Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer.


:Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and platelet count (PC) were shown to be prognostic in several solid malignancies. We analysed 603 R0 resected patients to assess whether NLR, PLR and PC correlate with other well-known prognostic factors and survival of patients with colorectal cancer (CRC). Receiver operating characteristic (ROC) curve analysis was performed to define cut-off values for high and low ratios of these indices. Univariate and multivariate analysis were used to determine the prognostic value of NLR, PLR and PC for overall and cancer-related survival. The distribution of NLR, PLR and PC in CRC patients was compared with 5270 healthy blood donors. The distribution of NLR, PLR and PC was significantly different between CRC patients and controls (all p < 0.05). A significant but heterogeneous association was found between the main CRC prognostic factors and high values of NLR, PLR and PC. Survival appeared to be worse in patients with high NLR with cancers in AJCC/UICC TNM Stages I-IV; nonetheless its prognostic value was not confirmed for cancer-related survival in multivariate analysis. After stratification of patients according to AJCC/UICC TNM stages, high PC value was significantly correlated with overall and cancer-related survival in TNM stage IV patients.


Sci Rep


Scientific reports


Pedrazzani C,Mantovani G,Fernandes E,Bagante F,Luca Salvagno G,Surci N,Campagnaro T,Ruzzenente A,Danese E,Lippi G,Guglielmi A




Has Abstract


2017-05-04 00:00:00












  • Neuron-derived FGF10 ameliorates cerebral ischemia injury via inhibiting NF-κB-dependent neuroinflammation and activating PI3K/Akt survival signaling pathway in mice.

    abstract::FGF10 is a member of fibroblast growth factors (FGFs). We previously showed that FGF10 protects neuron against oxygen-glucose deprivation injury in vitro; however, the effect of FGF10 in ischemic stroke in vivo is unknown. In the present study, we showed that FGF10 was mainly expressed in neurons but not astrocytes, a...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Li YH,Fu HL,Tian ML,Wang YQ,Chen W,Cai LL,Zhou XH,Yuan HB

    更新日期:2016-01-27 00:00:00

  • Positive Cofactor 4 (PC4) is critical for DNA repair pathway re-routing in DT40 cells.

    abstract::PC4 is an abundant single-strand DNA binding protein that has been implicated in transcription and DNA repair. Here, we show that PC4 is involved in the cellular DNA damage response. To elucidate the role, we used the DT40 chicken B cell model, which produces clustered DNA lesions at Ig loci via the action of activati...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Caldwell RB,Braselmann H,Schoetz U,Heuer S,Scherthan H,Zitzelsberger H

    更新日期:2016-07-04 00:00:00

  • The draft genome of mandrill (Mandrillus sphinx): An Old World monkey.

    abstract::Mandrill (Mandrillus sphinx) is a primate species, which belongs to the Old World monkey (Cercopithecidae) family. It is closely related to human, serving as a model for human health related research. However, the genetic studies on and genomic resources of mandrill are limited, especially in comparison to other prima...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yin Y,Yang T,Liu H,Huang Z,Zhang Y,Song Y,Wang W,Guang X,Sahu SK,Kristiansen K

    更新日期:2020-02-12 00:00:00

  • Identification of cytokine-induced modulation of microRNA expression and secretion as measured by a novel microRNA specific qPCR assay.

    abstract::microRNAs are an abundant class of small non-coding RNAs that control gene expression post-transcriptionally. Importantly, microRNA activity participates in the regulation of cellular processes and is a potentially valuable source of biomarkers in the diagnosis and prognosis of human diseases. Here we introduce miQPCR...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Benes V,Collier P,Kordes C,Stolte J,Rausch T,Muckentaler MU,Häussinger D,Castoldi M

    更新日期:2015-06-25 00:00:00

  • Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration.

    abstract::Alpha synuclein (α-syn) is a central player in neurodegeneration, but the mechanisms triggering its pathology are not fully understood. Here we found that α-syn is a highly efficient substrate for arginyltransferase ATE1 and is arginylated in vivo by a novel mid-chain mechanism that targets the acidic side chains of E...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang J,Han X,Leu NA,Sterling S,Kurosaka S,Fina M,Lee VM,Dong DW,Yates JR 3rd,Kashina A

    更新日期:2017-09-12 00:00:00

  • Simulation of head and neck cancer oxygenation and doubling time in a 4D cellular model with angiogenesis.

