Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer.

abstract：:FGF10 is a member of fibroblast growth factors (FGFs). We previously showed that FGF10 protects neuron against oxygen-glucose deprivation injury in vitro; however, the effect of FGF10 in ischemic stroke in vivo is unknown. In the present study, we showed that FGF10 was mainly expressed in neurons but not astrocytes, a...

journal_title：Scientific reports

authors： Li YH,Fu HL,Tian ML,Wang YQ,Chen W,Cai LL,Zhou XH,Yuan HB

更新日期：2016-01-27 00:00:00

abstract：:PC4 is an abundant single-strand DNA binding protein that has been implicated in transcription and DNA repair. Here, we show that PC4 is involved in the cellular DNA damage response. To elucidate the role, we used the DT40 chicken B cell model, which produces clustered DNA lesions at Ig loci via the action of activati...

journal_title：Scientific reports

authors： Caldwell RB,Braselmann H,Schoetz U,Heuer S,Scherthan H,Zitzelsberger H

更新日期：2016-07-04 00:00:00

abstract：:Mandrill (Mandrillus sphinx) is a primate species, which belongs to the Old World monkey (Cercopithecidae) family. It is closely related to human, serving as a model for human health related research. However, the genetic studies on and genomic resources of mandrill are limited, especially in comparison to other prima...

journal_title：Scientific reports

authors： Yin Y,Yang T,Liu H,Huang Z,Zhang Y,Song Y,Wang W,Guang X,Sahu SK,Kristiansen K

更新日期：2020-02-12 00:00:00

abstract：:microRNAs are an abundant class of small non-coding RNAs that control gene expression post-transcriptionally. Importantly, microRNA activity participates in the regulation of cellular processes and is a potentially valuable source of biomarkers in the diagnosis and prognosis of human diseases. Here we introduce miQPCR...

journal_title：Scientific reports

authors： Benes V,Collier P,Kordes C,Stolte J,Rausch T,Muckentaler MU,Häussinger D,Castoldi M

更新日期：2015-06-25 00:00:00

abstract：:Alpha synuclein (α-syn) is a central player in neurodegeneration, but the mechanisms triggering its pathology are not fully understood. Here we found that α-syn is a highly efficient substrate for arginyltransferase ATE1 and is arginylated in vivo by a novel mid-chain mechanism that targets the acidic side chains of E...

journal_title：Scientific reports

authors： Wang J,Han X,Leu NA,Sterling S,Kurosaka S,Fina M,Lee VM,Dong DW,Yates JR 3rd,Kashina A

更新日期：2017-09-12 00:00:00

abstract：:Tumor oxygenation has been correlated with treatment outcome for radiotherapy. In this work, the dependence of tumor oxygenation on tumor vascularity and blood oxygenation was determined quantitatively in a 4D stochastic computational model of head and neck squamous cell carcinoma (HNSCC) tumor growth and angiogenesis...

journal_title：Scientific reports

authors： Forster JC,Douglass MJJ,Harriss-Phillips WM,Bezak E

更新日期：2017-09-08 00:00:00

abstract：:HIV maturation inhibitors are an emerging class of anti-retroviral compounds that inhibit the viral protease-mediated cleavage of the Gag, CA-SP1 (capsid-spacer peptide 1) peptide to mature CA. The first-in-class maturation inhibitor bevirimat (BVM) displayed potent activity against HIV-1 clade B but was ineffective a...

journal_title：Scientific reports

authors： Ghimire D,Timilsina U,Srivastava TP,Gaur R

更新日期：2017-03-02 00:00:00

abstract：:Light's polarisation contains information about its source and interactions, from distant stars to biological samples. Polarimeters can recover this information, but reliance on birefringent or rotating optical elements limits their wavelength range and stability. Here we present a static, single-shot polarimeter base...

journal_title：Scientific reports

authors： Hawley RD,Cork J,Radwell N,Franke-Arnold S

更新日期：2019-02-25 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Beaudry-Richard A,Nadeau-Vallée M,Prairie É,Maurice N,Heckel É,Nezhady M,Pundir S,Madaan A,Boudreault A,Hou X,Quiniou C,Sierra EM,Beaulac A,Lodygensky G,Robertson SA,Keelan J,Adams Waldorf KM,Olson DM,Rivera JC,Lube

更新日期：2020-04-15 00:00:00

abstract：:Waves of any kinds, including sound waves and light waves, can interfere constructively or destructively when they are overlapped, allowing for myriad applications. However, unlike continuous waves of a single frequency, interference of photoacoustic pulses is often overlooked because of their broadband characteristic...

journal_title：Scientific reports

authors： Lee T,Li Q,Guo LJ

更新日期：2016-02-12 00:00:00

abstract：:Preclinical studies show that the dopamine D3 receptor (D3R) is involved in the reinstatement of drug seeking and motivation for drugs of abuse. A D3R gene variant, Ser9Gly (rs6280) has been linked to nicotine dependence, yet the mechanisms underlying its involvement in nicotine dependence is unclear. This study inves...

