchymal stem c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03145-6

    authors: Babb R,Chandrasekaran D,Carvalho Moreno Neves V,Sharpe PT

    更新日期:2017-06-08 00:00:00

  • A high-resolution history of the South American Monsoon from Last Glacial Maximum to the Holocene.

    abstract::The exact extent, by which the hydrologic cycle in the Neotropics was affected by external forcing during the last deglaciation, remains poorly understood. Here we present a new paleo-rainfall reconstruction based on high-resolution speleothem δ18O records from the core region of the South American Monsoon System (SAM...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44267

    authors: Novello VF,Cruz FW,Vuille M,Stríkis NM,Edwards RL,Cheng H,Emerick S,de Paula MS,Li X,Barreto ES,Karmann I,Santos RV

    更新日期:2017-03-10 00:00:00

  • Low Cost Inkjet Printed Smart Bandage for Wireless Monitoring of Chronic Wounds.

    abstract::Chronic wounds affect millions of patients around the world and their treatment is challenging as the early signs indicating their development are subtle. In addition, a type of chronic wound, known as pressure ulcer, develops in patients with limited mobility. Infection and frequent bleeding are indicators of chronic...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28949

    authors: Farooqui MF,Shamim A

    更新日期:2016-06-29 00:00:00

  • Effects of whole-body cryotherapy on 25-hydroxyvitamin D, irisin, myostatin, and interleukin-6 levels in healthy young men of different fitness levels.

    abstract::Skeletal muscle and adipose tissue play an important role in maintaining metabolic homeostasis and thermogenesis. We aimed to investigate the effects of single and repeated exposure to whole-body cryotherapy in volunteers with different physical fitness levels on 25-hydroxyvitamin D (25(OH)D) and myokines. The study i...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/s41598-020-63002-x

    authors: Śliwicka E,Cisoń T,Straburzyńska-Lupa A,Pilaczyńska-Szcześniak Ł

    更新日期:2020-04-10 00:00:00

  • Oxidative status and metabolic profile in a long-lived bird preparing for extreme endurance migration.

    abstract::The high metabolic activity associated with endurance flights and intense fuelling of migrant birds may produce large quantities of reactive oxygen species, which cause oxidative damage. Yet it remains unknown how long-lived birds prepare for oxidative challenges prior to extreme flights. We combined blood measurement...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-54057-6

    authors: Gutiérrez JS,Sabat P,Castañeda LE,Contreras C,Navarrete L,Peña-Villalobos I,Navedo JG

    更新日期:2019-11-26 00:00:00

  • Author Correction: A comprehensive bioinformatics analysis on multiple Gene Expression Omnibus datasets of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-019-39022-7

    authors: Huang S,Sun C,Hou Y,Tang Y,Zhu Z,Zhang Z,Zhang Y,Wang L,Zhao Q,Chen MG,Guo Z,Wang D,Ju W,Zhou Q,Wu L,He X

    更新日期:2019-05-03 00:00:00

  • Molecular chaperone accumulation as a function of stress evidences adaptation to high hydrostatic pressure in the piezophilic archaeon Thermococcus barophilus.

    abstract::The accumulation of mannosyl-glycerate (MG), the salinity stress response osmolyte of Thermococcales, was investigated as a function of hydrostatic pressure in Thermococcus barophilus strain MP, a hyperthermophilic, piezophilic archaeon isolated from the Snake Pit site (MAR), which grows optimally at 40 MPa. Strain MP...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29483

    authors: Cario A,Jebbar M,Thiel A,Kervarec N,Oger PM

    更新日期:2016-07-05 00:00:00

  • Tuning electronic properties of transition-metal dichalcogenides via defect charge.

    abstract::Defect engineering is a promising route for controlling the electronic properties of monolayer transition-metal dichalcogenide (TMD) materials. Here, we demonstrate that the electronic structure of MoS2 depends sensitively on the defect charge, both its sign and magnitude. In particular, we study shallow bound states ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31941-1

    authors: Aghajanian M,Mostofi AA,Lischner J

    更新日期:2018-09-11 00:00:00

  • Modulation of yellow expression contributes to thermal plasticity of female abdominal pigmentation in Drosophila melanogaster.

    abstract::Phenotypic plasticity describes the ability of a given genotype to produce distinct phenotypes in different environments. We use the temperature sensitivity of abdominal pigmentation in Drosophila melanogaster females as a model to analyse the effect of the environment on development. We reported previously that therm...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43370

    authors: Gibert JM,Mouchel-Vielh E,Peronnet F

    更新日期:2017-02-23 00:00:00

  • Recent pace of change in human impact on the world's ocean.

    abstract::Humans interact with the oceans in diverse and profound ways. The scope, magnitude, footprint and ultimate cumulative impacts of human activities can threaten ocean ecosystems and have changed over time, resulting in new challenges and threats to marine ecosystems. A fundamental gap in understanding how humanity is af...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47201-9

    authors: Halpern BS,Frazier M,Afflerbach J,Lowndes JS,Micheli F,O'Hara C,Scarborough C,Selkoe KA

    更新日期:2019-08-12 00:00:00