    abstract::Tumor oxygenation has been correlated with treatment outcome for radiotherapy. In this work, the dependence of tumor oxygenation on tumor vascularity and blood oxygenation was determined quantitatively in a 4D stochastic computational model of head and neck squamous cell carcinoma (HNSCC) tumor growth and angiogenesis...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Forster JC,Douglass MJJ,Harriss-Phillips WM,Bezak E

    更新日期:2017-09-08 00:00:00

  • Insights into the activity of maturation inhibitor PF-46396 on HIV-1 clade C.

    abstract::HIV maturation inhibitors are an emerging class of anti-retroviral compounds that inhibit the viral protease-mediated cleavage of the Gag, CA-SP1 (capsid-spacer peptide 1) peptide to mature CA. The first-in-class maturation inhibitor bevirimat (BVM) displayed potent activity against HIV-1 clade B but was ineffective a...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ghimire D,Timilsina U,Srivastava TP,Gaur R

    更新日期:2017-03-02 00:00:00

  • Passive broadband full Stokes polarimeter using a Fresnel cone.

    abstract::Light's polarisation contains information about its source and interactions, from distant stars to biological samples. Polarimeters can recover this information, but reliance on birefringent or rotating optical elements limits their wavelength range and stability. Here we present a static, single-shot polarimeter base...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Hawley RD,Cork J,Radwell N,Franke-Arnold S

    更新日期:2019-02-25 00:00:00

  • Author Correction: Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误


    authors: Beaudry-Richard A,Nadeau-Vallée M,Prairie É,Maurice N,Heckel É,Nezhady M,Pundir S,Madaan A,Boudreault A,Hou X,Quiniou C,Sierra EM,Beaulac A,Lodygensky G,Robertson SA,Keelan J,Adams Waldorf KM,Olson DM,Rivera JC,Lube

    更新日期:2020-04-15 00:00:00

  • Out-coupling of Longitudinal Photoacoustic Pulses by Mitigating the Phase Cancellation.

    abstract::Waves of any kinds, including sound waves and light waves, can interfere constructively or destructively when they are overlapped, allowing for myriad applications. However, unlike continuous waves of a single frequency, interference of photoacoustic pulses is often overlooked because of their broadband characteristic...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lee T,Li Q,Guo LJ

    更新日期:2016-02-12 00:00:00

  • Exploring the role of the Ser9Gly (rs6280) Dopamine D3 receptor polymorphism in nicotine reinforcement and cue-elicited craving.

    abstract::Preclinical studies show that the dopamine D3 receptor (D3R) is involved in the reinstatement of drug seeking and motivation for drugs of abuse. A D3R gene variant, Ser9Gly (rs6280) has been linked to nicotine dependence, yet the mechanisms underlying its involvement in nicotine dependence is unclear. This study inves...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Chukwueke CC,Kowalczyk WJ,Di Ciano P,Gendy M,Taylor R,Heishman SJ,Le Foll B

    更新日期:2020-03-05 00:00:00

  • On the interpretability of predictors in spatial data science: the information horizon.

    abstract::Two important theories in spatial modelling relate to structural and spatial dependence. Structural dependence refers to environmental state-factor models, where an environmental property is modelled as a function of the states and interactions of environmental predictors, such as climate, parent material or relief. C...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Behrens T,Viscarra Rossel RA

    更新日期:2020-10-07 00:00:00

  • Zebrafish crypt neurons project to a single, identified mediodorsal glomerulus.

    abstract::Crypt neurons are a third type of olfactory receptor neurons with a highly unusual "one cell type--one receptor" mode of expression, the same receptor being expressed by the entire population of crypt neurons. Attempts to identify the target region(s) of crypt neurons have been inconclusive so far. We report that TrkA...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ahuja G,Ivandic I,Saltürk M,Oka Y,Nadler W,Korsching SI

    更新日期:2013-01-01 00:00:00

  • Cross sectional evaluation of the gut-microbiome metabolome axis in an Italian cohort of IBD patients.

    abstract::Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract of uncertain origin, which includes ulcerative colitis (UC) and Crohn's disease (CD). The composition of gut microbiota may change in IBD affected individuals, but whether dysbiosis is the cause or the consequence of infla...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Santoru ML,Piras C,Murgia A,Palmas V,Camboni T,Liggi S,Ibba I,Lai MA,Orrù S,Blois S,Loizedda AL,Griffin JL,Usai P,Caboni P,Atzori L,Manzin A

    更新日期:2017-08-25 00:00:00

  • Autophagy-related protein MoAtg14 is involved in differentiation, development and pathogenicity in the rice blast fungus Magnaporthe oryzae.