journal_title：Scientific reports

authors： Chukwueke CC,Kowalczyk WJ,Di Ciano P,Gendy M,Taylor R,Heishman SJ,Le Foll B

更新日期：2020-03-05 00:00:00

abstract：:Two important theories in spatial modelling relate to structural and spatial dependence. Structural dependence refers to environmental state-factor models, where an environmental property is modelled as a function of the states and interactions of environmental predictors, such as climate, parent material or relief. C...

journal_title：Scientific reports

authors： Behrens T,Viscarra Rossel RA

更新日期：2020-10-07 00:00:00

abstract：:Crypt neurons are a third type of olfactory receptor neurons with a highly unusual "one cell type--one receptor" mode of expression, the same receptor being expressed by the entire population of crypt neurons. Attempts to identify the target region(s) of crypt neurons have been inconclusive so far. We report that TrkA...

journal_title：Scientific reports

authors： Ahuja G,Ivandic I,Saltürk M,Oka Y,Nadler W,Korsching SI

更新日期：2013-01-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract of uncertain origin, which includes ulcerative colitis (UC) and Crohn's disease (CD). The composition of gut microbiota may change in IBD affected individuals, but whether dysbiosis is the cause or the consequence of infla...

journal_title：Scientific reports

authors： Santoru ML,Piras C,Murgia A,Palmas V,Camboni T,Liggi S,Ibba I,Lai MA,Orrù S,Blois S,Loizedda AL,Griffin JL,Usai P,Caboni P,Atzori L,Manzin A

更新日期：2017-08-25 00:00:00

abstract：:Autophagy is the major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in the vacuole/lysosome in eukaryotic cells. MoAtg14 in M. oryzae, a hitherto uncharacterized protein, is the highly divergent homolog of the yeast Atg14 and the mammal BARKOR. The MoATG14 deletion muta...

journal_title：Scientific reports

authors： Liu XH,Zhao YH,Zhu XM,Zeng XQ,Huang LY,Dong B,Su ZZ,Wang Y,Lu JP,Lin FC

更新日期：2017-01-09 00:00:00

abstract：:In endometriosis, M2 MΦs are dominant in endometriotic lesions, but the actual role of M2 MΦ is unclear. CD206 positive (+) MΦ is classified in one of M2 type MΦs and are known to produce cytokines and chemokines. In the present study, we used CD206 diphtheria toxin receptor mice, which enable to deplete CD206+ cells ...

journal_title：Scientific reports

authors： Ono Y,Yoshino O,Hiraoka T,Sato E,Furue A,Nawaz A,Hatta H,Fukushi Y,Wada S,Tobe K,Hirota Y,Osuga Y,Unno N,Saito S

更新日期：2021-01-13 00:00:00

abstract：:There are three sex ratio strategies (SRS) in nature-male-biased sex ratio, female-biased sex ratio and, equal sex ratio. It was R. A. Fisher who first explained why most species in nature display a sex ratio of ½. Consequent SRS theories such as Hamilton's local mate competition (LMC) and Clark's local resource compe...

journal_title：Scientific reports

authors： Wang Y,Wang R,Li Y,Sam Ma Z

更新日期：2016-12-23 00:00:00

abstract：:Widely regarded as an imminent threat to our oceans, ocean acidification has been documented in all oceanic basins. Projected changes in seawater chemistry will have catastrophic biotic effects due to ocean acidification hindering biogenic carbonate production, which will in turn lead to substantial changes in marine ...

journal_title：Scientific reports

authors： Fox L,Stukins S,Hill T,Miller CG

更新日期：2020-01-31 00:00:00

abstract：:Some 1,3-diarylureas and 1-((1,4-trans)-4-aryloxycyclohexyl)-3-arylureas (cHAUs) activate heme-regulated kinase causing protein synthesis inhibition via phosphorylation of the eukaryotic translation initiation factor 2 (eIF2) in mammalian cancer cells. To evaluate if these agents have potential to inhibit trypanosome ...

journal_title：Scientific reports

authors： Machado FC,Franco CH,Dos Santos Neto JV,Dias-Teixeira KL,Moraes CB,Lopes UG,Aktas BH,Schenkman S

更新日期：2018-03-20 00:00:00

abstract：:In this work, we present a novel ascorbic acid (AA) sensor applied to the detection of AA in human sera and pharmaceuticals. A series of Au nanoparticles (NPs) and graphene oxide sheets (Au NP/GO) composites were successfully synthesized by reduction of gold (III) using sodium citrate. Then the Au NP/GO composites wer...

journal_title：Scientific reports

authors： Song J,Xu L,Xing R,Li Q,Zhou C,Liu D,Song H

更新日期：2014-12-17 00:00:00

abstract：:Joubert syndrome (JS) is an inherited ciliopathy characterized by a distinctive cerebellar and brain stem malformation which is known as the "molar tooth sign" on axial brain images, hypotonia, and developmental delay. Approximately 25-30% of patients with JS have kidney disease and many of them progress to end-stage ...