    abstract::Autophagy is the major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in the vacuole/lysosome in eukaryotic cells. MoAtg14 in M. oryzae, a hitherto uncharacterized protein, is the highly divergent homolog of the yeast Atg14 and the mammal BARKOR. The MoATG14 deletion muta...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Liu XH,Zhao YH,Zhu XM,Zeng XQ,Huang LY,Dong B,Su ZZ,Wang Y,Lu JP,Lin FC

    更新日期:2017-01-09 00:00:00

  • CD206+ macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model.

    abstract::In endometriosis, M2 MΦs are dominant in endometriotic lesions, but the actual role of M2 MΦ is unclear. CD206 positive (+) MΦ is classified in one of M2 type MΦs and are known to produce cytokines and chemokines. In the present study, we used CD206 diphtheria toxin receptor mice, which enable to deplete CD206+ cells ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ono Y,Yoshino O,Hiraoka T,Sato E,Furue A,Nawaz A,Hatta H,Fukushi Y,Wada S,Tobe K,Hirota Y,Osuga Y,Unno N,Saito S

    更新日期:2021-01-13 00:00:00

  • Sex Ratio Elasticity Influences the Selection of Sex Ratio Strategy.

    abstract::There are three sex ratio strategies (SRS) in nature-male-biased sex ratio, female-biased sex ratio and, equal sex ratio. It was R. A. Fisher who first explained why most species in nature display a sex ratio of ½. Consequent SRS theories such as Hamilton's local mate competition (LMC) and Clark's local resource compe...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang Y,Wang R,Li Y,Sam Ma Z

    更新日期:2016-12-23 00:00:00

  • Quantifying the Effect of Anthropogenic Climate Change on Calcifying Plankton.

    abstract::Widely regarded as an imminent threat to our oceans, ocean acidification has been documented in all oceanic basins. Projected changes in seawater chemistry will have catastrophic biotic effects due to ocean acidification hindering biogenic carbonate production, which will in turn lead to substantial changes in marine ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Fox L,Stukins S,Hill T,Miller CG

    更新日期:2020-01-31 00:00:00

  • Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation.

    abstract::Some 1,3-diarylureas and 1-((1,4-trans)-4-aryloxycyclohexyl)-3-arylureas (cHAUs) activate heme-regulated kinase causing protein synthesis inhibition via phosphorylation of the eukaryotic translation initiation factor 2 (eIF2) in mammalian cancer cells. To evaluate if these agents have potential to inhibit trypanosome ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Machado FC,Franco CH,Dos Santos Neto JV,Dias-Teixeira KL,Moraes CB,Lopes UG,Aktas BH,Schenkman S

    更新日期:2018-03-20 00:00:00

  • Synthesis of Au/graphene oxide composites for selective and sensitive electrochemical detection of ascorbic acid.

    abstract::In this work, we present a novel ascorbic acid (AA) sensor applied to the detection of AA in human sera and pharmaceuticals. A series of Au nanoparticles (NPs) and graphene oxide sheets (Au NP/GO) composites were successfully synthesized by reduction of gold (III) using sodium citrate. Then the Au NP/GO composites wer...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Song J,Xu L,Xing R,Li Q,Zhou C,Liu D,Song H

    更新日期:2014-12-17 00:00:00

  • Any modality of renal replacement therapy can be a treatment option for Joubert syndrome.

    abstract::Joubert syndrome (JS) is an inherited ciliopathy characterized by a distinctive cerebellar and brain stem malformation which is known as the "molar tooth sign" on axial brain images, hypotonia, and developmental delay. Approximately 25-30% of patients with JS have kidney disease and many of them progress to end-stage ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Takagi Y,Miura K,Yabuuchi T,Kaneko N,Ishizuka K,Takei M,Yajima C,Ikeuchi Y,Kobayashi Y,Takizawa T,Hisano M,Tsurusaki Y,Matsumoto N,Hattori M

    更新日期:2021-01-11 00:00:00

  • Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population.

    abstract::The common variants in lysyl oxidase-like 1 gene (LOXL1) are associated with exfoliation glaucoma (XFG) patients developed through exfoliation syndrome (XFS). However, the risk allele of a variant in LOXL1 has been found to be inverted between Asian and Caucasian populations. Therefore, we newly performed a genome-wid...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Nakano M,Ikeda Y,Tokuda Y,Fuwa M,Ueno M,Imai K,Sato R,Omi N,Adachi H,Kageyama M,Mori K,Kinoshita S,Tashiro K

    更新日期:2014-06-18 00:00:00

  • Escherichia coli outer membrane vesicles can contribute to sepsis induced cardiac dysfunction.

    abstract::Sepsis induced cardiac dysfunction (SIC) is a severe complication to sepsis which significantly worsens patient outcomes. It is known that bacteria have the capacity to release outer membrane vesicles (OMVs), which are nano-sized bilayered vesicles composed of lipids and proteins, that can induce a fatal inflammatory ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Svennerholm K,Park KS,Wikström J,Lässer C,Crescitelli R,Shelke GV,Jang SC,Suzuki S,Bandeira E,Olofsson CS,Lötvall J

    更新日期:2017-12-12 00:00:00

  • Ameliorative potential of desalted Salicornia europaea L. extract in multifaceted Alzheimer's-like scopolamine-induced amnesic mice model.

    abstract::The Salicornia europaea L. (SE) plant is a halophyte that has been widely consumed as a seasoned vegetable, and it has been recently reported to counteract chronic diseases related to oxidative and inflammatory stress. In this study, we performed an initial phytochemical analysis with in vitro biochemical tests and ch...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Karthivashan G,Park SY,Kweon MH,Kim J,Haque ME,Cho DY,Kim IS,Cho EA,Ganesan P,Choi DK

    更新日期:2018-05-08 00:00:00

  • Hybrid surgery versus anterior cervical discectomy and fusion for multilevel cervical degenerative disc diseases: a meta-analysis.

    abstract::The objective of this meta-analysis is to compare hybrid surgery (HS) and cervical discectomy and fusion (ACDF) for multilevel cervical degenerative disc diseases (DDD). Systematic searches of all published studies through March 2015 were identified from Cochrane Library, Medline, PubMed, Embase, ScienceDirect, CNKI, ...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析,评审


    authors: Tian P,Fu X,Li ZJ,Sun XL,Ma XL

    更新日期:2015-08-26 00:00:00

  • The CD63-Syntenin-1 Complex Controls Post-Endocytic Trafficking of Oncogenic Human Papillomaviruses.

    abstract::Human papillomaviruses enter host cells via a clathrin-independent endocytic pathway involving tetraspanin proteins. However, post-endocytic trafficking required for virus capsid disassembly remains unclear. Here we demonstrate that the early trafficking pathway of internalised HPV particles involves tetraspanin CD63,...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Gräßel L,Fast LA,Scheffer KD,Boukhallouk F,Spoden GA,Tenzer S,Boller K,Bago R,Rajesh S,Overduin M,Berditchevski F,Florin L

    更新日期:2016-08-31 00:00:00

  • Phantom vortices: hidden angular momentum in ultracold dilute Bose-Einstein condensates.

    abstract::Vortices are essential to angular momentum in quantum systems such as ultracold atomic gases. The existence of quantized vorticity in bosonic systems stimulated the development of the Gross-Pitaevskii mean-field approximation. However, the true dynamics of angular momentum in finite, interacting many-body systems like...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Weiner SE,Tsatsos MC,Cederbaum LS,Lode AU

    更新日期:2017-01-16 00:00:00

  • Refractory plasmonics enabling 20% efficient lead-free perovskite solar cells.

    abstract::Core-shell refractory plasmonic nanoparticles are used as excellent nanoantennas to improve the efficiency of lead-free perovskite solar cells (PSCs). SiO2 is used as the shell coating due to its high refractive index and low extinction coefficient, enabling the control over the sunlight directivity. An optoelectronic...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Mohsen AA,Zahran M,Habib SED,Allam NK

    更新日期:2020-04-21 00:00:00

  • Effects of patch contrast and arrangement on benefits of clonal integration in a rhizomatous clonal plant.

    abstract::The availabilities of light and soil water resources usually spatially co-vary in natural habitats, and the spatial pattern of such co-variation may affect the benefits of physiological integration between connected ramets of clonal plants. In a greenhouse experiment, we grew connected or disconnected ramet pairs [con...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang YJ,Shi XP,Wu XJ,Meng XF,Wang PC,Zhou ZX,Luo FL,Yu FH

    更新日期:2016-10-19 00:00:00

  • Highly Effective Conductance Modulation in Planar Silicene Field Effect Devices Due to Buckling.

    abstract::Silicene is an exciting two-dimensional material that shares many of graphene's electronic properties, but differs in its structural buckling. This buckling allows opening a bandgap in silicene through the application of a perpendicular electric field. Here we show that this buckling also enables highly effective modu...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Al-Dirini F,Hossain FM,Mohammed MA,Nirmalathas A,Skafidas E

    更新日期:2015-10-06 00:00:00