journal_title：Scientific reports

authors： Takagi Y,Miura K,Yabuuchi T,Kaneko N,Ishizuka K,Takei M,Yajima C,Ikeuchi Y,Kobayashi Y,Takizawa T,Hisano M,Tsurusaki Y,Matsumoto N,Hattori M

更新日期：2021-01-11 00:00:00

abstract：:The common variants in lysyl oxidase-like 1 gene (LOXL1) are associated with exfoliation glaucoma (XFG) patients developed through exfoliation syndrome (XFS). However, the risk allele of a variant in LOXL1 has been found to be inverted between Asian and Caucasian populations. Therefore, we newly performed a genome-wid...

journal_title：Scientific reports

authors： Nakano M,Ikeda Y,Tokuda Y,Fuwa M,Ueno M,Imai K,Sato R,Omi N,Adachi H,Kageyama M,Mori K,Kinoshita S,Tashiro K

更新日期：2014-06-18 00:00:00

abstract：:Sepsis induced cardiac dysfunction (SIC) is a severe complication to sepsis which significantly worsens patient outcomes. It is known that bacteria have the capacity to release outer membrane vesicles (OMVs), which are nano-sized bilayered vesicles composed of lipids and proteins, that can induce a fatal inflammatory ...

journal_title：Scientific reports

authors： Svennerholm K,Park KS,Wikström J,Lässer C,Crescitelli R,Shelke GV,Jang SC,Suzuki S,Bandeira E,Olofsson CS,Lötvall J

更新日期：2017-12-12 00:00:00

abstract：:The Salicornia europaea L. (SE) plant is a halophyte that has been widely consumed as a seasoned vegetable, and it has been recently reported to counteract chronic diseases related to oxidative and inflammatory stress. In this study, we performed an initial phytochemical analysis with in vitro biochemical tests and ch...

journal_title：Scientific reports

authors： Karthivashan G,Park SY,Kweon MH,Kim J,Haque ME,Cho DY,Kim IS,Cho EA,Ganesan P,Choi DK

更新日期：2018-05-08 00:00:00

abstract：:The objective of this meta-analysis is to compare hybrid surgery (HS) and cervical discectomy and fusion (ACDF) for multilevel cervical degenerative disc diseases (DDD). Systematic searches of all published studies through March 2015 were identified from Cochrane Library, Medline, PubMed, Embase, ScienceDirect, CNKI, ...

journal_title：Scientific reports

authors： Tian P,Fu X,Li ZJ,Sun XL,Ma XL

更新日期：2015-08-26 00:00:00

abstract：:Human papillomaviruses enter host cells via a clathrin-independent endocytic pathway involving tetraspanin proteins. However, post-endocytic trafficking required for virus capsid disassembly remains unclear. Here we demonstrate that the early trafficking pathway of internalised HPV particles involves tetraspanin CD63,...

journal_title：Scientific reports

authors： Gräßel L,Fast LA,Scheffer KD,Boukhallouk F,Spoden GA,Tenzer S,Boller K,Bago R,Rajesh S,Overduin M,Berditchevski F,Florin L

更新日期：2016-08-31 00:00:00

abstract：:Vortices are essential to angular momentum in quantum systems such as ultracold atomic gases. The existence of quantized vorticity in bosonic systems stimulated the development of the Gross-Pitaevskii mean-field approximation. However, the true dynamics of angular momentum in finite, interacting many-body systems like...

journal_title：Scientific reports

authors： Weiner SE,Tsatsos MC,Cederbaum LS,Lode AU

更新日期：2017-01-16 00:00:00

abstract：:Core-shell refractory plasmonic nanoparticles are used as excellent nanoantennas to improve the efficiency of lead-free perovskite solar cells (PSCs). SiO2 is used as the shell coating due to its high refractive index and low extinction coefficient, enabling the control over the sunlight directivity. An optoelectronic...

journal_title：Scientific reports

authors： Mohsen AA,Zahran M,Habib SED,Allam NK

更新日期：2020-04-21 00:00:00

abstract：:The availabilities of light and soil water resources usually spatially co-vary in natural habitats, and the spatial pattern of such co-variation may affect the benefits of physiological integration between connected ramets of clonal plants. In a greenhouse experiment, we grew connected or disconnected ramet pairs [con...

journal_title：Scientific reports

authors： Wang YJ,Shi XP,Wu XJ,Meng XF,Wang PC,Zhou ZX,Luo FL,Yu FH

更新日期：2016-10-19 00:00:00

abstract：:Silicene is an exciting two-dimensional material that shares many of graphene's electronic properties, but differs in its structural buckling. This buckling allows opening a bandgap in silicene through the application of a perpendicular electric field. Here we show that this buckling also enables highly effective modu...

journal_title：Scientific reports

authors： Al-Dirini F,Hossain FM,Mohammed MA,Nirmalathas A,Skafidas E

更新日期：2015-10-06 00:00:00